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VSSWSNSGSRDLHLDLREALRPGARGNRNALVAALREAVRSGRLSAGTTLPPSRALAADLGLARNTVADA YAELVAEGWLASRQGAGTWVVDTARASSQPPPVPPRPHGARVAPVHNLMPGSPDVAEFPRSQWAASARRA LTHAPTDAFRMGDPRGRPELRSALAEYLARARGVRTSPESLVICAGVRHAVELLARTLGGPVAVEAYGLF VFRDAIAACGVQTVPIGVDDDGAVIADLDDTSARSVLLTPAHHNPLGMPLHPSRRAAVIEWATRTGGYIL DDDYDGEFRYDRQPVGALQALRPDRVAYLGSTSKSLSQALRLGWMALPAELVDQVVETAGGQQFHVDVVS QLTLADFLTAGHYDRHIRRMRMRYRRRRDMLVSALSPFAVGIGGLAAGVNLLVTLPDGAEPELIRRAGEA GIALVGLSMMRHPRAGSGVAERDGLIVGFAAAPEHAFPAAVSALCEVLRASGL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1181 | - | - | 100% (474) | GntR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_4275 | - | 3e-25 | 27.55% (432) | GntR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1476 | - | 2e-09 | 25.10% (251) | aspartate aminotransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3595 | aspB | 2e-09 | 26.14% (264) | aspartate aminotransferase |
| M. tuberculosis H37Rv | Rv3565 | aspB | 2e-09 | 26.14% (264) | aspartate aminotransferase |
| M. leprae Br4923 | MLBr_01488 | - | 5e-07 | 25.67% (300) | N-succinyldiaminopimelate aminotransferase |
| M. abscessus ATCC 19977 | MAB_0196c | - | 1e-173 | 61.62% (482) | GntR family transcriptional regulator |
| M. marinum M | MMAR_2376 | - | 5e-20 | 25.81% (461) | GntR family transcriptional regulator |
| M. avium 104 | MAV_3214 | - | 3e-21 | 28.85% (454) | GntR-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_6371 | - | 1e-180 | 68.22% (472) | GntR-family protein regulator |
| M. thermoresistible (build 8) | TH_3588 | - | 1e-07 | 24.43% (352) | PUTATIVE histidinol-phosphate aminotransferase |
| M. ulcerans Agy99 | MUL_1552 | - | 2e-19 | 26.77% (396) | GntR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_5625 | - | 0.0 | 79.70% (473) | GntR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3595|M.bovis_AF2122/97 -----------------------------------------------MTD
Rv3565|M.tuberculosis_H37Rv -----------------------------------------------MTD
Mflv_1181|M.gilvum_PYR-GCK MVSSWSNSG-------SRDLHLDLREALRPGARGNRNALVAALREAVRSG
Mvan_5625|M.vanbaalenii_PYR-1 -MTSWANSA-------TRDLHLDLRDALVPGARGTKDALISALRDAARSG
MSMEG_6371|M.smegmatis_MC2_155 -MTSRANSG-------ARDLELHT--VITPGSRTAREDLVTALRDGIRSG
MAB_0196c|M.abscessus_ATCC_199 -MSSWANSAKAESRPLSHDLHLDLRQSITPGTRGVRELLTSALRDAVRSG
MMAR_2376|M.marinum_M ---------------------MPVQYRIAGGG---AESIAASIESAISQG
MUL_1552|M.ulcerans_Agy99 ---------------------MPVQNRIAGGG---AGSIAASIESAISQG
MAV_3214|M.avium_104 ---------------------MAVQKSITGTG---AESIAASIEAAISAG
MLBr_01488|M.leprae_Br4923 ---------------------------------------------MSPFG
TH_3588|M.thermoresistible__bu ---------------------------------------------MSIPG
.
Mb3595|M.bovis_AF2122/97 RVALRAGVPPFYVMDVWLAAAERQRTHGDLVNLSAGQPSAG---------
Rv3565|M.tuberculosis_H37Rv RVALRAGVPPFYVMDVWLAAAERQRTHGDLVNLSAGQPSAG---------
Mflv_1181|M.gilvum_PYR-GCK RLSAGTTLPPSRALAADLGLARNTVADAYAELVAEGWLASRQGAGTWVVD
Mvan_5625|M.vanbaalenii_PYR-1 RLTAGTMLPSSRTLATDLGLARNTVAEAYAELVAEGWLASRQGAGTWVAD
MSMEG_6371|M.smegmatis_MC2_155 RLGTGTVLPPSRVLAADLGLARNTVAEAYADLVAEGWLASRQGAGTWVAR
MAB_0196c|M.abscessus_ATCC_199 RLTVGSMLPPSRTLASDLGLARNTVAEAYAELVAEGWLESRQGSGTRVVN
MMAR_2376|M.marinum_M GLAPGDALPSIREVAGQLGVNPNTVAAAYRLLRDRGTVETAGRRGTRVRD
MUL_1552|M.ulcerans_Agy99 GLAPGDALPSIREVAGQLGVNPNTVAAAYRLLRDRGTVETAGRRGTRVRD
MAV_3214|M.avium_104 SLAPGDALPPVRELAARLGVNANTAAAAYRLLRHRGAVETAGRRGTRVRH
MLBr_01488|M.leprae_Br4923 RVSATLPVFPWDTLADAKAVAESHPDGIVDLSVGTP--------------
TH_3588|M.thermoresistible__bu RDVTLADLPLRENLRGKSPYGAPQLEVQVRLNTNEN--------------
: :
Mb3595|M.bovis_AF2122/97 -----------APEPVRAAAAAALHLNQLGYSVALGIP------------
Rv3565|M.tuberculosis_H37Rv -----------APEPVRAAAAAALHLNQLGYSVALGIP------------
Mflv_1181|M.gilvum_PYR-GCK TARASSQPPPVPPRPHGARVAP-VHNLMPGSPDVAEFPRSQWAASARRAL
Mvan_5625|M.vanbaalenii_PYR-1 VT----TPAHTPPRPHGVRVAP-THNLMPGSPDVAEFPRSQWLASTRRAL
MSMEG_6371|M.smegmatis_MC2_155 TE----APRLTPP-PLRIAGTP-KHNLMPGSPDVAEFPRTAWLASARRAL
MAB_0196c|M.abscessus_ATCC_199 RG-----KDQLPPRPRGAGTPP-PHNLMPGSGDVTAFPRADWLASARRAL
MMAR_2376|M.marinum_M RP------ASTPRSSLDLGVPAGARDLSTGNPAPELLP-----LAAVG-W
MUL_1552|M.ulcerans_Agy99 RP------ASTPRSSLDLGVPAGARDLSTGNPAPELLP-----LAAVG-W
MAV_3214|M.avium_104 RP------ATTPRSLLGLDVPAGVRDLSTGNPHPALLP-----LAAAAPA
MLBr_01488|M.leprae_Br4923 ----------VDPVAPLIQEALAAASSVAGYPTTAGTAR-----------
TH_3588|M.thermoresistible__bu -----------PHPPSQALIDDLTAAVRAEAAQLHRYPD-----------
.
Mb3595|M.bovis_AF2122/97 -----------------ELRDAIAADYQRRHGIT-VEPDAVVITTGSSGG
Rv3565|M.tuberculosis_H37Rv -----------------ELRDAIAADYQRRHGIT-VEPDAVVITTGSSGG
Mflv_1181|M.gilvum_PYR-GCK THAPTDAFRMGDPRGRPELRSALAEYLARARGVR-TSPESLVICAGVRHA
Mvan_5625|M.vanbaalenii_PYR-1 GGAPTEALRMGDPRGRPELRSALAEYLARARGVR-TSPESIVICAGVRHA
MSMEG_6371|M.smegmatis_MC2_155 SNAPASALRMGDPRGRLELRSALAEYLGRVRGVR-TTSESIVICSGVRNG
MAB_0196c|M.abscessus_ATCC_199 NHAPHEALRVGDPRGRHELRSAVAEYVSRVRGVR-TTPDSILICAGTRHA
MMAR_2376|M.marinum_M PDGSVLPLLYGAP----AMSAELVDYARAALAADGVAADHLAVTNGALDG
MUL_1552|M.ulcerans_Agy99 PDGSVLPLLYGAP----AMSAELVDYARAALAADGVAADHLAVTNGALDG
MAV_3214|M.avium_104 RPASGRAVLYGEP----AISPALAEYARAALSADGVPADHLALTSGALDG
MLBr_01488|M.leprae_Br4923 ------------------LREAAVAALDRRYGITGLTEAAVLPVIGTKEL
TH_3588|M.thermoresistible__bu -------------RDAVALRTDLAEYLSSQTGVQ-LGMENLWAANGSNEI
: . . : *
Mb3595|M.bovis_AF2122/97 FLL-AFLACFDAGDRVAMASPGYPCYRNILSALGCEVVEIPCGPQTRFQP
Rv3565|M.tuberculosis_H37Rv FLL-AFLACFDAGDRVAMASPGYPCYRNILSALGCEVVEIPCGPQTRFQP
Mflv_1181|M.gilvum_PYR-GCK VE--LLARTLG--GPVAVEAYGLFVFRDAIAACGVQTVPIGVDDDGAVIA
Mvan_5625|M.vanbaalenii_PYR-1 VE--LLTRALG--GPIAVESYGLFVFRDAIAAAGASTVPIGVDDRGAVVD
MSMEG_6371|M.smegmatis_MC2_155 VE--LLGKVFGTQRSIAVEAYGLFIFRDALAAMGIATAPIGLDEHGAVIS
MAB_0196c|M.abscessus_ATCC_199 VE--ILTRMYGLARPIAVEAYGLFIFRDCIEATGGSSTPIGFDGEGAVVS
MMAR_2376|M.marinum_M IER-ALSANLRPGDRVAVEDPGWANLLDLLAALGLPVEPMGVDDDGPLVA
MUL_1552|M.ulcerans_Agy99 IER-ALSANLRPGDRVAVEDPGWANLLDLLAALGLPVEPMGVDDDGPLVA
MAV_3214|M.avium_104 IER-ALTAHLRPGDRVAVEDPGWANLLDLLAALGFSAEPVRVDDAGPLPE
MLBr_01488|M.leprae_Br4923 IAWLPTLLGLRAGDVVVVPELAYPTYNVGARLAGARVLRADSLTQLGLQS
TH_3588|M.thermoresistible__bu LQQ-LLQAFGGPGRRAMGFVPSYSMHPIISDGTQTEWVQAARAADFGLDV
. . .
Mb3595|M.bovis_AF2122/97 TAQMLAEIDPPLRGVVVASPANPTGTVIPPEELAAIASWCDASDVRLISD
Rv3565|M.tuberculosis_H37Rv TAQMLAEIDPPLRGVVVASPANPTGTVIPPEELAAIASWCDASDVRLISD
Mflv_1181|M.gilvum_PYR-GCK DLD---DTSARSV-LLTPAHHNPLGMPLHPSRRAAVIEWATRTGGYILDD
Mvan_5625|M.vanbaalenii_PYR-1 ELD---GLDVPAV-LLTPAHHNPLGMPLHSSRRTAVIEWAQRTGGFVLDD
MSMEG_6371|M.smegmatis_MC2_155 DLD---MLDVPAV-LLTPAHHSPHGMPLHPSRRSEVIEWARRTGGYVIDD
MAB_0196c|M.abscessus_ATCC_199 DLE---NLDTSAA-LITPAHHFPHGLPLHPARRTAVVDWARRTDSYVLED
MMAR_2376|M.marinum_M DLQRALGRGVRAV-VVTSRAQNPTGAALSAARAEELREVLSQGAEEVLLV
MUL_1552|M.ulcerans_Agy99 DLQRALGRGVRAV-VVTSRAQNPTGAALSAARAEELREVLSQGAEEVLLV
MAV_3214|M.avium_104 DLARALGRGARAL-VLTTRAQNPTGAALSAERAAALRDLLSGRADDVLLV
MLBr_01488|M.leprae_Br4923 PAL-----------FYLNSPSNPTGQVLAVNHLRKMVGWARNRGVVVVSD
TH_3588|M.thermoresistible__bu DVAVRAITEQRPDVVFVASPNNPSGQSVTPDELRALLDAMPRG--ILIVD
. * * : . : ::
Mb3595|M.bovis_AF2122/97 EVYHGLVYQGAPQTSCAWQTS----RNAVVVNSFSKYYAMTGWRLGWLLV
Rv3565|M.tuberculosis_H37Rv EVYHGLVYQGAPQTSCAWQTS----RNAVVVNSFSKYYAMTGWRLGWLLV
Mflv_1181|M.gilvum_PYR-GCK DYDGEFRYDRQPVGALQALRP----DRVAYLGSTSKSLSQA-LRLGWMAL
Mvan_5625|M.vanbaalenii_PYR-1 DYDGEFRYDRQPVGALQSLRP----DRVAYLGSTSKSLSQT-LRLGWMAL
MSMEG_6371|M.smegmatis_MC2_155 DYDGEFRYDRQPVGALQSLDP----EHVAYLGSASKSLAQT-LRVGWMAL
MAB_0196c|M.abscessus_ATCC_199 DYDGEFRYDRQPVGALQSLDP----DRVVYLGSASKSLAPA-LRLGWMVL
MMAR_2376|M.marinum_M EDDHCAGIAGVPLHTLAGAT-----QHWAFVRSAAKAYGPD-LRLAVLAG
MUL_1552|M.ulcerans_Agy99 EDDHCAGIAGVPLHTLAGAT-----QHWAFVRSAAKAYGPD-LRLAVLAG
MAV_3214|M.avium_104 EDDHCAGISGAALHPVAGCT-----THWAFVRSASKAYGPD-LRVAVLAG
MLBr_01488|M.leprae_Br4923 ECYLGLGWDAEPFSVLHPLVCDGNHTGLLAVHSLSKSSSLAGYRAGFVAG
TH_3588|M.thermoresistible__bu EAYGEFSSQPSAVGLIADYPT-----KLVVSRTMSKAFAFAGGRLGYLAA
: . : :* . * . :
Mb3595|M.bovis_AF2122/97 PTVLRRAVDCLTGNFTICPPVLSQIAAVSAFTPEATAEADGNLAS-YAIN
Rv3565|M.tuberculosis_H37Rv PTVLRRAVDCLTGNFTICPPVLSQIAAVSAFTPEATAEADGNLAS-YAIN
Mflv_1181|M.gilvum_PYR-GCK PAELVDQVVETAGGQQFHVDVVSQLTLADFLTAGHYDRHIRRMRMRYRRR
Mvan_5625|M.vanbaalenii_PYR-1 PDNLIDAVLAAAGGQQFYVDAINQLTLADFIAGGHYDRHIRRMRMRYRRR
MSMEG_6371|M.smegmatis_MC2_155 PQALVEPVIAAAGGQQFNVDAITALTLADFIATGGYDRHIRRMRNRYRRR
MAB_0196c|M.abscessus_ATCC_199 PPEQMDAAVAATGGAQWYVGAISQLTMADFIAGGHYDRHIRRMRGRYRRR
MMAR_2376|M.marinum_M DQRTVERVHGRLRLGPGWVSHILQDLAVRLFADDAATGLVRQAQERYADA
MUL_1552|M.ulcerans_Agy99 DQRTVERVHGRLRLGPGWVSHILQDLAVRLFADDAATGLVRQAQERYADA
MAV_3214|M.avium_104 DQRTVDRVHGRLRLGPGWVSHVLQQLAVELWSDTAASELVATAERRYADR
MLBr_01488|M.leprae_Br4923 DPDLVAELLAVRKHAGMMVPTPVQAAMVAALGDDAHE---REQRDRYARR
TH_3588|M.thermoresistible__bu APALIDALLLVR-----LPYHLSSLTQAAARAALRHADDTLAGVATLIAE
.
Mb3595|M.bovis_AF2122/97 RSLLLDGLRRIGIDRLAPTDGAFYVYADVSDFTSDSLAFCSKLLADTGVA
Rv3565|M.tuberculosis_H37Rv RSLLLDGLRRIGIDRLAPTDGAFYVYADVSDFTSDSLAFCSKLLADTGVA
Mflv_1181|M.gilvum_PYR-GCK RDMLVSALSPFAVG-IGGLAAGVNLLVTLPDGAEPELIRR---AGEAGIA
Mvan_5625|M.vanbaalenii_PYR-1 RDVLVSALSPFDVG-IGGLAAGVNLLVTLPDGAEPEVMRR---AGESGLA
MSMEG_6371|M.smegmatis_MC2_155 RDHLVEALSGFDVG-IRGLAAGVNMLLTLPDGAEPEVLRR---AGEAGIA
MAB_0196c|M.abscessus_ATCC_199 RDLLVQRLAGYNVG-VRGLSAGLHLLLTLPEGTESDVLYR---AGEAGVA
MMAR_2376|M.marinum_M RGRLCAALSARGVA-AHGR-SGLNVWIPVPD--ETAAITR---LLNRGWA
MUL_1552|M.ulcerans_Agy99 RGRLCAALSARGVA-AHGR-SGLNVWIPVPD--ETAAITR---LLNRGWA
MAV_3214|M.avium_104 RRRLCGALAERGVD-AHGR-SGLNVWVRVPD--EAVAVSR---LLGAGWA
MLBr_01488|M.leprae_Br4923 RDVLLPAVVSAGFT-VDHSEAGLYLWASRGEPCRDSVEWF----AQRGIL
TH_3588|M.thermoresistible__bu RERVSEELRRMGFR-VIPSDANFVLFGEFADAPATWQRYLDDGVLIRDVG
* : : . . . : : .
Mb3595|M.bovis_AF2122/97 IAPGIDFDT------ARGGSFVRISFAGP-SGDIEEALRRIGSWLPSQ--
Rv3565|M.tuberculosis_H37Rv IAPGIDFDT------ARGGSFVRISFAGP-SGDIEEALRRIGSWLPSQ--
Mflv_1181|M.gilvum_PYR-GCK LVGLSMMRHPRAGSGVAERDGLIVGFAAAPEHAFPAAVSALCEVLRASGL
Mvan_5625|M.vanbaalenii_PYR-1 VSGLSIMRHPMAGP--ADVDGLIVGFAAPPEHAFSAAVAALCDVLRASGL
MSMEG_6371|M.smegmatis_MC2_155 LSGLALMRHPLAHPDIPAPDGIIVGFGAPAEHAFRPAVEALRGVLEDVLS
MAB_0196c|M.abscessus_ATCC_199 LAGLARLRHPLAGPHIPNPDGVVVSFGTPADHGFGPAVDALCRVLAATGL
MMAR_2376|M.marinum_M AAPGARFR-------IRSAPGIRVTIAGLSAEEIEPLADAIAEAIQRTGR
MUL_1552|M.ulcerans_Agy99 AAPGARFR-------VRSAPGIRVTIAGLSAEEIEPLADAIAGAIQRTGR
MAV_3214|M.avium_104 AAPGARFR-------MQTPAGIRITIADLTPDEIEPLADAVAQAVRPSGR
MLBr_01488|M.leprae_Br4923 VALGEFYGP-------GGCQHVRVALTAS-DERIAAVVARLS--------
TH_3588|M.thermoresistible__bu IPGHLRTTIG----LAHENDALLATSARLAATELKAAPSSPIGAP-----
: :
Mb3595|M.bovis_AF2122/97 ---
Rv3565|M.tuberculosis_H37Rv ---
Mflv_1181|M.gilvum_PYR-GCK ---
Mvan_5625|M.vanbaalenii_PYR-1 ---
MSMEG_6371|M.smegmatis_MC2_155 P--
MAB_0196c|M.abscessus_ATCC_199 ---
MMAR_2376|M.marinum_M PTV
MUL_1552|M.ulcerans_Agy99 PTV
MAV_3214|M.avium_104 PIV
MLBr_01488|M.leprae_Br4923 ---
TH_3588|M.thermoresistible__bu ---