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TRELHLLAFGNTRSAGPWRHPAADNTPAGVRRRLIAYAQTAEAGTFDALFFADGLNYGPPATWAYKITED FEPLTATAALSSVTEHIGLVVTGSATLAHPYHLARQLLSLDHLSGGRAGWNLVTSFARAAADNFSARGVI DHDDRYAIAEEALEVVRKLWDEWGEDTIVEDRPAGIFNDVGRIRPANHHGRYFDVAGPIGAARSAQGQPV LFQAGSSETGRAFAARHAEVIFTSHGNRERAQTFYGQIHEQSRQFGRGAPPLITPSLRYIVGSTDEEARR AEREEYEYFSPGYQAGWLLEVDVDVTGADLDGPVPDSAFPEHTETHQTALAGYRHLASEGNPTVREFLYR TVNGWGAAVVGTPERIADTIEEWFTTGAADGFVLRDSGLPGQHELFVEQVVPVLRKRGLFRHEYTGTTLR AHLGLDIPQRSVS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4552 | ssuD | - | 100% (434) | nitrilotriacetate monooxygenase component A |
| M. smegmatis MC2 155 | MSMEG_1162 | - | 2e-89 | 42.89% (429) | nitrilotriacetate monooxygenase component A |
| M. smegmatis MC2 155 | MSMEG_4590 | ssuD | 3e-72 | 40.73% (437) | nitrilotriacetate monooxygenase component A |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1886c | - | 4e-05 | 29.47% (207) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_0250 | - | 8e-53 | 33.04% (448) | hypothetical protein Mflv_0250 |
| M. tuberculosis H37Rv | Rv1855c | - | 4e-05 | 29.47% (207) | oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4125 | - | 1e-163 | 65.11% (427) | putative nitrilotriacetate monooxygenase |
| M. marinum M | MMAR_0703 | - | 3e-68 | 36.96% (441) | FMNH2-utilizing oxygenase |
| M. avium 104 | MAV_2048 | - | 7e-69 | 37.59% (439) | fmnh2-utilizing oxygenase |
| M. thermoresistible (build 8) | TH_4079 | - | 4e-85 | 46.58% (395) | PUTATIVE nitrilotriacetate monooxygenase component A |
| M. ulcerans Agy99 | MUL_4507 | fgd2 | 3e-07 | 23.74% (417) | F420-dependent glucose-6-phosphate dehydrogenase Fgd2 |
| M. vanbaalenii PYR-1 | Mvan_6020 | - | 1e-71 | 39.22% (436) | xenobiotic compound DszA family monooxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1886c|M.bovis_AF2122/97 ---------MTIRLGLQIPNFSYG-------TGVEKLFPS---VIAQARE
Rv1855c|M.tuberculosis_H37Rv ---------MTIRLGLQIPNFSYG-------TGVEKLFPS---VIAQARE
MSMEG_4552|M.smegmatis_MC2_155 --MT----RELHLLAFGNTRSAGPWRHPAADNTPAGVRRR---LIAYAQT
MAB_4125|M.abscessus_ATCC_1997 --MSSRNGRQLHLLAFGNVRAGGAWRLPGVRNGPANQLNT---LVATAKA
TH_4079|M.thermoresistible__bu ---------LPETRLSG-----------------ITDIDH---YLELARI
Mvan_6020|M.vanbaalenii_PYR-1 -------MMHLITWLMGNSYHAAGWRHQLAWERTAMRLDV---LIEIAKI
MMAR_0703|M.marinum_M ------MIRKPVHLAAHFPGVNNTTVWADPGAGSQIEFES---FVHLART
MAV_2048|M.avium_104 MTTRKARRRKQIHLGAHFPGVNNTTVWSDPSAGSQIAFES---FVHLART
Mflv_0250|M.gilvum_PYR-GCK MTDSAKRKAHLLGFVQHGVMNHASTMWAHPRDKVGYHWSRPEYWRDLGRT
MUL_4507|M.ulcerans_Agy99 ------MALLFHWFLPTYGDSRGLVAGGHGLPMSGNRPATLRYLNQIAAA
.
Mb1886c|M.bovis_AF2122/97 AEAAGYDSLFVMDHFYQLPMLGTPDQPM---------LEAYTALGALATA
Rv1855c|M.tuberculosis_H37Rv AEAAGYDSLFVMDHFYQLPMLGTPDQPM---------LEAYTALGALATA
MSMEG_4552|M.smegmatis_MC2_155 AEAGTFDALFFADGLNYGPPATWAYKITED-------FEPLTATAALSSV
MAB_4125|M.abscessus_ATCC_1997 AEAAKFDAVFFADGLNFGPKATWAHKSTED-------FEPLTATSYLAAV
TH_4079|M.thermoresistible__bu AERGKLDAIFFADHPVLKGKTEFRPFDA---------LDPVTLVTALSTA
Mvan_6020|M.vanbaalenii_PYR-1 AEEAKLDALFVADGNGVRNMDKVGLFEANTPSARPTVYDPVTLMAAISQH
MMAR_0703|M.marinum_M AERGLFDFFFLAEGLRLREHRGRIHDLDVVGR-----PDTFTLLAALAGV
MAV_2048|M.avium_104 AERGLFDFFFLAEGLRLREHRGKIHDLDVVGR-----PDTFTVLAALAAV
Mflv_0250|M.gilvum_PYR-GCK MERGLFDAMFIADELAPYTTYKGSSDPVVKFAGQCPVHEPASVVPIVGAF
MUL_4507|M.ulcerans_Agy99 AESNGFEAVLTPAGLWC--------------------EDAWLTTAMLVGT
* : .: :. :
Mb1886c|M.bovis_AF2122/97 TERLQLGALVTGNTYRSPTLLAKIITTLDVVSAGRAILGIGAGWFELEHR
Rv1855c|M.tuberculosis_H37Rv TERLQLGALVTGNTYRSPTLLAKIITTLDVVSAGRAILGIGAGWFELEHR
MSMEG_4552|M.smegmatis_MC2_155 TEHIGLVVTGS-ATLAHPYHLARQLLSLDHLSGGRAGWNLVTSFARAAAD
MAB_4125|M.abscessus_ATCC_1997 TERLGLVVTGS-STFQPPYHLARQLLSLDHLSSGRAGWNLVTSFAQAAAA
TH_4079|M.thermoresistible__bu TTHIGLVATAS-TTYTEPYGLARRFATLDHVSRGRAGWNIVTTANAAAAA
Mvan_6020|M.vanbaalenii_PYR-1 TKHIGLVGTAS-TTYESPWVVARRFASLDHLSNGRASWNVVTGSNPGDSE
MMAR_0703|M.marinum_M TDRIGLTGTIN-TTFNEPFEVARQFATLDHLSEGRAGWNIVTSSDAFTGA
MAV_2048|M.avium_104 TERLGLAGTIN-TTFNEPYEVARQFATLDHLSDGRAAWNMVTSSDAFTGE
Mflv_0250|M.gilvum_PYR-GCK TKHLGIGITLS-TSFVPPYMMARQLSTLDHLTGGRVGWNIVTSYSKSEFQ
MUL_4507|M.ulcerans_Agy99 TKTLKFLVALR-PGLVSPTLAAQMATTFQQQSGGRLLVNVVTGGEAHEQR
* : : * *: ::: : ** .: :
Mb1886c|M.bovis_AF2122/97 QLG-FEFGTFSDRFNRLEEALQILEPMVKGERP-----------------
Rv1855c|M.tuberculosis_H37Rv QLG-FEFGTFSDRFNRLEEALQILEPMVKGERP-----------------
MSMEG_4552|M.smegmatis_MC2_155 NFSARGVIDHDDRYAIAEEALEVVRKLWDEWGEDTIVEDRPAGIFNDVGR
MAB_4125|M.abscessus_ATCC_1997 NFGERGFLPHDERYRLAEETLQVVKSLWHSLEPDTVIEDRAAGIYSDINK
TH_4079|M.thermoresistible__bu NFGRPAHPDPEHRYSRADEFLQVALRLWDSWEDDAIVGDKQAPRFVDPDK
Mvan_6020|M.vanbaalenii_PYR-1 NFGLAHHPDRDSRYARAEEFVSACKALWNSWDEDAFVERKDTGQYLNARK
MMAR_0703|M.marinum_M NFRRGGYLDHADRYQRAEEFLTVARKFWDSWAPGAVLADIENGDYVDPER
MAV_2048|M.avium_104 NFRRGGFLAHADRYRRAEEFITVARKFWDSWSPGAVIADVDAGTYADPAR
Mflv_0250|M.gilvum_PYR-GCK AMGKENLTPRDKRYEVVEEYMQLLYQLWDSWDDDAIVYDRDNGVFADPAK
MUL_4507|M.ulcerans_Agy99 AYG--DFLDKQQRYRRTGEFLHVVRQLWASGQP-----------------
*: * : :
Mb1886c|M.bovis_AF2122/97 ----TFFGDWYTTESAMAEPRYRDRIPILIGGGGEKKTFAIAARFADHLN
Rv1855c|M.tuberculosis_H37Rv ----TFFGDWYTTESAMAEPRYRDRIPILIGGGGEKKTFAIAARFADHLN
MSMEG_4552|M.smegmatis_MC2_155 IRPANHHGRYFDVAGPIGAARSAQGQPVLFQAGSSETGRAFAARHAEVIF
MAB_4125|M.abscessus_ATCC_1997 IHVANHDGEFHKVKGPLGVTPSRQGHPVIFQAGSSTTGRAFAARHAEVVF
TH_4079|M.thermoresistible__bu IHAIDHRGEHFSVAGPLEVPRSPQGHPVLFQAGSSEPGKQLAAKYAEAIF
Mvan_6020|M.vanbaalenii_PYR-1 VRVPDYKGRHLSVKGPLNVSRSPQGRPVLFHAGQSEGGRRLAARHADCIF
MMAR_0703|M.marinum_M IRSVEHSGPQFEVRGFATLPAGPQGHPVLLQAGDSEQGRAFGARHADAMF
MAV_2048|M.avium_104 IGVVEHHGRQFDVRGVASLPAGPQGHPVLLQAGDSSDGRDFGAKHADALF
Mflv_0250|M.gilvum_PYR-GCK VREVNFQGEFFQSRGRHFVAPSPQKRPVLWQAGSSAQGREFASRHAESVF
MUL_4507|M.ulcerans_Agy99 ---VTFEGEHIHVH-QAQLGRLPDPPPPVFFGGSSESAGAVAARYADTYL
. * : * : .* . ..::.*:
Mb1886c|M.bovis_AF2122/97 -IVAAVDELPRKMRALAARCDEAGRDRSTLQTSLLLTVMIDET-------
Rv1855c|M.tuberculosis_H37Rv -IVAAVDELPRKMRALAARCDEAGRDRSTLQTSLLLTVMIDET-------
MSMEG_4552|M.smegmatis_MC2_155 TSHGNRERAQTFYGQIHEQSRQFGRGAPPL-ITPSLRYIVGSTDEEARRA
MAB_4125|M.abscessus_ATCC_1997 TGQTDVERAKNFYRQLHQEARAAGRTFAPL-VTPSLGVVVGSTEAEALAA
TH_4079|M.thermoresistible__bu TAQPTVEEARQFYADVKARVRQHGRDPDRVHILPGLSAIIGGTEEEARRI
Mvan_6020|M.vanbaalenii_PYR-1 EAAASVEAAREFYADLKRRRVEIGGEPDHLRIIVSVAVYLGRTESEAVEL
MMAR_0703|M.marinum_M TLHSSLRDGQRYYADVKGRARSYGRDPDQLKVFPAATFVIGDTPDQAGEK
MAV_2048|M.avium_104 TLHGSLEAGQRYYADVKSRAAAHGRDPEQLKVLPGATFALGDTPAEAADN
Mflv_0250|M.gilvum_PYR-GCK GIFPTPKSMRAYATDIRTRASDAGRDPESVKLIYGLQTIIDRDKGRANDR
MUL_4507|M.ulcerans_Agy99 TWGEPLSAVGKKIDWIRGLAADHGRALSYGLRIHVITRDTAEEAWRVADR
: *
Mb1886c|M.bovis_AF2122/97 ---------------------LSPDAIPAEMSG-----------------
Rv1855c|M.tuberculosis_H37Rv ---------------------LSPDAIPAEMSG-----------------
MSMEG_4552|M.smegmatis_MC2_155 EREE-YEYFSPGYQAGWLL-EVDVDVTGADLDGPVPDSAFPEHTETHQ--
MAB_4125|M.abscessus_ATCC_1997 ESTI-YEHFIPEYQAGWLL-EVDVNVVGADLDGPVPASAFPDSTETHQ--
TH_4079|M.thermoresistible__bu QRRL-EDLTVPDYGLEQLSRIVGYRVGRDDLDRRLQFGSDDPPAIHMQ--
Mvan_6020|M.vanbaalenii_PYR-1 YSEL-NSLISPDLGVDFLAKAVSEDLTGYPVDGPMPDLS--APVVGGN--
MMAR_0703|M.marinum_M ARQISYQQVSGATAIAMLEQVWGRDLSDYDPDGPLPDIDPIADAAISQGR
MAV_2048|M.avium_104 ARHIREQQVSGPTAIAFLEQVWGVDLSAYDPDGPLPDVEPVENPTITRGR
Mflv_0250|M.gilvum_PYR-GCK YAEF-VENVQIESALGILSGHTGFDFSTLGLDDNVVDADVQGIRGLFD--
MUL_4507|M.ulcerans_Agy99 LLAGIDPADIERMQANLARSESEGQRRMAELHGGVLDQLEIAPNLWAG--
Mb1886c|M.bovis_AF2122/97 -------------------------------------RVVVGSPAQIADQ
Rv1855c|M.tuberculosis_H37Rv -------------------------------------RVVVGSPAQIADQ
MSMEG_4552|M.smegmatis_MC2_155 -------TALAGYRHLASEGNPTVREFLYRTVNGWG-AAVVGTPERIADT
MAB_4125|M.abscessus_ATCC_1997 -------TALAGYKHLATVGNPTVREFLYRTLNAFG-TRFVGSAEQVADQ
TH_4079|M.thermoresistible__bu -------SRYALVRRLVSTENLTVRELLLRLSGGRGHRVFAGTPEQVADT
Mvan_6020|M.vanbaalenii_PYR-1 -------SIRGQLDAIAKAEQLTVRQMYERVVPTMGNTALIGTATQIADV
MMAR_0703|M.marinum_M VRHADPVAVARRYRERSQAENLSIRELVIAVTSRQQ---FVGTPSHIADE
MAV_2048|M.avium_104 VRHGDPKTVAETWRARARAENLSIRELIIEVTSRQQ---FVGTPQQVAAE
Mflv_0250|M.gilvum_PYR-GCK -----------AILEAKDGAPVTVREAAQIYGVSMGAPVAVGTPADVADQ
MUL_4507|M.ulcerans_Agy99 ----------------------------VGLVRGGAGTALVGSHQEVAER
*: :*
Mb1886c|M.bovis_AF2122/97 IQAKVLDAGVDGLIIN--------------LAPHGYLPG--VITTAAEAL
Rv1855c|M.tuberculosis_H37Rv IQAKVLDAGVDGLIIN--------------LAPHGYLPG--VITTAAEAL
MSMEG_4552|M.smegmatis_MC2_155 IEEWFTTGAADGFVLRDSGLPGQHELFVEQVVPVLRKRGLFRHEYTGTTL
MAB_4125|M.abscessus_ATCC_1997 IELWFSEGAADGFILSTSGLPGQFELFTEHVVPILVRRGLFRAEYTGSTL
TH_4079|M.thermoresistible__bu IEEWFTTGAADGFNLIPPALPSSLTAFVDHVVPELQRRGLFRTEYTGTTL
Mvan_6020|M.vanbaalenii_PYR-1 MEEWYTTGACDGFVLGASISPFTLLLIRDELVPELQRRGLFRRHYTGSTL
MMAR_0703|M.marinum_M IDRYVQADACDGFILVPHLTPHGLDEFVDRVVPLLQERGAFRTAYTGQTL
MAV_2048|M.avium_104 IDHYVQSDACDGFILVPHLTPHGLDEFVDKVVPLLQERGSFRAEYRGITL
Mflv_0250|M.gilvum_PYR-GCK MEQYLDEGDCNGFMMLATDTPGCFNDMTELLVPELQKRGRFRTRYPGTTL
MUL_4507|M.ulcerans_Agy99 IIEYARLG-ISHFILSGYPHLEEAYWFGEGVLPILERKRLWHRPHGSSPH
: . : : : * . .
Mb1886c|M.bovis_AF2122/97 RPLLGV-------------------
Rv1855c|M.tuberculosis_H37Rv RPLLGV-------------------
MSMEG_4552|M.smegmatis_MC2_155 RAHLGL--DIPQR-----SVS----
MAB_4125|M.abscessus_ATCC_1997 REHLALPWPVPAR-----PPALLA-
TH_4079|M.thermoresistible__bu RDHLGLP-RPRNRFTTGRPVAAAS-
Mvan_6020|M.vanbaalenii_PYR-1 RENLGLP-PVDN-----SPFAT---
MMAR_0703|M.marinum_M RDHLGLAGLPS--------------
MAV_2048|M.avium_104 REHLGLAPAPGSAPGADLESHCATG
Mflv_0250|M.gilvum_PYR-GCK RESLREY------------------
MUL_4507|M.ulcerans_Agy99 SAALPVAHSSVN-------------
*