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MEYRRVGDSGLVVSELSFGAATFGGSGDFFGAWGDTGVDAARAMVDMCLDAGVTLFDTADVYSDGASEEV LGAALRGRRDRVLISTKAALPTAPDDWGTSRSRLLRAVDTALRRLQTDHIDLFQLHAYDAYTPIDEVLHT LDTLVEQGKVRYTGVSNFSGWQLMKSLSLAERHGRTRYIAHQVYYSLIGRDYEWELMPLAAAEGVGALVW SPLGWGRLTGRIRRDTPLPQRSRLHATAAAGPPVDEDLLYAVVDELDAIAAETGRSVAQIALNWLLRRTS VSSVIIGARDEHQLRENLGAVGWQLDDDQVARLERVSSREAPYPHFPYYRQDGFARLNPPVGADR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5192 | - | - | 100% (345) | aldo/keto reductase |
| M. smegmatis MC2 155 | MSMEG_1304 | - | 8e-60 | 39.16% (332) | rhizopine catabolism protein |
| M. smegmatis MC2 155 | MSMEG_4654 | - | 3e-52 | 38.91% (329) | aldo/keto reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2320 | - | 1e-22 | 30.52% (308) | hypothetical protein Mb2320 |
| M. gilvum PYR-GCK | Mflv_0942 | - | 4e-17 | 28.29% (350) | aldo/keto reductase |
| M. tuberculosis H37Rv | Rv2298 | - | 1e-22 | 30.52% (308) | hypothetical protein Rv2298 |
| M. leprae Br4923 | MLBr_00458 | - | 1e-25 | 30.67% (313) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_4120c | - | 3e-36 | 34.08% (311) | aldo/keto reductase |
| M. marinum M | MMAR_3520 | - | 3e-23 | 30.84% (308) | hypothetical protein MMAR_3520 |
| M. avium 104 | MAV_2496 | - | 6e-42 | 39.30% (313) | aldo/keto reductase |
| M. thermoresistible (build 8) | TH_1525 | - | 1e-11 | 25.42% (299) | 2,5-diketo-D-gluconic acid reductase A |
| M. ulcerans Agy99 | MUL_2745 | - | 3e-23 | 30.84% (308) | hypothetical protein MUL_2745 |
| M. vanbaalenii PYR-1 | Mvan_2555 | - | 6e-24 | 32.57% (307) | aldo/keto reductase |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_00458|M.leprae_Br4923 MRRFWRTVVEVTSQNSQALAQASGAFTLGGDLKVNRLGFGAMRLTGKG--
Mvan_2555|M.vanbaalenii_PYR-1 ----------MTSGSS----RTAPTFLLGGELPVNRLGFGAMRLTGPG--
Mflv_0942|M.gilvum_PYR-GCK ----------MTTAIQ-------TTLTLGGELPVPRMGYGAMQLAGPG--
MAB_4120c|M.abscessus_ATCC_199 -----------------------MKHTWLGELSVSRIGLGAMSMSAYYRA
MAV_2496|M.avium_104 -----------------------MKQAQLGGLQVGRLGLGAMGMSVAY--
MSMEG_5192|M.smegmatis_MC2_155 ---------------------MEYRRVGDSGLVVSELSFGAATFGGSGDF
Mb2320|M.bovis_AF2122/97 ----------------------MKYLDVDGIGQVSRIGLGTWQFGSRE--
Rv2298|M.tuberculosis_H37Rv ----------------------MKYLDVDGIGQVSRIGLGTWQFGSRE--
MMAR_3520|M.marinum_M ----------------------MKHLEVDGIGNVSRIGLGTWQFGSRE--
MUL_2745|M.ulcerans_Agy99 ----------------------MKHLEVDGIGNVSRIGLGTWQFGSRE--
TH_1525|M.thermoresistible__bu -----------------VNMTTVPAITLNNGAQIPQVGFGVYQIPPDQ--
. : .:. *. :
MLBr_00458|M.leprae_Br4923 -VWGPPVDRYEAVRVLRRAVELGVNFIDTADSYGPYVSEEIIAEAL-HPY
Mvan_2555|M.vanbaalenii_PYR-1 -VWGPPADRDECLRVLRRAVDLGVDFIDTADSYGPYISEDLIREAL-HPY
Mflv_0942|M.gilvum_PYR-GCK -VLGLPDDVDNAVDVLRRAVDHGVRFFDTANAYGPRTVNQIIGRALGTPA
MAB_4120c|M.abscessus_ATCC_199 IGSESGPDEATSIDTLRRALDLGVSLIDTAEIYGPFVNEELVGRAIAGRR
MAV_2496|M.avium_104 --AGAGTDDAESIRTVHRAIELGVTLIDTAEVYGPYINEELLARALRGRR
MSMEG_5192|M.smegmatis_MC2_155 FGAWGDTGVDAARAMVDMCLDAGVTLFDTADVYSDGASEEVLGAALRGRR
Mb2320|M.bovis_AF2122/97 WGYGDRYATGAARDIVKRARALGVTLFDTAEIYGLGKSERILGEALGDDR
Rv2298|M.tuberculosis_H37Rv WGYGDRYATGAARDIVKRARALGVTLFDTAEIYGLGKSERILGEALGDDR
MMAR_3520|M.marinum_M WGYGDRYASGAARDIVARARALGVTLFDTAEVYGLGKSERILGEALGDER
MUL_2745|M.ulcerans_Agy99 WGYGDRYASGAARDIVARACALGVTLFDTAEVYGLGKSERILGEALGDER
TH_1525|M.thermoresistible__bu -----------TAAAVRTALDAGYRHIDTAQMYGNERGVAEGIRDAGLDR
: . * :***: *.
MLBr_00458|M.leprae_Br4923 KGLVIATKAGLLRTGRDVWIPL-GNPSYLRQELEMSLRRLNVDTIDLFQL
Mvan_2555|M.vanbaalenii_PYR-1 DGVVIATKAGLLRTAPDVWEPL-GFPAYLRQECEMSLRRLGTDTIDLFQL
Mflv_0942|M.gilvum_PYR-GCK DDLVIGNKVGAVRGPAGEWLQD-SRPEILRTQVEEALLDMRADASALTYL
MAB_4120c|M.abscessus_ATCC_199 DEVVLATKFGLVSHGNGASQVLDSTPGNISTAVEGSLRRLGVDHIDLYYQ
MAV_2496|M.avium_104 DRVVLATKFGLISHTG--RDGLDSSPANIRVAVDGSLRRLATDHIDLYYQ
MSMEG_5192|M.smegmatis_MC2_155 DRVLISTKAALPTAPDDWGTSR----SRLLRAVDTALRRLQTDHIDLFQL
Mb2320|M.bovis_AF2122/97 TEVVVASKVFPVAPFP----------AVIKNRERASARRLQLNRIPLYQI
Rv2298|M.tuberculosis_H37Rv TEVVVASKVFPVAPFP----------AVIKNRERASARRLQLNRIPLYQI
MMAR_3520|M.marinum_M AEVVVASKIMPVAPFP----------AVVKQRERASARRLQLDRIPLYQI
MUL_2745|M.ulcerans_Agy99 AEVVVASKIMPVAPFP----------AVVKQRERASARRLQLDRIPLYQI
TH_1525|M.thermoresistible__bu GEVFITSKLNNPYHRP----------DDARRAFDRTLTELGSDYVDLFLI
:.: .* : : : *
MLBr_00458|M.leprae_Br4923 HRIDPN---------FPLADQVGELFTLKNEGKIRHIGLSEIN------L
Mvan_2555|M.vanbaalenii_PYR-1 HRIAPK---------FPAEDQIGELAKLQQEGKVRHIGLSEVS------V
Mflv_0942|M.gilvum_PYR-GCK RLAGDIRGVGEGPGEVPLEESLGALVELRDQGKIRHIGLSGAS------P
MAB_4120c|M.abscessus_ATCC_199 HRVDPN---------VAIEDTIGAVAELVQQGKVRYIGLSEAA------A
MAV_2496|M.avium_104 HRLDRQ---------TPIEDTVGALAELVAAGKIRHIGLSEVG------V
MSMEG_5192|M.smegmatis_MC2_155 HAYDAY---------TPIDEVLHTLDTLVEQGKVRYTGVSNFSGWQLMKS
Mb2320|M.bovis_AF2122/97 HQPNPV---------VPDSVIMPGMRDLLDSGDIGAAGVSNYS----LAR
Rv2298|M.tuberculosis_H37Rv HQPNPV---------VPDSVIMPGMRDLLDSGDIGAAGVSNYS----LAR
MMAR_3520|M.marinum_M HQPNPV---------VPDSVIMPGMRELLDTGRIGAAGVSNYS----LAR
MUL_2745|M.ulcerans_Agy99 HQPNPV---------VPDSVIMPGIRELLDIGRIGAAGVSNYS----LAR
TH_1525|M.thermoresistible__bu HWPLPMHYDG------DFVSTWKTLEEFAADGRARSIGVSNFEP------
: : : * *:*
MLBr_00458|M.leprae_Br4923 DQLTAAQQITEIVSVQNMYNLSARA-AEPLLDAVTSRGIGFIPWSPLAAG
Mvan_2555|M.vanbaalenii_PYR-1 DQLTAARAVAPIVSVQNMYNLTMRA-AEPVLDACEADGIAFIPWFPLAAG
Mflv_0942|M.gilvum_PYR-GCK AALERAQQITTIAAVQNRFNLIDRS-GVEVLAACERDGIAFVPYFPLATG
MAB_4120c|M.abscessus_ATCC_199 GTIRRAHAVHPITALQNEYSLWTRDIEDEILPTIRELGIGLVAYSPLGRG
MAV_2496|M.avium_104 NSIRRAHAVHPITAVQSEYSLWTRDQEDEILPVLRELGIGFVAYSPLGRG
MSMEG_5192|M.smegmatis_MC2_155 LSLAERHGRTRYIAHQVYYSLIGRDYEWELMPLAAAEGVGALVWSPLGWG
Mb2320|M.bovis_AF2122/97 WRKADAALGRPVVSNQVHFSLAHPDALEDLVPFAELENRIVIAYSPLAQG
Rv2298|M.tuberculosis_H37Rv WRKADAALGRPVVSNQVHFSLAHPDALEDLVPFAELENRIVIAYSPLAQG
MMAR_3520|M.marinum_M WKKADAALGRPVVSNQVHFSLAHPGPLDDLVPFAERENRIIIAYSPLAQG
MUL_2745|M.ulcerans_Agy99 WKKADAALGRPVVSNQVHFSLAHPGPLDDLVPFAERENRIIIAYSPLAQG
TH_1525|M.thermoresistible__bu AHLDLLAAETSTVPAVNQVEIHPYFGNNDVRRYCAEHGIAVEAWAPIAKG
. .: : . : *:. *
MLBr_00458|M.leprae_Br4923 PLAAPDGPLQ-------------------------------RIAVNHHAT
Mvan_2555|M.vanbaalenii_PYR-1 PLAAADGPLH-------------------------------RIAAEHHAT
Mflv_0942|M.gilvum_PYR-GCK GLGD-DDELR-------------------------------RPGERLGVP
MAB_4120c|M.abscessus_ATCC_199 FLTGAIGSRDQLAEGDFRREQPRF-SAENFDANLALVEEVRSVASSIGAT
MAV_2496|M.avium_104 FLTGAIRSAHELPDTDYRRTNPRF-AEQNFAHNLRCADELRDIAADVGAT
MSMEG_5192|M.smegmatis_MC2_155 RLTGRIRRDTPLPQRSRLHATAAAGPPVDEDLLYAVVDELDAIAAETGRS
Mb2320|M.bovis_AF2122/97 LLGGKYGLENRPGGVRALNPLFGT---ENLRRIEPLLATLRAIAVDVDAK
Rv2298|M.tuberculosis_H37Rv LLGGKYGLENRPGGVRALNPLFGT---ENLRRIEPLLATLRAIAVDVDAK
MMAR_3520|M.marinum_M LLGGKYGVDNRPAGVRAVNPLFGT---ENLRRIEPLLQTLRAVATDVDAK
MUL_2745|M.ulcerans_Agy99 LLGGKYGVDNRPAGVRAVNPLFGT---ENLRRIEPLLQTLRAVAIDVDAK
TH_1525|M.thermoresistible__bu RVADDPVIAG--------------------------------IADRLGRT
: .
MLBr_00458|M.leprae_Br4923 PSQLALAWLLKRSPVMLPIPGTSRVAHLEENVAAAEIS--LSDDEFEMLS
Mvan_2555|M.vanbaalenii_PYR-1 PSQLALAWLLKRSPVMLPIPGTSKVAHLEENVAAAQID--LTDAEFETLG
Mflv_0942|M.gilvum_PYR-GCK MSTIALAWLLRRSPVIVPIPGTKSVAHLRDNLSAAQVADQLTEDEVHALT
MAB_4120c|M.abscessus_ATCC_199 SAQVALAWLLARGDDIVPIPGTTKVSRVNENVGAVDIE--LLPEHLVRLE
MAV_2496|M.avium_104 PAQVALAWLLAKGPDIVPIPGTKRVARLEENVGADALE--LTTEQLSRLD
MSMEG_5192|M.smegmatis_MC2_155 VAQIALNWLLRRTSVSSVIIGARDEHQLRENLGAVGWQ--LDDDQVARLE
Mb2320|M.bovis_AF2122/97 PAQVALAWLIS-LPGVVAIPGASSVEQLEFNVAAADIELSAQSRDALTDA
Rv2298|M.tuberculosis_H37Rv PAQVALAWLIS-LPGVVAIPGASSVEQLEFNVAAADIELSAQSRDALTDA
MMAR_3520|M.marinum_M PAQVALAWLIS-LPGVVAIPGASSVEQLEFNVAAADIELSADARAALTEA
MUL_2745|M.ulcerans_Agy99 PAQVALAWLIS-LPGVVAIPGASSVEQLEFNVAAADIELSADARAALTEA
TH_1525|M.thermoresistible__bu PAQVTLRWHIQRGDIVLPKS--VTPERVRSNIALFDFE--LSDADMAAIS
: ::* * : ::. *:.
MLBr_00458|M.leprae_Br4923 AAGAQ-----------------------------
Mvan_2555|M.vanbaalenii_PYR-1 NAGAAAS---------------------------
Mflv_0942|M.gilvum_PYR-GCK AVEDEQSATLSTMPSRMTDAFARVVSPPGSGRRR
MAB_4120c|M.abscessus_ATCC_199 CLAAAAGDRYNAEHLARLEG--------------
MAV_2496|M.avium_104 RLTPPVGGHHADAQLAWIDR--------------
MSMEG_5192|M.smegmatis_MC2_155 RVSSREAP-YPHFPYYRQDGFARLNPPVGADR--
Mb2320|M.bovis_AF2122/97 ARAFRPVSTGRFLTDMVREKVSRR----------
Rv2298|M.tuberculosis_H37Rv ARAFRPVSTGRFLTDMVREKVSRR----------
MMAR_3520|M.marinum_M ARAFHPVSARRFLTDTVREKLGRR----------
MUL_2745|M.ulcerans_Agy99 ARAFHPVSARRFLTDTVREKLGRR----------
TH_1525|M.thermoresistible__bu ALDKGEAGRMGPHPDKFDMI--------------