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AVQKSITGTGAESIAASIEAAISAGSLAPGDALPPVRELAARLGVNANTAAAAYRLLRHRGAVETAGRRG TRVRHRPATTPRSLLGLDVPAGVRDLSTGNPHPALLPLAAAAPARPASGRAVLYGEPAISPALAEYARAA LSADGVPADHLALTSGALDGIERALTAHLRPGDRVAVEDPGWANLLDLLAALGFSAEPVRVDDAGPLPED LARALGRGARALVLTTRAQNPTGAALSAERAAALRDLLSGRADDVLLVEDDHCAGISGAALHPVAGCTTH WAFVRSASKAYGPDLRVAVLAGDQRTVDRVHGRLRLGPGWVSHVLQQLAVELWSDTAASELVATAERRYA DRRRRLCGALAERGVDAHGRSGLNVWVRVPDEAVAVSRLLGAGWAAAPGARFRMQTPAGIRITIADLTPD EIEPLADAVAQAVRPSGRPIV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3214 | - | - | 100% (442) | GntR-family protein transcriptional regulator |
| M. avium 104 | MAV_1290 | - | 2e-08 | 45.16% (62) | regulatory protein GntR, HTH |
| M. avium 104 | MAV_4421 | - | 9e-08 | 28.23% (294) | histidinol-phosphate aminotransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3595 | aspB | 2e-09 | 29.58% (355) | aspartate aminotransferase |
| M. gilvum PYR-GCK | Mflv_1181 | - | 3e-21 | 28.85% (454) | GntR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv3565 | aspB | 2e-09 | 29.58% (355) | aspartate aminotransferase |
| M. leprae Br4923 | MLBr_01210 | - | 2e-12 | 55.93% (59) | hypothetical protein MLBr_01210 |
| M. abscessus ATCC 19977 | MAB_0810c | - | 2e-22 | 26.93% (427) | GntR family transcriptional regulator |
| M. marinum M | MMAR_2376 | - | 1e-178 | 72.27% (440) | GntR family transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_2104 | - | 8e-60 | 35.76% (453) | GntR-family protein transcriptional regulator |
| M. thermoresistible (build 8) | TH_2065 | aspB | 2e-12 | 30.53% (357) | POSSIBLE ASPARTATE AMINOTRANSFERASE ASPB (TRANSAMINASE A) |
| M. ulcerans Agy99 | MUL_1552 | - | 1e-177 | 72.05% (440) | GntR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_5625 | - | 1e-19 | 28.43% (415) | GntR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2376|M.marinum_M -----------------MPVQYRIAGGGAESIAASIESAISQGGLAPGDA
MUL_1552|M.ulcerans_Agy99 -----------------MPVQNRIAGGGAGSIAASIESAISQGGLAPGDA
MAV_3214|M.avium_104 -----------------MAVQKSITGTGAESIAASIEAAISAGSLAPGDA
MLBr_01210|M.leprae_Br4923 --------------------------------------------------
Mflv_1181|M.gilvum_PYR-GCK MVSSWSNSGSRDLHLDLREALRPGARGNRNALVAALREAVRSGRLSAGTT
Mvan_5625|M.vanbaalenii_PYR-1 -MTSWANSATRDLHLDLRDALVPGARGTKDALISALRDAARSGRLTAGTM
Mb3595|M.bovis_AF2122/97 ----------------------------------------MTDRVALRAG
Rv3565|M.tuberculosis_H37Rv ----------------------------------------MTDRVALRAG
TH_2065|M.thermoresistible__bu ----------------------------------------MNDRTALRAG
MSMEG_2104|M.smegmatis_MC2_155 ------------MLDVISEIENRLSDSSAKGLSQAVTRAIREGVLRPGDR
MAB_0810c|M.abscessus_ATCC_199 ----MAEQVRGEILALAPGSRIASHRELVRRFHVSASTVADALSLLAQQG
MMAR_2376|M.marinum_M LPSIREVAGQLGVNPNTVAAAYRLLRDRGTVETAGRRGTRVRDRPASTPR
MUL_1552|M.ulcerans_Agy99 LPSIREVAGQLGVNPNTVAAAYRLLRDRGTVETAGRRGTRVRDRPASTPR
MAV_3214|M.avium_104 LPPVRELAARLGVNANTAAAAYRLLRHRGAVETAGRRGTRVRHRPATTPR
MLBr_01210|M.leprae_Br4923 --------------------------------------------------
Mflv_1181|M.gilvum_PYR-GCK LPPSRALAADLGLARNTVADAYAELVAEGWLASRQGAGTWVVDTARASSQ
Mvan_5625|M.vanbaalenii_PYR-1 LPSSRTLATDLGLARNTVAEAYAELVAEGWLASRQGAGTWVADVT----T
Mb3595|M.bovis_AF2122/97 VPPFYVMDVWLAAAERQRTHGDLVNLSAGQPSAG----------------
Rv3565|M.tuberculosis_H37Rv VPPFYVMDVWLAAAERQRTHGDLVNLSAGQPSAG----------------
TH_2065|M.thermoresistible__bu IPPFYVMDVWLAAAERQRSHGDLVNLSAGQPSAG----------------
MSMEG_2104|M.smegmatis_MC2_155 LPPVRELAHQLALSPTTVSAAWALLVRAGTIQTAGRRGTIIMDLHTQRQV
MAB_0810c|M.abscessus_ATCC_199 LIESRPGAGSFRTENRPVPRPGDTSWQETALELGPQEESPPGIRRVFDAP
MMAR_2376|M.marinum_M SSLDLGVPAGARDLSTGN--PAPELLPLAAVG-WPDGSVLPLLYGA--PA
MUL_1552|M.ulcerans_Agy99 SSLDLGVPAGARDLSTGN--PAPELLPLAAVG-WPDGSVLPLLYGA--PA
MAV_3214|M.avium_104 SLLGLDVPAGVRDLSTGN--PHPALLPLAAAAPARPASGRAVLYGE--PA
MLBr_01210|M.leprae_Br4923 --------------------------------------------------
Mflv_1181|M.gilvum_PYR-GCK PPPVPPRPHGARVAPVHN--LMPGSPDVAEFPRSQWAASARRALTH--AP
Mvan_5625|M.vanbaalenii_PYR-1 PAHTPPRPHGVRVAPTHN--LMPGSPDVAEFPRSQWLASTRRALGG--AP
Mb3595|M.bovis_AF2122/97 ------APEPVRAAAAAA--LHLNQ------------LGYSVALGI--PE
Rv3565|M.tuberculosis_H37Rv ------APEPVRAAAAAA--LHLNQ------------LGYSVALGI--PE
TH_2065|M.thermoresistible__bu ------APAPVRAAAAAT--LERNQ------------LGYTVALGI--PE
MSMEG_2104|M.smegmatis_MC2_155 RYRNPANADRPYEFDLST--GAPDPRLLPDTTQAVQRALTGASRSG--YT
MAB_0810c|M.abscessus_ATCC_199 GLLSTLAPSAADVVDLNGGYLHPDLQPLSMLTASLARAARRPEAWDRPPP
MMAR_2376|M.marinum_M MSAELVDYARAALAADGVAADHLAVTNGALDGIERALSAN----------
MUL_1552|M.ulcerans_Agy99 MSAELVDYARAALAADGVAADHLAVTNGALDGIERALSAN----------
MAV_3214|M.avium_104 ISPALAEYARAALSADGVPADHLALTSGALDGIERALTAH----------
MLBr_01210|M.leprae_Br4923 --------------------------------------------------
Mflv_1181|M.gilvum_PYR-GCK TDAFRMGDPRGRPELRSALAEYLARARGVRTSPESLVICAGVRHAVELLA
Mvan_5625|M.vanbaalenii_PYR-1 TEALRMGDPRGRPELRSALAEYLARARGVRTSPESIVICAGVRHAVELLT
Mb3595|M.bovis_AF2122/97 LRDAIAADYQRRHGIT-VEPDAVVITTGSSGGFLLAFLAC----------
Rv3565|M.tuberculosis_H37Rv LRDAIAADYQRRHGIT-VEPDAVVITTGSSGGFLLAFLAC----------
TH_2065|M.thermoresistible__bu LREAIAAGYQSRYGLS-VGADEVVITTGSSGGFLLAFLAC----------
MSMEG_2104|M.smegmatis_MC2_155 EGAVDPSLMEVLTATWPYEPPAITVVDGALDALDLLIRSR----------
MAB_0810c|M.abscessus_ATCC_199 GGLPELRDWFAAELGGGLGRQDILICGAGQSALSTSLRAL----------
MMAR_2376|M.marinum_M LRPGDRVAVEDPGWANLLDLLAALGLPVEPMGVDDDGPLVADLQRALGRG
MUL_1552|M.ulcerans_Agy99 LRPGDRVAVEDPGWANLLDLLAALGLPVEPMGVDDDGPLVADLQRALGRG
MAV_3214|M.avium_104 LRPGDRVAVEDPGWANLLDLLAALGFSAEPVRVDDAGPLPEDLARALGRG
MLBr_01210|M.leprae_Br4923 --------------------------------------------------
Mflv_1181|M.gilvum_PYR-GCK RTLGGPVAVEAYGLFVFRDAIAACGVQTVPIGVDDDGAVIADLD---DTS
Mvan_5625|M.vanbaalenii_PYR-1 RALGGPIAVESYGLFVFRDAIAAAGASTVPIGVDDRGAVVDELD---GLD
Mb3595|M.bovis_AF2122/97 FDAGDRVAMASPGYPCYRNILSALGCEVVEIPCGPQTRFQPTAQMLAEID
Rv3565|M.tuberculosis_H37Rv FDAGDRVAMASPGYPCYRNILSALGCEVVEIPCGPQTRFQPTAQMLAEID
TH_2065|M.thermoresistible__bu FDVGDRVAIASPGYPCYRNILSALGCEVVELQCGPQTRFQPTARMLAELD
MSMEG_2104|M.smegmatis_MC2_155 LRMGDRVIVETPTVRGLLDLLVWAGIEPVGVPMDEEG-MVPEAFAAAMRT
MAB_0810c|M.abscessus_ATCC_199 CQPGDPVLLESPCYPGATAAARAAGLRPIAIPLDINGIRPDRLNEALSHT
MMAR_2376|M.marinum_M VRAV-VVTSRAQNPTGAALSAARAEELREVLSQGAEEVLLVEDDHCAGIA
MUL_1552|M.ulcerans_Agy99 VRAV-VVTSRAQNPTGAALSAARAEELREVLSQGAEEVLLVEDDHCAGIA
MAV_3214|M.avium_104 ARAL-VLTTRAQNPTGAALSAERAAALRDLLSGRADDVLLVEDDHCAGIS
MLBr_01210|M.leprae_Br4923 --------------------------------------------------
Mflv_1181|M.gilvum_PYR-GCK ARSV-LLTPAHHNPLGMPLHPSRRAAVIEWATRTGGYILDDDYDGEFRYD
Mvan_5625|M.vanbaalenii_PYR-1 VPAV-LLTPAHHNPLGMPLHSSRRTAVIEWAQRTGGFVLDDDYDGEFRYD
Mb3595|M.bovis_AF2122/97 PPLRGVVVASPANPTGTVIPPEELAAIASWCDASDVRLISDEVYHGLVYQ
Rv3565|M.tuberculosis_H37Rv PPLRGVVVASPANPTGTVIPPEELAAIASWCDASDVRLISDEVYHGLVYQ
TH_2065|M.thermoresistible__bu PPVRGVIVASPANPTGTVIPPEELAAIARWCEDNDVRLISDEVYHGLVYP
MSMEG_2104|M.smegmatis_MC2_155 PTQMVFLQPRAHNPTGIAMTTPRARLLANIVKN--TETLVVEDECGSAIS
MAB_0810c|M.abscessus_ATCC_199 NARAIVVQPLFQNPTGASLTPQRRDELREIARRHGAFLIEDDFARYMAHD
MMAR_2376|M.marinum_M GVP---LHTLAGAT-QHWAFVRSAAKAYGPD-LRLAVLAGDQRTVERVHG
MUL_1552|M.ulcerans_Agy99 GVP---LHTLAGAT-QHWAFVRSAAKAYGPD-LRLAVLAGDQRTVERVHG
MAV_3214|M.avium_104 GAA---LHPVAGCT-THWAFVRSASKAYGPD-LRVAVLAGDQRTVDRVHG
MLBr_01210|M.leprae_Br4923 --------------------------------------------------
Mflv_1181|M.gilvum_PYR-GCK RQP---VGALQALRPDRVAYLGSTSKSLSQA-LRLGWMALPAELVDQVVE
Mvan_5625|M.vanbaalenii_PYR-1 RQP---VGALQSLRPDRVAYLGSTSKSLSQT-LRLGWMALPDNLIDAVLA
Mb3595|M.bovis_AF2122/97 GAP---QTSCAWQTSRNAVVVNSFSKYYAMTGWRLGWLLVPTVLRRAVDC
Rv3565|M.tuberculosis_H37Rv GAP---QTSCAWQTSRNAVVVNSFSKYYAMTGWRLGWLLVPTVLRRAVDC
TH_2065|M.thermoresistible__bu GAP---ETSCAWQTSREAVVVNSFSKYFAMTGWRLGWLLVPPALLRAVDR
MSMEG_2104|M.smegmatis_MC2_155 AAR---EVTLGKLLPGQTVHVRSYSKSHGPD-LRLAAMGGPEDVIAGIGH
MAB_0810c|M.abscessus_ATCC_199 DGKPLVPPLISDDPDGTVVHIRSMTKVTSPN-LRVGAIAARGPVMARLRA
MMAR_2376|M.marinum_M RLRLGPGWVSHILQDLAVRLFADDAATGLVRQAQERYADARGRLCAALS-
MUL_1552|M.ulcerans_Agy99 RLRLGPGWVSHILQDLAVRLFADDAATGLVRQAQERYADARGRLCAALS-
MAV_3214|M.avium_104 RLRLGPGWVSHVLQQLAVELWSDTAASELVATAERRYADRRRRLCGALA-
MLBr_01210|M.leprae_Br4923 --------------------------------------------------
Mflv_1181|M.gilvum_PYR-GCK TAGGQQFHVDVVSQLTLADFLTAGHYDRHIRRMRMRYRRRRDMLVSALS-
Mvan_5625|M.vanbaalenii_PYR-1 AAGGQQFYVDAINQLTLADFIAGGHYDRHIRRMRMRYRRRRDVLVSALS-
Mb3595|M.bovis_AF2122/97 LTGNFTICPPVLSQIAAVSAFTPEATAEADGNLAS-YAINRSLLLDGLR-
Rv3565|M.tuberculosis_H37Rv LTGNFTICPPVLSQIAAVSAFTPEATAEADGNLAS-YAINRSLLLDGLR-
TH_2065|M.thermoresistible__bu LTGNFTICPPALAQVAAVEAFHPESIAEAEALLDH-YATNRRLLIDGLR-
MSMEG_2104|M.smegmatis_MC2_155 LRNLGQGWTSWLLQRVLRELLLDPRVTAQVEHARAEYARRQTSFASVLA-
MAB_0810c|M.abscessus_ATCC_199 ASVIDTMLVPAPLQYTTLEVVTSPSWRRGLATLGKTLKHRRATARDAIAA
MMAR_2376|M.marinum_M ARGVA-AHGRSG-LNVWIPVPD--ETAAITR---LLNRGWAAAPGARFRI
MUL_1552|M.ulcerans_Agy99 ARGVA-AHGRSG-LNVWIPVPD--ETAAITR---LLNRGWAAAPGARFRV
MAV_3214|M.avium_104 ERGVD-AHGRSG-LNVWVRVPD--EAVAVSR---LLGAGWAAAPGARFRM
MLBr_01210|M.leprae_Br4923 ------------------MVPD--EAVSITR---LLDSGWVAAPETHFRI
Mflv_1181|M.gilvum_PYR-GCK PFAVG-IGGLAAGVNLLVTLPDGAEPELIRR---AGEAGIALVGLSMMRH
Mvan_5625|M.vanbaalenii_PYR-1 PFDVG-IGGLAAGVNLLVTLPDGAEPEVMRR---AGESGLAVSGLSIMRH
Mb3595|M.bovis_AF2122/97 RIGIDRLAPTDGAFYVYADVSDFTSDSLAFCSKLLADTGVAIAPGIDFDT
Rv3565|M.tuberculosis_H37Rv RIGIDRLAPTDGAFYVYADVSDFTSDSLAFCSKLLADTGVAIAPGIDFDT
TH_2065|M.thermoresistible__bu SLGIDRLAPADGAFYVYADVSRYTEDSIEFCSKLLADTGVAIAPGIDFDT
MSMEG_2104|M.smegmatis_MC2_155 EHEIR-TVGHDG-LNAWVPVQD--ESAALMR---MAVEGVGAAPGHLFTV
MAB_0810c|M.abscessus_ATCC_199 AFPTELTHYPRGGYHLWVSLPPQSDSRQFAA--EALTRGVAITPGDNYFT
: . *
MMAR_2376|M.marinum_M RSAPG----IRVTIAGLSAEEIEPLADAIAEAIQRTGRPTV-
MUL_1552|M.ulcerans_Agy99 RSAPG----IRVTIAGLSAEEIEPLADAIAGAIQRTGRPTV-
MAV_3214|M.avium_104 QTPAG----IRITIADLTPDEIEPLADAVAQAVRPSGRPIV-
MLBr_01210|M.leprae_Br4923 RAGPG----MRIILADLTADEIEPFSD---DAIAHQGWPSI-
Mflv_1181|M.gilvum_PYR-GCK PRAGSGVAERDGLIVGFAAAPEHAFPAAVSALCEVLRASGL-
Mvan_5625|M.vanbaalenii_PYR-1 PMAGP--ADVDGLIVGFAAPPEHAFSAAVAALCDVLRASGL-
Mb3595|M.bovis_AF2122/97 ARGGS---FVRISFAGPSGDIEEALRRIGSWLPSQ-------
Rv3565|M.tuberculosis_H37Rv ARGGS---FVRISFAGPSGDIEEALRRIGSWLPSQ-------
TH_2065|M.thermoresistible__bu VHGDR---FVRFSFAGATSDIEEALRRIGGWLA---------
MSMEG_2104|M.smegmatis_MC2_155 GPGEK--PHVRITVGLVTGDVEDVAERVVRAAHAGGWHSTVR
MAB_0810c|M.abscessus_ATCC_199 SGGGRPHIRISYVAAPSPADISEGIRRLEPLVSKYIAEGAG-
. .