For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
SYGTFETTHTAADDRYDKIPYRRSGRSGLDLPAFSFGLWQKFGTDYPFETQREIILHAFDLGITHFDNAD RYGPPHRAAQQNFGRVLTKDLARYRDELILSTKAGNPIGPSPYLRGGSRKSLLTSLEHSLGDLGTDHVDI FYSHSTDLSTPLEETVGALVSAVEQGKALYVGISNYLPDRAHDTAALLAEAGVPLLVHQPRYSIFDRRIE QNGLLELAGQDGFGLVVYSPLAQGLLTNKYLESIPEGARAANSTFLKPDAITDTYRQRTAELNKVAESRG QSLAQLALQWVLRHPNVTSALIGASSTGQLDHNVNALQFPPFTDEELALIDEHGVHGTGLNL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4093 | - | - | 100% (343) | oxidoreductase, aldo/keto reductase family protein |
| M. smegmatis MC2 155 | MSMEG_6746 | - | 9e-88 | 51.23% (324) | oxidoreductase, aldo/keto reductase family protein |
| M. smegmatis MC2 155 | MSMEG_5192 | - | 1e-36 | 33.23% (322) | aldo/keto reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2320 | - | 5e-17 | 28.52% (305) | hypothetical protein Mb2320 |
| M. gilvum PYR-GCK | Mflv_0942 | - | 3e-16 | 26.56% (305) | aldo/keto reductase |
| M. tuberculosis H37Rv | Rv2298 | - | 5e-17 | 28.52% (305) | hypothetical protein Rv2298 |
| M. leprae Br4923 | MLBr_00458 | - | 6e-17 | 26.24% (282) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_4120c | - | 2e-27 | 30.09% (319) | aldo/keto reductase |
| M. marinum M | MMAR_3520 | - | 2e-17 | 28.01% (307) | hypothetical protein MMAR_3520 |
| M. avium 104 | MAV_3334 | - | 3e-38 | 34.50% (313) | general stress protein 69 |
| M. thermoresistible (build 8) | TH_1525 | - | 7e-08 | 24.17% (211) | 2,5-diketo-D-gluconic acid reductase A |
| M. ulcerans Agy99 | MUL_2745 | - | 3e-17 | 28.34% (307) | hypothetical protein MUL_2745 |
| M. vanbaalenii PYR-1 | Mvan_2555 | - | 2e-17 | 26.87% (294) | aldo/keto reductase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_4093|M.smegmatis_MC2_155 --MSYGTFETTHTAADDRYDKIPYRRSGRSGLDLPAFSFGLWQKFG----
MAV_3334|M.avium_104 ---------------------MKTITFGKTGLEVSRLAFGTWEFCSD---
Mb2320|M.bovis_AF2122/97 ---------------------MKYLDVDGIG-QVSRIGLGTWQFGSRE--
Rv2298|M.tuberculosis_H37Rv ---------------------MKYLDVDGIG-QVSRIGLGTWQFGSRE--
MMAR_3520|M.marinum_M ---------------------MKHLEVDGIG-NVSRIGLGTWQFGSRE--
MUL_2745|M.ulcerans_Agy99 ---------------------MKHLEVDGIG-NVSRIGLGTWQFGSRE--
MLBr_00458|M.leprae_Br4923 MRRFWRTVVEVTSQNSQALAQASGAFTLGGDLKVNRLGFGAMRLTGKG-V
Mvan_2555|M.vanbaalenii_PYR-1 ----------MTSGSS----RTAPTFLLGGELPVNRLGFGAMRLTGPG-V
Mflv_0942|M.gilvum_PYR-GCK ----------MTTAIQ-------TTLTLGGELPVPRMGYGAMQLAGPG-V
MAB_4120c|M.abscessus_ATCC_199 -----------------------MKHTWLGELSVSRIGLGAMSMSAYYRA
TH_1525|M.thermoresistible__bu -----------------VNMTTVPAITLNNGAQIPQVGFGVYQIPPDQ--
: .. *
MSMEG_4093|M.smegmatis_MC2_155 ----TDYPFETQREIILHAFDLGITHFDNADRYGPPHRAAQQNFGRVLTK
MAV_3334|M.avium_104 ---WGHADEDAAITMIRSARDLGINFFDTAQQYG--FGASERLLGKALRD
Mb2320|M.bovis_AF2122/97 WGYGDRYATGAARDIVKRARALGVTLFDTAEIYG--LGKSERILGEALGD
Rv2298|M.tuberculosis_H37Rv WGYGDRYATGAARDIVKRARALGVTLFDTAEIYG--LGKSERILGEALGD
MMAR_3520|M.marinum_M WGYGDRYASGAARDIVARARALGVTLFDTAEVYG--LGKSERILGEALGD
MUL_2745|M.ulcerans_Agy99 WGYGDRYASGAARDIVARACALGVTLFDTAEVYG--LGKSERILGEALGD
MLBr_00458|M.leprae_Br4923 WG--PPVDRYEAVRVLRRAVELGVNFIDTADSYG--PYVSEEIIAEAL-H
Mvan_2555|M.vanbaalenii_PYR-1 WG--PPADRDECLRVLRRAVDLGVDFIDTADSYG--PYISEDLIREAL-H
Mflv_0942|M.gilvum_PYR-GCK LG--LPDDVDNAVDVLRRAVDHGVRFFDTANAYG--PRTVNQIIGRALGT
MAB_4120c|M.abscessus_ATCC_199 IGSESGPDEATSIDTLRRALDLGVSLIDTAEIYG--PFVNEELVGRAIAG
TH_1525|M.thermoresistible__bu -----------TAAAVRTALDAGYRHIDTAQMYGNERGVAEGIRDAGLDR
: * * :*.*: ** : :
MSMEG_4093|M.smegmatis_MC2_155 DLARYRDELILSTKAGNPIGPS--PYLRGGSRKSLLTSLEHSLGDLGTDH
MAV_3334|M.avium_104 DLARARDEVVIATKGGLRATDS--GLVRDASPQWLRKGVESSLTALGIDH
Mb2320|M.bovis_AF2122/97 D----RTEVVVASKVFPVAPFP--AVIKNRER--------ASARRLQLNR
Rv2298|M.tuberculosis_H37Rv D----RTEVVVASKVFPVAPFP--AVIKNRER--------ASARRLQLNR
MMAR_3520|M.marinum_M E----RAEVVVASKIMPVAPFP--AVVKQRER--------ASARRLQLDR
MUL_2745|M.ulcerans_Agy99 E----RAEVVVASKIMPVAPFP--AVVKQRER--------ASARRLQLDR
MLBr_00458|M.leprae_Br4923 P----YKGLVIATKAGLLRTGRDVWIPLG-NPSYLRQELEMSLRRLNVDT
Mvan_2555|M.vanbaalenii_PYR-1 P----YDGVVIATKAGLLRTAPDVWEPLG-FPAYLRQECEMSLRRLGTDT
Mflv_0942|M.gilvum_PYR-GCK P----ADDLVIGNKVGAVRGPAGEWLQDS-RPEILRTQVEEALLDMRADA
MAB_4120c|M.abscessus_ATCC_199 R----RDEVVLATKFGLVSHGNGASQVLDSTPGNISTAVEGSLRRLGVDH
TH_1525|M.thermoresistible__bu G------EVFITSKLNNPYHRP-----DDARR-----AFDRTLTELGSDY
:.: .* : : :
MSMEG_4093|M.smegmatis_MC2_155 VDIFYSHSTDLS---------TPLEETVGALVSAVEQGKALYVGISNYLP
MAV_3334|M.avium_104 IDVYLVHWPDPR---------MPAAETAGALAELVSEGKIRHVGVSNYDT
Mb2320|M.bovis_AF2122/97 IPLYQIHQPNPV---------VPDSVIMPGMRDLLDSGDIGAAGVSNYSL
Rv2298|M.tuberculosis_H37Rv IPLYQIHQPNPV---------VPDSVIMPGMRDLLDSGDIGAAGVSNYSL
MMAR_3520|M.marinum_M IPLYQIHQPNPV---------VPDSVIMPGMRELLDTGRIGAAGVSNYSL
MUL_2745|M.ulcerans_Agy99 IPLYQIHQPNPV---------VPDSVIMPGIRELLDIGRIGAAGVSNYSL
MLBr_00458|M.leprae_Br4923 IDLFQLHRIDPN---------FPLADQVGELFTLKNEGKIRHIGLSEINL
Mvan_2555|M.vanbaalenii_PYR-1 IDLFQLHRIAPK---------FPAEDQIGELAKLQQEGKVRHIGLSEVSV
Mflv_0942|M.gilvum_PYR-GCK SALTYLRLAGDIRGVGEGPGEVPLEESLGALVELRDQGKIRHIGLSGASP
MAB_4120c|M.abscessus_ATCC_199 IDLYYQHRVDPN---------VAIEDTIGAVAELVQQGKVRYIGLSEAAA
TH_1525|M.thermoresistible__bu VDLFLIHWPLPMHYDG------DFVSTWKTLEEFAADGRARSIGVSNFEP
: : : * *:*
MSMEG_4093|M.smegmatis_MC2_155 DRAHDTAALLAEAGVPLLVHQPRYSIFDRRIEQNGLLELAGQDGFGLVVY
MAV_3334|M.avium_104 AQVEEFS-----ATLPVEVVQPPYHLFRRDIEDT-LLPYAREHDIGVMVY
Mb2320|M.bovis_AF2122/97 ARWRKADAALG---RPVVSNQVHFSLAHPDALED-LVPFAELENRIVIAY
Rv2298|M.tuberculosis_H37Rv ARWRKADAALG---RPVVSNQVHFSLAHPDALED-LVPFAELENRIVIAY
MMAR_3520|M.marinum_M ARWKKADAALG---RPVVSNQVHFSLAHPGPLDD-LVPFAERENRIIIAY
MUL_2745|M.ulcerans_Agy99 ARWKKADAALG---RPVVSNQVHFSLAHPGPLDD-LVPFAERENRIIIAY
MLBr_00458|M.leprae_Br4923 DQLTAAQQITE-----IVSVQNMYNLSAR-AAEPLLDAVTS-RGIGFIPW
Mvan_2555|M.vanbaalenii_PYR-1 DQLTAARAVAP-----IVSVQNMYNLTMR-AAEPVLDACEA-DGIAFIPW
Mflv_0942|M.gilvum_PYR-GCK AALERAQQITT-----IAAVQNRFNLIDR-SGVEVLAACER-DGIAFVPY
MAB_4120c|M.abscessus_ATCC_199 GTIRRAHAVHP-----ITALQNEYSLWTRDIEDEILPTIRE-LGIGLVAY
TH_1525|M.thermoresistible__bu AHLDLLAAETS------TVPAVNQVEIHPYFGNNDVRRYCAEHGIAVEAW
: . . :
MSMEG_4093|M.smegmatis_MC2_155 SPLAQGLLTNKYLES---IPEGARAANSTFLKPDAITDTYRQRTAELNKV
MAV_3334|M.avium_104 GPLAHGLLTGTVKPDTRFAPQDWRAKSDIFSGDGFLRN--LEVVAQLQEL
Mb2320|M.bovis_AF2122/97 SPLAQGLLGGKYGLENR--PGGVRALNPLFGTENLRRI--EPLLATLRAI
Rv2298|M.tuberculosis_H37Rv SPLAQGLLGGKYGLENR--PGGVRALNPLFGTENLRRI--EPLLATLRAI
MMAR_3520|M.marinum_M SPLAQGLLGGKYGVDNR--PAGVRAVNPLFGTENLRRI--EPLLQTLRAV
MUL_2745|M.ulcerans_Agy99 SPLAQGLLGGKYGVDNR--PAGVRAVNPLFGTENLRRI--EPLLQTLRAV
MLBr_00458|M.leprae_Br4923 SPLAAGPLAAPDGPLQRIAV------------------------------
Mvan_2555|M.vanbaalenii_PYR-1 FPLAAGPLAAADGPLHRIAA------------------------------
Mflv_0942|M.gilvum_PYR-GCK FPLATGGLGD-DDELRRPGE------------------------------
MAB_4120c|M.abscessus_ATCC_199 SPLGRGFLTGAIGSRDQLAEGDFRREQPRFSAENFDAN--LALVEEVRSV
TH_1525|M.thermoresistible__bu APIAKGRVADDPVIAG---------------------------------I
*:. * :
MSMEG_4093|M.smegmatis_MC2_155 AESRGQSLAQLALQWVLRHPNVTSALIGASSTGQLDHNVNALQFPP-FTD
MAV_3334|M.avium_104 ASDLGVTISQLAIARVLAQPGVHVAIVGAQHLHYLQESARAADVT--LSD
Mb2320|M.bovis_AF2122/97 AVDVDAKPAQVALAWLISLPGV-VAIPGASSVEQLEFNVAAADIEL-SAQ
Rv2298|M.tuberculosis_H37Rv AVDVDAKPAQVALAWLISLPGV-VAIPGASSVEQLEFNVAAADIEL-SAQ
MMAR_3520|M.marinum_M ATDVDAKPAQVALAWLISLPGV-VAIPGASSVEQLEFNVAAADIEL-SAD
MUL_2745|M.ulcerans_Agy99 AIDVDAKPAQVALAWLISLPGV-VAIPGASSVEQLEFNVAAADIEL-SAD
MLBr_00458|M.leprae_Br4923 --NHHATPSQLALAWLLKRSPVMLPIPGTSRVAHLEENVAAAEIS--LSD
Mvan_2555|M.vanbaalenii_PYR-1 --EHHATPSQLALAWLLKRSPVMLPIPGTSKVAHLEENVAAAQID--LTD
Mflv_0942|M.gilvum_PYR-GCK --RLGVPMSTIALAWLLRRSPVIVPIPGTKSVAHLRDNLSAAQVADQLTE
MAB_4120c|M.abscessus_ATCC_199 ASSIGATSAQVALAWLLARGDDIVPIPGTTKVSRVNENVGAVDIE--LLP
TH_1525|M.thermoresistible__bu ADRLGRTPAQVTLRWHIQRGDIVLPKS--VTPERVRSNIALFDFE--LSD
: ::: : . : . :.
MSMEG_4093|M.smegmatis_MC2_155 EELALIDEHGVHGTGLNL-----------------------
MAV_3334|M.avium_104 ADLAAVDNVLAAATPVGGPYPEMHQKAS-------------
Mb2320|M.bovis_AF2122/97 SRDALTDAARAFRPVSTGRFLTDMVREKVSRR---------
Rv2298|M.tuberculosis_H37Rv SRDALTDAARAFRPVSTGRFLTDMVREKVSRR---------
MMAR_3520|M.marinum_M ARAALTEAARAFHPVSARRFLTDTVREKLGRR---------
MUL_2745|M.ulcerans_Agy99 ARAALTEAARAFHPVSARRFLTDTVREKLGRR---------
MLBr_00458|M.leprae_Br4923 DEFEMLSAAGAQ-----------------------------
Mvan_2555|M.vanbaalenii_PYR-1 AEFETLGNAGAAAS---------------------------
Mflv_0942|M.gilvum_PYR-GCK DEVHALTAVEDEQSATLSTMPSRMTDAFARVVSPPGSGRRR
MAB_4120c|M.abscessus_ATCC_199 EHLVRLECLAAAAGDRYNAEHLARLEG--------------
TH_1525|M.thermoresistible__bu ADMAAISALDKGEAGRMGPHPDKFDMI--------------