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STQPARQLHLNANITDAGKHPSAWRHQRDPLAFLTPDYFVEIGQIAERATFDAVFLSDWPALADNPPTKP WQSLDPTVVLATVAQATSRIGLIGTASTTFNAPYELARRFASLDHLSRGRVAWNIVTTMHPQAAANFGVE GIPGHDERYAQADEFVDVVTKLWDSWPADGLRPDAATGVFSGPEPIPGVDHVGAHYRVGGPLNVPRTPQG RPVLVQAGSSEQGKNLAARWADVVFTVQTVFSEAQQFYADMAARARGHGRPAGSVLVLPGLFPVVGSTEA EALSRLREFNEQLDYGRELRRLAHQLGVAVDDLHLDKPLDPRCLGDTRSVQTSHGFLNTTVSFALRSGLT IRELIDRNGGAHRMVVGTPEQIADDMAQWLNGYAADGFNLNFDVYPDGLQRFAEHVVPELRRRGLFRHEY ESTTLRGHLGLPEHTPTAPALSAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4590 | ssuD | - | 100% (445) | nitrilotriacetate monooxygenase component A |
| M. smegmatis MC2 155 | MSMEG_2842 | ssuD | e-105 | 45.65% (425) | nitrilotriacetate monooxygenase component A |
| M. smegmatis MC2 155 | MSMEG_1162 | - | e-103 | 45.66% (449) | nitrilotriacetate monooxygenase component A |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0137c | fgd2 | 5e-08 | 29.18% (257) | putative f420-dependant glucose-6-phosphate dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0250 | - | 1e-51 | 33.02% (424) | hypothetical protein Mflv_0250 |
| M. tuberculosis H37Rv | Rv0132c | fgd2 | 5e-08 | 29.18% (257) | putative f420-dependent glucose-6-phosphate dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4125 | - | 2e-69 | 40.67% (450) | putative nitrilotriacetate monooxygenase |
| M. marinum M | MMAR_0703 | - | 3e-66 | 37.99% (408) | FMNH2-utilizing oxygenase |
| M. avium 104 | MAV_3425 | - | 4e-95 | 44.75% (438) | nitrilotriacetate monooxygenase component A |
| M. thermoresistible (build 8) | TH_4079 | - | 3e-99 | 47.78% (406) | PUTATIVE nitrilotriacetate monooxygenase component A |
| M. ulcerans Agy99 | MUL_3458 | - | 7e-07 | 24.14% (232) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_6020 | - | 2e-71 | 36.96% (441) | xenobiotic compound DszA family monooxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_4590|M.smegmatis_MC2_155 ---MSTQPARQLHLNANITDAGKHPSAWRHQRDP---------------L
MAV_3425|M.avium_104 ---MSRR-ERGLTLNVNVLNLGIHTASWRRSAEPP--------------T
TH_4079|M.thermoresistible__bu ------------LPETRLSG------------------------------
Mvan_6020|M.vanbaalenii_PYR-1 ----------MMHLITWLMGNSYHAAGWRHQLAWE--------------R
MAB_4125|M.abscessus_ATCC_1997 -----MSSRNGRQLHLLAFGNVRAGGAWRLPGVRN--------------G
MMAR_0703|M.marinum_M -------MIRKPVHLAAHFPGVNNTTVWADPGA----------------G
Mflv_0250|M.gilvum_PYR-GCK ---MTDSAKRKAHLLGFVQHGVMNHASTMWAHPRDK-----------VGY
Mb0137c|M.bovis_AF2122/97 MTGISRRTFGLAAGFGAIGAGGLGGGCSTRSGPTPTPEPASRGVGVVLSH
Rv0132c|M.tuberculosis_H37Rv MTGISRRTFGLAAGFGAIGAGGLGGGCSTRSGPTPTPEPASRGVGVVLSH
MUL_3458|M.ulcerans_Agy99 ---------MRVGVLTFVTDEGIGP-------------------------
MSMEG_4590|M.smegmatis_MC2_155 AFLTPDYFVEIGQIAERATFDAVFLSDWPALADNPPTKPWQS--------
MAV_3425|M.avium_104 AFTDPGYYVRMARIAERGTLDALFLADGPAVRDHPALRPSQA--------
TH_4079|M.thermoresistible__bu -ITDIDHYLELARIAERGKLDAIFFADHPVLKGKTEFRPFDA--------
Mvan_6020|M.vanbaalenii_PYR-1 TAMRLDVLIEIAKIAEEAKLDALFVADGNGVRNMDKVGLFEANTPS-ARP
MAB_4125|M.abscessus_ATCC_1997 PANQLNTLVATAKAAEAAKFDAVFFADGLNFG-PKATWAHKST-----ED
MMAR_0703|M.marinum_M SQIEFESFVHLARTAERGLFDFFFLAEGLRLR-EHRGRIHDLD-----VV
Mflv_0250|M.gilvum_PYR-GCK HWSRPEYWRDLGRTMERGLFDAMFIADELAPYTTYKGSSDPVVKFA-GQC
Mb0137c|M.bovis_AF2122/97 EQFRTDRLVAHAQAAEQAGFRYVWASDHLQPWQDNEGHSMFP--------
Rv0132c|M.tuberculosis_H37Rv EQFRTDRLVAHAQAAEQAGFRYVWASDHLQPWQDNEGHSMFP--------
MUL_3458|M.ulcerans_Agy99 --------AELGAALEERGFESLFLAEHTHIPVNNQSPYPPGGPIPRKYY
. * : .: ::
MSMEG_4590|M.smegmatis_MC2_155 --LDPTVVLATVAQATSRIGL-IGTASTTFNAPYELARRFASLDHLSRGR
MAV_3425|M.avium_104 --LEPSVILAAVAAETEHLGL-IGTFSSTFNDPVELAHRLLSLDQLSGGR
TH_4079|M.thermoresistible__bu --LDPVTLVTALSTATTHIGL-VATASTTYTEPYGLARRFATLDHVSRGR
Mvan_6020|M.vanbaalenii_PYR-1 TVYDPVTLMAAISQHTKHIGL-VGTASTTYESPWVVARRFASLDHLSNGR
MAB_4125|M.abscessus_ATCC_1997 FEP--LTATSYLAAVTERLGL-VVTGSSTFQPPYHLARQLLSLDHLSSGR
MMAR_0703|M.marinum_M GRPDTFTLLAALAGVTDRIGL-TGTINTTFNEPFEVARQFATLDHLSEGR
Mflv_0250|M.gilvum_PYR-GCK PVHEPASVVPIVGAFTKHLGI-GITLSTSFVPPYMMARQLSTLDHLTGGR
Mb0137c|M.bovis_AF2122/97 ---WLTLALVGNSTSSILFGT-GVTCPIYRYHPATVAQAFASLAILNPGR
Rv0132c|M.tuberculosis_H37Rv ---WLTLALVGNSTSSILFGT-GVTCPIYRYHPATVAQAFASLAILNPGR
MUL_3458|M.ulcerans_Agy99 RTLDPFVALTAAAVATESLVLGTGIALIPERDPIVTAKEVASLDVVSGGR
. : : * *: . :* :. **
MSMEG_4590|M.smegmatis_MC2_155 VAWNIVTTMHPQAAANFGVEGIPGHDERYAQADEFVDVVTKLWDSWPADG
MAV_3425|M.avium_104 LAWNIVTTYSEAAGGNFGLADLPDRSTRYRRAAEFVDVALALWR------
TH_4079|M.thermoresistible__bu AGWNIVTTANAAAAANFGRPAHPDPEHRYSRADEFLQVALRLWDSWEDDA
Mvan_6020|M.vanbaalenii_PYR-1 ASWNVVTGSNPGDSENFGLAHHPDRDSRYARAEEFVSACKALWNSWDEDA
MAB_4125|M.abscessus_ATCC_1997 AGWNLVTSFAQAAAANFGERGFLPHDERYRLAEETLQVVKSLWHSLEPDT
MMAR_0703|M.marinum_M AGWNIVTSSDAFTGANFRRGGYLDHADRYQRAEEFLTVARKFWDSWAPGA
Mflv_0250|M.gilvum_PYR-GCK VGWNIVTSYSKSEFQAMGKENLTPRDKRYEVVEEYMQLLYQLWDSWDDDA
Mb0137c|M.bovis_AF2122/97 VFLGLGTG--KRLNEQAATDTFGNYRERHDRLIEAIVLIRQLWSG-----
Rv0132c|M.tuberculosis_H37Rv VFLGLGTG--ERLNEQAATDTFGNYRERHDRLIEAIVLIRQLWSG-----
MUL_3458|M.ulcerans_Agy99 FCFGVGVGWLREEVANHG----VDPAVRGRVSDERLGAMIEIWTQ-----
.: . * * : :*
MSMEG_4590|M.smegmatis_MC2_155 LRPDAATGVFSGPEPIPGVDHVGAHYRVGGPLNVPRTPQGRPVLVQAGSS
MAV_3425|M.avium_104 ---DAATG---G-----GVDHRGEFFAVTGSLPQGPSPQGHPLLVQAGGS
TH_4079|M.thermoresistible__bu IVGDKQAPRFVDPDKIHAIDHRGEHFSVAGPLEVPRSPQGHPVLFQAGSS
Mvan_6020|M.vanbaalenii_PYR-1 FVERKDTGQYLNARKVRVPDYKGRHLSVKGPLNVSRSPQGRPVLFHAGQS
MAB_4125|M.abscessus_ATCC_1997 VIEDRAAGIYSDINKIHVANHDGEFHKVKGPLGVTPSRQGHPVIFQAGSS
MMAR_0703|M.marinum_M VLADIENGDYVDPERIRSVEHSGPQFEVRGFATLPAGPQGHPVLLQAGDS
Mflv_0250|M.gilvum_PYR-GCK IVYDRDNGVFADPAKVREVNFQGEFFQSRGRHFVAPSPQKRPVLWQAGSS
Mb0137c|M.bovis_AF2122/97 ----------------ERISFTGHYFR-TDELKLYDTPAMPPPIFVAASG
Rv0132c|M.tuberculosis_H37Rv ----------------ERISFTGHYFR-TDELKLYDTPAMPPPIFVAASG
MUL_3458|M.ulcerans_Agy99 ----------------DNAEYHGKYVDFDPICCWPKPVTKPHPPLYIGGG
.. * . .
MSMEG_4590|M.smegmatis_MC2_155 EQGKNLAARWADVVFTVQTVFSEAQQFYADMAARARGHGRPAGSVLVLPG
MAV_3425|M.avium_104 PQGRELAGRVADAVFSAELDLDAAIEHYRYVKDAAVAHGRGRDAVRILPG
TH_4079|M.thermoresistible__bu EPGKQLAAKYAEAIFTAQPTVEEARQFYADVKARVRQHGRDPDRVHILPG
Mvan_6020|M.vanbaalenii_PYR-1 EGGRRLAARHADCIFEAAASVEAAREFYADLKRRRVEIGGEPDHLRIIVS
MAB_4125|M.abscessus_ATCC_1997 TTGRAFAARHAEVVFTGQTDVERAKNFYRQLHQEARAAGR-TFAPLVTPS
MMAR_0703|M.marinum_M EQGRAFGARHADAMFTLHSSLRDGQRYYADVKGRARSYGRDPDQLKVFPA
Mflv_0250|M.gilvum_PYR-GCK AQGREFASRHAESVFGIFPTPKSMRAYATDIRTRASDAGRDPESVKLIYG
Mb0137c|M.bovis_AF2122/97 PQSATLAGRYGDGWIAQARDINDAK-LLAAFAAGAQAAGRDPTTLGKRAE
Rv0132c|M.tuberculosis_H37Rv PQSATLAGRYGDGWIAQARDINDAK-LLAAFAAGAQAAGRDPTTLGKRAE
MUL_3458|M.ulcerans_Agy99 PASFGRIARLGAGWIAISPSP------------------------QLLAG
. .: . :
MSMEG_4590|M.smegmatis_MC2_155 LFPVVGSTEAEALSRLREFNEQLDYGRE-LRRLAHQLGVAVDDLHLDKPL
MAV_3425|M.avium_104 LITTIGSSRAEAQRRYEEQNALLPAGHD-VERLSQTLGADLSGLPLDEPI
TH_4079|M.thermoresistible__bu LSAIIGGTEEEARRIQRRLEDLTVPDYG-LEQLSRIVGYRVGRDDLDRRL
Mvan_6020|M.vanbaalenii_PYR-1 VAVYLGRTESEAVELYSELNSLISPDLG-VDFLAKAVSEDLTGYPVDGPM
MAB_4125|M.abscessus_ATCC_1997 LGVVVGSTEAEALAAESTIYEHFIPEYQAGWLLEVDVNVVGADLDG----
MMAR_0703|M.marinum_M ATFVIGDTPDQAGEKARQISYQQVSGATAIAMLEQVWGRDLSDYDPDGPL
Mflv_0250|M.gilvum_PYR-GCK LQTIIDRDKGRANDRYAEFVENVQIESA-LGILSGHTGFDFSTLGLDDNV
Mb0137c|M.bovis_AF2122/97 LFAVVG--DDKAAARAADLWRFTAGAVDQPNPVEIQRAAESN--------
Rv0132c|M.tuberculosis_H37Rv LFAVVG--DDKAAARAADLWRFTAGAVDQPNPVEIQRAAESN--------
MUL_3458|M.ulcerans_Agy99 PLEELRSLAGEEVAVTVCLSDETKVS------------------------
: .
MSMEG_4590|M.smegmatis_MC2_155 DPRCLG---DTRSVQTSHGFLNTTVS------FALRSGLTIRELID-RNG
MAV_3425|M.avium_104 PARLLGSVPDPSKFVGSLGFRESVVR------LVVSGGLTLRQTLR-AFS
TH_4079|M.thermoresistible__bu QF--GSDDPPAIHMQSRYALVRRLVS---------TENLTVRELLLRLSG
Mvan_6020|M.vanbaalenii_PYR-1 PD--LS--APVVGGNSIRGQLDAIAK---------AEQLTVRQMYERVVP
MAB_4125|M.abscessus_ATCC_1997 ------PVPASAFPDSTETHQTALAG---YKHLATVGNPTVREFLYRTLN
MMAR_0703|M.marinum_M PD--IDPIADAAISQGRVRHADPVAVARRYRERSQAENLSIRELVIAVTS
Mflv_0250|M.gilvum_PYR-GCK VD---------ADVQGIRGLFDAILEAK------DGAPVTVREAAQIYGV
Mb0137c|M.bovis_AF2122/97 ---------------------------------------PIEKVLANWAV
Rv0132c|M.tuberculosis_H37Rv ---------------------------------------PIEKVLANWAV
MUL_3458|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4590|M.smegmatis_MC2_155 G-AHRMVVGTPEQIADDMAQWLNGYAADGFNLNFDVYPDGLQRFAEHVVP
MAV_3425|M.avium_104 GSGHRVIVGSPVDVADTIEQWFGAGAADGFNLMPDVFPDGLEVFVDEVVP
TH_4079|M.thermoresistible__bu GRGHRVFAGTPEQVADTIEEWFTTGAADGFNLIPPALPSSLTAFVDHVVP
Mvan_6020|M.vanbaalenii_PYR-1 TMGNTALIGTATQIADVMEEWYTTGACDGFVLGASISPFTLLLIRDELVP
MAB_4125|M.abscessus_ATCC_1997 AFG-TRFVGSAEQVADQIELWFSEGAADGFILSTSGLPGQFELFTEHVVP
MMAR_0703|M.marinum_M RQ---QFVGTPSHIADEIDRYVQADACDGFILVPHLTPHGLDEFVDRVVP
Mflv_0250|M.gilvum_PYR-GCK SMGAPVAVGTPADVADQMEQYLDEGDCNGFMMLATDTPGCFNDMTELLVP
Mb0137c|M.bovis_AF2122/97 GTDPGVHIG-------AVQAVLDAGAVPFLHFPQDDPITAIDFYRTNVLP
Rv0132c|M.tuberculosis_H37Rv GTDPGVHIG-------AVQAVLDAGAVPFLHFPQDDPITAIDFYRTNVLP
MUL_3458|M.ulcerans_Agy99 ----------------DLEGYLPLGVERVLLGLPTEPRDQTLRYLDQMES
: : : .
MSMEG_4590|M.smegmatis_MC2_155 ELRRRGLFRHEYESTTLRGHLGLPEHTPTAPALSAG----
MAV_3425|M.avium_104 ILRSRGLFRASYAEATLRERLTGDRHVVAA----------
TH_4079|M.thermoresistible__bu ELQRRGLFRTEYTGTTLRDHLGLPRPRNRFTTGRPVAAAS
Mvan_6020|M.vanbaalenii_PYR-1 ELQRRGLFRRHYTGSTLRENLGLPPVDN-----SPFAT--
MAB_4125|M.abscessus_ATCC_1997 ILVRRGLFRAEYTGSTLREHLALPWPVPARPPALLA----
MMAR_0703|M.marinum_M LLQERGAFRTAYTGQTLRDHLGLAG-LPS-----------
Mflv_0250|M.gilvum_PYR-GCK ELQKRGRFRTRYPGTTLRESLREY----------------
Mb0137c|M.bovis_AF2122/97 ELR-------------------------------------
Rv0132c|M.tuberculosis_H37Rv ELR-------------------------------------
MUL_3458|M.ulcerans_Agy99 ELVQLG----------------------------------
*