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QTQAAVLFERNTPWSIETIELDGPKATEVLVELHASGMCHSDDHLVTGDMPIALPCIGGHEGAGVVKAVG EHVSWLAPGDHVVFSFIPSCGRCPSCSTGHQSLCDLGAKIYSGMQIHDGTARHHLNDKDLALACGIGSFA HHTVVHEASCVKIPDHYRLDLACLLGCGFITGWGSAVYAAEVRPGDTVAIAGVGGIGAAAVQGAKLAGAR TITVIDPSEHKREEAMKMGATHTAADWQEAKGVVAKATWDRGVDKFICAMGVGDGQLIGQALAMTAKRGK LVVTNIHPMLEREIRANLMDLTLTEKQIIGTLYGSGNPRADIPKILELFSAGQVDLEAMVTRTYPLDKVN DGYADMHAGANIRGVLLYPPAENANC*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1943 | - | - | 100% (377) | alcohol dehydrogenase B |
| M. avium 104 | MAV_2646 | - | 0.0 | 92.53% (375) | alcohol dehydrogenase B |
| M. avium 104 | MAV_0705 | - | 3e-98 | 47.33% (374) | alcohol dehydrogenase B |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0784c | adhB | 1e-99 | 47.57% (370) | zinc-containing alcohol dehydrogenase NAD dependant ADHB |
| M. gilvum PYR-GCK | Mflv_1486 | - | 1e-105 | 50.41% (369) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv0761c | adhB | 1e-99 | 47.57% (370) | zinc-containing alcohol dehydrogenase NAD dependent ADHB |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 2e-44 | 31.67% (360) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_2084 | - | 1e-101 | 50.14% (369) | zinc-type alcohol dehydrogenase AdhD |
| M. marinum M | MMAR_3150 | - | 1e-100 | 49.32% (369) | zinc-containing alcohol dehydrogenase NAD- dependent |
| M. smegmatis MC2 155 | MSMEG_5866 | - | 1e-101 | 48.93% (374) | alcohol dehydrogenase B |
| M. thermoresistible (build 8) | TH_1254 | - | 1e-101 | 48.65% (370) | alcohol dehydrogenase B |
| M. ulcerans Agy99 | MUL_0470 | adhB | 6e-97 | 46.52% (374) | zinc-containing alcohol dehydrogenase NAD- dependent AdhB |
| M. vanbaalenii PYR-1 | Mvan_5270 | - | 1e-105 | 50.95% (369) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0784c|M.bovis_AF2122/97 --MKTKGALIWEFNQPWSVEEIEIGDPRKDEVKIQMEAAGMCRSDHHLVT
Rv0761c|M.tuberculosis_H37Rv --MKTKGALIWEFNQPWSVEEIEIGDPRKDEVKIQMEAAGMCRSDHHLVT
MUL_0470|M.ulcerans_Agy99 --MKTKGALIWEFNQPWSVEDIEIGDPVKDEVKIQMEAAGMCRSDNHLVT
MSMEG_5866|M.smegmatis_MC2_155 --MKTKGALIWEFNQPWSIEEIEIGDPVKDEVKIQMEASGMCHSDHHLVT
TH_1254|M.thermoresistible__bu --MKTKGALIWEFNQPWSVEEIEIGDPVKDEVKIRMEASGMCHSDHHLVT
Mflv_1486|M.gilvum_PYR-GCK --MKTNAAILWEYGGDWTVEEIDLDPPGDGEVLVSWQATGLCHSDEHIRT
Mvan_5270|M.vanbaalenii_PYR-1 --MKTNAAILWEYGGDWTVEEIDLDPPGDGEVLVSWEATGLCHSDEHIRT
MAB_2084|M.abscessus_ATCC_1997 --MKTRAAVLWGLEQKWEVEEVDLDPPGPGEVLVRLAATGLCHSDEHLVT
MMAR_3150|M.marinum_M --MKTRAAVLWGLGEKWEVEDIELDPPGPDEVLVQLTATGLCHSDEHLVT
MAV_1943|M.avium_104 --MQTQAAVLFERNTPWSIETIELDGPKATEVLVELHASGMCHSDDHLVT
MLBr_01784|M.leprae_Br4923 MSQTVRGVISRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCHTDLTYRE
....: : : : * *. : * *:*::*
Mb0784c|M.bovis_AF2122/97 GDIPMAGFPVLGGHEGAGIVTEVGPGVDDFAPGDHVVLAFIPSCGKCPSC
Rv0761c|M.tuberculosis_H37Rv GDIPMAGFPVLGGHEGAGIVTEVGPGVDDFAPGDHVVLAFIPSCGKCPSC
MUL_0470|M.ulcerans_Agy99 GGIPMAGFPVLGGHEGAGVVTEVGPGVDDIAPGDHVVLSFIPSCGRCPTC
MSMEG_5866|M.smegmatis_MC2_155 GGIPMGGFPVLGGHEGAGIVTEVGPGVEGIEPGDHVVLSFIPSCGSCPSC
TH_1254|M.thermoresistible__bu GGIPMGGFPVLGGHEGAGVVEEVGPGVEEVQPGDHVVLSFIPSCGQCPSC
Mflv_1486|M.gilvum_PYR-GCK GDLPAP-LPLIGGHEGAGIVREVGAGVVGLAPGDHVVASFLPACGRCRFC
Mvan_5270|M.vanbaalenii_PYR-1 GDLPAP-LPLIGGHEGAGIVREVGPGVVGLAPGDHVVASFLPACGRCRFC
MAB_2084|M.abscessus_ATCC_1997 GDLPIP-LPVVGGHEGAGTVVECGEGVEDLSEGDSVILTFLPSCGRCSYC
MMAR_3150|M.marinum_M GDLPIP-LPVVGGHEGAGTVVEVGAGVENVAEGDSVILTFLPSCGHCSYC
MAV_1943|M.avium_104 GDMPIA-LPCIGGHEGAGVVKAVGEHVSWLAPGDHVVFSFIPSCGRCPSC
MLBr_01784|M.leprae_Br4923 GGINDR-YPFLLGHEAAGTVEVVGPGVTAVEPGDFVILNWRAVCGQCRAC
*.: * : ***.** * * * . ** *: : . ** * *
Mb0784c|M.bovis_AF2122/97 QAGMRNLCDLGAGLLAGESVTDGSFRIQARGQNVYPMTLLGTFSPYMVVH
Rv0761c|M.tuberculosis_H37Rv QAGMRNLCDLGAGLLAGESVTDGSFRIQARGQNVYPMTLLGTFSPYMVVH
MUL_0470|M.ulcerans_Agy99 QAGLRNLCDLGAGLLAGAAVSDGTFRIQARGQNVYPMTLLGTFSPYMVVH
MSMEG_5866|M.smegmatis_MC2_155 QAGLRNLCDLGAGLLGGVAVADGTHRIHANGKPVFPMTLLGTFSPYMVVH
TH_1254|M.thermoresistible__bu QAGLRNLCDLGAGLLNGAAVSDGTFRITARGQNVYPMTLLGTFSPYMVVH
Mflv_1486|M.gilvum_PYR-GCK STGHQNLCDLGAMIMAGTQL-DGTYRRHINGQDVGVMALVGTFSQYGTVP
Mvan_5270|M.vanbaalenii_PYR-1 STGHQNLCDLGAMIMAGTQL-DGTYRRHVRGQDVGVMALVGTFSQYGTVP
MAB_2084|M.abscessus_ATCC_1997 ARGMGNLCELGAALMMGPQI-DGTYRFHARGEDVGQMCLLGTFSEYTVVP
MMAR_3150|M.marinum_M ARGMGNMCDLGAALMMGPQI-DGTYRFHARGEDVGQMCLLGTFSEYTVVP
MAV_1943|M.avium_104 STGHQSLCDLGAKIYSGMQIHDGTARHHLNDKDLALACGIGSFAHHTVVH
MLBr_01784|M.leprae_Br4923 KRGRPSYCFDTFNAQQKMTLIDGTELTPALG--------IGAFADKTLVH
* . * : **: . :*:*: *
Mb0784c|M.bovis_AF2122/97 RSSVVKIDPSVPFEVACLVGCGVTTGYGSAVRTADVRPGDDVAIVGLGGV
Rv0761c|M.tuberculosis_H37Rv RSSVVKIDPSVPFEVACLVGCGVTTGYGSAVRTADVRPGDDVAIVGLGGV
MUL_0470|M.ulcerans_Agy99 RSSVVKIDPAIPFEVAALVGCGVTTGYGSAVRTADVRPGDDVAIVGLGGV
MSMEG_5866|M.smegmatis_MC2_155 KSSVVKIDKSIPFEVACLVGCGVTTGYGSAVRSGDIRPGDDVAIFGIGGV
TH_1254|M.thermoresistible__bu KSSVVKIDKDIPFEVACLVGCGVTTGYGSAVRSGDVRPGDDVAIVGVGGV
Mflv_1486|M.gilvum_PYR-GCK EASIVKIDDDIPLSRACLLGCGVTTGWGSAVNTADVSPGDTVVIIGLGGI
Mvan_5270|M.vanbaalenii_PYR-1 EASIVKIDDDIPLSRACLLGCGVTTGWGSAVNTADVSPGDTVVIIGLGGI
MAB_2084|M.abscessus_ATCC_1997 QASVVKIDGGIPLDRAALIGCGVTTGYGSAVRTGEVRAGDTVVVVGAGGI
MMAR_3150|M.marinum_M KASLVKIDQGTPLDKAALIGCGVTTGYGSAVRTGEVRAGDTVAVIGAGGI
MAV_1943|M.avium_104 EASCVKIPDHYRLDLACLLGCGFITGWGSAVYAAEVRPGDTVAIAGVGGI
MLBr_01784|M.leprae_Br4923 SGQCTKVDPAADPAVAGLLGCGVMAGLGAAINTAAVSRDDTVAVIGCGGV
.. .*: * *:***. :* *:*: :. : .* *.: * **:
Mb0784c|M.bovis_AF2122/97 GMAALQGAVSAGARYVFAVEPVEWKRDQALKFGATHVYPDIN-AALMGIA
Rv0761c|M.tuberculosis_H37Rv GMAALQGAVSAGARYVFAVEPVEWKRDQALKFGATHVYPDIN-AALMGIA
MUL_0470|M.ulcerans_Agy99 GMAALQGAVTAGARYIFAVEPVEWKRDQALKFGATHVYPDME-AALMGIA
MSMEG_5866|M.smegmatis_MC2_155 GMGALQGAVNAGARYIFAIDPVEWKRDQALKFGATHVYPDVF-SAMAGIA
TH_1254|M.thermoresistible__bu GMGALQGAVNAGARYIFAIDPVEWKRDQALKFGATHVYPDIE-SAMAGIA
Mflv_1486|M.gilvum_PYR-GCK GSGAIQGARLAGAEKIVVVEPVETKRDLAFRFGATHFVTSME-EATALVA
Mvan_5270|M.vanbaalenii_PYR-1 GSGAIQGARLAGAEKIVVIEPVESKRELAFRFGATHFVTSME-EATALVA
MAB_2084|M.abscessus_ATCC_1997 GMNAIQGARIAGALAIVAVDPVNFKREQASGFGATHTAASMD-EAWSLVS
MMAR_3150|M.marinum_M GMNAIQGARIAGALNIVAVDPVAFKREQAGGFGATHAVATID-EAWSLIS
MAV_1943|M.avium_104 GAAAVQGAKLAGARTITVIDPSEHKREEAMKMGATHTAADWQ-EAKGVVA
MLBr_01784|M.leprae_Br4923 GDAAISGAALVGANRIIAVDIDDTKLEWARTFGATHTVNALELEVVKTIQ
* *:.** .** : .:: * : * :**** . :
Mb0784c|M.bovis_AF2122/97 EVTYGLMAQKVIITVGKLDGADVDSYLTITAKGGTCVLTAIGSLVDTQVT
Rv0761c|M.tuberculosis_H37Rv EVTYGLMAQKVIITVGKLDGADVDSYLTITAKGGTCVLTAIGSLVDTQVT
MUL_0470|M.ulcerans_Agy99 EVTYGLMAKKVMITVGELQGSDIDTYLAITSKGGTCVVTAIGSLLDTQVN
MSMEG_5866|M.smegmatis_MC2_155 EVTAGGMAKKVIVTVGELHGEDIDNYLNVTSKGGTCVVTAVGSMLDTNAN
TH_1254|M.thermoresistible__bu EVTWGLMAKKVIVTVGELKGEDIDAYVNLTAKGGTCVLTAIGSLLDTQVN
Mflv_1486|M.gilvum_PYR-GCK ELTRGVMADSAILTVGLLAGSMLEEAANIIRKGGAVVMTALSTMADNQPT
Mvan_5270|M.vanbaalenii_PYR-1 DLTRGVMADSAILTVGLLEGSMLEEAANIIRKGGAVVMTALSTMADNQPT
MAB_2084|M.abscessus_ATCC_1997 DMTRGKLADVCILTTDVAEGSYTAEALALVGKRGRVVVTAIGHPDESSIS
MMAR_3150|M.marinum_M DITRGKLADVCVLTTDVAEGSYIGEALSLVGKRGRVVVTAIGHPEDTSMS
MAV_1943|M.avium_104 KATWDRGVDKFICAMGVGDGQLIGQALAMTAKRGKLVVTNIHPMLEREIR
MLBr_01784|M.leprae_Br4923 DLTSGFGVDVVIDTVGRPE--TWKQAFYARDLAGTVVLVGVPTP-DMRLD
. * . .. : : . * *:. : :
Mb0784c|M.bovis_AF2122/97 LNLAMLTLLQKNIQGTIFGGGNPHYDIPKLLSMYKAGKLNLDDMVTTAYK
Rv0761c|M.tuberculosis_H37Rv LNLAMLTLLQKNIQGTIFGGGNPHYDIPKLLSMYKAGKLNLDDMVTTAYK
MUL_0470|M.ulcerans_Agy99 LNLAMLTLMQKNLQGTIFGGGNPQYDIPHLLSMYKARNLNIDDMITRQYR
MSMEG_5866|M.smegmatis_MC2_155 INLAMLTLLQKNLQGTIFGGGNPHHDIPQLLSMYKAGKLNLDDMVTRQYR
TH_1254|M.thermoresistible__bu LNLSMLTLLQKNLQGTIFGGGNPHHDIPQLLSMYKAGKLNLDDMVTRQYK
Mflv_1486|M.gilvum_PYR-GCK LGMMMFTLFQKRLLGSLYGEANPRADIPRLLSLYREGKLLLDETVTHEYK
Mvan_5270|M.vanbaalenii_PYR-1 LGMMMFTLFQKRLLGSLYGEANPRADIPRLLSLYREGKLLLDETVTHEYK
MAB_2084|M.abscessus_ATCC_1997 GSLLEMTLYEKQIRGALYGSSNAPHDIPRLVELYSAGLLKLDELVTREYS
MMAR_3150|M.marinum_M GSLLELTLYEKQIRGALYGSSNAAHDIPRLVELYNAGHLKLDELITREYT
MAV_1943|M.avium_104 ANLMDLTLTEKQIIGTLYGSGNPRADIPKILELFSAGQVDLEAMVTRTYP
MLBr_01784|M.leprae_Br4923 MPLLDFFSHGGSLKSSWYGDCLPERDFPTLVDLYLQGRLPLGKFVSERIG
: : : .: :* . *:* ::.:: : : ::
Mb0784c|M.bovis_AF2122/97 LEQINDGYQDMLNGKNIRGVIRYTDDDR---
Rv0761c|M.tuberculosis_H37Rv LEQINDGYQDMLNGKNIRGVIRYTDDDR---
MUL_0470|M.ulcerans_Agy99 LEQINEGYQDMIDGKNIRGVIRFTDADR---
MSMEG_5866|M.smegmatis_MC2_155 LEQINDGYQDMLEGRNIRGVIRYTDADR---
TH_1254|M.thermoresistible__bu LEQINEGYQDMLEGRNIRGVIRYTDDDR---
Mflv_1486|M.gilvum_PYR-GCK LAEVNEGYEDMREGRNIRGVILHDH------
Mvan_5270|M.vanbaalenii_PYR-1 LAEVNEGYEDMRAGRNIRGVILHDH------
MAB_2084|M.abscessus_ATCC_1997 LDQINEGYQDMRSGRNIRGLVRF--------
MMAR_3150|M.marinum_M LDQINEGYADMRSGRNIRGLIRF--------
MAV_1943|M.avium_104 LDKVNDGYADMHAGANIRGVLLYPPAENANC
MLBr_01784|M.leprae_Br4923 LGDVEEAFHKIHGGKVLRSVVML--------
* .:::.: .: * :*.::