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MDRIAGLDLHLDRPAGRTREALMDAVRDAIRSGRLVSGTRLPSSRALAADLGVARNTVARAYAELIAEGW LTSQHGSHTTVSQRAAEAVRSVTPPARPRPPRRLDHDLRPGHPDLSSFPRTEWSRAVKRALANAPSEAFG YAEPQGRPELRRALAEYLARARGVRARPCNIVVCCGAAEGLNLVAGALAEMGVAATAVEAYGLPTQRAAL ARAGLRCPPLAVDADGADINALNTMPEVGAVLLTPSHQFPLGVPLHSDRRAAVIDWARRTGGMIIEDDYD GEFRYDRSPVGALHGVDPAHVIYLGTASKSLAPGLRLGWLVLPDRLVDAVLRQKGETEETSGFVDQLTMA EFIESGSYDRHIRTMRAQYRRRREQLVAAVTAASPATTVAGLPAGLHVMLEIAGANASALAHQLAWRRLG VESLDRYRHPEFDNERSGLVFSYAAPSPSAWSAALDAVVRLLP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5760 | - | - | 100% (463) | GntR-family protein regulator |
| M. smegmatis MC2 155 | MSMEG_4140 | - | e-129 | 54.11% (462) | GntR-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_6371 | - | e-106 | 47.26% (457) | GntR-family protein regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1211 | - | 2e-10 | 26.62% (278) | N-succinyldiaminopimelate aminotransferase |
| M. gilvum PYR-GCK | Mflv_1181 | - | 1e-114 | 48.60% (465) | GntR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv1178 | - | 2e-10 | 26.62% (278) | N-succinyldiaminopimelate aminotransferase |
| M. leprae Br4923 | MLBr_01488 | - | 3e-08 | 26.16% (279) | N-succinyldiaminopimelate aminotransferase |
| M. abscessus ATCC 19977 | MAB_0196c | - | 1e-107 | 46.48% (469) | GntR family transcriptional regulator |
| M. marinum M | MMAR_2376 | - | 2e-15 | 28.95% (411) | GntR family transcriptional regulator |
| M. avium 104 | MAV_3214 | - | 3e-18 | 29.33% (375) | GntR-family protein transcriptional regulator |
| M. thermoresistible (build 8) | TH_1831 | - | 5e-12 | 27.34% (278) | PROBABLE AMINOTRANSFERASE |
| M. ulcerans Agy99 | MUL_1552 | - | 7e-15 | 28.64% (412) | GntR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_5625 | - | 1e-113 | 49.03% (463) | GntR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1181|M.gilvum_PYR-GCK MVSSWSNSG-------SRDLHLDLREALRPGARGNRNALVAALREAVRSG
Mvan_5625|M.vanbaalenii_PYR-1 -MTSWANSA-------TRDLHLDLRDALVPGARGTKDALISALRDAARSG
MAB_0196c|M.abscessus_ATCC_199 -MSSWANSAKAESRPLSHDLHLDLRQSITPGTRGVRELLTSALRDAVRSG
MSMEG_5760|M.smegmatis_MC2_155 -MDRIAGLD----------LHLDR-----PAGR-TREALMDAVRDAIRSG
MMAR_2376|M.marinum_M -MPVQYRIAG-----------------------GGAESIAASIESAISQG
MUL_1552|M.ulcerans_Agy99 -MPVQNRIAG-----------------------GGAGSIAASIESAISQG
MAV_3214|M.avium_104 -MAVQKSITG-----------------------TGAESIAASIEAAISAG
Mb1211|M.bovis_AF2122/97 --------------------------------------------------
Rv1178|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01488|M.leprae_Br4923 --------------------------------------------------
TH_1831|M.thermoresistible__bu --------------------------------------------------
Mflv_1181|M.gilvum_PYR-GCK RLSAGTTLPPSRALAADLGLARNTVADAYAELVAEGWLASRQGAGTWVVD
Mvan_5625|M.vanbaalenii_PYR-1 RLTAGTMLPSSRTLATDLGLARNTVAEAYAELVAEGWLASRQGAGTWVAD
MAB_0196c|M.abscessus_ATCC_199 RLTVGSMLPPSRTLASDLGLARNTVAEAYAELVAEGWLESRQGSGTRVVN
MSMEG_5760|M.smegmatis_MC2_155 RLVSGTRLPSSRALAADLGVARNTVARAYAELIAEGWLTSQHGSHTTVSQ
MMAR_2376|M.marinum_M GLAPGDALPSIREVAGQLGVNPNTVAAAYRLLRDRGTVETAGRRGTRVRD
MUL_1552|M.ulcerans_Agy99 GLAPGDALPSIREVAGQLGVNPNTVAAAYRLLRDRGTVETAGRRGTRVRD
MAV_3214|M.avium_104 SLAPGDALPPVRELAARLGVNANTAAAAYRLLRHRGAVETAGRRGTRVRH
Mb1211|M.bovis_AF2122/97 -------------------MSASLPVFPWDTLADAKALAGAHPDG-----
Rv1178|M.tuberculosis_H37Rv -------------------MSASLPVFPWDTLADAKALAGAHPDG-----
MLBr_01488|M.leprae_Br4923 -------------MSPFGRVSATLPVFPWDTLADAKAVAESHPDG-----
TH_1831|M.thermoresistible__bu --------------------------------------------------
Mflv_1181|M.gilvum_PYR-GCK TARASSQPPPVPPRPHGARVAPVHNLMPGSPDVAEFPRSQWAASARRALT
Mvan_5625|M.vanbaalenii_PYR-1 VT----TPAHTPPRPHGVRVAPTHNLMPGSPDVAEFPRSQWLASTRRALG
MAB_0196c|M.abscessus_ATCC_199 RG-----KDQLPPRPRGAGTPPPHNLMPGSGDVTAFPRADWLASARRALN
MSMEG_5760|M.smegmatis_MC2_155 RAAEAVRSVTPPARPRPPRR-LDHDLRPGHPDLSSFPRTEWSRAVKRALA
MMAR_2376|M.marinum_M RP-----ASTPRSSLDLGVPAGARDLSTGNPAPELLP-----LAAVG-WP
MUL_1552|M.ulcerans_Agy99 RP-----ASTPRSSLDLGVPAGARDLSTGNPAPELLP-----LAAVG-WP
MAV_3214|M.avium_104 RP-----ATTPRSLLGLDVPAGVRDLSTGNPHPALLP-----LAAAAPAR
Mb1211|M.bovis_AF2122/97 ----------------------IVDLSVGTPVDPVAP-------LIQEAL
Rv1178|M.tuberculosis_H37Rv ----------------------IVDLSVGTPVDPVAP-------LIQEAL
MLBr_01488|M.leprae_Br4923 ----------------------IVDLSVGTPVDPVAP-------LIQEAL
TH_1831|M.thermoresistible__bu ----------------------------------VAP-------VIRAAL
*
Mflv_1181|M.gilvum_PYR-GCK HAPTDAFRMGDPRGRPELRSALAEYLARARGVR-TSPESLVICAGVRHAV
Mvan_5625|M.vanbaalenii_PYR-1 GAPTEALRMGDPRGRPELRSALAEYLARARGVR-TSPESIVICAGVRHAV
MAB_0196c|M.abscessus_ATCC_199 HAPHEALRVGDPRGRHELRSAVAEYVSRVRGVR-TTPDSILICAGTRHAV
MSMEG_5760|M.smegmatis_MC2_155 NAPSEAFGYAEPQGRPELRRALAEYLARARGVR-ARPCNIVVCCGAAEGL
MMAR_2376|M.marinum_M DGSVLPLLYGAPAMSAELVDYARAALAADG----VAADHLAVTNGALDGI
MUL_1552|M.ulcerans_Agy99 DGSVLPLLYGAPAMSAELVDYARAALAADG----VAADHLAVTNGALDGI
MAV_3214|M.avium_104 PASGRAVLYGEPAISPALAEYARAALSADG----VPADHLALTSGALDGI
Mb1211|M.bovis_AF2122/97 AAASAAPGYPATAGTARLRESVVAALARRYGITRLTEAAVLPVIGTKELI
Rv1178|M.tuberculosis_H37Rv AAASAAPGYPATAGTARLRESVVAALARRYGITRLTEAAVLPVIGTKELI
MLBr_01488|M.leprae_Br4923 AAASSVAGYPTTAGTARLREAAVAALDRRYGITGLTEAAVLPVIGTKELI
TH_1831|M.thermoresistible__bu AEASAAPGYPTTAGTPALRASAAAALERRYGITGLTPDAVLPAIGTKELI
. . * : : *. . :
Mflv_1181|M.gilvum_PYR-GCK ELLARTLG----GPVAVEAYGLFVFRDAIAACGVQTVPIGVDDDGAVIAD
Mvan_5625|M.vanbaalenii_PYR-1 ELLTRALG----GPIAVESYGLFVFRDAIAAAGASTVPIGVDDRGAVVDE
MAB_0196c|M.abscessus_ATCC_199 EILTRMYGLA--RPIAVEAYGLFIFRDCIEATGGSSTPIGFDGEGAVVSD
MSMEG_5760|M.smegmatis_MC2_155 NLVAGALAEMGVAATAVEAYGLPTQRAALARAGLRCPPLAVDADGADINA
MMAR_2376|M.marinum_M ERALSANLRPG-DRVAVEDPGWANLLDLLAALGLPVEPMGVDDDGPLVAD
MUL_1552|M.ulcerans_Agy99 ERALSANLRPG-DRVAVEDPGWANLLDLLAALGLPVEPMGVDDDGPLVAD
MAV_3214|M.avium_104 ERALTAHLRPG-DRVAVEDPGWANLLDLLAALGFSAEPVRVDDAGPLPED
Mb1211|M.bovis_AF2122/97 AWLPTLLGLGGADLVVVPELAYPTYDVGARLAGTR----------VLRAD
Rv1178|M.tuberculosis_H37Rv AWLPTLLGLGGADLVVVPELAYPTYDVGARLAGTR----------VLRAD
MLBr_01488|M.leprae_Br4923 AWLPTLLGLRAGDVVVVPELAYPTYNVGARLAGAR----------VLRAD
TH_1831|M.thermoresistible__bu AWLPTLLGLGGDDTVVVPELAYPTYDVGARLAGAR----------VFRAD
.* . *
Mflv_1181|M.gilvum_PYR-GCK LDDT---SARSVLLTPAHHNPLGMPLHPSRRAAVIEWATRTGGYILDDDY
Mvan_5625|M.vanbaalenii_PYR-1 LDGL---DVPAVLLTPAHHNPLGMPLHSSRRTAVIEWAQRTGGFVLDDDY
MAB_0196c|M.abscessus_ATCC_199 LENL---DTSAALITPAHHFPHGLPLHPARRTAVVDWARRTDSYVLEDDY
MSMEG_5760|M.smegmatis_MC2_155 LNTMP--EVGAVLLTPSHQFPLGVPLHSDRRAAVIDWARRTGGMIIEDDY
MMAR_2376|M.marinum_M LQRALGRGVRAVVVTSRAQNPTGAALSAARAEELREVLSQGAEEVLLVED
MUL_1552|M.ulcerans_Agy99 LQRALGRGVRAVVVTSRAQNPTGAALSAARAEELREVLSQGAEEVLLVED
MAV_3214|M.avium_104 LARALGRGARALVLTTRAQNPTGAALSAERAAALRDLLSGRADDVLLVED
Mb1211|M.bovis_AF2122/97 ALTQLGPQSPALLYLNSPSNPTGRVLGVDHLRKVVEWARGRGVLVVSDEC
Rv1178|M.tuberculosis_H37Rv ALTQLGPQSPALLYLNSPSNPTGRVLGVDHLRKVVEWARGRGVLVVSDEC
MLBr_01488|M.leprae_Br4923 SLTQLGLQSPALFYLNSPSNPTGQVLAVNHLRKMVGWARNRGVVVVSDEC
TH_1831|M.thermoresistible__bu SLTQLGPQTPALIYLNSPSNPTGRVLGVDHLRKVVGWARDRGVIVASDEC
: . * * * : : : :
Mflv_1181|M.gilvum_PYR-GCK DGEFRYDRQPVGALQ-----ALRPDRVAYLGSTSKSLSQALRLGWMALPA
Mvan_5625|M.vanbaalenii_PYR-1 DGEFRYDRQPVGALQ-----SLRPDRVAYLGSTSKSLSQTLRLGWMALPD
MAB_0196c|M.abscessus_ATCC_199 DGEFRYDRQPVGALQ-----SLDPDRVVYLGSASKSLAPALRLGWMVLPP
MSMEG_5760|M.smegmatis_MC2_155 DGEFRYDRSPVGALH-----GVDPAHVIYLGTASKSLAPGLRLGWLVLPD
MMAR_2376|M.marinum_M DHCAGIAGVPLHTLA-----GAT-QHWAFVRSAAKAYGPDLRLAVLAGDQ
MUL_1552|M.ulcerans_Agy99 DHCAGIAGVPLHTLA-----GAT-QHWAFVRSAAKAYGPDLRLAVLAGDQ
MAV_3214|M.avium_104 DHCAGISGAALHPVA-----GCT-THWAFVRSASKAYGPDLRVAVLAGDQ
Mb1211|M.bovis_AF2122/97 YLGLGWDAEPVSVLHPSVCDGDHTGLLAVHSLSKSSSLAGYRAGFVVGDL
Rv1178|M.tuberculosis_H37Rv YLGLGWDAEPVSVLHPSVCDGDHTGLLAVHSLSKSSSLAGYRAGFVVGDL
MLBr_01488|M.leprae_Br4923 YLGLGWDAEPFSVLHPLVCDGNHTGLLAVHSLSKSSSLAGYRAGFVAGDP
TH_1831|M.thermoresistible__bu YLGLGWDETPVSVLHPTVCGGDHTNLLAIHSLSKTSSLAGYRAGFVAGDP
.. : . : .: * . :.
Mflv_1181|M.gilvum_PYR-GCK ELVDQVVETAGGQQFHVDVVSQLTLADFLTAGHYDRHIRRMRMRYRRRRD
Mvan_5625|M.vanbaalenii_PYR-1 NLIDAVLAAAGGQQFYVDAINQLTLADFIAGGHYDRHIRRMRMRYRRRRD
MAB_0196c|M.abscessus_ATCC_199 EQMDAAVAATGGAQWYVGAISQLTMADFIAGGHYDRHIRRMRGRYRRRRD
MSMEG_5760|M.smegmatis_MC2_155 RLVDAVLRQKGETEETSGFVDQLTMAEFIESGSYDRHIRTMRAQYRRRRE
MMAR_2376|M.marinum_M RTVERVHGRLRLGPGWVSHILQDLAVRLFADDAATGLVRQAQERYADARG
MUL_1552|M.ulcerans_Agy99 RTVERVHGRLRLGPGWVSHILQDLAVRLFADDAATGLVRQAQERYADARG
MAV_3214|M.avium_104 RTVDRVHGRLRLGPGWVSHVLQQLAVELWSDTAASELVATAERRYADRRR
Mb1211|M.bovis_AF2122/97 EIVAELLAVRKHAGMMVPAPVQAAMVAALDDDAHE---RQQRERYAQRRA
Rv1178|M.tuberculosis_H37Rv EIVAELLAVRKHAGMMVPAPVQAAMVAALDDDAHE---RQQRERYAQRRA
MLBr_01488|M.leprae_Br4923 DLVAELLAVRKHAGMMVPTPVQAAMVAALGDDAHE---REQRDRYARRRD
TH_1831|M.thermoresistible__bu ALVAELLAVRKHAGMMVPTPVQAAMVAALDDDAHE---RQQRERYQRRRR
: * . . :* *
Mflv_1181|M.gilvum_PYR-GCK MLVSALSPFAVG--IGGLAAGVNLLVTLPDGAEPELIRRAGEAGIALVGL
Mvan_5625|M.vanbaalenii_PYR-1 VLVSALSPFDVG--IGGLAAGVNLLVTLPDGAEPEVMRRAGESGLAVSGL
MAB_0196c|M.abscessus_ATCC_199 LLVQRLAGYNVG--VRGLSAGLHLLLTLPEGTESDVLYRAGEAGVALAGL
MSMEG_5760|M.smegmatis_MC2_155 QLVAAVTAASPATTVAGLPAGLHVMLEIAGANASALAHQLAWRRLGVESL
MMAR_2376|M.marinum_M RLCAALSARGVA---AHGRSGLNVWIPVPD--ETAAITRLLNRGWAAAPG
MUL_1552|M.ulcerans_Agy99 RLCAALSARGVA---AHGRSGLNVWIPVPD--ETAAITRLLNRGWAAAPG
MAV_3214|M.avium_104 RLCGALAERGVD---AHGRSGLNVWVRVPD--EAVAVSRLLGAGWAAAPG
Mb1211|M.bovis_AF2122/97 ALLPALGSAGFA--VDYSDAGLYLWATRGE-PCRDSVAWLAQRGILVAPG
Rv1178|M.tuberculosis_H37Rv ALLPALGSAGFA--VDYSDAGLYLWATRGE-PCRDSAAWLAQRGILVAPG
MLBr_01488|M.leprae_Br4923 VLLPAVVSAGFT--VDHSEAGLYLWASRGE-PCRDSVEWFAQRGILVALG
TH_1831|M.thermoresistible__bu ELLPALQQAGFT--VDHSEAGLYLWATRGE-PCRATVDWLARRGILVAPG
* : :*: :
Mflv_1181|M.gilvum_PYR-GCK SMMRHPRAGSGVAERDGLIVGFAAAPEHAFPAAVSALCEVLRASGL
Mvan_5625|M.vanbaalenii_PYR-1 SIMRHPMAGP--ADVDGLIVGFAAPPEHAFSAAVAALCDVLRASGL
MAB_0196c|M.abscessus_ATCC_199 ARLRHPLAGPHIPNPDGVVVSFGTPADHGFGPAVDALCRVLAATGL
MSMEG_5760|M.smegmatis_MC2_155 DRYRHPEFDN---ERSGLVFSYAAPSPSAWSAALDAVVRLLP----
MMAR_2376|M.marinum_M ARFRIRSAPGIRVTIAGLSAEEIEPLADAIAEAIQRTGRPTV----
MUL_1552|M.ulcerans_Agy99 ARFRVRSAPGIRVTIAGLSAEEIEPLADAIAGAIQRTGRPTV----
MAV_3214|M.avium_104 ARFRMQTPAGIRITIADLTPDEIEPLADAVAQAVRPSGRPIV----
Mb1211|M.bovis_AF2122/97 DFYGP--------GGAQHVRVALTATDERVAAAVGRLTC-------
Rv1178|M.tuberculosis_H37Rv DFYGP--------GGAQHVRVALTATDERVAAAVGRLTC-------
MLBr_01488|M.leprae_Br4923 EFYGP--------GGCQHVRVALTASDERIAAVVARLS--------
TH_1831|M.thermoresistible__bu EFYGP--------RGAEHVRIALTAPDERITAAAARLAQAG-----
. .