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M. smegmatis MC2 155 MSMEG_2279 (-)

annotation: 3-hydroxyacyl-CoA dehydrogenase type-2
coordinates: 2362387 - 2363154
length: 255

MEIEGKKAVIVGGASGFGRATAEALAKRGATVAVLDRPQSKGQEVADSIGGSFFAVDVTDFDGTEKVLQE
AVDALGGLHIAVTTAGGGIGERTVKKDGPHSLDSFRSTIDLNLIGTFNVSRLAAWHMSKNDPVDAEGEER
GVIINTASIAAFEGQIGQVAYTASKAAIAGMSLTMARDLGSLGIRALAIAPSLFATGLTEGIPDDFAKVL
TKDAAFPKRLGKPDEYARLALAIVENPMLNGQCIRLDGGQRFAPK

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. smegmatis MC2 155 MSMEG_2279 - - 100% (255) 3-hydroxyacyl-CoA dehydrogenase type-2
M. smegmatis MC2 155 MSMEG_5183 - 2e-62 50.58% (257) 3-hydroxyacyl-CoA dehydrogenase
M. smegmatis MC2 155 MSMEG_0216 - 7e-54 42.37% (262) 3-hydroxyacyl-CoA dehydrogenase

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb1176 - 9e-58 47.86% (257) short-chain type dehydrogenase/reductase
M. gilvum PYR-GCK Mflv_4319 - 1e-127 87.84% (255) short-chain dehydrogenase/reductase SDR
M. tuberculosis H37Rv Rv1144 - 9e-58 47.86% (257) short-chain type dehydrogenase/reductase
M. leprae Br4923 MLBr_01807 fabG1 2e-18 29.72% (249) 3-oxoacyl-
M. abscessus ATCC 19977 MAB_0368 - 7e-57 47.71% (262) Short-chain dehydrogenase/reductas
M. marinum M MMAR_1624 - 1e-105 73.33% (255) short-chain type dehydrogenase/reductase
M. avium 104 MAV_3936 - 1e-108 76.47% (255) 3-hydroxyacyl-CoA dehydrogenase type-2
M. thermoresistible (build 8) TH_3183 - 1e-131 91.37% (255) PUTATIVE short-chain dehydrogenase/reductase SDR
M. ulcerans Agy99 MUL_3412 - 1e-105 73.33% (255) short-chain type dehydrogenase/reductase
M. vanbaalenii PYR-1 Mvan_2027 - 1e-129 89.80% (255) short-chain dehydrogenase/reductase SDR

CLUSTAL 2.0.9 multiple sequence alignment


Mb1176|M.bovis_AF2122/97            ----------------MKTKDAVAVVTGGASGLGLATTKRLLDAGAQVVV
Rv1144|M.tuberculosis_H37Rv         ----------------MKTKDAVAVVTGGASGLGLATTKRLLDAGAQVVV
Mflv_4319|M.gilvum_PYR-GCK          ----------------MEIEGKKAIIVGGASGFGRATAEALAKRGATVAV
Mvan_2027|M.vanbaalenii_PYR-1       ----------------MEIEGKKAVVVGGASGFGRATAEALAKRGASVAV
TH_3183|M.thermoresistible__bu      ----------------MEIEGKKAVVVGGASGFGRATAEALAKRGASVAV
MSMEG_2279|M.smegmatis_MC2_155      ----------------MEIEGKKAVIVGGASGFGRATAEALAKRGATVAV
MMAR_1624|M.marinum_M               ----------------MEISGKKAVVIGGASGMGRATAELLAKRGADVAI
MUL_3412|M.ulcerans_Agy99           ----------------MEISGKKAVVIGGASGMGRATAELLAKRGADVAI
MAV_3936|M.avium_104                ----------------MEINGKKAVVVGGASGMGRASAELFAARGADVAI
MAB_0368|M.abscessus_ATCC_1997      ----------------MDINGVSAIVTGGASGLGAATARLLAAQGAKVVI
MLBr_01807|M.leprae_Br4923          MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
                                                        .   :: **  *:* * :. :   *  *.:

Mb1176|M.bovis_AF2122/97            VDLR---GDDVVGGLGDRARFAQADVTDEAAVSNALELA-DSLGPVRVVV
Rv1144|M.tuberculosis_H37Rv         VDLR---GDDVVGGLGDRARFAQADVTDEAAVSNALELA-DSLGPVRVVV
Mflv_4319|M.gilvum_PYR-GCK          LDRPQSKGKEVADQIG--GTFYEVDITDFEGTESVLNKVVEDLGGLHIAV
Mvan_2027|M.vanbaalenii_PYR-1       LDRPQSKGKEVADQIG--GSFFEVDITDFEGTESVLNQAVEALGGLHIAV
TH_3183|M.thermoresistible__bu      LDRPQSKGKEVAEQIG--GSFFDVDVTDFDGTEKVLQQAVDALGGLHIAV
MSMEG_2279|M.smegmatis_MC2_155      LDRPQSKGQEVADSIG--GSFFAVDVTDFDGTEKVLQEAVDALGGLHIAV
MMAR_1624|M.marinum_M               LDREGSDGKSVAEAIG--AAFYPVDVTDFAGTEEILQTAVDRLGGLHVIV
MUL_3412|M.ulcerans_Agy99           LDREGSDGKSVAEAIG--AAFYPVDVTDFAGTEEILQTAVDRLGGLHVIV
MAV_3936|M.avium_104                LDRESSDGKAVAEGIG--AAFYPVDVTDFAGTEETLQSAVDKLGGLHVIV
MAB_0368|M.abscessus_ATCC_1997      ADVQDEKGEALAKELG--GAFVHTDVTSEADGIAAVDAA-KELGPVRVLI
MLBr_01807|M.leprae_Br4923          THRAS---VVPDWFFG-----VECDVTDNDAIGAAFKAVEEHQGPVEVLV
                                     .            :*        *:*.       .. . .  * :.: :

Mb1176|M.bovis_AF2122/97            NCAGTGNAIRVLSRDG----VFPLAAFRKIVDINLVGTFNVLRLGAERIA
Rv1144|M.tuberculosis_H37Rv         NCAGTGNAIRVLSRDG----VFPLAAFRKIVDINLVGTFNVLRLGAERIA
Mflv_4319|M.gilvum_PYR-GCK          TTAGGGIAERTVKKDG----PHSLDSFRKSIDLNLIGTFNISRIAAWHMS
Mvan_2027|M.vanbaalenii_PYR-1       TTAGGGIAERTVKKDG----PHSLESFRKSIDLNLIGTFNISRLAAWHMS
TH_3183|M.thermoresistible__bu      TTAGGGIAERTVKKDG----PHSLESFRQSVDLNLIGTFNISRLAAWHMS
MSMEG_2279|M.smegmatis_MC2_155      TTAGGGIGERTVKKDG----PHSLDSFRSTIDLNLIGTFNVSRLAAWHMS
MMAR_1624|M.marinum_M               TTAGGGIAKRTLTKSG----PHDLESFRSVVDLNLIATFNISRLAAAHMA
MUL_3412|M.ulcerans_Agy99           TTAGGGIAKRTLTKSG----PHDLESFRSVVDLNLIATFNISRLAAAHMA
MAV_3936|M.avium_104                TTAGGGIAKRTLTKNG----PHDLESFQSVIDLNLIATFNISRLAAAHMA
MAB_0368|M.abscessus_ATCC_1997      NCAGVGWPGRTIGKDGQYASAHSLDIFSKVIGINLIGSFNLIRLAATAIS
MLBr_01807|M.leprae_Br4923          ANAGITSDMLIMRMSE--------EQFQKVIDVNLTGVFRVAKLASRNMI
                                      **       :  .           * . :.:** . *.: ::.:  : 

Mb1176|M.bovis_AF2122/97            KTEPIG---EERGVIINTASVAAFDGQIGQAAYSASKGGVVGMTLPIARD
Rv1144|M.tuberculosis_H37Rv         KTEPIG---EERGVIINTASVAAFDGQIGQAAYSASKGGVVGMTLPIARD
Mflv_4319|M.gilvum_PYR-GCK          KNEPVDDEAEERGVIINTASIAAFEGQIGQLAYTASKAAIAGMCLTMARD
Mvan_2027|M.vanbaalenii_PYR-1       KNDPVDDEAEERGVIINTASIAAFEGQIGQVAYTASKAAIAGMCLTMARD
TH_3183|M.thermoresistible__bu      KNEPVDDEKEERGVIINTASIAAFEGQIGQVAYTASKAAIAGMCLTMARD
MSMEG_2279|M.smegmatis_MC2_155      KNDPVDAEGEERGVIINTASIAAFEGQIGQVAYTASKAAIAGMSLTMARD
MMAR_1624|M.marinum_M               NNEPED---DERGVIINTASIAAFEGQIGQVAYTAAKAGIAGMCLTMARD
MUL_3412|M.ulcerans_Agy99           NNEPED---DERGVIINTASIAAFEGQIGQVAYTAAKAGIAGMCLTMARD
MAV_3936|M.avium_104                KNEPED---EERGVIINTASIAAFEGQIGQVAYTAAKAAIAGMCLTMARD
MAB_0368|M.abscessus_ATCC_1997      QEEPVD-EFGERGAIVNTASVAAFDGQIGQAAYSASKGGIVGMTLPIARD
MLBr_01807|M.leprae_Br4923          K--------QRFGRYIFMGSVVGLSGVPGQANYAASKSGLIGMARSLARE
                                    :         . *  :  .*:..:.*  **  *:*:*..: **  .:**:

Mb1176|M.bovis_AF2122/97            LASKLIRVVTIAPGLFDTPLLAS--LPAEAKASLGQQVPHPSRLGNPDEY
Rv1144|M.tuberculosis_H37Rv         LASKLIRVVTIAPGLFDTPLLAS--LPAEAKASLGQQVPHPSRLGNPDEY
Mflv_4319|M.gilvum_PYR-GCK          LGSLGIRALAIAPSLFATGLTEG--IPDEFATVLTKDAAFPKRLGKPEEY
Mvan_2027|M.vanbaalenii_PYR-1       LGSLGIRALAIAPSLFATGLTEG--IPDEFASVLTKDAAFPKRLGKPEEY
TH_3183|M.thermoresistible__bu      LGSLGIRALAIAPSLFATGLTEG--IPDEFAKQLTKDAAFPKRLGKPEEY
MSMEG_2279|M.smegmatis_MC2_155      LGSLGIRALAIAPSLFATGLTEG--IPDDFAKVLTKDAAFPKRLGKPDEY
MMAR_1624|M.marinum_M               LGSMGIRVLAIAPSLFLTGLTAM--VPDEMAAQLVKDAAFPKRMGRPEEY
MUL_3412|M.ulcerans_Agy99           LGSMGIRVLAIAPSLFLTGLTAM--VPDEMAAQLVKDAAFPKRMGRPEEY
MAV_3936|M.avium_104                LGSVGVRVLAIAPSLFATGLTQG--IPDEFATQLTKDAAFPKRLGRPEEY
MAB_0368|M.abscessus_ATCC_1997      LSVVGIRVNTIAPGLIDTPIYGEGESAQQFKDRLAPNVLYPQRLGNPEEF
MLBr_01807|M.leprae_Br4923          LGSRSITANVVAPGFIDTEMTRA--MDSKYQEAALQAIPLG-RIGAVEEI
                                    *.   : . .:**.:: * :        .             *:*  :* 

Mb1176|M.bovis_AF2122/97            GALVLHIIEN--PMLNGEVIRLDGAIRMAPR
Rv1144|M.tuberculosis_H37Rv         GALVLHIIEN--PMLNGEVIRLDGAIRMAPR
Mflv_4319|M.gilvum_PYR-GCK          AKLAVAIVEN--PMLNGQCLRLDAGQRFAPK
Mvan_2027|M.vanbaalenii_PYR-1       AKLAVAIVEN--PMLNGQCLRLDAGQRFAPK
TH_3183|M.thermoresistible__bu      AKLALAIVEN--PMLNGQCIRLDAGQRFAPK
MSMEG_2279|M.smegmatis_MC2_155      ARLALAIVEN--PMLNGQCIRLDGGQRFAPK
MMAR_1624|M.marinum_M               AKLVAAIVDN--PMLNGQCLRLDAGQRFAPK
MUL_3412|M.ulcerans_Agy99           AKLVAAIVDN--PMLNGQCLRLDAGQRFAPK
MAV_3936|M.avium_104                AKLALAIVDN--PMLNGQCLRLDAGQRFAPK
MAB_0368|M.abscessus_ATCC_1997      ASLALELVTN--SYMNAETIRIDGGARLQPK
MLBr_01807|M.leprae_Br4923          AGAVSFLASEDAGYISGAVIPVDGGLGMGH-
                                    .  .  :  :    :..  : :*..  :

species	id	gene	e-value	identity (len)	annotation
M. smegmatis MC2 155	MSMEG_2279	-	-	100% (255)	3-hydroxyacyl-CoA dehydrogenase type-2
M. smegmatis MC2 155	MSMEG_5183	-	2e-62	50.58% (257)	3-hydroxyacyl-CoA dehydrogenase
M. smegmatis MC2 155	MSMEG_0216	-	7e-54	42.37% (262)	3-hydroxyacyl-CoA dehydrogenase