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MPVQYRIAGGGAESIAASIESAISQGGLAPGDALPSIREVAGQLGVNPNTVAAAYRLLRDRGTVETAGRR GTRVRDRPASTPRSSLDLGVPAGARDLSTGNPAPELLPLAAVGWPDGSVLPLLYGAPAMSAELVDYARAA LAADGVAADHLAVTNGALDGIERALSANLRPGDRVAVEDPGWANLLDLLAALGLPVEPMGVDDDGPLVAD LQRALGRGVRAVVVTSRAQNPTGAALSAARAEELREVLSQGAEEVLLVEDDHCAGIAGVPLHTLAGATQH WAFVRSAAKAYGPDLRLAVLAGDQRTVERVHGRLRLGPGWVSHILQDLAVRLFADDAATGLVRQAQERYA DARGRLCAALSARGVAAHGRSGLNVWIPVPDETAAITRLLNRGWAAAPGARFRIRSAPGIRVTIAGLSAE EIEPLADAIAEAIQRTGRPTV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2376 | - | - | 100% (441) | GntR family transcriptional regulator |
| M. marinum M | MMAR_4301 | - | 2e-09 | 46.67% (60) | transcriptional regulatory protein |
| M. marinum M | MMAR_5054 | aspB | 6e-09 | 27.69% (390) | aspartate aminotransferase AspB |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3595 | aspB | 2e-10 | 29.68% (401) | aspartate aminotransferase |
| M. gilvum PYR-GCK | Mflv_1181 | - | 4e-20 | 25.81% (461) | GntR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv3565 | aspB | 2e-10 | 29.68% (401) | aspartate aminotransferase |
| M. leprae Br4923 | MLBr_01210 | - | 2e-13 | 52.38% (63) | hypothetical protein MLBr_01210 |
| M. abscessus ATCC 19977 | MAB_1353c | - | 8e-22 | 27.32% (377) | GntR family transcriptional regulator |
| M. avium 104 | MAV_3214 | - | 1e-178 | 72.27% (440) | GntR-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_2104 | - | 3e-58 | 34.67% (450) | GntR-family protein transcriptional regulator |
| M. thermoresistible (build 8) | TH_2065 | aspB | 7e-09 | 27.32% (377) | POSSIBLE ASPARTATE AMINOTRANSFERASE ASPB (TRANSAMINASE A) |
| M. ulcerans Agy99 | MUL_1552 | - | 0.0 | 99.09% (441) | GntR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_2084 | - | 1e-18 | 25.83% (422) | GntR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2376|M.marinum_M --------------------------------------------MPVQYR
MUL_1552|M.ulcerans_Agy99 --------------------------------------------MPVQNR
MAV_3214|M.avium_104 --------------------------------------------MAVQKS
MLBr_01210|M.leprae_Br4923 --------------------------------------------------
Mb3595|M.bovis_AF2122/97 --------------------------------------------------
Rv3565|M.tuberculosis_H37Rv --------------------------------------------------
TH_2065|M.thermoresistible__bu --------------------------------------------------
MSMEG_2104|M.smegmatis_MC2_155 ---------------------------------------MLDVISEIENR
Mvan_2084|M.vanbaalenii_PYR-1 MRHVANNLAHLACLSISSSAILASMTEAMVARSLDVDLLVRELGNWRTSS
Mflv_1181|M.gilvum_PYR-GCK ---------------------------MVSSWSNSGSRDLHLDLREALRP
MAB_1353c|M.abscessus_ATCC_199 --------------------------------------------MRVDRA
MMAR_2376|M.marinum_M IAGGGAESIAASIESAISQGGLAPGDALPSIREVAGQLGVNPNTVAAAYR
MUL_1552|M.ulcerans_Agy99 IAGGGAGSIAASIESAISQGGLAPGDALPSIREVAGQLGVNPNTVAAAYR
MAV_3214|M.avium_104 ITGTGAESIAASIEAAISAGSLAPGDALPPVRELAARLGVNANTAAAAYR
MLBr_01210|M.leprae_Br4923 --------------------------------------------------
Mb3595|M.bovis_AF2122/97 --------------------------------------------------
Rv3565|M.tuberculosis_H37Rv --------------------------------------------------
TH_2065|M.thermoresistible__bu --------------------------------------------------
MSMEG_2104|M.smegmatis_MC2_155 LSDSSAKGLSQAVTRAIREGVLRPGDRLPPVRELAHQLALSPTTVSAAWA
Mvan_2084|M.vanbaalenii_PYR-1 RSGPAYHGLADAIRLLIIDGRLPVGARLPSERLLAEVLHVSRTTVTAAYA
Mflv_1181|M.gilvum_PYR-GCK GARGNRNALVAALREAVRSGRLSAGTTLPPSRALAADLGLARNTVADAYA
MAB_1353c|M.abscessus_ATCC_199 SRLSIRAQIVQQLRSALESGVLGPGSPVPSSRAVASALGVSRSTVVAALQ
MMAR_2376|M.marinum_M LLRDRGTVETAGRRGTRVRDRPASTPRSSLDLGVPAGARDLSTGNPAP--
MUL_1552|M.ulcerans_Agy99 LLRDRGTVETAGRRGTRVRDRPASTPRSSLDLGVPAGARDLSTGNPAP--
MAV_3214|M.avium_104 LLRHRGAVETAGRRGTRVRHRPATTPRSLLGLDVPAGVRDLSTGNPHP--
MLBr_01210|M.leprae_Br4923 --------------------------------------------------
Mb3595|M.bovis_AF2122/97 -MTDRVALRAGVPPFYVMDVWLAAAERQRTHGDLVNLSAGQPSAGAPE--
Rv3565|M.tuberculosis_H37Rv -MTDRVALRAGVPPFYVMDVWLAAAERQRTHGDLVNLSAGQPSAGAPE--
TH_2065|M.thermoresistible__bu -MNDRTALRAGIPPFYVMDVWLAAAERQRSHGDLVNLSAGQPSAGAPA--
MSMEG_2104|M.smegmatis_MC2_155 LLVRAGTIQTAGRRGTIIMDLHTQRQVRYRNPANADRPYEFDLSTGAP--
Mvan_2084|M.vanbaalenii_PYR-1 QLRDDGYLNARRGARSTTALPLRPAAPAPLAPTGANLAAATLAAPAAI--
Mflv_1181|M.gilvum_PYR-GCK ELVAEGWLASRQGAGTWVVDTARASSQPPPVPPRPHGARVAPVHNLMPGS
MAB_1353c|M.abscessus_ATCC_199 ELEGEGWIESSQGSGTVVSHRPHATSDVARDPAGSATMSDEDIEIDMRP-
MMAR_2376|M.marinum_M ------------ELLPLAAVG-WPDGSVLPLLYGAPAMSAELVDYARAAL
MUL_1552|M.ulcerans_Agy99 ------------ELLPLAAVG-WPDGSVLPLLYGAPAMSAELVDYARAAL
MAV_3214|M.avium_104 ------------ALLPLAAAAPARPASGRAVLYGEPAISPALAEYARAAL
MLBr_01210|M.leprae_Br4923 --------------------------------------------------
Mb3595|M.bovis_AF2122/97 ------------PVRAAAAAALHLNQLGYSVALGIPELRDAIAADYQRRH
Rv3565|M.tuberculosis_H37Rv ------------PVRAAAAAALHLNQLGYSVALGIPELRDAIAADYQRRH
TH_2065|M.thermoresistible__bu ------------PVRAAAAATLERNQLGYTVALGIPELREAIAAGYQSRY
MSMEG_2104|M.smegmatis_MC2_155 ------------DPRLLPDTTQAVQRALTGASRSGYTEGAVDPSLMEVLT
Mvan_2084|M.vanbaalenii_PYR-1 ------------AARAFAEAAEEVTPYLHQIGVELTGVLPLRTAIAEKYC
Mflv_1181|M.gilvum_PYR-GCK PDVAEFPRSQWAASARRALTHAPTDAFRMGDPRGRPELRSALAEYLARAR
MAB_1353c|M.abscessus_ATCC_199 ---GDLNPGDISRVGWRAAWRSIEPSTTPPPPPGSAALRAALSTYLRSSR
MMAR_2376|M.marinum_M AADG-VAADHLAVTNGALDGIERALSANLRPGDRVAVEDPGWANLLDLLA
MUL_1552|M.ulcerans_Agy99 AADG-VAADHLAVTNGALDGIERALSANLRPGDRVAVEDPGWANLLDLLA
MAV_3214|M.avium_104 SADG-VPADHLALTSGALDGIERALTAHLRPGDRVAVEDPGWANLLDLLA
MLBr_01210|M.leprae_Br4923 --------------------------------------------------
Mb3595|M.bovis_AF2122/97 GIT--VEPDAVVITTGSSGGFLLAFLACFDAGDRVAMASPGYPCYRNILS
Rv3565|M.tuberculosis_H37Rv GIT--VEPDAVVITTGSSGGFLLAFLACFDAGDRVAMASPGYPCYRNILS
TH_2065|M.thermoresistible__bu GLS--VGADEVVITTGSSGGFLLAFLACFDVGDRVAIASPGYPCYRNILS
MSMEG_2104|M.smegmatis_MC2_155 ATWP-YEPPAITVVDGALDALDLLIRSRLRMGDRVIVETPTVRGLLDLLV
Mvan_2084|M.vanbaalenii_PYR-1 ARGLPTDPDEIMVTTGALHAIGLILATYTQPDDRVLVEQPTYHGALAAMA
Mflv_1181|M.gilvum_PYR-GCK GVR--TSPESLVICAGVRHAVELLART---LGGPVAVEAYGLFVFRDAIA
MAB_1353c|M.abscessus_ATCC_199 GLP--CDPSQIVVCAGTAEALTLLTLAFQWRERAVAVEDPGYPDIRRTFQ
MMAR_2376|M.marinum_M ALGLPVEPMGVDDDG--PLVADLQRALGRGVRAVVVTSRAQNPTGAALSA
MUL_1552|M.ulcerans_Agy99 ALGLPVEPMGVDDDG--PLVADLQRALGRGVRAVVVTSRAQNPTGAALSA
MAV_3214|M.avium_104 ALGFSAEPVRVDDAG--PLPEDLARALGRGARALVLTTRAQNPTGAALSA
MLBr_01210|M.leprae_Br4923 --------------------------------------------------
Mb3595|M.bovis_AF2122/97 ALGCEVVEIPCGPQTRFQPTAQMLAEIDPPLRGVVVASPAN-PTGTVIPP
Rv3565|M.tuberculosis_H37Rv ALGCEVVEIPCGPQTRFQPTAQMLAEIDPPLRGVVVASPAN-PTGTVIPP
TH_2065|M.thermoresistible__bu ALGCEVVELQCGPQTRFQPTARMLAELDPPVRGVIVASPAN-PTGTVIPP
MSMEG_2104|M.smegmatis_MC2_155 WAGIEPVGVPMDEEG--MVPEAFAAAMRTPTQMVFLQPRAHNPTGIAMTT
Mvan_2084|M.vanbaalenii_PYR-1 SRGLRTVPVAMAPDG-WELDAVEAAIRQLAPNLAYLVPDNHNPTGMTLPV
Mflv_1181|M.gilvum_PYR-GCK ACGVQTVPIGVDDDG-----AVIADLDDTSARSVLLTPAHHNPLGMPLHP
MAB_1353c|M.abscessus_ATCC_199 TLGVRWVPVDVTDAD---QFLSGLQSIEKPIEAAYLTPSHQYPLGHRISP
MMAR_2376|M.marinum_M ARAEELREVLSQGAEEVLLVEDDHCAGIAGVPLHTLAGATQH---WAFVR
MUL_1552|M.ulcerans_Agy99 ARAEELREVLSQGAEEVLLVEDDHCAGIAGVPLHTLAGATQH---WAFVR
MAV_3214|M.avium_104 ERAAALRDLLSGRADDVLLVEDDHCAGISGAALHPVAGCTTH---WAFVR
MLBr_01210|M.leprae_Br4923 --------------------------------------------------
Mb3595|M.bovis_AF2122/97 EELAAIASWCDASDVRLISDEVYHGLVYQGAPQTSCAWQTSR---NAVVV
Rv3565|M.tuberculosis_H37Rv EELAAIASWCDASDVRLISDEVYHGLVYQGAPQTSCAWQTSR---NAVVV
TH_2065|M.thermoresistible__bu EELAAIARWCEDNDVRLISDEVYHGLVYPGAPETSCAWQTSR---EAVVV
MSMEG_2104|M.smegmatis_MC2_155 PRARLLANIVKN--TETLVVEDECGSAISAAREVTLGKLLPG---QTVHV
Mvan_2084|M.vanbaalenii_PYR-1 PERKRLAHIISDTRTRTIVDETITDMWLDEPVPAPLAASMTGRRDLVLTV
Mflv_1181|M.gilvum_PYR-GCK SRRAAVIEWATRTGGYILDDDYDGEFRYDRQPVGALQALRPD---RVAYL
MAB_1353c|M.abscessus_ATCC_199 GVRGDILRWARDAGVILVEDDYDSEFRFGVAPLPSLAGLDTT--ASTIYL
MMAR_2376|M.marinum_M -SAAKAYGPDLRLAVLAGDQRTVERVHGRLRLGPGWVSHILQDLAVRLFA
MUL_1552|M.ulcerans_Agy99 -SAAKAYGPDLRLAVLAGDQRTVERVHGRLRLGPGWVSHILQDLAVRLFA
MAV_3214|M.avium_104 -SASKAYGPDLRVAVLAGDQRTVDRVHGRLRLGPGWVSHVLQQLAVELWS
MLBr_01210|M.leprae_Br4923 --------------------------------------------------
Mb3595|M.bovis_AF2122/97 NSFSKYYAMTGWRLGWLLVPTVLRRAVDCLTGNFTICPPVLSQIAAVSAF
Rv3565|M.tuberculosis_H37Rv NSFSKYYAMTGWRLGWLLVPTVLRRAVDCLTGNFTICPPVLSQIAAVSAF
TH_2065|M.thermoresistible__bu NSFSKYFAMTGWRLGWLLVPPALLRAVDRLTGNFTICPPALAQVAAVEAF
MSMEG_2104|M.smegmatis_MC2_155 RSYSKSHGPDLRLAAMGGPEDVIAGIGHLRNLGQGWTSWLLQRVLRELLL
Mvan_2084|M.vanbaalenii_PYR-1 GSMSKSFWGGLRIG-WIRAERSTLATVAVQRPAVDMGTPIFEQLAAAKLL
Mflv_1181|M.gilvum_PYR-GCK GSTSKSLSQALRLGWMALPAELVDQVVETAGGQQFHVDVVSQLTLADFLT
MAB_1353c|M.abscessus_ATCC_199 GTMSKVLDPGLRLSYLRVPTHLLQPVLDTRDALGATVSAPVQQAVTHLLT
MMAR_2376|M.marinum_M DDAATGLVRQAQERYADARGRLCAALSARGVAAHGRSG------LNVWIP
MUL_1552|M.ulcerans_Agy99 DDAATGLVRQAQERYADARGRLCAALSARGVAAHGRSG------LNVWIP
MAV_3214|M.avium_104 DTAASELVATAERRYADRRRRLCGALAERGVDAHGRSG------LNVWVR
MLBr_01210|M.leprae_Br4923 -------------------------------------------------M
Mb3595|M.bovis_AF2122/97 TPEATAEADGNLASYAINRSLLLDGLRRIGIDRLAPTDGAFYVYADVSDF
Rv3565|M.tuberculosis_H37Rv TPEATAEADGNLASYAINRSLLLDGLRRIGIDRLAPTDGAFYVYADVSDF
TH_2065|M.thermoresistible__bu HPESIAEAEALLDHYATNRRLLIDGLRSLGIDRLAPADGAFYVYADVSRY
MSMEG_2104|M.smegmatis_MC2_155 DPRVTAQVEHARAEYARRQTSFASVLAEHEIRTVGHDG------LNAWVP
Mvan_2084|M.vanbaalenii_PYR-1 ASEDEVLPE-RREILRSRRALLLALLAEHLPDWRPAPGKG---GLSLWVR
Mflv_1181|M.gilvum_PYR-GCK AGHYDRHIRRMRMRYRRRRDMLVSALSPFAVGIGGLAAG-----VNLLVT
MAB_1353c|M.abscessus_ATCC_199 SGELARHIARVRKLYQDRRATMLQSLEKIAAVTHVTGTEAG---LHVLAS
MMAR_2376|M.marinum_M VPDET-AAITRLLN-RGWAAA-------PGARFRIRSAPG----------
MUL_1552|M.ulcerans_Agy99 VPDET-AAITRLLN-RGWAAA-------PGARFRVRSAPG----------
MAV_3214|M.avium_104 VPDEA-VAVSRLLG-AGWAAA-------PGARFRMQTPAG----------
MLBr_01210|M.leprae_Br4923 VPDEA-VSITRLLD-SGWVAA-------PETHFRIRAGPG----------
Mb3595|M.bovis_AF2122/97 TSDSL-AFCSKLLADTGVAIA-------PGIDFDTARGGS----------
Rv3565|M.tuberculosis_H37Rv TSDSL-AFCSKLLADTGVAIA-------PGIDFDTARGGS----------
TH_2065|M.thermoresistible__bu TEDSI-EFCSKLLADTGVAIA-------PGIDFDTVHGDR----------
MSMEG_2104|M.smegmatis_MC2_155 VQDES-AALMRMAV-EGVGAA-------PGHLFTVGPGEKP---------
Mvan_2084|M.vanbaalenii_PYR-1 LPAPMSSALSAAASRMGLEIP-------PGPRFGVDGSLER---------
Mflv_1181|M.gilvum_PYR-GCK LPDGAEPELIRRAGEAGIALVGLSMMRHPRAGSGVAERDG----------
MAB_1353c|M.abscessus_ATCC_199 LRQGISASAAVEQARSHRYAHHRPR-RLPGPSRPVESRAGPRIRTAQTGH
*
MMAR_2376|M.marinum_M ------------------------IRVTIAGLSAEEIEPLADAIAEAIQR
MUL_1552|M.ulcerans_Agy99 ------------------------IRVTIAGLSAEEIEPLADAIAGAIQR
MAV_3214|M.avium_104 ------------------------IRITIADLTPDEIEPLADAVAQAVRP
MLBr_01210|M.leprae_Br4923 ------------------------MRIILADLTADEIEPFSD---DAIAH
Mb3595|M.bovis_AF2122/97 ------------------------FVRISFAGPSGDIEEALRRIGSWLPS
Rv3565|M.tuberculosis_H37Rv ------------------------FVRISFAGPSGDIEEALRRIGSWLPS
TH_2065|M.thermoresistible__bu ------------------------FVRFSFAGATSDIEEALRRIGGWLA-
MSMEG_2104|M.smegmatis_MC2_155 ------------------------HVRITVGLVTGDVEDVAERVVRAAHA
Mvan_2084|M.vanbaalenii_PYR-1 ------------------------FIRVPYTLPDGQLVEAIELLARAWRS
Mflv_1181|M.gilvum_PYR-GCK ------------------------LIVGFAAAPEHAFPAAVSALCEVLRA
MAB_1353c|M.abscessus_ATCC_199 NPARGQPTGHPARITGGRRPVTGDRAQIQTPLPTATTPPALTLKRSRSRS
MMAR_2376|M.marinum_M TGRPTV--------------------------------------------
MUL_1552|M.ulcerans_Agy99 TGRPTV--------------------------------------------
MAV_3214|M.avium_104 SGRPIV--------------------------------------------
MLBr_01210|M.leprae_Br4923 QGWPSI--------------------------------------------
Mb3595|M.bovis_AF2122/97 Q-------------------------------------------------
Rv3565|M.tuberculosis_H37Rv Q-------------------------------------------------
TH_2065|M.thermoresistible__bu --------------------------------------------------
MSMEG_2104|M.smegmatis_MC2_155 GGWHSTVR------------------------------------------
Mvan_2084|M.vanbaalenii_PYR-1 VTGMTASEPTAVVV------------------------------------
Mflv_1181|M.gilvum_PYR-GCK SGL-----------------------------------------------
MAB_1353c|M.abscessus_ATCC_199 ISTPTCSPTPTTTFLSRIACRTTAPRPTRTPGISTLPSTTAPSSITTLED
MMAR_2376|M.marinum_M --------------------------------------------------
MUL_1552|M.ulcerans_Agy99 --------------------------------------------------
MAV_3214|M.avium_104 --------------------------------------------------
MLBr_01210|M.leprae_Br4923 --------------------------------------------------
Mb3595|M.bovis_AF2122/97 --------------------------------------------------
Rv3565|M.tuberculosis_H37Rv --------------------------------------------------
TH_2065|M.thermoresistible__bu --------------------------------------------------
MSMEG_2104|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2084|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1181|M.gilvum_PYR-GCK --------------------------------------------------
MAB_1353c|M.abscessus_ATCC_199 STELRTDAADTMLPAPTTDSCADPPLTNLAGARFSDSPRIGQRRLYRLNT
MMAR_2376|M.marinum_M -----------
MUL_1552|M.ulcerans_Agy99 -----------
MAV_3214|M.avium_104 -----------
MLBr_01210|M.leprae_Br4923 -----------
Mb3595|M.bovis_AF2122/97 -----------
Rv3565|M.tuberculosis_H37Rv -----------
TH_2065|M.thermoresistible__bu -----------
MSMEG_2104|M.smegmatis_MC2_155 -----------
Mvan_2084|M.vanbaalenii_PYR-1 -----------
Mflv_1181|M.gilvum_PYR-GCK -----------
MAB_1353c|M.abscessus_ATCC_199 GCTDTRSMCAS