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TGISRRTFGLAAGFGAIGAGGLGGGCSTRSGPTPTPEPASRGVGVVLSHEQFRTDRLVAHAQAAEQAGFR YVWASDHLQPWQDNEGHSMFPWLTLALVGNSTSSILFGTGVTCPIYRYHPATVAQAFASLAILNPGRVFL GLGTGERLNEQAATDTFGNYRERHDRLIEAIVLIRQLWSGERISFTGHYFRTDELKLYDTPAMPPPIFVA ASGPQSATLAGRYGDGWIAQARDINDAKLLAAFAAGAQAAGRDPTTLGKRAELFAVVGDDKAAARAADLW RFTAGAVDQPNPVEIQRAAESNPIEKVLANWAVGTDPGVHIGAVQAVLDAGAVPFLHFPQDDPITAIDFY RTNVLPELR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0132c | fgd2 | - | 100% (360) | PUTATIVE F420-DEPENDENT GLUCOSE-6-PHOSPHATE DEHYDROGENASE FGD2 |
| M. tuberculosis H37Rv | Rv0407 | fgd1 | 8e-53 | 36.28% (328) | F420-dependent glucose-6-phosphate dehydrogenase |
| M. tuberculosis H37Rv | Rv2951c | - | 5e-16 | 34.47% (206) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0137c | fgd2 | 0.0 | 99.72% (360) | putative f420-dependant glucose-6-phosphate dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0211 | - | 6e-55 | 36.28% (328) | luciferase family protein |
| M. leprae Br4923 | MLBr_00269 | - | 2e-51 | 35.06% (328) | putative F420-dependent glucose-6-phosphate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4230c | - | 4e-52 | 37.16% (331) | F420-dependent glucose-6-phosphate dehydrogenase |
| M. marinum M | MMAR_0709 | fgd1 | 1e-50 | 35.06% (328) | F420-dependent glucose-6-phosphate dehydrogenase Fgd1 |
| M. avium 104 | MAV_5172 | - | 1e-135 | 75.39% (317) | F420-dependent glucose-6-phosphate dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0777 | - | 2e-53 | 35.98% (328) | F420-dependent glucose-6-phosphate dehydrogenase |
| M. thermoresistible (build 8) | TH_2304 | - | 6e-56 | 38.11% (328) | PROBABLE F420-DEPENDENT GLUCOSE-6-PHOSPHATE DEHYDROGENASE FGD1 |
| M. ulcerans Agy99 | MUL_2814 | fgd1 | 6e-51 | 35.37% (328) | F420-dependent glucose-6-phosphate dehydrogenase Fgd1 |
| M. vanbaalenii PYR-1 | Mvan_0698 | - | 3e-56 | 36.89% (328) | luciferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0211|M.gilvum_PYR-GCK -------------------------------------------MAELKLG
Mvan_0698|M.vanbaalenii_PYR-1 -------------------------------------------MAELKLG
MSMEG_0777|M.smegmatis_MC2_155 ------------------------------------------MVAELKLG
MAB_4230c|M.abscessus_ATCC_199 ------------------------------------------MARELKLG
TH_2304|M.thermoresistible__bu -------------------------------------------VAELKLG
MMAR_0709|M.marinum_M -------------------------------------------MAELKLG
MUL_2814|M.ulcerans_Agy99 -------------------------------------------MAELKLG
MLBr_00269|M.leprae_Br4923 -------------------------------------------MAELRLG
Rv0132c|M.tuberculosis_H37Rv MTGISRRTFG-LAAGFGAIG----AGGLGGGCSTRSGPTPTPEPASRGVG
Mb0137c|M.bovis_AF2122/97 MTGISRRTFG-LAAGFGAIG----AGGLGGGCSTRSGPTPTPEPASRGVG
MAV_5172|M.avium_104 MTGISRRTLGRLAVGAGVLASAVQACAKPGAGHGRSG--APPAPAGKGVG
:*
Mflv_0211|M.gilvum_PYR-GCK YKASAEQFAPRELVELAVAAEEHGMDSATVSDHFQPWRHEGGHAPFSLAW
Mvan_0698|M.vanbaalenii_PYR-1 YKASAEQFAPRELVELAVAAEEHGMDSATVSDHFQPWRHEGGHAPFSLAW
MSMEG_0777|M.smegmatis_MC2_155 YKASAEQFAPRELVELAVLAESAGMDSATVSDHFQPWRHEGGHAPFSLAW
MAB_4230c|M.abscessus_ATCC_199 YKASAEQFAPRELVELAVATESHGFDSATVSDHFQPWRYNGGHAPFSLAW
TH_2304|M.thermoresistible__bu YKASAEQFAPRELVELGVAAEEHGMDSATVSDHFQPWRHKGGHAPFSLAW
MMAR_0709|M.marinum_M YKASAEQFAPRELVELAVAAEAHGMDSATVSDHFQPWRHEGGHAPFSLAW
MUL_2814|M.ulcerans_Agy99 YKASAEQFAPRELVELAVAAEAHGMDSATVSDHFQPWRHEGGHAPFSLAW
MLBr_00269|M.leprae_Br4923 YKASAEQFAPRELVELGVAAEAHGMDSATVSDHFQPWRHQGGHASFSLSW
Rv0132c|M.tuberculosis_H37Rv VVLSHEQFRTDRLVAHAQAAEQAGFRYVWASDHLQPWQDNEGHSMFPWLT
Mb0137c|M.bovis_AF2122/97 VVLSHEQFRTDRLVAHAQAAEQAGFRYVWASDHLQPWQDNEGHSMFPWLT
MAV_5172|M.avium_104 FVLSHEQFRTDRLVAHAQAAERAGFTHGWASDHIQPWQDNEGHSMFPWLT
* *** . .** . :* *: .***:***: : **: *.
Mflv_0211|M.gilvum_PYR-GCK MTAVGERTTRLQLGTSVLTPTFRYNPAVIAQAFATMGCLYPDRIFLGVGT
Mvan_0698|M.vanbaalenii_PYR-1 MTAVGERTKRLQLGTSVLTPTFRYNPAVIAQAFATMGCLYPGRIFLGVGT
MSMEG_0777|M.smegmatis_MC2_155 MTAVGERTKNLVLGTSVLTPTFRYNPAVIAQAFATMGCLYPGRIFLGVGT
MAB_4230c|M.abscessus_ATCC_199 MTAVGERTQRLQLGTSVLTPTFRYNPAVTAQAFATMGCLYPGRIFLGVGT
TH_2304|M.thermoresistible__bu MTAVGERTKRITLGTSVLTPTFRYNPAVIAQAFATMACLYPDRIFLGVGT
MMAR_0709|M.marinum_M MTAVGERTKRMQLGTSVLTPTFRYNPAVIAQAFATMGCLYPNRIFLGVGT
MUL_2814|M.ulcerans_Agy99 MTAVGERTKRMQLGTSVLTPTFRYNPAVIAQAFATMGCLYPNRIFLGVGT
MLBr_00269|M.leprae_Br4923 MTAVGERTNRILLGTSVLTPTFRYNPAVIGQAFATMGCLYPNRVFLGVGT
Rv0132c|M.tuberculosis_H37Rv LALVGNSTSSILFGTGVTCPIYRYHPATVAQAFASLAILNPGRVFLGLGT
Mb0137c|M.bovis_AF2122/97 LALVGNSTSSILFGTGVTCPIYRYHPATVAQAFASLAILNPGRVFLGLGT
MAV_5172|M.avium_104 LALVGSSTSHVSFGTGVTCPTYRYHPATVAQAFASLAILNPGRVFLGVGT
:: **. * : :**.* * :**:**. .****::. * *.*:***:**
Mflv_0211|M.gilvum_PYR-GCK GEALNEIATGYEGEWPEFKERYARLRESVRLMRELWLGDRVDFEGEYYKT
Mvan_0698|M.vanbaalenii_PYR-1 GEALNEIATGYEGDWPEFKERYARLRESVRLMRDLWLGDRVDFEGEYYKT
MSMEG_0777|M.smegmatis_MC2_155 GEALNEIATGYAGEWPEFKERFARLRESVRLMRELWLGDRVDFDGEYYRT
MAB_4230c|M.abscessus_ATCC_199 GEALNEIATGYIGEWPEFKERFARLRESVRLMRELWTGERVDFEGEYYRT
TH_2304|M.thermoresistible__bu GEALNEIATGYEGEWPEFKERFARLREAVRLMRELWLGDRVDFDGEYYRT
MMAR_0709|M.marinum_M GEALNEVATGYQGVWPEFKERFARLRESVRLMRELWRGDRVDFDGEYYRL
MUL_2814|M.ulcerans_Agy99 GEALNEVATGYQGVWPEFKERFARLRESVRLMRELWRGDRVDFDGEYYRL
MLBr_00269|M.leprae_Br4923 GEALNEVATGYQGAWPEFKERFARLRESVRLMRELWRGDRVDFDGDYYQL
Rv0132c|M.tuberculosis_H37Rv GERLNEQAATDT--FGNYRERHDRLIEAIVLIRQLWSGERISFTGHYFRT
Mb0137c|M.bovis_AF2122/97 GKRLNEQAATDT--FGNYRERHDRLIEAIVLIRQLWSGERISFTGHYFRT
MAV_5172|M.avium_104 GERLNEQATTNG--YGNYTERHDRLAEAIALIRQLWSGSRISFSGRYFQT
*: *** *: : :: **. ** *:: *:*:** *.*:.* * *::
Mflv_0211|M.gilvum_PYR-GCK KGASIYDVPEGGIPIYIAAGGPQVAKYAGRAGDGFICTSGKGEELYKEKL
Mvan_0698|M.vanbaalenii_PYR-1 KGASIYDVPEGGIPIYIAAGGPQVAKYAGRAGDGFICTSGKGEELYKDKL
MSMEG_0777|M.smegmatis_MC2_155 KGASIYDVPEGGIPVYIAAGGPVVAKYAGRAGDGFICTSGKGEELYAEKL
MAB_4230c|M.abscessus_ATCC_199 QGAAIYDVPEGGIPVYIAAGGAVVAKYAGRAGDGFICTSGKGEELYSGKL
TH_2304|M.thermoresistible__bu KGASIYDVPEGGVPVYIAAGGPVVAKYAGRAGDGFICTSGKGAELYQDKL
MMAR_0709|M.marinum_M RGASIYDVPEGGVPVYIAAGGPAVAKYAGRAGDGFICTSGKGEELYSEKL
MUL_2814|M.ulcerans_Agy99 RGASIYDVPEGGVPVYTAAGGPAVAKYAGRAGDGFICTSGKGEDLYSEKL
MLBr_00269|M.leprae_Br4923 KGASIYDVPEGGVPIYIAAGGPEVAKYAGRAGEGFVCTSGKGEELYTEKL
Rv0132c|M.tuberculosis_H37Rv DELKLYDTPAMPPPIFVAASGPQSATLAGRYGDGWIAQAR---DINDAKL
Mb0137c|M.bovis_AF2122/97 DELKLYDTPAMPPPIFVAASGPQSATLAGRYGDGWIAQAR---DINDAKL
MAV_5172|M.avium_104 NSLKLYDVPATPPPIFVAAGGPKSAKLAGQFGDGWITQSG---DVTNPKL
:**.* *:: **.*. *. **: *:*:: : :: **
Mflv_0211|M.gilvum_PYR-GCK IPAMREGAEAAGKNPDDVDRMIEIKISYDTDPELALENTRFWAPLSLTAE
Mvan_0698|M.vanbaalenii_PYR-1 IPAMREGAEAAGKNPDDIDRMIEIKISYDTDPELALENTRFWAPLSLTAE
MSMEG_0777|M.smegmatis_MC2_155 IPAVKEGAAAADRDADAIDRMIEIKISYDTDPELALENTRFWAPLSLTAE
MAB_4230c|M.abscessus_ATCC_199 IPAVREGAALAERSFDDIDRMIEIKISYDPDPDKALENTRFWAPLSLTPE
TH_2304|M.thermoresistible__bu IPAVAEGAAAAGRDADEIDKMIEIKISYDPDPELALENTRFWAPLSLTAE
MMAR_0709|M.marinum_M MPAVREGAAINNRNIDDIDKMIEIKISYDPDPELALNNTRFWAPLSLSAE
MUL_2814|M.ulcerans_Agy99 MPAVREGAAINNRNIDDIDKMIEIKISYDPDPELALNNTRFWAPLSLSAE
MLBr_00269|M.leprae_Br4923 IPAVLEGAAVAGRDADDIDKMIEIKMSYDPDPEQALSNIRFWAPLSLAAE
Rv0132c|M.tuberculosis_H37Rv LAAFAAGAQAAGRDPTTLGKRAELFAVVGDD-KAAARAADLWRFTAGAVD
Mb0137c|M.bovis_AF2122/97 LAAFAAGAQAAGRDPTTLGKRAELFAVVGDD-KAAARAADLWRFTAGAVD
MAV_5172|M.avium_104 LAAFGAGAQAAGRDVATLGKRAEMFAVVGDD-AVAARAATLWRFTAGAVD
:.*. ** :. :.: *: . * * :* : : :
Mflv_0211|M.gilvum_PYR-GCK QKHSIDDPMEMEKAADELPIEQVAKRWI----------------------
Mvan_0698|M.vanbaalenii_PYR-1 QKHSIDDPIEMEKAADALPIEQVAKRWI----------------------
MSMEG_0777|M.smegmatis_MC2_155 QKHSIDDPIEMEKAADALPIEQVAKRWI----------------------
MAB_4230c|M.abscessus_ATCC_199 QKHSIHDPIEMERAADELPIEQVAKRWI----------------------
TH_2304|M.thermoresistible__bu QKHSIDDPIEMERAADELPIEQVAKRWI----------------------
MMAR_0709|M.marinum_M QKRSIGDPIEMEAAAEALPIEQIAKRWI----------------------
MUL_2814|M.ulcerans_Agy99 QKRSIGDPIEMEAAAEALPIEQIAKRWI----------------------
MLBr_00269|M.leprae_Br4923 QKHSIDDPIEMEKVADALPIEQVAKRWI----------------------
Rv0132c|M.tuberculosis_H37Rv QP----NPVEIQRAAESNPIEKVLANWA----------------------
Mb0137c|M.bovis_AF2122/97 QP----NPVEIQRAAESNPIEKVLANWA----------------------
MAV_5172|M.avium_104 QP----DPVDIQRAAESNPTDKVLGGWTGRHRRGSARRGRAAGPRRGRRS
* :*:::: .*: * ::: *
Mflv_0211|M.gilvum_PYR-GCK -----VASDPDEA-------------------------------VAKVAD
Mvan_0698|M.vanbaalenii_PYR-1 -----VASDPDEA-------------------------------VAKVKD
MSMEG_0777|M.smegmatis_MC2_155 -----VASDPDEA-------------------------------VEKVGQ
MAB_4230c|M.abscessus_ATCC_199 -----VASDPDEA-------------------------------VEKVAD
TH_2304|M.thermoresistible__bu -----VASDPDEA-------------------------------VEQVAQ
MMAR_0709|M.marinum_M -----VASDPDEA-------------------------------VEKVGQ
MUL_2814|M.ulcerans_Agy99 -----VASDPDEA-------------------------------VEKVGQ
MLBr_00269|M.leprae_Br4923 -----VVSDPDEA-------------------------------VARVGQ
Rv0132c|M.tuberculosis_H37Rv -----VGTDPGVH-------------------------------IGAVQA
Mb0137c|M.bovis_AF2122/97 -----VGTDPGVH-------------------------------IGAVQA
MAV_5172|M.avium_104 LPALSAGRPDGRHRLLPGQCLTEIALNPLRATPVSPLPATNSRRIGQNRD
. . :
Mflv_0211|M.gilvum_PYR-GCK YVDYG-------LNHLVFHAPG--------HDQRRFLELFQRDLEP----
Mvan_0698|M.vanbaalenii_PYR-1 YVDWG-------LNHLVFHAPG--------HDQRRFLELFRRDLEP----
MSMEG_0777|M.smegmatis_MC2_155 YVKWG-------LNHLVFHAPG--------HDQRRFLELFKRDLEP----
MAB_4230c|M.abscessus_ATCC_199 YVGWG-------LNHLVFHAPG--------HDQKRFLELFKTDLEP----
TH_2304|M.thermoresistible__bu YVKWG-------LNHLVFHAPG--------HDQRRFLELFRTDLEP----
MMAR_0709|M.marinum_M YVAWG-------LNHLVLHAPG--------HDQLRFLELFEKDLAP----
MUL_2814|M.ulcerans_Agy99 YVAWG-------LNHLVLHAPG--------HDQLRFLELFEKDLAP----
MLBr_00269|M.leprae_Br4923 YVTWG-------LNHLVFHAPG--------HNQRRFLELFEKDLAP----
Rv0132c|M.tuberculosis_H37Rv VLDAG--------AVPFLHFPQ--------DDPITAIDFYRTNVLP----
Mb0137c|M.bovis_AF2122/97 VLDAG--------AVPFLHFPQ--------DDPITAIDFYRTNVLP----
MAV_5172|M.avium_104 VMDAVDPDSRHQLAVRMAELVRGMAAPRRLDQVLAEVTAAAVEVIPGADI
: . . .: : :: *
Mflv_0211|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0698|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0777|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4230c|M.abscessus_ATCC_199 --------------------------------------------------
TH_2304|M.thermoresistible__bu --------------------------------------------------
MMAR_0709|M.marinum_M --------------------------------------------------
MUL_2814|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00269|M.leprae_Br4923 --------------------------------------------------
Rv0132c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0137c|M.bovis_AF2122/97 --------------------------------------------------
MAV_5172|M.avium_104 AGVLLVRKGGEFETLADTDSLAARLDVLQHDFGEGPCAQAALQETIVRSD
Mflv_0211|M.gilvum_PYR-GCK RLRKLG--------------------------------------------
Mvan_0698|M.vanbaalenii_PYR-1 RLRKLG--------------------------------------------
MSMEG_0777|M.smegmatis_MC2_155 RLRKLA--------------------------------------------
MAB_4230c|M.abscessus_ATCC_199 RLRKLG--------------------------------------------
TH_2304|M.thermoresistible__bu RLRRLG--------------------------------------------
MMAR_0709|M.marinum_M RLRRLG--------------------------------------------
MUL_2814|M.ulcerans_Agy99 RLRRLG--------------------------------------------
MLBr_00269|M.leprae_Br4923 RLRRLG--------------------------------------------
Rv0132c|M.tuberculosis_H37Rv ELR-----------------------------------------------
Mb0137c|M.bovis_AF2122/97 ELR-----------------------------------------------
MAV_5172|M.avium_104 DLRREPRWPCYAPAAVQLGVLSSLSFKLYTADRTAGALNLFSHRPDAWDT
**
Mflv_0211|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0698|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0777|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4230c|M.abscessus_ATCC_199 --------------------------------------------------
TH_2304|M.thermoresistible__bu --------------------------------------------------
MMAR_0709|M.marinum_M --------------------------------------------------
MUL_2814|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00269|M.leprae_Br4923 --------------------------------------------------
Rv0132c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0137c|M.bovis_AF2122/97 --------------------------------------------------
MAV_5172|M.avium_104 EAETIGSVFAAHAAAAILAGSRAEQLYSAVSTRDRIGQAKGIIMERFGVD
Mflv_0211|M.gilvum_PYR-GCK ----------------------------------
Mvan_0698|M.vanbaalenii_PYR-1 ----------------------------------
MSMEG_0777|M.smegmatis_MC2_155 ----------------------------------
MAB_4230c|M.abscessus_ATCC_199 ----------------------------------
TH_2304|M.thermoresistible__bu ----------------------------------
MMAR_0709|M.marinum_M ----------------------------------
MUL_2814|M.ulcerans_Agy99 ----------------------------------
MLBr_00269|M.leprae_Br4923 ----------------------------------
Rv0132c|M.tuberculosis_H37Rv ----------------------------------
Mb0137c|M.bovis_AF2122/97 ----------------------------------
MAV_5172|M.avium_104 DVRAFDLLRRLSQESQVKLVEIAQQIIDTRGQGA