For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
ADDLVISGVPFTHDPWMASQNRYDAMPYRRVGTSGLLLPAISLGLWYNFGDNRPFDVQRAVLRHAFDRGI THFDLANNYGPPYGSAEENFGRMLRRDFKPYRNELIISTKAGWDMWPGPYGQLGSRAYVLASLDESLDRM GIDHVDIFYSHRIDPVTPLEETIGALDTAVRAGKARYVGVSSYSAAKTAEAAEIAKRLGTPLVIHQPSYS LLNRWIEGGLTDELRKAGMGAIAFTALAQGLLTDRYLQKPASDIDRATARPTFDDDLVTDQVREQLRGLA EIAKRRGQTLAQLALAWVLRDPAVSSTLIGASSVEQLDENLGALDNLEFSDEELSQIDQYAKDSGIDLWR QSSDV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6746 | - | - | 100% (356) | oxidoreductase, aldo/keto reductase family protein |
| M. smegmatis MC2 155 | MSMEG_4093 | - | 9e-88 | 51.23% (324) | oxidoreductase, aldo/keto reductase family protein |
| M. smegmatis MC2 155 | MSMEG_5192 | - | 1e-42 | 36.47% (329) | aldo/keto reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2320 | - | 5e-17 | 28.25% (308) | hypothetical protein Mb2320 |
| M. gilvum PYR-GCK | Mflv_0942 | - | 2e-12 | 27.21% (283) | aldo/keto reductase |
| M. tuberculosis H37Rv | Rv2298 | - | 5e-17 | 28.25% (308) | hypothetical protein Rv2298 |
| M. leprae Br4923 | MLBr_00458 | - | 4e-24 | 31.56% (282) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_4120c | - | 8e-30 | 30.58% (327) | aldo/keto reductase |
| M. marinum M | MMAR_2086 | - | 2e-20 | 30.94% (278) | oxidoreductase |
| M. avium 104 | MAV_3334 | - | 1e-34 | 33.97% (312) | general stress protein 69 |
| M. thermoresistible (build 8) | TH_1525 | - | 7e-07 | 25.56% (313) | 2,5-diketo-D-gluconic acid reductase A |
| M. ulcerans Agy99 | MUL_2745 | - | 1e-17 | 28.85% (312) | hypothetical protein MUL_2745 |
| M. vanbaalenii PYR-1 | Mvan_2555 | - | 1e-21 | 30.60% (317) | aldo/keto reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2320|M.bovis_AF2122/97 ---------------------MKYLDVDGIG-QVSRIGLGTWQFGSREWG
Rv2298|M.tuberculosis_H37Rv ---------------------MKYLDVDGIG-QVSRIGLGTWQFGSREWG
MUL_2745|M.ulcerans_Agy99 ---------------------MKHLEVDGIG-NVSRIGLGTWQFGSREWG
MAV_3334|M.avium_104 ---------------------MKTITFGKTGLEVSRLAFGTWEFCS-DWG
MLBr_00458|M.leprae_Br4923 MRRFWRTVVEVTSQNSQALAQASGAFTLGGDLKVNRLGFGAMRLTG-KGV
MMAR_2086|M.marinum_M ------------------MAAASATLTLGGDLTVNRLGFGAMRLTG-DGV
Mvan_2555|M.vanbaalenii_PYR-1 --------------MTSGSSRTAPTFLLGGELPVNRLGFGAMRLTG-PGV
Mflv_0942|M.gilvum_PYR-GCK -----------------MTTAIQTTLTLGGELPVPRMGYGAMQLAG-PGV
MAB_4120c|M.abscessus_ATCC_199 -----------------------MKHTWLGELSVSRIGLGAMSMSAYYRA
MSMEG_6746|M.smegmatis_MC2_155 -----MADDLVISGVPFTHDPWMASQNRYDAMPYRRVGTSGLLLPAISLG
TH_1525|M.thermoresistible__bu -----------------VNMTTVPAITLNNGAQIPQVGFGVYQIPP----
::. . :
Mb2320|M.bovis_AF2122/97 YGDR----YATGAARDIVKRARALGVTLFDTAEIYGLGK--SERILGEAL
Rv2298|M.tuberculosis_H37Rv YGDR----YATGAARDIVKRARALGVTLFDTAEIYGLGK--SERILGEAL
MUL_2745|M.ulcerans_Agy99 YGDR----YASGAARDIVARACALGVTLFDTAEVYGLGK--SERILGEAL
MAV_3334|M.avium_104 HAD-------EDAAITMIRSARDLGINFFDTAQQYGFGA--SERLLGKAL
MLBr_00458|M.leprae_Br4923 WGPP----VDRYEAVRVLRRAVELGVNFIDTADSYGPYV--SEEIIAEAL
MMAR_2086|M.marinum_M WGPP----ADRAEAVRVLRRAAELGVNFIDTADSYGPYV--SEEIIHEAL
Mvan_2555|M.vanbaalenii_PYR-1 WGPP----ADRDECLRVLRRAVDLGVDFIDTADSYGPYI--SEDLIREAL
Mflv_0942|M.gilvum_PYR-GCK LGLP----DDVDNAVDVLRRAVDHGVRFFDTANAYGPRT--VNQIIGRAL
MAB_4120c|M.abscessus_ATCC_199 IGSESG--PDEATSIDTLRRALDLGVSLIDTAEIYGPFV--NEELVGRAI
MSMEG_6746|M.smegmatis_MC2_155 LWYNFGDNRPFDVQRAVLRHAFDRGITHFDLANNYGPPYGSAEENFGRML
TH_1525|M.thermoresistible__bu -----------DQTAAAVRTALDAGYRHIDTAQMYGNERGVAEGIRDAGL
: * * :* *: ** : :
Mb2320|M.bovis_AF2122/97 GDD----RTEVVVASKVFPVAPFPAVIKNR--ERASARR--------LQL
Rv2298|M.tuberculosis_H37Rv GDD----RTEVVVASKVFPVAPFPAVIKNR--ERASARR--------LQL
MUL_2745|M.ulcerans_Agy99 GDE----RAEVVVASKIMPVAPFPAVVKQR--ERASARR--------LQL
MAV_3334|M.avium_104 RDDLARARDEVVIATKGGLRATDSGLVRDA--SPQWLRKGVESSLTALGI
MLBr_00458|M.leprae_Br4923 -HP----YKGLVIATKAGLLRTGRDVWIPL-GNPSYLRQELEMSLRRLNV
MMAR_2086|M.marinum_M -HP----YTGLVIATKAGLLRTGPGVWVPL-GNPSYLRQECEMSLRRLGV
Mvan_2555|M.vanbaalenii_PYR-1 -HP----YDGVVIATKAGLLRTAPDVWEPL-GFPAYLRQECEMSLRRLGT
Mflv_0942|M.gilvum_PYR-GCK GTP----ADDLVIGNKVGAVRGPAGEWLQD-SRPEILRTQVEEALLDMRA
MAB_4120c|M.abscessus_ATCC_199 AGR----RDEVVLATKFGLVSHGNGASQVLDSTPGNISTAVEGSLRRLGV
MSMEG_6746|M.smegmatis_MC2_155 RRDFKPYRNELIISTKAGWDMWPGPYGQLG--SRAYVLASLDESLDRMGI
TH_1525|M.thermoresistible__bu DRG------EVFITSKLNNPYHR----------PDDARRAFDRTLTELGS
:.: .* :
Mb2320|M.bovis_AF2122/97 NRIPLYQIHQPNPV---------VPDSVIMPGMRDLLDSGDIGAAGVSNY
Rv2298|M.tuberculosis_H37Rv NRIPLYQIHQPNPV---------VPDSVIMPGMRDLLDSGDIGAAGVSNY
MUL_2745|M.ulcerans_Agy99 DRIPLYQIHQPNPV---------VPDSVIMPGIRELLDIGRIGAAGVSNY
MAV_3334|M.avium_104 DHIDVYLVHWPDPR---------MPAAETAGALAELVSEGKIRHVGVSNY
MLBr_00458|M.leprae_Br4923 DTIDLFQLHRIDPN---------FPLADQVGELFTLKNEGKIRHIGLSEI
MMAR_2086|M.marinum_M DTIDLFQLHRIDRN---------YPLADQVGELLALKNEGKIRHIGLSEI
Mvan_2555|M.vanbaalenii_PYR-1 DTIDLFQLHRIAPK---------FPAEDQIGELAKLQQEGKVRHIGLSEV
Mflv_0942|M.gilvum_PYR-GCK DASALTYLRLAGDIRGVGEGPGEVPLEESLGALVELRDQGKIRHIGLSGA
MAB_4120c|M.abscessus_ATCC_199 DHIDLYYQHRVDPN---------VAIEDTIGAVAELVQQGKVRYIGLSEA
MSMEG_6746|M.smegmatis_MC2_155 DHVDIFYSHRIDPVT---------PLEETIGALDTAVRAGKARYVGVSSY
TH_1525|M.thermoresistible__bu DYVDLFLIHWPLPMHYDG------DFVSTWKTLEEFAADGRARSIGVSNF
: : : : * *:*
Mb2320|M.bovis_AF2122/97 SLARWRKADAALG---RPVVSNQVHFSLAHPDALEDLVPFAELENRIVIA
Rv2298|M.tuberculosis_H37Rv SLARWRKADAALG---RPVVSNQVHFSLAHPDALEDLVPFAELENRIVIA
MUL_2745|M.ulcerans_Agy99 SLARWKKADAALG---RPVVSNQVHFSLAHPGPLDDLVPFAERENRIIIA
MAV_3334|M.avium_104 DTAQVEEFSATL-----PVEVVQPPYHLFRRDIEDTLLPYAREHDIGVMV
MLBr_00458|M.leprae_Br4923 NLDQLTAAQQIT-----EIVSVQNMYNLSAR-AAEPLLDAVTSRGIGFIP
MMAR_2086|M.marinum_M DVDQLEAAQQIT-----EIVSVQNMYNLAAR-GAEPLLEAATSQGIAFIP
Mvan_2555|M.vanbaalenii_PYR-1 SVDQLTAARAVA-----PIVSVQNMYNLTMR-AAEPVLDACEADGIAFIP
Mflv_0942|M.gilvum_PYR-GCK SPAALERAQQIT-----TIAAVQNRFNLIDR-SGVEVLAACERDGIAFVP
MAB_4120c|M.abscessus_ATCC_199 AAGTIRRAHAVH-----PITALQNEYSLWTRDIEDEILPTIRELGIGLVA
MSMEG_6746|M.smegmatis_MC2_155 SAAKTAEAAEIAKRLGTPLVIHQPSYSLLNRWIEGGLTDELRKAGMGAIA
TH_1525|M.thermoresistible__bu EPAHLDLLAAET-----STVPAVNQVEIHPYFGNNDVRRYCAEHGIAVEA
: : .
Mb2320|M.bovis_AF2122/97 YSPLAQGLLGGKYGLENR--PGGVRALNPLFGTENLRRIEPLLATLRAIA
Rv2298|M.tuberculosis_H37Rv YSPLAQGLLGGKYGLENR--PGGVRALNPLFGTENLRRIEPLLATLRAIA
MUL_2745|M.ulcerans_Agy99 YSPLAQGLLGGKYGVDNR--PAGVRAVNPLFGTENLRRIEPLLQTLRAVA
MAV_3334|M.avium_104 YGPLAHGLLTGTVKPDTRFAPQDWRAKSDIFSGDGFLRNLEVVAQLQELA
MLBr_00458|M.leprae_Br4923 WSPLA----AGPLAAP----DGPLQR----------------------IA
MMAR_2086|M.marinum_M WFPLA----SGPLAAP----DGPLRK----------------------IA
Mvan_2555|M.vanbaalenii_PYR-1 WFPLA----AGPLAAA----DGPLHR----------------------IA
Mflv_0942|M.gilvum_PYR-GCK YFPLA----TGGLGD-----DDELRR----------------------PG
MAB_4120c|M.abscessus_ATCC_199 YSPLGRGFLTGAIGSRDQLAEGDFRREQPRFSAENFDANLALVEEVRSVA
MSMEG_6746|M.smegmatis_MC2_155 FTALAQGLLTDRYLQKPASDIDRATARPTFDDDLVTDQVREQLRGLAEIA
TH_1525|M.thermoresistible__bu WAPIAKGRVADDPVIAG-------------------------------IA
: .:. . .
Mb2320|M.bovis_AF2122/97 VDVDAKPAQVALAWLISLPGV-VAIPGASSVEQLEFNVAAADIE--LSAQ
Rv2298|M.tuberculosis_H37Rv VDVDAKPAQVALAWLISLPGV-VAIPGASSVEQLEFNVAAADIE--LSAQ
MUL_2745|M.ulcerans_Agy99 IDVDAKPAQVALAWLISLPGV-VAIPGASSVEQLEFNVAAADIE--LSAD
MAV_3334|M.avium_104 SDLGVTISQLAIARVLAQPGVHVAIVGAQHLHYLQESARAADVT--LSDA
MLBr_00458|M.leprae_Br4923 VNHHATPSQLALAWLLKRSPVMLPIPGTSRVAHLEENVAAAEIS--LSDD
MMAR_2086|M.marinum_M DDHHATPSQLALAWLLKRSPVMLPIPGTSRVAHLQENVAAAEIV--LSDQ
Mvan_2555|M.vanbaalenii_PYR-1 AEHHATPSQLALAWLLKRSPVMLPIPGTSKVAHLEENVAAAQID--LTDA
Mflv_0942|M.gilvum_PYR-GCK ERLGVPMSTIALAWLLRRSPVIVPIPGTKSVAHLRDNLSAAQVADQLTED
MAB_4120c|M.abscessus_ATCC_199 SSIGATSAQVALAWLLARGDDIVPIPGTTKVSRVNENVGAVDIE--LLPE
MSMEG_6746|M.smegmatis_MC2_155 KRRGQTLAQLALAWVLRDPAVSSTLIGASSVEQLDENLGALDNL-EFSDE
TH_1525|M.thermoresistible__bu DRLGRTPAQVTLRWHIQRGDIVLPKS--VTPERVRSNIALFDFE--LSDA
: ::: : . : . : :
Mb2320|M.bovis_AF2122/97 SRDALTDAARAFRPVSTGRFLTDMVREKVSRR--------
Rv2298|M.tuberculosis_H37Rv SRDALTDAARAFRPVSTGRFLTDMVREKVSRR--------
MUL_2745|M.ulcerans_Agy99 ARAALTEAARAFHPVSARRFLTDTVREKLGRR--------
MAV_3334|M.avium_104 DLAAVDNVLAAATPVGG---PYPEMHQKAS----------
MLBr_00458|M.leprae_Br4923 EFEMLSAAGAQ-----------------------------
MMAR_2086|M.marinum_M EFEALSVAGAAHGG--------------------------
Mvan_2555|M.vanbaalenii_PYR-1 EFETLGNAGAAAS---------------------------
Mflv_0942|M.gilvum_PYR-GCK EVHALTAVEDEQSATLSTMPSRMTDAFARVVSPPGSGRRR
MAB_4120c|M.abscessus_ATCC_199 HLVRLECLAAAAGDRYN------AEHLARLEG--------
MSMEG_6746|M.smegmatis_MC2_155 ELSQIDQYAKDSGIDLWRQSSDV-----------------
TH_1525|M.thermoresistible__bu DMAAISALDKGEAGRMGPHPDKFDMI--------------
: