For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VTSWANSATRDLHLDLRDALVPGARGTKDALISALRDAARSGRLTAGTMLPSSRTLATDLGLARNTVAEA YAELVAEGWLASRQGAGTWVADVTTPAHTPPRPHGVRVAPTHNLMPGSPDVAEFPRSQWLASTRRALGGA PTEALRMGDPRGRPELRSALAEYLARARGVRTSPESIVICAGVRHAVELLTRALGGPIAVESYGLFVFRD AIAAAGASTVPIGVDDRGAVVDELDGLDVPAVLLTPAHHNPLGMPLHSSRRTAVIEWAQRTGGFVLDDDY DGEFRYDRQPVGALQSLRPDRVAYLGSTSKSLSQTLRLGWMALPDNLIDAVLAAAGGQQFYVDAINQLTL ADFIAGGHYDRHIRRMRMRYRRRRDVLVSALSPFDVGIGGLAAGVNLLVTLPDGAEPEVMRRAGESGLAV SGLSIMRHPMAGPADVDGLIVGFAAPPEHAFSAAVAALCDVLRASGL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5625 | - | - | 100% (467) | GntR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_2084 | - | 9e-24 | 28.31% (438) | GntR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_4528 | - | 1e-11 | 26.67% (390) | N-succinyldiaminopimelate aminotransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1211 | - | 1e-09 | 24.86% (358) | N-succinyldiaminopimelate aminotransferase |
| M. gilvum PYR-GCK | Mflv_1181 | - | 0.0 | 79.70% (473) | GntR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv1178 | - | 2e-09 | 25.42% (358) | N-succinyldiaminopimelate aminotransferase |
| M. leprae Br4923 | MLBr_01488 | - | 4e-10 | 25.28% (360) | N-succinyldiaminopimelate aminotransferase |
| M. abscessus ATCC 19977 | MAB_0196c | - | 1e-178 | 65.27% (478) | GntR family transcriptional regulator |
| M. marinum M | MMAR_2376 | - | 5e-18 | 27.88% (391) | GntR family transcriptional regulator |
| M. avium 104 | MAV_3214 | - | 1e-19 | 28.43% (415) | GntR-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_6371 | - | 0.0 | 71.73% (467) | GntR-family protein regulator |
| M. thermoresistible (build 8) | TH_1831 | - | 5e-11 | 26.51% (332) | PROBABLE AMINOTRANSFERASE |
| M. ulcerans Agy99 | MUL_1552 | - | 7e-18 | 27.88% (391) | GntR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5625|M.vanbaalenii_PYR-1 -MTSWANSA-------TRDLHLDLRDALVPGARGTKDALISALRDAARSG
Mflv_1181|M.gilvum_PYR-GCK MVSSWSNSG-------SRDLHLDLREALRPGARGNRNALVAALREAVRSG
MSMEG_6371|M.smegmatis_MC2_155 -MTSRANSG-------ARDLELHT--VITPGSRTAREDLVTALRDGIRSG
MAB_0196c|M.abscessus_ATCC_199 -MSSWANSAKAESRPLSHDLHLDLRQSITPGTRGVRELLTSALRDAVRSG
MMAR_2376|M.marinum_M ---------------------MPVQYRIAGGG---AESIAASIESAISQG
MUL_1552|M.ulcerans_Agy99 ---------------------MPVQNRIAGGG---AGSIAASIESAISQG
MAV_3214|M.avium_104 ---------------------MAVQKSITGTG---AESIAASIEAAISAG
Mb1211|M.bovis_AF2122/97 --------------------------------------------------
Rv1178|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01488|M.leprae_Br4923 --------------------------------------------------
TH_1831|M.thermoresistible__bu --------------------------------------------------
Mvan_5625|M.vanbaalenii_PYR-1 RLTAGTMLPSSRTLATDLGLARNTVAEAYAELVAEGWLASRQGAGTWVAD
Mflv_1181|M.gilvum_PYR-GCK RLSAGTTLPPSRALAADLGLARNTVADAYAELVAEGWLASRQGAGTWVVD
MSMEG_6371|M.smegmatis_MC2_155 RLGTGTVLPPSRVLAADLGLARNTVAEAYADLVAEGWLASRQGAGTWVAR
MAB_0196c|M.abscessus_ATCC_199 RLTVGSMLPPSRTLASDLGLARNTVAEAYAELVAEGWLESRQGSGTRVVN
MMAR_2376|M.marinum_M GLAPGDALPSIREVAGQLGVNPNTVAAAYRLLRDRGTVETAGRRGTRVRD
MUL_1552|M.ulcerans_Agy99 GLAPGDALPSIREVAGQLGVNPNTVAAAYRLLRDRGTVETAGRRGTRVRD
MAV_3214|M.avium_104 SLAPGDALPPVRELAARLGVNANTAAAAYRLLRHRGAVETAGRRGTRVRH
Mb1211|M.bovis_AF2122/97 -------------------MSASLPVFPWDTLADAKALAGAHPDGIVDLS
Rv1178|M.tuberculosis_H37Rv -------------------MSASLPVFPWDTLADAKALAGAHPDGIVDLS
MLBr_01488|M.leprae_Br4923 -------------MSPFGRVSATLPVFPWDTLADAKAVAESHPDGIVDLS
TH_1831|M.thermoresistible__bu --------------------------------------------------
Mvan_5625|M.vanbaalenii_PYR-1 VT----TPAHTPPRPHGVRVAP-THNLMPGSPDVAEFPRSQWLASTRRAL
Mflv_1181|M.gilvum_PYR-GCK TARASSQPPPVPPRPHGARVAP-VHNLMPGSPDVAEFPRSQWAASARRAL
MSMEG_6371|M.smegmatis_MC2_155 TE----APRLTPP-PLRIAGTP-KHNLMPGSPDVAEFPRTAWLASARRAL
MAB_0196c|M.abscessus_ATCC_199 RG-----KDQLPPRPRGAGTPP-PHNLMPGSGDVTAFPRADWLASARRAL
MMAR_2376|M.marinum_M RP------ASTPRSSLDLGVPAGARDLSTGNPAPELLP-----LAAVG-W
MUL_1552|M.ulcerans_Agy99 RP------ASTPRSSLDLGVPAGARDLSTGNPAPELLP-----LAAVG-W
MAV_3214|M.avium_104 RP------ATTPRSLLGLDVPAGVRDLSTGNPHPALLP-----LAAAAPA
Mb1211|M.bovis_AF2122/97 VG------TPVDPVAPLIQEALAAASAAPGYPATAGTAR-----------
Rv1178|M.tuberculosis_H37Rv VG------TPVDPVAPLIQEALAAASAAPGYPATAGTAR-----------
MLBr_01488|M.leprae_Br4923 VG------TPVDPVAPLIQEALAAASSVAGYPTTAGTAR-----------
TH_1831|M.thermoresistible__bu -------------VAPVIRAALAEASAAPGYPTTAGTPA-----------
. . .* .
Mvan_5625|M.vanbaalenii_PYR-1 GGAPTEALRMGDPRGRPELRSALAEYLARARGVR-TSPESIVICAGVRHA
Mflv_1181|M.gilvum_PYR-GCK THAPTDAFRMGDPRGRPELRSALAEYLARARGVR-TSPESLVICAGVRHA
MSMEG_6371|M.smegmatis_MC2_155 SNAPASALRMGDPRGRLELRSALAEYLGRVRGVR-TTSESIVICSGVRNG
MAB_0196c|M.abscessus_ATCC_199 NHAPHEALRVGDPRGRHELRSAVAEYVSRVRGVR-TTPDSILICAGTRHA
MMAR_2376|M.marinum_M PDGSVLPLLYGAP----AMSAELVDYARAALAADGVAADHLAVTNGALDG
MUL_1552|M.ulcerans_Agy99 PDGSVLPLLYGAP----AMSAELVDYARAALAADGVAADHLAVTNGALDG
MAV_3214|M.avium_104 RPASGRAVLYGEP----AISPALAEYARAALSADGVPADHLALTSGALDG
Mb1211|M.bovis_AF2122/97 ------------------LRESVVAALARRYGITRLTEAAVLPVIGTKEL
Rv1178|M.tuberculosis_H37Rv ------------------LRESVVAALARRYGITRLTEAAVLPVIGTKEL
MLBr_01488|M.leprae_Br4923 ------------------LREAAVAALDRRYGITGLTEAAVLPVIGTKEL
TH_1831|M.thermoresistible__bu ------------------LRASAAAALERRYGITGLTPDAVLPAIGTKEL
: . . . : *. .
Mvan_5625|M.vanbaalenii_PYR-1 VE-LLTRALG--GPIAVESYGLFVFRDAIAAAGASTVPIGVDDRGAVVDE
Mflv_1181|M.gilvum_PYR-GCK VE-LLARTLG--GPVAVEAYGLFVFRDAIAACGVQTVPIGVDDDGAVIAD
MSMEG_6371|M.smegmatis_MC2_155 VE-LLGKVFGTQRSIAVEAYGLFIFRDALAAMGIATAPIGLDEHGAVISD
MAB_0196c|M.abscessus_ATCC_199 VE-ILTRMYGLARPIAVEAYGLFIFRDCIEATGGSSTPIGFDGEGAVVSD
MMAR_2376|M.marinum_M IERALSANLRPGDRVAVEDPGWANLLDLLAALGLPVEPMGVDDDGPLVAD
MUL_1552|M.ulcerans_Agy99 IERALSANLRPGDRVAVEDPGWANLLDLLAALGLPVEPMGVDDDGPLVAD
MAV_3214|M.avium_104 IERALTAHLRPGDRVAVEDPGWANLLDLLAALGFSAEPVRVDDAGPLPED
Mb1211|M.bovis_AF2122/97 IA-WLPTLLGLGGADLVVVPELAYPTYDVGARLAGTRVLRADA----LTQ
Rv1178|M.tuberculosis_H37Rv IA-WLPTLLGLGGADLVVVPELAYPTYDVGARLAGTRVLRADA----LTQ
MLBr_01488|M.leprae_Br4923 IA-WLPTLLGLRAGDVVVVPELAYPTYNVGARLAGARVLRADS----LTQ
TH_1831|M.thermoresistible__bu IA-WLPTLLGLGGDDTVVVPELAYPTYDVGARLAGARVFRADS----LTQ
: * * : * . * :
Mvan_5625|M.vanbaalenii_PYR-1 LD---GLDVPAVLLTPAHHNPLGMPLHSSRRTAVIEWAQRTGGFVLDDDY
Mflv_1181|M.gilvum_PYR-GCK LD---DTSARSVLLTPAHHNPLGMPLHPSRRAAVIEWATRTGGYILDDDY
MSMEG_6371|M.smegmatis_MC2_155 LD---MLDVPAVLLTPAHHSPHGMPLHPSRRSEVIEWARRTGGYVIDDDY
MAB_0196c|M.abscessus_ATCC_199 LE---NLDTSAALITPAHHFPHGLPLHPARRTAVVDWARRTDSYVLEDDY
MMAR_2376|M.marinum_M LQRALGRGVRAVVVTSRAQNPTGAALSAARAEELREVLSQGAEEVLLVED
MUL_1552|M.ulcerans_Agy99 LQRALGRGVRAVVVTSRAQNPTGAALSAARAEELREVLSQGAEEVLLVED
MAV_3214|M.avium_104 LARALGRGARALVLTTRAQNPTGAALSAERAAALRDLLSGRADDVLLVED
Mb1211|M.bovis_AF2122/97 LG----PQSPALLYLNSPSNPTGRVLGVDHLRKVVEWARGRGVLVVSDEC
Rv1178|M.tuberculosis_H37Rv LG----PQSPALLYLNSPSNPTGRVLGVDHLRKVVEWARGRGVLVVSDEC
MLBr_01488|M.leprae_Br4923 LG----LQSPALFYLNSPSNPTGQVLAVNHLRKMVGWARNRGVVVVSDEC
TH_1831|M.thermoresistible__bu LG----PQTPALIYLNSPSNPTGRVLGVDHLRKVVGWARDRGVIVASDEC
* : . * * * : : : :
Mvan_5625|M.vanbaalenii_PYR-1 DGEFRYDRQPVGALQ--SLRPDRVAYLGSTSKSLSQTLR---LGWMALPD
Mflv_1181|M.gilvum_PYR-GCK DGEFRYDRQPVGALQ--ALRPDRVAYLGSTSKSLSQALR---LGWMALPA
MSMEG_6371|M.smegmatis_MC2_155 DGEFRYDRQPVGALQ--SLDPEHVAYLGSASKSLAQTLR---VGWMALPQ
MAB_0196c|M.abscessus_ATCC_199 DGEFRYDRQPVGALQ--SLDPDRVVYLGSASKSLAPALR---LGWMVLPP
MMAR_2376|M.marinum_M DHCAGIAGVPLHTLA--GAT-QHWAFVRSAAKAYGPDLR---LAVLAGDQ
MUL_1552|M.ulcerans_Agy99 DHCAGIAGVPLHTLA--GAT-QHWAFVRSAAKAYGPDLR---LAVLAGDQ
MAV_3214|M.avium_104 DHCAGISGAALHPVA--GCT-THWAFVRSASKAYGPDLR---VAVLAGDQ
Mb1211|M.bovis_AF2122/97 YLGLGWDAEPVSVLHPSVCDGDHTGLLAVHSLSKSSSLAGYRAGFVVGDL
Rv1178|M.tuberculosis_H37Rv YLGLGWDAEPVSVLHPSVCDGDHTGLLAVHSLSKSSSLAGYRAGFVVGDL
MLBr_01488|M.leprae_Br4923 YLGLGWDAEPFSVLHPLVCDGNHTGLLAVHSLSKSSSLAGYRAGFVAGDP
TH_1831|M.thermoresistible__bu YLGLGWDETPVSVLHPTVCGGDHTNLLAIHSLSKTSSLAGYRAGFVAGDP
.. : : : : : * . :.
Mvan_5625|M.vanbaalenii_PYR-1 NLIDAVLAAAGGQQFYVDAINQLTLADFIAGGHYDRHIRRMRMRYRRRRD
Mflv_1181|M.gilvum_PYR-GCK ELVDQVVETAGGQQFHVDVVSQLTLADFLTAGHYDRHIRRMRMRYRRRRD
MSMEG_6371|M.smegmatis_MC2_155 ALVEPVIAAAGGQQFNVDAITALTLADFIATGGYDRHIRRMRNRYRRRRD
MAB_0196c|M.abscessus_ATCC_199 EQMDAAVAATGGAQWYVGAISQLTMADFIAGGHYDRHIRRMRGRYRRRRD
MMAR_2376|M.marinum_M RTVERVHGRLRLGPGWVSHILQDLAVRLFADDAATGLVRQAQERYADARG
MUL_1552|M.ulcerans_Agy99 RTVERVHGRLRLGPGWVSHILQDLAVRLFADDAATGLVRQAQERYADARG
MAV_3214|M.avium_104 RTVDRVHGRLRLGPGWVSHVLQQLAVELWSDTAASELVATAERRYADRRR
Mb1211|M.bovis_AF2122/97 EIVAELLAVRKHAGMMVPAPVQAAMVAALDDDAHE---RQQRERYAQRRA
Rv1178|M.tuberculosis_H37Rv EIVAELLAVRKHAGMMVPAPVQAAMVAALDDDAHE---RQQRERYAQRRA
MLBr_01488|M.leprae_Br4923 DLVAELLAVRKHAGMMVPTPVQAAMVAALGDDAHE---REQRDRYARRRD
TH_1831|M.thermoresistible__bu ALVAELLAVRKHAGMMVPTPVQAAMVAALDDDAHE---RQQRERYQRRRR
: * . . ** *
Mvan_5625|M.vanbaalenii_PYR-1 VLVSALSPFDVGIGGLAAGVNLLVTLPDGAEPEVMRRAGESGLAVSGLSI
Mflv_1181|M.gilvum_PYR-GCK MLVSALSPFAVGIGGLAAGVNLLVTLPDGAEPELIRRAGEAGIALVGLSM
MSMEG_6371|M.smegmatis_MC2_155 HLVEALSGFDVGIRGLAAGVNMLLTLPDGAEPEVLRRAGEAGIALSGLAL
MAB_0196c|M.abscessus_ATCC_199 LLVQRLAGYNVGVRGLSAGLHLLLTLPEGTESDVLYRAGEAGVALAGLAR
MMAR_2376|M.marinum_M RLCAALSARGVAAHGR-SGLNVWIPVPD--ETAAITRLLNRGWAAAPGAR
MUL_1552|M.ulcerans_Agy99 RLCAALSARGVAAHGR-SGLNVWIPVPD--ETAAITRLLNRGWAAAPGAR
MAV_3214|M.avium_104 RLCGALAERGVDAHGR-SGLNVWVRVPD--EAVAVSRLLGAGWAAAPGAR
Mb1211|M.bovis_AF2122/97 ALLPALGSAGFAVDYSDAGLYLWATRGE-PCRDSVAWLAQRGILVAPGDF
Rv1178|M.tuberculosis_H37Rv ALLPALGSAGFAVDYSDAGLYLWATRGE-PCRDSAAWLAQRGILVAPGDF
MLBr_01488|M.leprae_Br4923 VLLPAVVSAGFTVDHSEAGLYLWASRGE-PCRDSVEWFAQRGILVALGEF
TH_1831|M.thermoresistible__bu ELLPALQQAGFTVDHSEAGLYLWATRGE-PCRATVDWLARRGILVAPGEF
* : . :*: : : *
Mvan_5625|M.vanbaalenii_PYR-1 MRHPMAGP--ADVDGLIVGFAAPPEHAFSAAVAALCDVLRASGL---
Mflv_1181|M.gilvum_PYR-GCK MRHPRAGSGVAERDGLIVGFAAAPEHAFPAAVSALCEVLRASGL---
MSMEG_6371|M.smegmatis_MC2_155 MRHPLAHPDIPAPDGIIVGFGAPAEHAFRPAVEALRGVLEDVLSP--
MAB_0196c|M.abscessus_ATCC_199 LRHPLAGPHIPNPDGVVVSFGTPADHGFGPAVDALCRVLAATGL---
MMAR_2376|M.marinum_M FR-------IRSAPGIRVTIAGLSAEEIEPLADAIAEAIQRTGRPTV
MUL_1552|M.ulcerans_Agy99 FR-------VRSAPGIRVTIAGLSAEEIEPLADAIAGAIQRTGRPTV
MAV_3214|M.avium_104 FR-------MQTPAGIRITIADLTPDEIEPLADAVAQAVRPSGRPIV
Mb1211|M.bovis_AF2122/97 YG-------PGGAQHVRVALTATDERVAAAVGRLTC-----------
Rv1178|M.tuberculosis_H37Rv YG-------PGGAQHVRVALTATDERVAAAVGRLTC-----------
MLBr_01488|M.leprae_Br4923 YG-------PGGCQHVRVALTASDERIAAVVARLS------------
TH_1831|M.thermoresistible__bu YG-------PRGAEHVRIALTAPDERITAAAARLAQAG---------
: : :