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KHTWLGELSVSRIGLGAMSMSAYYRAIGSESGPDEATSIDTLRRALDLGVSLIDTAEIYGPFVNEELVGR AIAGRRDEVVLATKFGLVSHGNGASQVLDSTPGNISTAVEGSLRRLGVDHIDLYYQHRVDPNVAIEDTIG AVAELVQQGKVRYIGLSEAAAGTIRRAHAVHPITALQNEYSLWTRDIEDEILPTIRELGIGLVAYSPLGR GFLTGAIGSRDQLAEGDFRREQPRFSAENFDANLALVEEVRSVASSIGATSAQVALAWLLARGDDIVPIP GTTKVSRVNENVGAVDIELLPEHLVRLECLAAAAGDRYNAEHLARLEG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4120c | - | - | 100% (329) | aldo/keto reductase |
| M. abscessus ATCC 19977 | MAB_1528c | - | 8e-13 | 27.34% (278) | oxidoreductase |
| M. abscessus ATCC 19977 | MAB_2941 | - | 2e-09 | 27.56% (283) | putative oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2320 | - | 3e-31 | 33.22% (292) | hypothetical protein Mb2320 |
| M. gilvum PYR-GCK | Mflv_0942 | - | 3e-34 | 33.11% (302) | aldo/keto reductase |
| M. tuberculosis H37Rv | Rv2298 | - | 3e-31 | 33.22% (292) | hypothetical protein Rv2298 |
| M. leprae Br4923 | MLBr_00458 | - | 2e-42 | 34.95% (309) | putative oxidoreductase |
| M. marinum M | MMAR_2086 | - | 7e-42 | 35.58% (312) | oxidoreductase |
| M. avium 104 | MAV_2496 | - | 1e-110 | 61.28% (328) | aldo/keto reductase |
| M. smegmatis MC2 155 | MSMEG_2920 | - | 5e-91 | 56.66% (323) | aldo/keto reductase |
| M. thermoresistible (build 8) | TH_1364 | - | 7e-14 | 27.60% (279) | PROBABLE OXIDOREDUCTASE |
| M. ulcerans Agy99 | MUL_2745 | - | 7e-32 | 33.00% (303) | hypothetical protein MUL_2745 |
| M. vanbaalenii PYR-1 | Mvan_2555 | - | 9e-44 | 38.19% (309) | aldo/keto reductase |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_4120c|M.abscessus_ATCC_199 -----------------------MKHTWLGELSVSRIGLG---AMSMSAY
MAV_2496|M.avium_104 -----------------------MKQAQLGGLQVGRLGLG---AMGMSVA
MSMEG_2920|M.smegmatis_MC2_155 -----------------------MTVAPLR-TDRRRLGSGGPEVSAIGLG
MLBr_00458|M.leprae_Br4923 MRRFWRTVVEVTSQNSQALAQASGAFTLGGDLKVNRLGFG-------AMR
MMAR_2086|M.marinum_M ------------------MAAASATLTLGGDLTVNRLGFG-------AMR
Mvan_2555|M.vanbaalenii_PYR-1 --------------MTSGSSRTAPTFLLGGELPVNRLGFG-------AMR
Mflv_0942|M.gilvum_PYR-GCK -----------------MTTAIQTTLTLGGELPVPRMGYG-------AMQ
Mb2320|M.bovis_AF2122/97 ----------------------MKYLDVDGIGQVSRIGLG------TWQF
Rv2298|M.tuberculosis_H37Rv ----------------------MKYLDVDGIGQVSRIGLG------TWQF
MUL_2745|M.ulcerans_Agy99 ----------------------MKHLEVDGIGNVSRIGLG------TWQF
TH_1364|M.thermoresistible__bu -----------------------MTSSPGEAAATPTVTLN------DDRS
: .
MAB_4120c|M.abscessus_ATCC_199 YRAIGSESGPDE-ATSIDTLRRALDLGVSLIDTAEIYGPFVNEELVGRAI
MAV_2496|M.avium_104 Y----AGAGTDD-AESIRTVHRAIELGVTLIDTAEVYGPYINEELLARAL
MSMEG_2920|M.smegmatis_MC2_155 FMSFRAGSGPDDEKQAKDIVDAAIDLGVTLFDTADIYGPEHSEVLLGKAI
MLBr_00458|M.leprae_Br4923 LTGKGVWGPPVDRYEAVRVLRRAVELGVNFIDTADSYGPYVSEEIIAEAL
MMAR_2086|M.marinum_M LTGDGVWGPPADRAEAVRVLRRAAELGVNFIDTADSYGPYVSEEIIHEAL
Mvan_2555|M.vanbaalenii_PYR-1 LTGPGVWGPPADRDECLRVLRRAVDLGVDFIDTADSYGPYISEDLIREAL
Mflv_0942|M.gilvum_PYR-GCK LAGPGVLGLPDDVDNAVDVLRRAVDHGVRFFDTANAYGPRTVNQIIGRAL
Mb2320|M.bovis_AF2122/97 GSREWGYGDRYATGAARDIVKRARALGVTLFDTAEIYGLGKSERILGEAL
Rv2298|M.tuberculosis_H37Rv GSREWGYGDRYATGAARDIVKRARALGVTLFDTAEIYGLGKSERILGEAL
MUL_2745|M.ulcerans_Agy99 GSREWGYGDRYASGAARDIVARACALGVTLFDTAEVYGLGKSERILGEAL
TH_1364|M.thermoresistible__bu MPVLGLGVGELSDDEAERAVAAALEAGYRLIDTAASYGNEAGVGRAIAAS
. : * * ::*** ** *
MAB_4120c|M.abscessus_ATCC_199 AGRRDEVVLATKFG--LVSHGNGASQVLDSTPGNISTAVEGSLRRLGVDH
MAV_2496|M.avium_104 RGRRDRVVLATKFG--LISHTG--RDGLDSSPANIRVAVDGSLRRLATDH
MSMEG_2920|M.smegmatis_MC2_155 RGRRDSLVIATKFGNRLDRGTSTDGRALDGRPEYVRSAIEGSLRRLGVDH
MLBr_00458|M.leprae_Br4923 -HPYKGLVIATKAG---LLRTGRDVWIPLGNPSYLRQELEMSLRRLNVDT
MMAR_2086|M.marinum_M -HPYTGLVIATKAG---LLRTGPGVWVPLGNPSYLRQECEMSLRRLGVDT
Mvan_2555|M.vanbaalenii_PYR-1 -HPYDGVVIATKAG---LLRTAPDVWEPLGFPAYLRQECEMSLRRLGTDT
Mflv_0942|M.gilvum_PYR-GCK GTPADDLVIGNKVG---AVRGPAGEWLQDSRPEILRTQVEEALLDMRADA
Mb2320|M.bovis_AF2122/97 GDDRTEVVVASKVFP------------VAPFPAVIKNRERASARRLQLNR
Rv2298|M.tuberculosis_H37Rv GDDRTEVVVASKVFP------------VAPFPAVIKNRERASARRLQLNR
MUL_2745|M.ulcerans_Agy99 GDERAEVVVASKIMP------------VAPFPAVVKQRERASARRLQLDR
TH_1364|M.thermoresistible__bu GLPREEIFVTTKLAT------------TDQGFQSSQDAVRASLERLGLEY
:.: .* : : :
MAB_4120c|M.abscessus_ATCC_199 IDLYYQHRVDPN---------VAIEDTIGAVAELVQQGKVRYIGLSEAAA
MAV_2496|M.avium_104 IDLYYQHRLDRQ---------TPIEDTVGALAELVAAGKIRHIGLSEVGV
MSMEG_2920|M.smegmatis_MC2_155 VDLYYQHRVDPQ---------VPIEDTVGALAELVQAGKVRHIGLSEPGP
MLBr_00458|M.leprae_Br4923 IDLFQLHRIDPN---------FPLADQVGELFTLKNEGKIRHIGLSEINL
MMAR_2086|M.marinum_M IDLFQLHRIDRN---------YPLADQVGELLALKNEGKIRHIGLSEIDV
Mvan_2555|M.vanbaalenii_PYR-1 IDLFQLHRIAPK---------FPAEDQIGELAKLQQEGKVRHIGLSEVSV
Mflv_0942|M.gilvum_PYR-GCK SALTYLRLAGDIRGVGEGPGEVPLEESLGALVELRDQGKIRHIGLSGASP
Mb2320|M.bovis_AF2122/97 IPLYQIHQPNPV---------VPDSVIMPGMRDLLDSGDIGAAGVSNYSL
Rv2298|M.tuberculosis_H37Rv IPLYQIHQPNPV---------VPDSVIMPGMRDLLDSGDIGAAGVSNYSL
MUL_2745|M.ulcerans_Agy99 IPLYQIHQPNPV---------VPDSVIMPGIRELLDIGRIGAAGVSNYSL
TH_1364|M.thermoresistible__bu VDLYLIHWPAGE--------QGKYVDSWGGFLKIREDGLTRSIGVSNFDE
* : . : * *:*
MAB_4120c|M.abscessus_ATCC_199 GTIRRAHAVH--PITALQNEYSLWTRDIEDEILPTIRELGIGLVAYSPLG
MAV_2496|M.avium_104 NSIRRAHAVH--PITAVQSEYSLWTRDQEDEILPVLRELGIGFVAYSPLG
MSMEG_2920|M.smegmatis_MC2_155 QTLRRAHAVH--PVAAIQNEWSLFTRDIEDETVPIARELGIGIVPYSPLG
MLBr_00458|M.leprae_Br4923 DQLTAAQQIT--EIVSVQNMYNLSARA-AEPLLDAVTSRGIGFIPWSPLA
MMAR_2086|M.marinum_M DQLEAAQQIT--EIVSVQNMYNLAARG-AEPLLEAATSQGIAFIPWFPLA
Mvan_2555|M.vanbaalenii_PYR-1 DQLTAARAVA--PIVSVQNMYNLTMRA-AEPVLDACEADGIAFIPWFPLA
Mflv_0942|M.gilvum_PYR-GCK AALERAQQIT--TIAAVQNRFNLIDRS-GVEVLAACERDGIAFVPYFPLA
Mb2320|M.bovis_AF2122/97 ARWRKADAALGRPVVSNQVHFSLAHPDALEDLVPFAELENRIVIAYSPLA
Rv2298|M.tuberculosis_H37Rv ARWRKADAALGRPVVSNQVHFSLAHPDALEDLVPFAELENRIVIAYSPLA
MUL_2745|M.ulcerans_Agy99 ARWKKADAALGRPVVSNQVHFSLAHPGPLDDLVPFAERENRIIIAYSPLA
TH_1364|M.thermoresistible__bu EYLSDIIDLS--FVTPAVNQIELHPLLNQADLRKVHAERNVLTQAYSPLG
:.. .* . .: **.
MAB_4120c|M.abscessus_ATCC_199 RG-----FLTGAIGSRDQLAEGDFRREQPRFSAENFDANLALVEEVRS--
MAV_2496|M.avium_104 RG-----FLTGAIRSAHELPDTDYRRTNPRFAEQNFAHNLRCADELRD--
MSMEG_2920|M.smegmatis_MC2_155 RG-----WLTGRVQSRDNISG--THRDHPRFSDEAFDRNRALADTVVT--
MLBr_00458|M.leprae_Br4923 AG-----PLAAP------------------------------DGPLQR--
MMAR_2086|M.marinum_M SG-----PLAAP------------------------------DGPLRK--
Mvan_2555|M.vanbaalenii_PYR-1 AG-----PLAAA------------------------------DGPLHR--
Mflv_0942|M.gilvum_PYR-GCK TG-----GLGD-------------------------------DDELRR--
Mb2320|M.bovis_AF2122/97 QG-----LLGGKYGLENRPGG--VRALNPLFGTENLRRIEPLLATLRA--
Rv2298|M.tuberculosis_H37Rv QG-----LLGGKYGLENRPGG--VRALNPLFGTENLRRIEPLLATLRA--
MUL_2745|M.ulcerans_Agy99 QG-----LLGGKYGVDNRPAG--VRAVNPLFGTENLRRIEPLLQTLRA--
TH_1364|M.thermoresistible__bu VGNLLADPTIGAVAQAHGKSPAQVLLRWNLQLGNAVVVRSSNPDRMRENL
* :
MAB_4120c|M.abscessus_ATCC_199 VASSIGATSAQVALAWLLARGDDIVPIPGTTKVSRVNENVGAVDIE--LL
MAV_2496|M.avium_104 IAADVGATPAQVALAWLLAKGPDIVPIPGTKRVARLEENVGADALE--LT
MSMEG_2920|M.smegmatis_MC2_155 VAGELGVQPGQVALAWVLSRGQDVVPIPGTRHVGFLRENLCAVGIE--LS
MLBr_00458|M.leprae_Br4923 IAVNHHATPSQLALAWLLKRSPVMLPIPGTSRVAHLEENVAAAEIS--LS
MMAR_2086|M.marinum_M IADDHHATPSQLALAWLLKRSPVMLPIPGTSRVAHLQENVAAAEIV--LS
Mvan_2555|M.vanbaalenii_PYR-1 IAAEHHATPSQLALAWLLKRSPVMLPIPGTSKVAHLEENVAAAQID--LT
Mflv_0942|M.gilvum_PYR-GCK PGERLGVPMSTIALAWLLRRSPVIVPIPGTKSVAHLRDNLSAAQVADQLT
Mb2320|M.bovis_AF2122/97 IAVDVDAKPAQVALAWLIS-LPGVVAIPGASSVEQLEFNVAAADIE--LS
Rv2298|M.tuberculosis_H37Rv IAVDVDAKPAQVALAWLIS-LPGVVAIPGASSVEQLEFNVAAADIE--LS
MUL_2745|M.ulcerans_Agy99 VAIDVDAKPAQVALAWLIS-LPGVVAIPGASSVEQLEFNVAAADIE--LS
TH_1364|M.thermoresistible__bu AVFDFELTDDEMNTINGMDNGTRYRPDPXXGEGAAAEHQSADSAAGTAVP
: : . * . : :
MAB_4120c|M.abscessus_ATCC_199 PEHLVRLECLAAAAGDRYNA--EHLARLEG------------
MAV_2496|M.avium_104 TEQLSRLDRLTPPVGGHHAD--AQLAWIDR------------
MSMEG_2920|M.smegmatis_MC2_155 DDHLRRLEGIAGQVAGHRSARPEHLGTEAPQADSGVQNR---
MLBr_00458|M.leprae_Br4923 DDEFEMLSAAGAQ-----------------------------
MMAR_2086|M.marinum_M DQEFEALSVAGAAHGG--------------------------
Mvan_2555|M.vanbaalenii_PYR-1 DAEFETLGNAGAAAS---------------------------
Mflv_0942|M.gilvum_PYR-GCK EDEVHALTAVEDEQSATLSTMPSRMTDAFARVVSPPGSGRRR
Mb2320|M.bovis_AF2122/97 AQSRDALTDAARAFRPVSTGRFLTDMVREKVSRR--------
Rv2298|M.tuberculosis_H37Rv AQSRDALTDAARAFRPVSTGRFLTDMVREKVSRR--------
MUL_2745|M.ulcerans_Agy99 ADARAALTEAARAFHPVSARRFLTDTVREKLGRR--------
TH_1364|M.thermoresistible__bu GHPVRRGGCARRQRRPGTAADHLLHRRSDGLSVEQVDHQR--