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VSRRERGLTLNVNVLNLGIHTASWRRSAEPPTAFTDPGYYVRMARIAERGTLDALFLADGPAVRDHPALR PSQALEPSVILAAVAAETEHLGLIGTFSSTFNDPVELAHRLLSLDQLSGGRLAWNIVTTYSEAAGGNFGL ADLPDRSTRYRRAAEFVDVALALWRDAATGGGVDHRGEFFAVTGSLPQGPSPQGHPLLVQAGGSPQGREL AGRVADAVFSAELDLDAAIEHYRYVKDAAVAHGRGRDAVRILPGLITTIGSSRAEAQRRYEEQNALLPAG HDVERLSQTLGADLSGLPLDEPIPARLLGSVPDPSKFVGSLGFRESVVRLVVSGGLTLRQTLRAFSGSGH RVIVGSPVDVADTIEQWFGAGAADGFNLMPDVFPDGLEVFVDEVVPILRSRGLFRASYAEATLRERLTGD RHVVAA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3425 | - | - | 100% (426) | nitrilotriacetate monooxygenase component A |
| M. avium 104 | MAV_2048 | - | 5e-61 | 36.67% (439) | fmnh2-utilizing oxygenase |
| M. avium 104 | MAV_3809 | - | 2e-55 | 34.80% (431) | dibenzothiophene desulfurization enzyme A |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1971 | - | 1e-08 | 24.66% (219) | monooxygenase |
| M. gilvum PYR-GCK | Mflv_0250 | - | 1e-43 | 31.46% (410) | hypothetical protein Mflv_0250 |
| M. tuberculosis H37Rv | Rv1936 | - | 1e-08 | 24.66% (219) | monooxygenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4232c | - | 9e-61 | 35.21% (426) | putative oxygenase |
| M. marinum M | MMAR_0703 | - | 3e-57 | 33.56% (435) | FMNH2-utilizing oxygenase |
| M. smegmatis MC2 155 | MSMEG_4590 | ssuD | 6e-95 | 44.75% (438) | nitrilotriacetate monooxygenase component A |
| M. thermoresistible (build 8) | TH_4079 | - | 8e-82 | 43.46% (405) | PUTATIVE nitrilotriacetate monooxygenase component A |
| M. ulcerans Agy99 | MUL_4507 | fgd2 | 4e-09 | 25.37% (335) | F420-dependent glucose-6-phosphate dehydrogenase Fgd2 |
| M. vanbaalenii PYR-1 | Mvan_6020 | - | 4e-65 | 36.15% (426) | xenobiotic compound DszA family monooxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_3425|M.avium_104 ----------MSRR-ERGLTLNVNVLNLGIHTASWRRSAEPPTAFTDPGY
MSMEG_4590|M.smegmatis_MC2_155 ----------MSTQPARQLHLNANITDAGKHPSAWRHQRDP-LAFLTPDY
TH_4079|M.thermoresistible__bu -------------------LPETRLSG-----------------ITDIDH
Mvan_6020|M.vanbaalenii_PYR-1 -----------------MMHLITWLMGNSYHAAGWRHQLAWERTAMRLDV
MAB_4232c|M.abscessus_ATCC_199 MSNPADAVRTREGKDRKPVHLAAHFPGVNNTTVWSDPASGS---QIDFDS
MMAR_0703|M.marinum_M -------------MIRKPVHLAAHFPGVNNTTVWADPGAGS---QIEFES
Mflv_0250|M.gilvum_PYR-GCK -------MTDSAKRKAHLLGFVQHGVMNHASTMWAHPRDKVGYHWSRPEY
Mb1971|M.bovis_AF2122/97 --------------------------------------MEIGIFLMPAHP
Rv1936|M.tuberculosis_H37Rv --------------------------------------MEIGIFLMPAHP
MUL_4507|M.ulcerans_Agy99 -------------MALLFHWFLPTYGDSRGLVAGGHGLPMSGNRPATLRY
MAV_3425|M.avium_104 YVRMARIAERGTLDALFLADGPAVRDHPALRPSQA---------LEPSVI
MSMEG_4590|M.smegmatis_MC2_155 FVEIGQIAERATFDAVFLSDWPALADNPPTKPWQS---------LDPTVV
TH_4079|M.thermoresistible__bu YLELARIAERGKLDAIFFADHPVLKGKTEFRPFDA---------LDPVTL
Mvan_6020|M.vanbaalenii_PYR-1 LIEIAKIAEEAKLDALFVADGNGVRNMDKVGLFEANTPSARPTVYDPVTL
MAB_4232c|M.abscessus_ATCC_199 FVHLARTAERGLFDFFFLAEGLRLREHRERIYDLDVVGR-----PDTFTV
MMAR_0703|M.marinum_M FVHLARTAERGLFDFFFLAEGLRLREHRGRIHDLDVVGR-----PDTFTL
Mflv_0250|M.gilvum_PYR-GCK WRDLGRTMERGLFDAMFIADELAPYTTYKGSSDPVVKFAGQCPVHEPASV
Mb1971|M.bovis_AF2122/97 PERTLYDATRWDLDVIELADQLGYVEAWVGEHFTVPWEP----ICAPDLL
Rv1936|M.tuberculosis_H37Rv PERTLYDATRWDLDVIELADQLGYVEAWVGEHFTVPWEP----ICAPDLL
MUL_4507|M.ulcerans_Agy99 LNQIAAAAESNGFEAVLTPAGLWCED--------------------AWLT
:: . . .
MAV_3425|M.avium_104 LAAVAAETEHLGLIG-TFSSTFNDPVELAHRLLSLDQLSGGRLAWNIVTT
MSMEG_4590|M.smegmatis_MC2_155 LATVAQATSRIGLIG-TASTTFNAPYELARRFASLDHLSRGRVAWNIVTT
TH_4079|M.thermoresistible__bu VTALSTATTHIGLVA-TASTTYTEPYGLARRFATLDHVSRGRAGWNIVTT
Mvan_6020|M.vanbaalenii_PYR-1 MAAISQHTKHIGLVG-TASTTYESPWVVARRFASLDHLSNGRASWNVVTG
MAB_4232c|M.abscessus_ATCC_199 LAALGAVTERLGLVG-TINTTFNEPFNVARQFASLDHLSDGRAGWNMVTS
MMAR_0703|M.marinum_M LAALAGVTDRIGLTG-TINTTFNEPFEVARQFATLDHLSEGRAGWNIVTS
Mflv_0250|M.gilvum_PYR-GCK VPIVGAFTKHLGIGI-TLSTSFVPPYMMARQLSTLDHLTGGRVGWNIVTS
Mb1971|M.bovis_AF2122/97 LAQALLRTQQIKLAPGAHLLPYHHPVELAHRVAYFDHLAQGRFMLGVGAS
Rv1936|M.tuberculosis_H37Rv LAQALLRTQQIKLAPGAHLLPYHHPVELAHRVAYFDHLAQGRFMLGVGAS
MUL_4507|M.ulcerans_Agy99 TAMLVGTTKTLKFLV-ALRPGLVSPTLAAQMATTFQQQSGGRLLVNVVTG
. * : : : * *: ::: : ** .: :
MAV_3425|M.avium_104 YSEAAGGNFGLADLPDRSTRYRRAAEFVDVALALWR---------DAATG
MSMEG_4590|M.smegmatis_MC2_155 MHPQAAANFGVEGIPGHDERYAQADEFVDVVTKLWDSWPADGLRPDAATG
TH_4079|M.thermoresistible__bu ANAAAAANFGRPAHPDPEHRYSRADEFLQVALRLWDSWEDDAIVGDKQAP
Mvan_6020|M.vanbaalenii_PYR-1 SNPGDSENFGLAHHPDRDSRYARAEEFVSACKALWNSWDEDAFVERKDTG
MAB_4232c|M.abscessus_ATCC_199 SDAFTGENFRRGGFLDHADRYRRAEEFITVARKFWDSWDAAG--------
MMAR_0703|M.marinum_M SDAFTGANFRRGGYLDHADRYQRAEEFLTVARKFWDSWAPGAVLADIENG
Mflv_0250|M.gilvum_PYR-GCK YSKSEFQAMGKENLTPRDKRYEVVEEYMQLLYQLWDSWDDDAIVYDRDNG
Mb1971|M.bovis_AF2122/97 GIPGDWALYDVDGK--NGEHREMTREALEIMLRIWTEDEP----------
Rv1936|M.tuberculosis_H37Rv GIPGDWALYDVDGK--NGEHREMTREALEIMLRIWTEDEP----------
MUL_4507|M.ulcerans_Agy99 GEAHEQRAYG--DFLDKQQRYRRTGEFLHVVRQLWASGQP----------
: . * : :*
MAV_3425|M.avium_104 ---G-----GVDHRGEFFAVTGSLPQGPSPQGHPLLVQAGGSP--QGREL
MSMEG_4590|M.smegmatis_MC2_155 VFSGPEPIPGVDHVGAHYRVGGPLNVPRTPQGRPVLVQAGSSE--QGKNL
TH_4079|M.thermoresistible__bu RFVDPDKIHAIDHRGEHFSVAGPLEVPRSPQGHPVLFQAGSSE--PGKQL
Mvan_6020|M.vanbaalenii_PYR-1 QYLNARKVRVPDYKGRHLSVKGPLNVSRSPQGRPVLFHAGQSE--GGRRL
MAB_4232c|M.abscessus_ATCC_199 ---EP---LPVNHRGPQFTVRGVATAPASPQRHPVLLQAGDSA--DGRDF
MMAR_0703|M.marinum_M DYVDPERIRSVEHSGPQFEVRGFATLPAGPQGHPVLLQAGDSE--QGRAF
Mflv_0250|M.gilvum_PYR-GCK VFADPAKVREVNFQGEFFQSRGRHFVAPSPQKRPVLWQAGSSA--QGREF
Mb1971|M.bovis_AF2122/97 -WEHRGKYWNANGIAPMFEGLMRRHIKPYQKPHPPIGVTGFSAGSETLKL
Rv1936|M.tuberculosis_H37Rv -WEHRGKYWNANGIAPMFEGLMRRHIKPYQKPHPPIGVTGFSAGSETLKL
MUL_4507|M.ulcerans_Agy99 ----------VTFEGEHIHVH-QAQLGRLPDPPPPVFFGGSSE--SAGAV
. . * : * * .
MAV_3425|M.avium_104 AGRVADAVFSAELDLDAAIEHYRYVKDAAVAHGRGRDAVRILPGLITTIG
MSMEG_4590|M.smegmatis_MC2_155 AARWADVVFTVQTVFSEAQQFYADMAARARGHGRPAGSVLVLPGLFPVVG
TH_4079|M.thermoresistible__bu AAKYAEAIFTAQPTVEEARQFYADVKARVRQHGRDPDRVHILPGLSAIIG
Mvan_6020|M.vanbaalenii_PYR-1 AARHADCIFEAAASVEAAREFYADLKRRRVEIGGEPDHLRIIVSVAVYLG
MAB_4232c|M.abscessus_ATCC_199 GAKHADALFTIHSSIPAGQKYYADVKARAVAHGRNPDQLKVFPGVTYVLG
MMAR_0703|M.marinum_M GARHADAMFTLHSSLRDGQRYYADVKGRARSYGRDPDQLKVFPAATFVIG
Mflv_0250|M.gilvum_PYR-GCK ASRHAESVFGIFPTPKSMRAYATDIRTRASDAGRDPESVKLIYGLQTIID
Mb1971|M.bovis_AF2122/97 AGERGYIPMSLDLNTEYVATHWDAVEEGALRSGRTPDRRDWRLVREVLVA
Rv1936|M.tuberculosis_H37Rv AGERGYIPMSLDLNTEYVATHWDAVEEGALRSGRTPDRRDWRLVREVLVA
MUL_4507|M.ulcerans_Agy99 AARYADTYLTWGEPLSAVGKKIDWIRGLAADHGR---ALSYGLRIHVITR
... . : : *
MAV_3425|M.avium_104 SSRAEAQRRYEEQ-NALLPAGHDVERLSQTLGADLSGLPLDEPIPARLLG
MSMEG_4590|M.smegmatis_MC2_155 STEAEALSRLREF-NEQLDYGRELRRLAHQLGVAVDDLHLDKPLDPRCLG
TH_4079|M.thermoresistible__bu GTEEEARRIQRRL-EDLTVPDYGLEQLSRIVGYRVGRDDLDRRLQFGSDD
Mvan_6020|M.vanbaalenii_PYR-1 RTESEAVELYSEL-NSLISPDLGVDFLAKAVSEDLTGYPVDGPMPDLS--
MAB_4232c|M.abscessus_ATCC_199 DTEQEAIEKAAYIRDQQVGPQTAIAYLEQVWGRDLSEYDPEGPLPDVDPT
MMAR_0703|M.marinum_M DTPDQAGEKARQISYQQVSGATAIAMLEQVWGRDLSDYDPDGPLPDIDPI
Mflv_0250|M.gilvum_PYR-GCK RDKGRANDRYAEF-VENVQIESALGILSGHTGFDFSTLGLDDNVVDAD--
Mb1971|M.bovis_AF2122/97 ETDEQAFRYAVDG---TMGRAMREYVLPTFRMFGMTKFYKHNPSVPDD--
Rv1936|M.tuberculosis_H37Rv ETDEQAFRYAVDG---TMGRAMREYVLPTFRMFGMTKFYKHNPSVPDD--
MUL_4507|M.ulcerans_Agy99 DTAEEAWRVADRLLAGIDPADIERMQANLARSESEGQRRMAELHGG----
.*
MAV_3425|M.avium_104 SVPDPSKFVGSLG----FRESVVRLVVSGGLTLRQTLRAFS-GSGHRVIV
MSMEG_4590|M.smegmatis_MC2_155 ---DTRSVQTSHG----FLNTTVSFALRSGLTIRELIDRN--GGAHRMVV
TH_4079|M.thermoresistible__bu -----PPAIHMQS----RYALVRRLVSTENLTVRELLLRLSGGRGHRVFA
Mvan_6020|M.vanbaalenii_PYR-1 -----APVVGGNS----IRGQLDAIAKAEQLTVRQMYERVVPTMGNTALI
MAB_4232c|M.abscessus_ATCC_199 GDASITRGKARHGDPREIAAKYREIAEAKKLSIRELIKEVT---SRQQFI
MMAR_0703|M.marinum_M ADAAISQGRVRHADPVAVARRYRERSQAENLSIRELVIAVT---SRQQFV
Mflv_0250|M.gilvum_PYR-GCK -------VQGIRG----LFDAILEAKDGAPVTVREAAQIYGVSMGAPVAV
Mb1971|M.bovis_AF2122/97 -----------------------------EVTPEYLAEN-------TFVV
Rv1936|M.tuberculosis_H37Rv -----------------------------EVTPEYLAEN-------TFVV
MUL_4507|M.ulcerans_Agy99 --------------------VLDQLEIAPNLWAGVGLVRGG---AGTALV
:
MAV_3425|M.avium_104 GSPVDVADTIEQWFGAGAADGFNLMPDVFPDGLEVFVDEVVPILRSRGLF
MSMEG_4590|M.smegmatis_MC2_155 GTPEQIADDMAQWLNGYAADGFNLNFDVYPDGLQRFAEHVVPELRRRGLF
TH_4079|M.thermoresistible__bu GTPEQVADTIEEWFTTGAADGFNLIPPALPSSLTAFVDHVVPELQRRGLF
Mvan_6020|M.vanbaalenii_PYR-1 GTATQIADVMEEWYTTGACDGFVLGASISPFTLLLIRDELVPELQRRGLF
MAB_4232c|M.abscessus_ATCC_199 GTPSQVATEVDRYIQADACDGFILVPHLTPGGLDDFVDTVVPLLQERGAF
MMAR_0703|M.marinum_M GTPSHIADEIDRYVQADACDGFILVPHLTPHGLDEFVDRVVPLLQERGAF
Mflv_0250|M.gilvum_PYR-GCK GTPADVADQMEQYLDEGDCNGFMMLATDTPGCFNDMTELLVPELQKRGRF
Mb1971|M.bovis_AF2122/97 GSVQTVVDKLEATYDQVGGFGHLLILGFDYSDNPGPWKESLRLLAHEVMP
Rv1936|M.tuberculosis_H37Rv GSVQTVVDKLEATYDQVGGFGHLLILGFDYSDNPGPWKESLRLLAHEVMP
MUL_4507|M.ulcerans_Agy99 GSHQEVAERIIEYARLG-ISHFILSGYPHLEEAYWFGEGVLPILERKRLW
*: :. : . : . : * .
MAV_3425|M.avium_104 RASYAEATLRERLTGDRHVVAA----------
MSMEG_4590|M.smegmatis_MC2_155 RHEYESTTLRGHLGLPEHTPTAPALSAG----
TH_4079|M.thermoresistible__bu RTEYTGTTLRDHLGLPRPRNRFTTGRPVAAAS
Mvan_6020|M.vanbaalenii_PYR-1 RRHYTGSTLRENLGLPPVDN-----SPFAT--
MAB_4232c|M.abscessus_ATCC_199 RAEYEHETLREHLGLDPISRASGDFRRETASA
MMAR_0703|M.marinum_M RTAYTGQTLRDHLGLAGLPS------------
Mflv_0250|M.gilvum_PYR-GCK RTRYPGTTLRESLREY----------------
Mb1971|M.bovis_AF2122/97 RLNARLATKPATAVV-----------------
Rv1936|M.tuberculosis_H37Rv RLNARLATKPATAVV-----------------
MUL_4507|M.ulcerans_Agy99 HRPHGSSPHSAALPVAHSSVN-----------
: .