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MTDGWSTPEPTRAAALGTDLHLELAVGAGLRSGLEDALRTAVRSGRLAPGTRLPSSRALAADLGVARNTV ADAYAELTAEGWLTAQQGSGTRVAHRAEPRSNPPSTDYRALIHQRPAHALVPGSPNLAEFPRVQWLAAAR RALTAAPYDAFGYGDPAGRIELRTALATYLSRARGVHTNPNHIVICSGFHHGLQLIAQALTARRVRAVAV EAYGFDAYRDILTGAGLRIPPLYVDERGARTVDLRSLGNVGAALLTPAHQYPTGVELRPDRRTAAIDWAR SSGGLILEDDYDGEFRYDRRPVGALQSLDPDRVAYFGSTSKSLAPGLRLAWMVLPADIVPDVLDAKGIVD AASTLDQLTLAEFIESGAYDRHVRAMRLRYKARRDQLVAVLADRAPEVRVCGMAAGLQAVLELAPGTERT VVQAAARKGLAICGMQEFRYEGAGVELPTRDALVVGYAAPSDSAWASALDALCSVLP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4140 | - | - | 100% (477) | GntR-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_5760 | - | e-129 | 54.11% (462) | GntR-family protein regulator |
| M. smegmatis MC2 155 | MSMEG_6371 | - | e-120 | 50.11% (473) | GntR-family protein regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3595 | aspB | 4e-09 | 25.50% (200) | aspartate aminotransferase |
| M. gilvum PYR-GCK | Mflv_1181 | - | 1e-126 | 52.47% (465) | GntR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv3565 | aspB | 5e-09 | 25.50% (200) | aspartate aminotransferase |
| M. leprae Br4923 | MLBr_01488 | - | 1e-06 | 26.67% (255) | N-succinyldiaminopimelate aminotransferase |
| M. abscessus ATCC 19977 | MAB_0196c | - | 1e-120 | 48.96% (482) | GntR family transcriptional regulator |
| M. marinum M | MMAR_2376 | - | 1e-17 | 30.67% (388) | GntR family transcriptional regulator |
| M. avium 104 | MAV_3214 | - | 1e-23 | 34.12% (381) | GntR-family protein transcriptional regulator |
| M. thermoresistible (build 8) | TH_4188 | - | 1e-07 | 44.44% (63) | PUTATIVE transcriptional regulator, GntR family |
| M. ulcerans Agy99 | MUL_1552 | - | 9e-18 | 30.99% (384) | GntR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_5625 | - | 1e-122 | 52.46% (467) | GntR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1181|M.gilvum_PYR-GCK MVSSWSNSG-------SRDLHLDLREALRPGARGNRNALVAALREAVRSG
Mvan_5625|M.vanbaalenii_PYR-1 -MTSWANSA-------TRDLHLDLRDALVPGARGTKDALISALRDAARSG
MAB_0196c|M.abscessus_ATCC_199 -MSSWANSAKAESRPLSHDLHLDLRQSITPGTRGVRELLTSALRDAVRSG
MSMEG_4140|M.smegmatis_MC2_155 MTDGWSTPEPTR----AAALGTDLHLELAVGA-GLRSGLEDALRTAVRSG
MMAR_2376|M.marinum_M ---------------------MPVQYRIAGGG---AESIAASIESAISQG
MUL_1552|M.ulcerans_Agy99 ---------------------MPVQNRIAGGG---AGSIAASIESAISQG
MAV_3214|M.avium_104 ---------------------MAVQKSITGTG---AESIAASIEAAISAG
Mb3595|M.bovis_AF2122/97 -----------------------------------------------MTD
Rv3565|M.tuberculosis_H37Rv -----------------------------------------------MTD
MLBr_01488|M.leprae_Br4923 ---------------------------------------------MSPFG
TH_4188|M.thermoresistible__bu -----------------------------VRPRPAYQVLRDRLRDDIAAG
.
Mflv_1181|M.gilvum_PYR-GCK RLSAGTTLPPSRALAADLGLARNTVADAYAELVAEGWLASRQGAGTWVVD
Mvan_5625|M.vanbaalenii_PYR-1 RLTAGTMLPSSRTLATDLGLARNTVAEAYAELVAEGWLASRQGAGTWVAD
MAB_0196c|M.abscessus_ATCC_199 RLTVGSMLPPSRTLASDLGLARNTVAEAYAELVAEGWLESRQGSGTRVVN
MSMEG_4140|M.smegmatis_MC2_155 RLAPGTRLPSSRALAADLGVARNTVADAYAELTAEGWLTAQQGSGTRVAH
MMAR_2376|M.marinum_M GLAPGDALPSIREVAGQLGVNPNTVAAAYRLLRDRGTVETAGRRGTRVRD
MUL_1552|M.ulcerans_Agy99 GLAPGDALPSIREVAGQLGVNPNTVAAAYRLLRDRGTVETAGRRGTRVRD
MAV_3214|M.avium_104 SLAPGDALPPVRELAARLGVNANTAAAAYRLLRHRGAVETAGRRGTRVRH
Mb3595|M.bovis_AF2122/97 RVALRAGVPPFYVMDVWLAAAERQRTHGDLVNLSAGQPSAGAPEPVRAAA
Rv3565|M.tuberculosis_H37Rv RVALRAGVPPFYVMDVWLAAAERQRTHGDLVNLSAGQPSAGAPEPVRAAA
MLBr_01488|M.leprae_Br4923 RVSATLPVFPWDTLADAKAVAESHPDGIVDLSVGTPVDPVAPLIQEALAA
TH_4188|M.thermoresistible__bu RYRDGTRLPTESELMAQYGVSRQTVRRAFQDLVAEGSVYRVPGRGTYAAD
: . : .
Mflv_1181|M.gilvum_PYR-GCK TARASSQPPPVPPRPHGARVAP-VHNLMPGSPDVAEFPRSQWAASARRAL
Mvan_5625|M.vanbaalenii_PYR-1 VT----TPAHTPPRPHGVRVAP-THNLMPGSPDVAEFPRSQWLASTRRAL
MAB_0196c|M.abscessus_ATCC_199 RG-----KDQLPPRPRGAGTPP-PHNLMPGSGDVTAFPRADWLASARRAL
MSMEG_4140|M.smegmatis_MC2_155 RAEPRSNPPSTDYR-ALIHQRP-AHALVPGSPNLAEFPRVQWLAAARRAL
MMAR_2376|M.marinum_M RP------ASTPRSSLDLGVPAGARDLSTGNPAPELLP-----LAAVG-W
MUL_1552|M.ulcerans_Agy99 RP------ASTPRSSLDLGVPAGARDLSTGNPAPELLP-----LAAVG-W
MAV_3214|M.avium_104 RP------ATTPRSLLGLDVPAGVRDLSTGNPHPALLP-----LAAAAPA
Mb3595|M.bovis_AF2122/97 AA------------------------------------------------
Rv3565|M.tuberculosis_H37Rv AA------------------------------------------------
MLBr_01488|M.leprae_Br4923 AS------------------------------------------------
TH_4188|M.thermoresistible__bu RY------------------------------------------------
Mflv_1181|M.gilvum_PYR-GCK THAPTDAFRMGDPRGRPELRSALAEYLARARGVR-TSPESLVICAGVRHA
Mvan_5625|M.vanbaalenii_PYR-1 GGAPTEALRMGDPRGRPELRSALAEYLARARGVR-TSPESIVICAGVRHA
MAB_0196c|M.abscessus_ATCC_199 NHAPHEALRVGDPRGRHELRSAVAEYVSRVRGVR-TTPDSILICAGTRHA
MSMEG_4140|M.smegmatis_MC2_155 TAAPYDAFGYGDPAGRIELRTALATYLSRARGVH-TNPNHIVICSGFHHG
MMAR_2376|M.marinum_M PDGSVLPLLYGAPAMSAELVDYARAALAADG----VAADHLAVTNGALDG
MUL_1552|M.ulcerans_Agy99 PDGSVLPLLYGAPAMSAELVDYARAALAADG----VAADHLAVTNGALDG
MAV_3214|M.avium_104 RPASGRAVLYGEPAISPALAEYARAALSADG----VPADHLALTSGALDG
Mb3595|M.bovis_AF2122/97 -ALHLNQLGYSVALGIPELRDAIAADYQRRHGIT-VEPDAVVITTGSSGG
Rv3565|M.tuberculosis_H37Rv -ALHLNQLGYSVALGIPELRDAIAADYQRRHGIT-VEPDAVVITTGSSGG
MLBr_01488|M.leprae_Br4923 -----SVAGYPTTAGTARLREAAVAALDRRYGITGLTEAAVLPVIGTKEL
TH_4188|M.thermoresistible__bu ------LRQFGSIEDLMALS----------------DDTTMEVRSGLRRR
* : *
Mflv_1181|M.gilvum_PYR-GCK VELLARTLG----GPVAVEAYGLFVFRDAIAACGVQTVPIGVDDDGAVIA
Mvan_5625|M.vanbaalenii_PYR-1 VELLTRALG----GPIAVESYGLFVFRDAIAAAGASTVPIGVDDRGAVVD
MAB_0196c|M.abscessus_ATCC_199 VEILTRMYGL--ARPIAVEAYGLFIFRDCIEATGGSSTPIGFDGEGAVVS
MSMEG_4140|M.smegmatis_MC2_155 LQLIAQALTARRVRAVAVEAYGFDAYRDILTGAGLRIPPLYVDERGARTV
MMAR_2376|M.marinum_M IERALSANLRP-GDRVAVEDPGWANLLDLLAALGLPVEPMGVDDDGPLVA
MUL_1552|M.ulcerans_Agy99 IERALSANLRP-GDRVAVEDPGWANLLDLLAALGLPVEPMGVDDDGPLVA
MAV_3214|M.avium_104 IERALTAHLRP-GDRVAVEDPGWANLLDLLAALGFSAEPVRVDDAGPLPE
Mb3595|M.bovis_AF2122/97 FLLAFLACFDA-GDRVAMASPGYPCYRNILSALGCEVVEIPCGPQTRFQP
Rv3565|M.tuberculosis_H37Rv FLLAFLACFDA-GDRVAMASPGYPCYRNILSALGCEVVEIPCGPQTRFQP
MLBr_01488|M.leprae_Br4923 IAWLPTLLGLRAGDVVVVPELAYPTYNVGARLAGARVLRADSLTQLGLQS
TH_4188|M.thermoresistible__bu VDVDAASRLRLDDDVVHT-----VVFRRLHAGAP----------------
. :
Mflv_1181|M.gilvum_PYR-GCK DLDDT---SARSV-LLTPAHHNPLGMPLHPSRRAAVIEWATRTGGYILDD
Mvan_5625|M.vanbaalenii_PYR-1 ELDGL---DVPAV-LLTPAHHNPLGMPLHSSRRTAVIEWAQRTGGFVLDD
MAB_0196c|M.abscessus_ATCC_199 DLENL---DTSAA-LITPAHHFPHGLPLHPARRTAVVDWARRTDSYVLED
MSMEG_4140|M.smegmatis_MC2_155 DLRSLG--NVGAA-LLTPAHQYPTGVELRPDRRTAAIDWARSSGGLILED
MMAR_2376|M.marinum_M DLQRALGRGVRAV-VVTSRAQNPTGAALSAARAEELREVLSQGAEEVLLV
MUL_1552|M.ulcerans_Agy99 DLQRALGRGVRAV-VVTSRAQNPTGAALSAARAEELREVLSQGAEEVLLV
MAV_3214|M.avium_104 DLARALGRGARAL-VLTTRAQNPTGAALSAERAAALRDLLSGRADDVLLV
Mb3595|M.bovis_AF2122/97 TAQMLAEIDPPLRGVVVASPANPTGTVIPPEELAAIASWCDASDVRLISD
Rv3565|M.tuberculosis_H37Rv TAQMLAEIDPPLRGVVVASPANPTGTVIPPEELAAIASWCDASDVRLISD
MLBr_01488|M.leprae_Br4923 -----------PALFYLNSPSNPTGQVLAVNHLRKMVGWARNRGVVVVSD
TH_4188|M.thermoresistible__bu --------------FVSTVVHLPDRAAHHLHGCAELRTGAVSTHTVIGLL
. * :
Mflv_1181|M.gilvum_PYR-GCK DYDGEFRYDRQPVGALQALRP----DRVAYLGSTSKSLSQA-LRLGWMAL
Mvan_5625|M.vanbaalenii_PYR-1 DYDGEFRYDRQPVGALQSLRP----DRVAYLGSTSKSLSQT-LRLGWMAL
MAB_0196c|M.abscessus_ATCC_199 DYDGEFRYDRQPVGALQSLDP----DRVVYLGSASKSLAPA-LRLGWMVL
MSMEG_4140|M.smegmatis_MC2_155 DYDGEFRYDRRPVGALQSLDP----DRVAYFGSTSKSLAPG-LRLAWMVL
MMAR_2376|M.marinum_M EDDHCAGIAGVPLHTLAGAT-----QHWAFVRSAAKAYGPD-LRLAVLAG
MUL_1552|M.ulcerans_Agy99 EDDHCAGIAGVPLHTLAGAT-----QHWAFVRSAAKAYGPD-LRLAVLAG
MAV_3214|M.avium_104 EDDHCAGISGAALHPVAGCT-----THWAFVRSASKAYGPD-LRVAVLAG
Mb3595|M.bovis_AF2122/97 EVYHGLVYQGAPQTSCAWQTS----RNAVVVNSFSKYYAMTGWRLGWLLV
Rv3565|M.tuberculosis_H37Rv EVYHGLVYQGAPQTSCAWQTS----RNAVVVNSFSKYYAMTGWRLGWLLV
MLBr_01488|M.leprae_Br4923 ECYLGLGWDAEPFSVLHPLVCDGNHTGLLAVHSLSKSSSLAGYRAGFVAG
TH_4188|M.thermoresistible__bu EPHLEEPIDQAAQS------------------------------ITVAPA
: .
Mflv_1181|M.gilvum_PYR-GCK PAELVDQVVETAGGQQFHVDVVSQLTLADFLTAGHYDRHIRRMRMRYRRR
Mvan_5625|M.vanbaalenii_PYR-1 PDNLIDAVLAAAGGQQFYVDAINQLTLADFIAGGHYDRHIRRMRMRYRRR
MAB_0196c|M.abscessus_ATCC_199 PPEQMDAAVAATGGAQWYVGAISQLTMADFIAGGHYDRHIRRMRGRYRRR
MSMEG_4140|M.smegmatis_MC2_155 PADIVPDVLDAKG-IVDAASTLDQLTLAEFIESGAYDRHVRAMRLRYKAR
MMAR_2376|M.marinum_M DQRTVERVHGRLRLGPGWVSHILQDLAVRLFADDAATGLVRQAQERYADA
MUL_1552|M.ulcerans_Agy99 DQRTVERVHGRLRLGPGWVSHILQDLAVRLFADDAATGLVRQAQERYADA
MAV_3214|M.avium_104 DQRTVDRVHGRLRLGPGWVSHVLQQLAVELWSDTAASELVATAERRYADR
Mb3595|M.bovis_AF2122/97 PTVLRRAVDCLTGNFTICPPVLSQIAAVSAFTPEATAEADGNLAS-YAIN
Rv3565|M.tuberculosis_H37Rv PTVLRRAVDCLTGNFTICPPVLSQIAAVSAFTPEATAEADGNLAS-YAIN
MLBr_01488|M.leprae_Br4923 DPDLVAELLAVRKHAGMMVPTPVQAAMVAALGDDAHE---REQRDRYARR
TH_4188|M.thermoresistible__bu DDDTADAVGVEPGHPMLRIDRLYSDRTGRPVELSVSHFLPEQYTYRVTLR
.
Mflv_1181|M.gilvum_PYR-GCK RDMLVSALSP--FAVGIGGLAAGVNLLVTLPDGAEPELIRRAGEAGIALV
Mvan_5625|M.vanbaalenii_PYR-1 RDVLVSALSP--FDVGIGGLAAGVNLLVTLPDGAEPEVMRRAGESGLAVS
MAB_0196c|M.abscessus_ATCC_199 RDLLVQRLAG--YNVGVRGLSAGLHLLLTLPEGTESDVLYRAGEAGVALA
MSMEG_4140|M.smegmatis_MC2_155 RDQLVAVLADRAPEVRVCGMAAGLQAVLELAPGTERTVVQAAARKGLAIC
MMAR_2376|M.marinum_M RGRLCAALSAR--GVAAHGR-SGLNVWIPVPD--ETAAITRLLNRGWAAA
MUL_1552|M.ulcerans_Agy99 RGRLCAALSAR--GVAAHGR-SGLNVWIPVPD--ETAAITRLLNRGWAAA
MAV_3214|M.avium_104 RRRLCGALAER--GVDAHGR-SGLNVWVRVPD--EAVAVSRLLGAGWAAA
Mb3595|M.bovis_AF2122/97 RSLLLDGLRR----IGIDRLAPTDGAFYVYADVSDFTSDSLAFCSKLLAD
Rv3565|M.tuberculosis_H37Rv RSLLLDGLRR----IGIDRLAPTDGAFYVYADVSDFTSDSLAFCSKLLAD
MLBr_01488|M.leprae_Br4923 RDVLLPAVVS--AGFTVDHSEAGLYLWASRGE-PCRDSVEWFAQRGILVA
TH_4188|M.thermoresistible__bu RE------------------------------------------------
*
Mflv_1181|M.gilvum_PYR-GCK GLSMMRHPRAGSGVAERDGLIVGFAAAPEHAFPAAVSALCEVLRASGL
Mvan_5625|M.vanbaalenii_PYR-1 GLSIMRHPMAGP--ADVDGLIVGFAAPPEHAFSAAVAALCDVLRASGL
MAB_0196c|M.abscessus_ATCC_199 GLARLRHPLAGPHIPNPDGVVVSFGTPADHGFGPAVDALCRVLAATGL
MSMEG_4140|M.smegmatis_MC2_155 GMQEFRYEGAGVELPTRDALVVGYAAPSDSAWASALDALCSVLP----
MMAR_2376|M.marinum_M PGARFRIRSAPGIRVTIAGLSAEEIEPLADAIAEAIQRTGRPTV----
MUL_1552|M.ulcerans_Agy99 PGARFRVRSAPGIRVTIAGLSAEEIEPLADAIAGAIQRTGRPTV----
MAV_3214|M.avium_104 PGARFRMQTPAGIRITIADLTPDEIEPLADAVAQAVRPSGRPIV----
Mb3595|M.bovis_AF2122/97 TGVAIAPGIDFDTARGGSFVRISFAGPSG-DIEEALRRIGSWLPSQ--
Rv3565|M.tuberculosis_H37Rv TGVAIAPGIDFDTARGGSFVRISFAGPSG-DIEEALRRIGSWLPSQ--
MLBr_01488|M.leprae_Br4923 LGEFYGPGGCQHVRVALT--------ASDERIAAVVARLS--------
TH_4188|M.thermoresistible__bu ------------------------------------------------