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KTITFGKTGLEVSRLAFGTWEFCSDWGHADEDAAITMIRSARDLGINFFDTAQQYGFGASERLLGKALRD DLARARDEVVIATKGGLRATDSGLVRDASPQWLRKGVESSLTALGIDHIDVYLVHWPDPRMPAAETAGAL AELVSEGKIRHVGVSNYDTAQVEEFSATLPVEVVQPPYHLFRRDIEDTLLPYAREHDIGVMVYGPLAHGL LTGTVKPDTRFAPQDWRAKSDIFSGDGFLRNLEVVAQLQELASDLGVTISQLAIARVLAQPGVHVAIVGA QHLHYLQESARAADVTLSDADLAAVDNVLAAATPVGGPYPEMHQKAS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3334 | - | - | 100% (328) | general stress protein 69 |
| M. avium 104 | MAV_2496 | - | 6e-48 | 36.83% (315) | aldo/keto reductase |
| M. avium 104 | MAV_4098 | - | 2e-33 | 33.33% (309) | aldo/keto reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2320 | - | 2e-37 | 34.41% (311) | hypothetical protein Mb2320 |
| M. gilvum PYR-GCK | Mflv_0942 | - | 3e-19 | 28.88% (322) | aldo/keto reductase |
| M. tuberculosis H37Rv | Rv2298 | - | 3e-37 | 34.41% (311) | hypothetical protein Rv2298 |
| M. leprae Br4923 | MLBr_00458 | - | 2e-30 | 32.65% (294) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_4120c | - | 1e-49 | 36.98% (311) | aldo/keto reductase |
| M. marinum M | MMAR_3520 | - | 2e-37 | 35.16% (310) | hypothetical protein MMAR_3520 |
| M. smegmatis MC2 155 | MSMEG_2920 | - | 2e-50 | 39.09% (307) | aldo/keto reductase |
| M. thermoresistible (build 8) | TH_1525 | - | 5e-16 | 25.62% (320) | 2,5-diketo-D-gluconic acid reductase A |
| M. ulcerans Agy99 | MUL_2745 | - | 5e-36 | 34.84% (310) | hypothetical protein MUL_2745 |
| M. vanbaalenii PYR-1 | Mvan_2555 | - | 6e-32 | 33.44% (308) | aldo/keto reductase |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_00458|M.leprae_Br4923 MRRFWRTVVEVTSQNSQALAQASGAFTLGGDLKVNRLGFGAMRLTGKGVW
Mvan_2555|M.vanbaalenii_PYR-1 ----------MTSGSS----RTAPTFLLGGELPVNRLGFGAMRLTGPGVW
Mflv_0942|M.gilvum_PYR-GCK ----------MTTAIQ-------TTLTLGGELPVPRMGYGAMQLAGPGVL
Mb2320|M.bovis_AF2122/97 ---------------------MKYLDVDGIG-QVSRIGLGTWQFGSREWG
Rv2298|M.tuberculosis_H37Rv ---------------------MKYLDVDGIG-QVSRIGLGTWQFGSREWG
MMAR_3520|M.marinum_M ---------------------MKHLEVDGIG-NVSRIGLGTWQFGSREWG
MUL_2745|M.ulcerans_Agy99 ---------------------MKHLEVDGIG-NVSRIGLGTWQFGSREWG
MAV_3334|M.avium_104 ---------------------MKTITFGKTGLEVSRLAFGTWEFCS-DWG
MAB_4120c|M.abscessus_ATCC_199 ---------------------MKHTWLGELS--VSRIGLGAMSMSAY---
MSMEG_2920|M.smegmatis_MC2_155 ---------------------MTVAPL-RTD--RRRLGSGGPEVSAIGLG
TH_1525|M.thermoresistible__bu -----------------VNMTTVPAITLNNGAQIPQVGFGVYQIPP----
::. * .
MLBr_00458|M.leprae_Br4923 GPPVDR-------YEAVRVLRRAVELGVNFIDTADSYGPYVSEEIIAEAL
Mvan_2555|M.vanbaalenii_PYR-1 GPPADR-------DECLRVLRRAVDLGVDFIDTADSYGPYISEDLIREAL
Mflv_0942|M.gilvum_PYR-GCK GLPDDV-------DNAVDVLRRAVDHGVRFFDTANAYGPRTVNQIIGRAL
Mb2320|M.bovis_AF2122/97 YGDRYA------TGAARDIVKRARALGVTLFDTAEIYGLGKSERILGEAL
Rv2298|M.tuberculosis_H37Rv YGDRYA------TGAARDIVKRARALGVTLFDTAEIYGLGKSERILGEAL
MMAR_3520|M.marinum_M YGDRYA------SGAARDIVARARALGVTLFDTAEVYGLGKSERILGEAL
MUL_2745|M.ulcerans_Agy99 YGDRYA------SGAARDIVARACALGVTLFDTAEVYGLGKSERILGEAL
MAV_3334|M.avium_104 HAD---------EDAAITMIRSARDLGINFFDTAQQYGFGASERLLGKAL
MAB_4120c|M.abscessus_ATCC_199 YRAIGSESGPD-EATSIDTLRRALDLGVSLIDTAEIYGPFVNEELVGRAI
MSMEG_2920|M.smegmatis_MC2_155 FMSFRAGSGPDDEKQAKDIVDAAIDLGVTLFDTADIYGPEHSEVLLGKAI
TH_1525|M.thermoresistible__bu -------------DQTAAAVRTALDAGYRHIDTAQMYG---NERGVAEGI
: * * :***: ** : : ..:
MLBr_00458|M.leprae_Br4923 -HP----YKGLVIATKAGLLRTGRDVWIP---LGNPSYLRQELEMSLRRL
Mvan_2555|M.vanbaalenii_PYR-1 -HP----YDGVVIATKAGLLRTAPDVWEP---LGFPAYLRQECEMSLRRL
Mflv_0942|M.gilvum_PYR-GCK GTP----ADDLVIGNKVGAVRGPAGEWLQ---DSRPEILRTQVEEALLDM
Mb2320|M.bovis_AF2122/97 GDD----RTEVVVASKVFPVAPFPAVIK----NRERASARR--------L
Rv2298|M.tuberculosis_H37Rv GDD----RTEVVVASKVFPVAPFPAVIK----NRERASARR--------L
MMAR_3520|M.marinum_M GDE----RAEVVVASKIMPVAPFPAVVK----QRERASARR--------L
MUL_2745|M.ulcerans_Agy99 GDE----RAEVVVASKIMPVAPFPAVVK----QRERASARR--------L
MAV_3334|M.avium_104 RDDLARARDEVVIATKGGLRATDSGLVR----DASPQWLRKGVESSLTAL
MAB_4120c|M.abscessus_ATCC_199 AGR----RDEVVLATKFG-LVSHGNGAS-QVLDSTPGNISTAVEGSLRRL
MSMEG_2920|M.smegmatis_MC2_155 RGR----RDSLVIATKFGNRLDRGTSTDGRALDGRPEYVRSAIEGSLRRL
TH_1525|M.thermoresistible__bu RDAG-LDRGEVFITSKLNNPYHR------------PDDARRAFDRTLTEL
:.: .* :
MLBr_00458|M.leprae_Br4923 NVDTIDLFQLHRIDPN---------FPLADQVGELFTLKNEGKIRHIGLS
Mvan_2555|M.vanbaalenii_PYR-1 GTDTIDLFQLHRIAPK---------FPAEDQIGELAKLQQEGKVRHIGLS
Mflv_0942|M.gilvum_PYR-GCK RADASALTYLRLAGDIRGVGEGPGEVPLEESLGALVELRDQGKIRHIGLS
Mb2320|M.bovis_AF2122/97 QLNRIPLYQIHQPNPV---------VPDSVIMPGMRDLLDSGDIGAAGVS
Rv2298|M.tuberculosis_H37Rv QLNRIPLYQIHQPNPV---------VPDSVIMPGMRDLLDSGDIGAAGVS
MMAR_3520|M.marinum_M QLDRIPLYQIHQPNPV---------VPDSVIMPGMRELLDTGRIGAAGVS
MUL_2745|M.ulcerans_Agy99 QLDRIPLYQIHQPNPV---------VPDSVIMPGIRELLDIGRIGAAGVS
MAV_3334|M.avium_104 GIDHIDVYLVHWPDPR---------MPAAETAGALAELVSEGKIRHVGVS
MAB_4120c|M.abscessus_ATCC_199 GVDHIDLYYQHRVDPN---------VAIEDTIGAVAELVQQGKVRYIGLS
MSMEG_2920|M.smegmatis_MC2_155 GVDHVDLYYQHRVDPQ---------VPIEDTVGALAELVQAGKVRHIGLS
TH_1525|M.thermoresistible__bu GSDYVDLFLIHWPLPMHYDG------DFVSTWKTLEEFAADGRARSIGVS
: : : : : * *:*
MLBr_00458|M.leprae_Br4923 EINLDQLTAAQQIT--EIVSVQNMYNLSAR-AAEPLLDAVTSRGIGFIPW
Mvan_2555|M.vanbaalenii_PYR-1 EVSVDQLTAARAVA--PIVSVQNMYNLTMR-AAEPVLDACEADGIAFIPW
Mflv_0942|M.gilvum_PYR-GCK GASPAALERAQQIT--TIAAVQNRFNLIDR-SGVEVLAACERDGIAFVPY
Mb2320|M.bovis_AF2122/97 NYSLARWRKADAALGRPVVSNQVHFSLAHPDALEDLVPFAELENRIVIAY
Rv2298|M.tuberculosis_H37Rv NYSLARWRKADAALGRPVVSNQVHFSLAHPDALEDLVPFAELENRIVIAY
MMAR_3520|M.marinum_M NYSLARWKKADAALGRPVVSNQVHFSLAHPGPLDDLVPFAERENRIIIAY
MUL_2745|M.ulcerans_Agy99 NYSLARWKKADAALGRPVVSNQVHFSLAHPGPLDDLVPFAERENRIIIAY
MAV_3334|M.avium_104 NYDTAQVEEFSATL--PVEVVQPPYHLFRRDIEDTLLPYAREHDIGVMVY
MAB_4120c|M.abscessus_ATCC_199 EAAAGTIRRAHAVH--PITALQNEYSLWTRDIEDEILPTIRELGIGLVAY
MSMEG_2920|M.smegmatis_MC2_155 EPGPQTLRRAHAVH--PVAAIQNEWSLFTRDIEDETVPIARELGIGIVPY
TH_1525|M.thermoresistible__bu NFEPAHLDLLAAET--STVPAVNQVEIHPYFGNNDVRRYCAEHGIAVEAW
: . . :
MLBr_00458|M.leprae_Br4923 SPLAAGPLAAPDGPLQR------------------------------IAV
Mvan_2555|M.vanbaalenii_PYR-1 FPLAAGPLAAADGPLHR------------------------------IAA
Mflv_0942|M.gilvum_PYR-GCK FPLATGGLGD-DDELRR------------------------------PGE
Mb2320|M.bovis_AF2122/97 SPLAQGLLGGKYGLENR--PGGVRALNPLFGTENLRRIEPLLATLRAIAV
Rv2298|M.tuberculosis_H37Rv SPLAQGLLGGKYGLENR--PGGVRALNPLFGTENLRRIEPLLATLRAIAV
MMAR_3520|M.marinum_M SPLAQGLLGGKYGVDNR--PAGVRAVNPLFGTENLRRIEPLLQTLRAVAT
MUL_2745|M.ulcerans_Agy99 SPLAQGLLGGKYGVDNR--PAGVRAVNPLFGTENLRRIEPLLQTLRAVAI
MAV_3334|M.avium_104 GPLAHGLLTGTVKPDTRFAPQDWRAKSDIFSGDGFLRNLEVVAQLQELAS
MAB_4120c|M.abscessus_ATCC_199 SPLGRGFLTGAIGSRDQLAEGDFRREQPRFSAENFDANLALVEEVRSVAS
MSMEG_2920|M.smegmatis_MC2_155 SPLGRGWLTGRVQSRDNISG--THRDHPRFSDEAFDRNRALADTVVTVAG
TH_1525|M.thermoresistible__bu APIAKGRVADDPVIAGI-------------------------------AD
*:. * : .
MLBr_00458|M.leprae_Br4923 NHHATPSQLALAWLLKRSPVMLPIPGTSRVAHLEENVAAAEIS--LSDDE
Mvan_2555|M.vanbaalenii_PYR-1 EHHATPSQLALAWLLKRSPVMLPIPGTSKVAHLEENVAAAQID--LTDAE
Mflv_0942|M.gilvum_PYR-GCK RLGVPMSTIALAWLLRRSPVIVPIPGTKSVAHLRDNLSAAQVADQLTEDE
Mb2320|M.bovis_AF2122/97 DVDAKPAQVALAWLISLPGV-VAIPGASSVEQLEFNVAAADIE--LSAQS
Rv2298|M.tuberculosis_H37Rv DVDAKPAQVALAWLISLPGV-VAIPGASSVEQLEFNVAAADIE--LSAQS
MMAR_3520|M.marinum_M DVDAKPAQVALAWLISLPGV-VAIPGASSVEQLEFNVAAADIE--LSADA
MUL_2745|M.ulcerans_Agy99 DVDAKPAQVALAWLISLPGV-VAIPGASSVEQLEFNVAAADIE--LSADA
MAV_3334|M.avium_104 DLGVTISQLAIARVLAQPGVHVAIVGAQHLHYLQESARAADVT--LSDAD
MAB_4120c|M.abscessus_ATCC_199 SIGATSAQVALAWLLARGDDIVPIPGTTKVSRVNENVGAVDIE--LLPEH
MSMEG_2920|M.smegmatis_MC2_155 ELGVQPGQVALAWVLSRGQDVVPIPGTRHVGFLRENLCAVGIE--LSDDH
TH_1525|M.thermoresistible__bu RLGRTPAQVTLRWHIQRGDIVLPKS--VTPERVRSNIALFDFE--LSDAD
. ::: : :. :. . . *
MLBr_00458|M.leprae_Br4923 FEMLSAAGAQ-----------------------------
Mvan_2555|M.vanbaalenii_PYR-1 FETLGNAGAAAS---------------------------
Mflv_0942|M.gilvum_PYR-GCK VHALTAVEDEQSATLSTMPSRMTDAFARVVSPPGSGRRR
Mb2320|M.bovis_AF2122/97 RDALTDAARAFRPVSTGRFLTDMVREKVSRR--------
Rv2298|M.tuberculosis_H37Rv RDALTDAARAFRPVSTGRFLTDMVREKVSRR--------
MMAR_3520|M.marinum_M RAALTEAARAFHPVSARRFLTDTVREKLGRR--------
MUL_2745|M.ulcerans_Agy99 RAALTEAARAFHPVSARRFLTDTVREKLGRR--------
MAV_3334|M.avium_104 LAAVDNVLAAATPVGG---PYPEMHQKAS----------
MAB_4120c|M.abscessus_ATCC_199 LVRLECLA-AAAGDRYN-AEHLARLEG------------
MSMEG_2920|M.smegmatis_MC2_155 LRRLEGIAGQVAGHRSARPEHLGTEAPQADSGVQNR---
TH_1525|M.thermoresistible__bu MAAISALDKGEAGRMGPHPDKFDMI--------------
: