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RRFWRTVVEVTSQNSQALAQASGAFTLGGDLKVNRLGFGAMRLTGKGVWGPPVDRYEAVRVLRRAVELGV NFIDTADSYGPYVSEEIIAEALHPYKGLVIATKAGLLRTGRDVWIPLGNPSYLRQELEMSLRRLNVDTID LFQLHRIDPNFPLADQVGELFTLKNEGKIRHIGLSEINLDQLTAAQQITEIVSVQNMYNLSARAAEPLLD AVTSRGIGFIPWSPLAAGPLAAPDGPLQRIAVNHHATPSQLALAWLLKRSPVMLPIPGTSRVAHLEENVA AAEISLSDDEFEMLSAAGAQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. leprae Br4923 | MLBr_00458 | - | - | 100% (301) | putative oxidoreductase |
| M. leprae Br4923 | MLBr_01669 | - | 8e-10 | 25.00% (264) | putative oxidoreductase of Aldo/keto reductase family |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2320 | - | 4e-20 | 30.90% (301) | hypothetical protein Mb2320 |
| M. gilvum PYR-GCK | Mflv_1329 | - | 4e-56 | 44.76% (286) | aldo/keto reductase |
| M. tuberculosis H37Rv | Rv2298 | - | 4e-20 | 30.90% (301) | hypothetical protein Rv2298 |
| M. abscessus ATCC 19977 | MAB_4120c | - | 6e-42 | 34.95% (309) | aldo/keto reductase |
| M. marinum M | MMAR_2086 | - | 1e-136 | 85.46% (282) | oxidoreductase |
| M. avium 104 | MAV_3494 | - | 1e-139 | 86.32% (285) | putative oxidoreductase YdbC |
| M. smegmatis MC2 155 | MSMEG_6730 | - | 2e-85 | 58.36% (281) | putative oxidoreductase YdbC |
| M. thermoresistible (build 8) | TH_1525 | - | 2e-14 | 27.40% (281) | 2,5-diketo-D-gluconic acid reductase A |
| M. ulcerans Agy99 | MUL_2745 | - | 2e-21 | 31.56% (301) | hypothetical protein MUL_2745 |
| M. vanbaalenii PYR-1 | Mvan_2555 | - | 1e-121 | 75.44% (281) | aldo/keto reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2320|M.bovis_AF2122/97 ----------------------MKYLDVDGIGQVSRIGLGTWQFGSRE--
Rv2298|M.tuberculosis_H37Rv ----------------------MKYLDVDGIGQVSRIGLGTWQFGSRE--
MUL_2745|M.ulcerans_Agy99 ----------------------MKHLEVDGIGNVSRIGLGTWQFGSRE--
MLBr_00458|M.leprae_Br4923 MRRFWRTVVEVTSQNSQALAQASGAFTLGGDLKVNRLGFGAMRLTGKG-V
MMAR_2086|M.marinum_M ------------------MAAASATLTLGGDLTVNRLGFGAMRLTGDG-V
MAV_3494|M.avium_104 ------------MSAPQTIAQASGTLTLGGDLTVNRLGFGAMRLTGAG-V
Mvan_2555|M.vanbaalenii_PYR-1 --------------MTSGSSRTAPTFLLGGELPVNRLGFGAMRLTGPG-V
MSMEG_6730|M.smegmatis_MC2_155 ----------------MTATVHRDTFEIAG-KTVSRLGFGTMRFTGRG-I
Mflv_1329|M.gilvum_PYR-GCK ----------------------MDTFPLGS-HTVGRVGFGAMQLPGPG-V
MAB_4120c|M.abscessus_ATCC_199 -----------------------MKHTWLGELSVSRIGLGAMSMSAYYRA
TH_1525|M.thermoresistible__bu -----------------VNMTTVPAITLNNGAQIPQVGFGVYQIPPDQ--
. : ::*:*. :
Mb2320|M.bovis_AF2122/97 WGYGDRYATGAARDIVKRARALGVTLFDTAEIYGLGKSERILGEALGDDR
Rv2298|M.tuberculosis_H37Rv WGYGDRYATGAARDIVKRARALGVTLFDTAEIYGLGKSERILGEALGDDR
MUL_2745|M.ulcerans_Agy99 WGYGDRYASGAARDIVARACALGVTLFDTAEVYGLGKSERILGEALGDER
MLBr_00458|M.leprae_Br4923 WGPPV--DRYEAVRVLRRAVELGVNFIDTADSYGPYVSEEIIAEALHPYK
MMAR_2086|M.marinum_M WGPPA--DRAEAVRVLRRAAELGVNFIDTADSYGPYVSEEIIHEALHPYT
MAV_3494|M.avium_104 WGPPA--DRDECVRVLRRAVELGVNFIDTADSYGPYVSEEIIREALHPYD
Mvan_2555|M.vanbaalenii_PYR-1 WGPPA--DRDECLRVLRRAVDLGVDFIDTADSYGPYISEDLIREALHPYD
MSMEG_6730|M.smegmatis_MC2_155 WGEPA--DRAECIAVMRRAVELGVQFIDTANSYGPYVAEEIIREALYPYA
Mflv_1329|M.gilvum_PYR-GCK FGPPR--DHDQALAVLRRVVELGINHIDTAQIYGPNVANELIREALHPYA
MAB_4120c|M.abscessus_ATCC_199 IGSESGPDEATSIDTLRRALDLGVSLIDTAEIYGPFVNEELVGRAIAGRR
TH_1525|M.thermoresistible__bu -----------TAAAVRTALDAGYRHIDTAQMYGNERGVAEGIRDAGLDR
: . * :***: ** .
Mb2320|M.bovis_AF2122/97 TEVVVASKVFP-----------------------VAPFPAVIKNRERASA
Rv2298|M.tuberculosis_H37Rv TEVVVASKVFP-----------------------VAPFPAVIKNRERASA
MUL_2745|M.ulcerans_Agy99 AEVVVASKIMP-----------------------VAPFPAVVKQRERASA
MLBr_00458|M.leprae_Br4923 G-LVIATKAGLLRTGR--------------DVWIPLGNPSYLRQELEMSL
MMAR_2086|M.marinum_M G-LVIATKAGLLRTGP--------------GVWVPLGNPSYLRQECEMSL
MAV_3494|M.avium_104 G-LVIATKAGLLRTGP--------------DIWIPLGNPSYLRQECEMSL
Mvan_2555|M.vanbaalenii_PYR-1 G-VVIATKAGLLRTAP--------------DVWEPLGFPAYLRQECEMSL
MSMEG_6730|M.smegmatis_MC2_155 DDIVIATKAGLTRNGPDVIDTAEGPKRLGPAAWPPVGRPEYLRQEALMSL
Mflv_1329|M.gilvum_PYR-GCK DGLALVSKVGGRRDEQ--------------GNWLPAQDPDDLRRQLEENL
MAB_4120c|M.abscessus_ATCC_199 DEVVLATKFGLVSHGNG-------------ASQVLDSTPGNISTAVEGSL
TH_1525|M.thermoresistible__bu GEVFITSKLNN-----------------------PYHRPDDARRAFDRTL
: :.:* * .
Mb2320|M.bovis_AF2122/97 RRLQLN---RIPLYQIHQPNPVVP-------DSVIMPGMRDLLDSGDIGA
Rv2298|M.tuberculosis_H37Rv RRLQLN---RIPLYQIHQPNPVVP-------DSVIMPGMRDLLDSGDIGA
MUL_2745|M.ulcerans_Agy99 RRLQLD---RIPLYQIHQPNPVVP-------DSVIMPGIRELLDIGRIGA
MLBr_00458|M.leprae_Br4923 RRLNVD---TIDLFQLHRIDPNFP-------LADQVGELFTLKNEGKIRH
MMAR_2086|M.marinum_M RRLGVD---TIDLFQLHRIDRNYP-------LADQVGELLALKNEGKIRH
MAV_3494|M.avium_104 RRLGTD---TIDLFQLHRIDPNFP-------LQDQVGELLTLKNEGKIRH
Mvan_2555|M.vanbaalenii_PYR-1 RRLGTD---TIDLFQLHRIAPKFP-------AEDQIGELAKLQQEGKVRH
MSMEG_6730|M.smegmatis_MC2_155 RRLGLD---QIDLFQLHRIDPKVP-------LADQVGELKALQDEGKIVA
Mflv_1329|M.gilvum_PYR-GCK STLDTDRLAAVNLRAFNHDDPSLPAVLDRDLFDRQLTAMIAARDEGLIAG
MAB_4120c|M.abscessus_ATCC_199 RRLGVD---HIDLYYQHRVDPNVA-------IEDTIGAVAELVQQGKVRY
TH_1525|M.thermoresistible__bu TELGSD---YVDLFLIHWPLPMHYDG----DFVSTWKTLEEFAADGRARS
* : : * : : *
Mb2320|M.bovis_AF2122/97 AGVSNYSLARWRKADAALGRPVVSNQVHFSLAHPDALEDLVPFAELENRI
Rv2298|M.tuberculosis_H37Rv AGVSNYSLARWRKADAALGRPVVSNQVHFSLAHPDALEDLVPFAELENRI
MUL_2745|M.ulcerans_Agy99 AGVSNYSLARWKKADAALGRPVVSNQVHFSLAHPGPLDDLVPFAERENRI
MLBr_00458|M.leprae_Br4923 IGLSEINLDQLTAAQQIT--EIVSVQNMYNLSARAAE-PLLDAVTSRGIG
MMAR_2086|M.marinum_M IGLSEIDVDQLEAAQQIT--EIVSVQNMYNLAARGAE-PLLEAATSQGIA
MAV_3494|M.avium_104 IGLSEITPDQLAAAQQIT--EIVSVQNMYNVTARRAE-PLLDAATRQGIA
Mvan_2555|M.vanbaalenii_PYR-1 IGLSEVSVDQLTAARAVA--PIVSVQNMYNLTMRAAE-PVLDACEADGIA
MSMEG_6730|M.smegmatis_MC2_155 IGLSQVTPEQLAEAHQIA--EIVTVQNRFNVIDRSSQ-AVLDICERDGLG
Mflv_1329|M.gilvum_PYR-GCK IGLSNVSADHLRVALERT--EIVCVQNAYNLLDRTSQ-PVLDLSAEHGIA
MAB_4120c|M.abscessus_ATCC_199 IGLSEAAAGTIRRAHAVH--PITALQNEYSLWTRDIEDEILPTIRELGIG
TH_1525|M.thermoresistible__bu IGVSNFEPAHLDLLAAET--STVPAVNQVEIHPYFGNNDVRRYCAEHGIA
*:*: . .: : .
Mb2320|M.bovis_AF2122/97 VIAYSPLAQGLLGGKYG--LENRPGGVRALNPLFGTENLRRIEPLLATLR
Rv2298|M.tuberculosis_H37Rv VIAYSPLAQGLLGGKYG--LENRPGGVRALNPLFGTENLRRIEPLLATLR
MUL_2745|M.ulcerans_Agy99 IIAYSPLAQGLLGGKYG--VDNRPAGVRAVNPLFGTENLRRIEPLLQTLR
MLBr_00458|M.leprae_Br4923 FIPWSPLAAGPLAAP------------------------------DGPLQ
MMAR_2086|M.marinum_M FIPWFPLASGPLAAP------------------------------DGPLR
MAV_3494|M.avium_104 FIPWFPLAAGPLAAP------------------------------DGPLQ
Mvan_2555|M.vanbaalenii_PYR-1 FIPWFPLAAGPLAAA------------------------------DGPLH
MSMEG_6730|M.smegmatis_MC2_155 FIPWAPVAQGGLGQA------------------------------GDVLA
Mflv_1329|M.gilvum_PYR-GCK FVPFFPLGSGFVADNP--------------------------VLKHPAVV
MAB_4120c|M.abscessus_ATCC_199 LVAYSPLGRGFLTGAIGSRDQLAEGDFRREQPRFSAENFDANLALVEEVR
TH_1525|M.thermoresistible__bu VEAWAPIAKGRVADD-------------------------------PVIA
. .: *:. * : :
Mb2320|M.bovis_AF2122/97 AIAVDVDAKPAQVALAWLIS-LPGVVAIPGASSVEQLEFNVAAADIELSA
Rv2298|M.tuberculosis_H37Rv AIAVDVDAKPAQVALAWLIS-LPGVVAIPGASSVEQLEFNVAAADIELSA
MUL_2745|M.ulcerans_Agy99 AVAIDVDAKPAQVALAWLIS-LPGVVAIPGASSVEQLEFNVAAADIELSA
MLBr_00458|M.leprae_Br4923 RIAVNHHATPSQLALAWLLKRSPVMLPIPGTSRVAHLEENVAAAEISLSD
MMAR_2086|M.marinum_M KIADDHHATPSQLALAWLLKRSPVMLPIPGTSRVAHLQENVAAAEIVLSD
MAV_3494|M.avium_104 RIAAEHDATPSQLALAWLLKRSPVMLPIPGTSKVAHLEENVAAARITLSD
Mvan_2555|M.vanbaalenii_PYR-1 RIAAEHHATPSQLALAWLLKRSPVMLPIPGTSKVAHLEENVAAAQIDLTD
MSMEG_6730|M.smegmatis_MC2_155 EIARAHGCSVEQVAIAWLLRVSPVMLPIPGTSQRKHLEENLAAARVQLSA
Mflv_1329|M.gilvum_PYR-GCK REAEKLGRTPAQIVLAWTLSVAPNVLLIPGTSSVAHLEQNTAVRDITLDD
MAB_4120c|M.abscessus_ATCC_199 SVASSIGATSAQVALAWLLARGDDIVPIPGTTKVSRVNENVGAVDIELLP
TH_1525|M.thermoresistible__bu GIADRLGRTPAQVTLRWHIQRGDIVLPKSVTP--ERVRSNIALFDFELSD
* . *:.: * : :: . :. ::. * . . *
Mb2320|M.bovis_AF2122/97 QSRDALTDAARAFRPVSTGRFLTDMVREKVSRR
Rv2298|M.tuberculosis_H37Rv QSRDALTDAARAFRPVSTGRFLTDMVREKVSRR
MUL_2745|M.ulcerans_Agy99 DARAALTEAARAFHPVSARRFLTDTVREKLGRR
MLBr_00458|M.leprae_Br4923 DEFEMLSAAGAQ---------------------
MMAR_2086|M.marinum_M QEFEALSVAGAAHGG------------------
MAV_3494|M.avium_104 EEFEALSTAGTQQTV------------------
Mvan_2555|M.vanbaalenii_PYR-1 AEFETLGNAGAAAS-------------------
MSMEG_6730|M.smegmatis_MC2_155 DEVARLSRSGTAGI-------------------
Mflv_1329|M.gilvum_PYR-GCK DTRRDLDAAA-----------------------
MAB_4120c|M.abscessus_ATCC_199 EHLVRLECLAAAAGDRYNAEHLARLEG------
TH_1525|M.thermoresistible__bu ADMAAISALDKGEAGRMGPHPDKFDMI------
: