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MTTAIQTTLTLGGELPVPRMGYGAMQLAGPGVLGLPDDVDNAVDVLRRAVDHGVRFFDTANAYGPRTVNQ IIGRALGTPADDLVIGNKVGAVRGPAGEWLQDSRPEILRTQVEEALLDMRADASALTYLRLAGDIRGVGE GPGEVPLEESLGALVELRDQGKIRHIGLSGASPAALERAQQITTIAAVQNRFNLIDRSGVEVLAACERDG IAFVPYFPLATGGLGDDDELRRPGERLGVPMSTIALAWLLRRSPVIVPIPGTKSVAHLRDNLSAAQVADQ LTEDEVHALTAVEDEQSATLSTMPSRMTDAFARVVSPPGSGRRR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0942 | - | - | 100% (324) | aldo/keto reductase |
| M. gilvum PYR-GCK | Mflv_1329 | - | 2e-47 | 41.33% (271) | aldo/keto reductase |
| M. gilvum PYR-GCK | Mflv_4697 | - | 5e-09 | 24.48% (290) | 2,5-didehydrogluconate reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2320 | - | 5e-11 | 27.85% (316) | hypothetical protein Mb2320 |
| M. tuberculosis H37Rv | Rv2298 | - | 5e-11 | 27.85% (316) | hypothetical protein Rv2298 |
| M. leprae Br4923 | MLBr_00458 | - | 5e-53 | 43.82% (283) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_4120c | - | 3e-34 | 33.11% (302) | aldo/keto reductase |
| M. marinum M | MMAR_2086 | - | 4e-56 | 44.79% (288) | oxidoreductase |
| M. avium 104 | MAV_3494 | - | 2e-58 | 44.67% (291) | putative oxidoreductase YdbC |
| M. smegmatis MC2 155 | MSMEG_6730 | - | 6e-53 | 42.76% (304) | putative oxidoreductase YdbC |
| M. thermoresistible (build 8) | TH_1525 | - | 5e-14 | 25.00% (308) | 2,5-diketo-D-gluconic acid reductase A |
| M. ulcerans Agy99 | MUL_2745 | - | 1e-11 | 26.62% (308) | hypothetical protein MUL_2745 |
| M. vanbaalenii PYR-1 | Mvan_2555 | - | 2e-56 | 45.23% (283) | aldo/keto reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2320|M.bovis_AF2122/97 ----------------------MKYLDVDGIGQVSRIGLGTWQFGSRE--
Rv2298|M.tuberculosis_H37Rv ----------------------MKYLDVDGIGQVSRIGLGTWQFGSRE--
MUL_2745|M.ulcerans_Agy99 ----------------------MKHLEVDGIGNVSRIGLGTWQFGSRE--
MLBr_00458|M.leprae_Br4923 MRRFWRTVVEVTSQNSQALAQASGAFTLGGDLKVNRLGFGAMRLTGKG-V
MMAR_2086|M.marinum_M ------------------MAAASATLTLGGDLTVNRLGFGAMRLTGDG-V
MAV_3494|M.avium_104 ------------MSAPQTIAQASGTLTLGGDLTVNRLGFGAMRLTGAG-V
Mvan_2555|M.vanbaalenii_PYR-1 --------------MTSGSSRTAPTFLLGGELPVNRLGFGAMRLTGPG-V
MSMEG_6730|M.smegmatis_MC2_155 ----------------MTATVHRDTFEIAG-KTVSRLGFGTMRFTGRG-I
Mflv_0942|M.gilvum_PYR-GCK -----------------MTTAIQTTLTLGGELPVPRMGYGAMQLAGPG-V
MAB_4120c|M.abscessus_ATCC_199 -----------------------MKHTWLGELSVSRIGLGAMSMSAYYRA
TH_1525|M.thermoresistible__bu -----------------VNMTTVPAITLNNGAQIPQVGFGVYQIPPDQ--
. : ::* *. :
Mb2320|M.bovis_AF2122/97 WGYGDRYATGAARDIVKRARALGVTLFDTAEIYGLGKSERILGEALGDDR
Rv2298|M.tuberculosis_H37Rv WGYGDRYATGAARDIVKRARALGVTLFDTAEIYGLGKSERILGEALGDDR
MUL_2745|M.ulcerans_Agy99 WGYGDRYASGAARDIVARACALGVTLFDTAEVYGLGKSERILGEALGDER
MLBr_00458|M.leprae_Br4923 WG--PPVDRYEAVRVLRRAVELGVNFIDTADSYGPYVSEEIIAEALHPYK
MMAR_2086|M.marinum_M WG--PPADRAEAVRVLRRAAELGVNFIDTADSYGPYVSEEIIHEALHPYT
MAV_3494|M.avium_104 WG--PPADRDECVRVLRRAVELGVNFIDTADSYGPYVSEEIIREALHPYD
Mvan_2555|M.vanbaalenii_PYR-1 WG--PPADRDECLRVLRRAVDLGVDFIDTADSYGPYISEDLIREALHPYD
MSMEG_6730|M.smegmatis_MC2_155 WG--EPADRAECIAVMRRAVELGVQFIDTANSYGPYVAEEIIREALYPYA
Mflv_0942|M.gilvum_PYR-GCK LG--LPDDVDNAVDVLRRAVDHGVRFFDTANAYGPRTVNQIIGRALGTPA
MAB_4120c|M.abscessus_ATCC_199 IGSESGPDEATSIDTLRRALDLGVSLIDTAEIYGPFVNEELVGRAIAGRR
TH_1525|M.thermoresistible__bu -----------TAAAVRTALDAGYRHIDTAQMYGNERGVAEGIRDAGLDR
: * * :***: ** .
Mb2320|M.bovis_AF2122/97 TEVVVASKVFPVAPFP-----------------------AVIKNRERASA
Rv2298|M.tuberculosis_H37Rv TEVVVASKVFPVAPFP-----------------------AVIKNRERASA
MUL_2745|M.ulcerans_Agy99 AEVVVASKIMPVAPFP-----------------------AVVKQRERASA
MLBr_00458|M.leprae_Br4923 G-LVIATKAGLLRTGR--------------DVWIPLGNPSYLRQELEMSL
MMAR_2086|M.marinum_M G-LVIATKAGLLRTGP--------------GVWVPLGNPSYLRQECEMSL
MAV_3494|M.avium_104 G-LVIATKAGLLRTGP--------------DIWIPLGNPSYLRQECEMSL
Mvan_2555|M.vanbaalenii_PYR-1 G-VVIATKAGLLRTAP--------------DVWEPLGFPAYLRQECEMSL
MSMEG_6730|M.smegmatis_MC2_155 DDIVIATKAGLTRNGPDVIDTAEGPKRLGPAAWPPVGRPEYLRQEALMSL
Mflv_0942|M.gilvum_PYR-GCK DDLVIGNKVGAVRGPA--------------GEWLQDSRPEILRTQVEEAL
MAB_4120c|M.abscessus_ATCC_199 DEVVLATKFGLVSHGNG-------------ASQVLDSTPGNISTAVEGSL
TH_1525|M.thermoresistible__bu GEVFITSKLNNPYHRP-----------------------DDARRAFDRTL
:.: .* :
Mb2320|M.bovis_AF2122/97 RRLQLNRIPLYQIHQPNPV---------VPDSVIMPGMRDLLDSGDIGAA
Rv2298|M.tuberculosis_H37Rv RRLQLNRIPLYQIHQPNPV---------VPDSVIMPGMRDLLDSGDIGAA
MUL_2745|M.ulcerans_Agy99 RRLQLDRIPLYQIHQPNPV---------VPDSVIMPGIRELLDIGRIGAA
MLBr_00458|M.leprae_Br4923 RRLNVDTIDLFQLHRIDPN---------FPLADQVGELFTLKNEGKIRHI
MMAR_2086|M.marinum_M RRLGVDTIDLFQLHRIDRN---------YPLADQVGELLALKNEGKIRHI
MAV_3494|M.avium_104 RRLGTDTIDLFQLHRIDPN---------FPLQDQVGELLTLKNEGKIRHI
Mvan_2555|M.vanbaalenii_PYR-1 RRLGTDTIDLFQLHRIAPK---------FPAEDQIGELAKLQQEGKVRHI
MSMEG_6730|M.smegmatis_MC2_155 RRLGLDQIDLFQLHRIDPK---------VPLADQVGELKALQDEGKIVAI
Mflv_0942|M.gilvum_PYR-GCK LDMRADASALTYLRLAGDIRGVGEGPGEVPLEESLGALVELRDQGKIRHI
MAB_4120c|M.abscessus_ATCC_199 RRLGVDHIDLYYQHRVDPN---------VAIEDTIGAVAELVQQGKVRYI
TH_1525|M.thermoresistible__bu TELGSDYVDLFLIHWPLPMHYDG------DFVSTWKTLEEFAADGRARSI
: : * : : : *
Mb2320|M.bovis_AF2122/97 GVSNYSLARWRKADAALGRPVVSNQVHFSLAHPDALEDLVPFAELENRIV
Rv2298|M.tuberculosis_H37Rv GVSNYSLARWRKADAALGRPVVSNQVHFSLAHPDALEDLVPFAELENRIV
MUL_2745|M.ulcerans_Agy99 GVSNYSLARWKKADAALGRPVVSNQVHFSLAHPGPLDDLVPFAERENRII
MLBr_00458|M.leprae_Br4923 GLSEINLDQLTAAQQIT--EIVSVQNMYNLSARAAE-PLLDAVTSRGIGF
MMAR_2086|M.marinum_M GLSEIDVDQLEAAQQIT--EIVSVQNMYNLAARGAE-PLLEAATSQGIAF
MAV_3494|M.avium_104 GLSEITPDQLAAAQQIT--EIVSVQNMYNVTARRAE-PLLDAATRQGIAF
Mvan_2555|M.vanbaalenii_PYR-1 GLSEVSVDQLTAARAVA--PIVSVQNMYNLTMRAAE-PVLDACEADGIAF
MSMEG_6730|M.smegmatis_MC2_155 GLSQVTPEQLAEAHQIA--EIVTVQNRFNVIDRSSQ-AVLDICERDGLGF
Mflv_0942|M.gilvum_PYR-GCK GLSGASPAALERAQQIT--TIAAVQNRFNLIDRSGV-EVLAACERDGIAF
MAB_4120c|M.abscessus_ATCC_199 GLSEAAAGTIRRAHAVH--PITALQNEYSLWTRDIEDEILPTIRELGIGL
TH_1525|M.thermoresistible__bu GVSNFEPAHLDLLAAET--STVPAVNQVEIHPYFGNNDVRRYCAEHGIAV
*:* .. .: : . .
Mb2320|M.bovis_AF2122/97 IAYSPLAQGLLGGKYGLENRPGGVRALN--PLFGTENLRRIEPLLATLRA
Rv2298|M.tuberculosis_H37Rv IAYSPLAQGLLGGKYGLENRPGGVRALN--PLFGTENLRRIEPLLATLRA
MUL_2745|M.ulcerans_Agy99 IAYSPLAQGLLGGKYGVDNRPAGVRAVN--PLFGTENLRRIEPLLQTLRA
MLBr_00458|M.leprae_Br4923 IPWSPLAAGPLAAPDGPLQRIAV---------------------------
MMAR_2086|M.marinum_M IPWFPLASGPLAAPDGPLRKIAD---------------------------
MAV_3494|M.avium_104 IPWFPLAAGPLAAPDGPLQRIAA---------------------------
Mvan_2555|M.vanbaalenii_PYR-1 IPWFPLAAGPLAAADGPLHRIAA---------------------------
MSMEG_6730|M.smegmatis_MC2_155 IPWAPVAQGGLGQAGDVLAEIAR---------------------------
Mflv_0942|M.gilvum_PYR-GCK VPYFPLATGGLGD-DDELRRPGE---------------------------
MAB_4120c|M.abscessus_ATCC_199 VAYSPLGRGFLTGAIGSRDQLAEGDFRREQPRFSAENFDANLALVEEVRS
TH_1525|M.thermoresistible__bu EAWAPIAKGRVADDPVIAGIADR---------------------------
.: *:. * :
Mb2320|M.bovis_AF2122/97 IAVDVDAKPAQVALAWLIS-LPGVVAIPGASSVEQLEFNVAAADIE--LS
Rv2298|M.tuberculosis_H37Rv IAVDVDAKPAQVALAWLIS-LPGVVAIPGASSVEQLEFNVAAADIE--LS
MUL_2745|M.ulcerans_Agy99 VAIDVDAKPAQVALAWLIS-LPGVVAIPGASSVEQLEFNVAAADIE--LS
MLBr_00458|M.leprae_Br4923 ---NHHATPSQLALAWLLKRSPVMLPIPGTSRVAHLEENVAAAEIS--LS
MMAR_2086|M.marinum_M ---DHHATPSQLALAWLLKRSPVMLPIPGTSRVAHLQENVAAAEIV--LS
MAV_3494|M.avium_104 ---EHDATPSQLALAWLLKRSPVMLPIPGTSKVAHLEENVAAARIT--LS
Mvan_2555|M.vanbaalenii_PYR-1 ---EHHATPSQLALAWLLKRSPVMLPIPGTSKVAHLEENVAAAQID--LT
MSMEG_6730|M.smegmatis_MC2_155 ---AHGCSVEQVAIAWLLRVSPVMLPIPGTSQRKHLEENLAAARVQ--LS
Mflv_0942|M.gilvum_PYR-GCK ---RLGVPMSTIALAWLLRRSPVIVPIPGTKSVAHLRDNLSAAQVADQLT
MAB_4120c|M.abscessus_ATCC_199 VASSIGATSAQVALAWLLARGDDIVPIPGTTKVSRVNENVGAVDIE--LL
TH_1525|M.thermoresistible__bu ----LGRTPAQVTLRWHIQRGDIVLPKSVTP--ERVRSNIALFDFE--LS
::: * : ::. . : ::. *:. . *
Mb2320|M.bovis_AF2122/97 AQSRDALTDAARAFRPVSTGRFLTDMVREKVSRR--------
Rv2298|M.tuberculosis_H37Rv AQSRDALTDAARAFRPVSTGRFLTDMVREKVSRR--------
MUL_2745|M.ulcerans_Agy99 ADARAALTEAARAFHPVSARRFLTDTVREKLGRR--------
MLBr_00458|M.leprae_Br4923 DDEFEMLSAAGAQ-----------------------------
MMAR_2086|M.marinum_M DQEFEALSVAGAAHGG--------------------------
MAV_3494|M.avium_104 DEEFEALSTAGTQQTV--------------------------
Mvan_2555|M.vanbaalenii_PYR-1 DAEFETLGNAGAAAS---------------------------
MSMEG_6730|M.smegmatis_MC2_155 ADEVARLSRSGTAGI---------------------------
Mflv_0942|M.gilvum_PYR-GCK EDEVHALTAVEDEQSATLSTMPSRMTDAFARVVSPPGSGRRR
MAB_4120c|M.abscessus_ATCC_199 PEHLVRLECLAAAAGDRYNAEHLARLEG--------------
TH_1525|M.thermoresistible__bu DADMAAISALDKGEAGRMGPHPDKFDMI--------------
: