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MKHLEVDGIGNVSRIGLGTWQFGSREWGYGDRYASGAARDIVARARALGVTLFDTAEVYGLGKSERILGE ALGDERAEVVVASKIMPVAPFPAVVKQRERASARRLQLDRIPLYQIHQPNPVVPDSVIMPGMRELLDTGR IGAAGVSNYSLARWKKADAALGRPVVSNQVHFSLAHPGPLDDLVPFAERENRIIIAYSPLAQGLLGGKYG VDNRPAGVRAVNPLFGTENLRRIEPLLQTLRAVATDVDAKPAQVALAWLISLPGVVAIPGASSVEQLEFN VAAADIELSADARAALTEAARAFHPVSARRFLTDTVREKLGRR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3520 | - | - | 100% (323) | hypothetical protein MMAR_3520 |
| M. marinum M | MMAR_2086 | - | 2e-19 | 30.87% (311) | oxidoreductase |
| M. marinum M | MMAR_1744 | - | 3e-11 | 28.25% (269) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2320 | - | 1e-163 | 87.93% (323) | hypothetical protein Mb2320 |
| M. gilvum PYR-GCK | Mflv_1329 | - | 6e-12 | 26.11% (314) | aldo/keto reductase |
| M. tuberculosis H37Rv | Rv2298 | - | 1e-163 | 87.93% (323) | hypothetical protein Rv2298 |
| M. leprae Br4923 | MLBr_00458 | - | 2e-21 | 31.56% (301) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_4120c | - | 5e-32 | 33.00% (303) | aldo/keto reductase |
| M. avium 104 | MAV_4098 | - | 1e-151 | 82.35% (323) | aldo/keto reductase |
| M. smegmatis MC2 155 | MSMEG_2920 | - | 1e-31 | 34.13% (293) | aldo/keto reductase |
| M. thermoresistible (build 8) | TH_1364 | - | 7e-08 | 29.50% (261) | PROBABLE OXIDOREDUCTASE |
| M. ulcerans Agy99 | MUL_2745 | - | 1e-180 | 98.76% (323) | hypothetical protein MUL_2745 |
| M. vanbaalenii PYR-1 | Mvan_2555 | - | 1e-19 | 31.06% (293) | aldo/keto reductase |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_00458|M.leprae_Br4923 MRRFWRTVVEVTSQNSQALAQASGAFTLGGDLKVNRLGFGAMRLTGKGVW
Mvan_2555|M.vanbaalenii_PYR-1 ----------MTSGSS----RTAPTFLLGGELPVNRLGFGAMRLTGPGVW
Mflv_1329|M.gilvum_PYR-GCK ----------------------MDTFPLG-SHTVGRVGFGAMQLPGPGVF
MMAR_3520|M.marinum_M ----------------------MKHLEVDGIGNVSRIGLGTWQFGSREWG
MUL_2745|M.ulcerans_Agy99 ----------------------MKHLEVDGIGNVSRIGLGTWQFGSREWG
Mb2320|M.bovis_AF2122/97 ----------------------MKYLDVDGIGQVSRIGLGTWQFGSREWG
Rv2298|M.tuberculosis_H37Rv ----------------------MKYLDVDGIGQVSRIGLGTWQFGSREWG
MAV_4098|M.avium_104 ----------------------MKYVDVDGVGRLSRIGLGTWQFGSREWG
MAB_4120c|M.abscessus_ATCC_199 ----------------------MKHTWLG-ELSVSRIGLGAMSMSAY---
MSMEG_2920|M.smegmatis_MC2_155 ----------------------MTVAPL--RTDRRRLGSGGPEVSAIGLG
TH_1364|M.thermoresistible__bu ----------------------MTSSPGEAAATPTVTLNDDRSMPVLGLG
. .
MLBr_00458|M.leprae_Br4923 GPPVDRYEAVR-------VLRRAVELGVNFIDTADSYGPYVSEEIIAEAL
Mvan_2555|M.vanbaalenii_PYR-1 GPPADRDECLR-------VLRRAVDLGVDFIDTADSYGPYISEDLIREAL
Mflv_1329|M.gilvum_PYR-GCK GPPRDHDQALA-------VLRRVVELGINHIDTAQIYGPNVANELIREAL
MMAR_3520|M.marinum_M YGDRYASGAAR------DIVARARALGVTLFDTAEVYGLGKSERILGEAL
MUL_2745|M.ulcerans_Agy99 YGDRYASGAAR------DIVARACALGVTLFDTAEVYGLGKSERILGEAL
Mb2320|M.bovis_AF2122/97 YGDRYATGAAR------DIVKRARALGVTLFDTAEIYGLGKSERILGEAL
Rv2298|M.tuberculosis_H37Rv YGDRYATGAAR------DIVKRARALGVTLFDTAEIYGLGKSERILGEAL
MAV_4098|M.avium_104 YGDSYAAGAAG------DIVRRALALGVTLFDTAEIYGFGKSERILGDAL
MAB_4120c|M.abscessus_ATCC_199 YRAIGSESGPD-EATSIDTLRRALDLGVSLIDTAEIYGPFVNEELVGRAI
MSMEG_2920|M.smegmatis_MC2_155 FMSFRAGSGPDDEKQAKDIVDAAIDLGVTLFDTADIYGPEHSEVLLGKAI
TH_1364|M.thermoresistible__bu VGELSDDEAER-------AVAAALEAGYRLIDTAASYGNEAGVGRAIAAS
: . * :*** ** *
MLBr_00458|M.leprae_Br4923 HPY-KGLVIATKAG---LLRTGRDVWIPLGNPSYLRQELEMSLRRLNVD-
Mvan_2555|M.vanbaalenii_PYR-1 HPY-DGVVIATKAG---LLRTAPDVWEPLGFPAYLRQECEMSLRRLGTD-
Mflv_1329|M.gilvum_PYR-GCK HPYADGLALVSKVG---GRRDEQGNWLPAQDPDDLRRQLEENLSTLDTDR
MMAR_3520|M.marinum_M GDERAEVVVASKIM------------PVAPFPAVVKQRERASARRLQLD-
MUL_2745|M.ulcerans_Agy99 GDERAEVVVASKIM------------PVAPFPAVVKQRERASARRLQLD-
Mb2320|M.bovis_AF2122/97 GDDRTEVVVASKVF------------PVAPFPAVIKNRERASARRLQLN-
Rv2298|M.tuberculosis_H37Rv GDDRTEVVVASKVF------------PVAPFPAVIKNRERASARRLQLN-
MAV_4098|M.avium_104 GEQRAEVAVASKIM------------PVAPFPAVVRQRARASARRLGLD-
MAB_4120c|M.abscessus_ATCC_199 AGRRDEVVLATKFG-LVSHGNGAS-QVLDSTPGNISTAVEGSLRRLGVD-
MSMEG_2920|M.smegmatis_MC2_155 RGRRDSLVIATKFGNRLDRGTSTDGRALDGRPEYVRSAIEGSLRRLGVD-
TH_1364|M.thermoresistible__bu GLPREEIFVTTKLA------------TTDQGFQSSQDAVRASLERLGLE-
: :.:* . . * :
MLBr_00458|M.leprae_Br4923 --TIDLFQLHRIDPNFP-------LADQVGELFTLKNEGKIRHIGLSEIN
Mvan_2555|M.vanbaalenii_PYR-1 --TIDLFQLHRIAPKFP-------AEDQIGELAKLQQEGKVRHIGLSEVS
Mflv_1329|M.gilvum_PYR-GCK LAAVNLRAFNHDDPSLPAVLDRDLFDRQLTAMIAARDEGLIAGIGLSNVS
MMAR_3520|M.marinum_M --RIPLYQIHQPNPVVP-------DSVIMPGMRELLDTGRIGAAGVSNYS
MUL_2745|M.ulcerans_Agy99 --RIPLYQIHQPNPVVP-------DSVIMPGIRELLDIGRIGAAGVSNYS
Mb2320|M.bovis_AF2122/97 --RIPLYQIHQPNPVVP-------DSVIMPGMRDLLDSGDIGAAGVSNYS
Rv2298|M.tuberculosis_H37Rv --RIPLYQIHQPNPVVP-------DSVIMPGMRDLLDSGDIGAAGVSNYS
MAV_4098|M.avium_104 --RIPLYQVHQPNPVFP-------DSVIMPGMRDLLDSGEIGAAGVSNYS
MAB_4120c|M.abscessus_ATCC_199 --HIDLYYQHRVDPNVA-------IEDTIGAVAELVQQGKVRYIGLSEAA
MSMEG_2920|M.smegmatis_MC2_155 --HVDLYYQHRVDPQVP-------IEDTVGALAELVQAGKVRHIGLSEPG
TH_1364|M.thermoresistible__bu --YVDLYLIHWPAGEQGK------YVDSWGGFLKIREDGLTRSIGVSNFD
: * : . : * *:*:
MLBr_00458|M.leprae_Br4923 LDQLTAAQQIT--EIVSVQNMYNLSAR-AAEPLLDAVTSRGIGFIPWSPL
Mvan_2555|M.vanbaalenii_PYR-1 VDQLTAARAVA--PIVSVQNMYNLTMR-AAEPVLDACEADGIAFIPWFPL
Mflv_1329|M.gilvum_PYR-GCK ADHLRVALERT--EIVCVQNAYNLLDR-TSQPVLDLSAEHGIAFVPFFPL
MMAR_3520|M.marinum_M LARWKKADAALGRPVVSNQVHFSLAHPGPLDDLVPFAERENRIIIAYSPL
MUL_2745|M.ulcerans_Agy99 LARWKKADAALGRPVVSNQVHFSLAHPGPLDDLVPFAERENRIIIAYSPL
Mb2320|M.bovis_AF2122/97 LARWRKADAALGRPVVSNQVHFSLAHPDALEDLVPFAELENRIVIAYSPL
Rv2298|M.tuberculosis_H37Rv LARWRKADAALGRPVVSNQVHFSLAHPDALEDLVPFAELENRIVIAYSPL
MAV_4098|M.avium_104 LQRWRKADAALGRPVISNQVHFSLAYPKALKNLVPFAERENRIVIAYSPL
MAB_4120c|M.abscessus_ATCC_199 AGTIRRAHAVH--PITALQNEYSLWTRDIEDEILPTIRELGIGLVAYSPL
MSMEG_2920|M.smegmatis_MC2_155 PQTLRRAHAVH--PVAAIQNEWSLFTRDIEDETVPIARELGIGIVPYSPL
TH_1364|M.thermoresistible__bu EEYLSDIIDLS--FVTPAVNQIELHPLLNQADLRKVHAERNVLTQAYSPL
: .* . .: **
MLBr_00458|M.leprae_Br4923 AAGPLAAP-------------------------------------DGPLQ
Mvan_2555|M.vanbaalenii_PYR-1 AAGPLAAA-------------------------------------DGPLH
Mflv_1329|M.gilvum_PYR-GCK GSGFVADNPVLK---------------------------------HPAVV
MMAR_3520|M.marinum_M AQGLLGGKYGVDNRPAG---------VRAVNPLFGTENLRRIEPLLQTLR
MUL_2745|M.ulcerans_Agy99 AQGLLGGKYGVDNRPAG---------VRAVNPLFGTENLRRIEPLLQTLR
Mb2320|M.bovis_AF2122/97 AQGLLGGKYGLENRPGG---------VRALNPLFGTENLRRIEPLLATLR
Rv2298|M.tuberculosis_H37Rv AQGLLGGKYGLENRPGG---------VRALNPLFGTENLRRIEPLLATLR
MAV_4098|M.avium_104 EQGLLGGKYGVDNRPGG---------VRAVNALFGTENLRRIEPLLQLLR
MAB_4120c|M.abscessus_ATCC_199 GRGFLTGAIGSRDQLAEGD-------FRREQPRFSAENFDANLALVEEVR
MSMEG_2920|M.smegmatis_MC2_155 GRGWLTGRVQSRDNISG---------THRDHPRFSDEAFDRNRALADTVV
TH_1364|M.thermoresistible__bu GVGNLLADPTIGAVAQAHGKSPAQVLLRWNLQLGNAVVVRSSNPDRMREN
* :
MLBr_00458|M.leprae_Br4923 RIAVNHHATPSQLALAWLLKRSPVMLPIP--GTSRVAHLEENVAAAEISL
Mvan_2555|M.vanbaalenii_PYR-1 RIAAEHHATPSQLALAWLLKRSPVMLPIP--GTSKVAHLEENVAAAQIDL
Mflv_1329|M.gilvum_PYR-GCK REAEKLGRTPAQIVLAWTLSVAPNVLLIP--GTSSVAHLEQNTAVRDITL
MMAR_3520|M.marinum_M AVATDVDAKPAQVALAWLISLPG-VVAIP--GASSVEQLEFNVAAADIEL
MUL_2745|M.ulcerans_Agy99 AVAIDVDAKPAQVALAWLISLPG-VVAIP--GASSVEQLEFNVAAADIEL
Mb2320|M.bovis_AF2122/97 AIAVDVDAKPAQVALAWLISLPG-VVAIP--GASSVEQLEFNVAAADIEL
Rv2298|M.tuberculosis_H37Rv AIAVDVDAKPAQVALAWLISLPG-VVAIP--GASSVEQLEFNVAAADIEL
MAV_4098|M.avium_104 DVAAQVDAKPAQVALAWLISYPG-VVAIP--GASSVEQLEFNVAAADIEL
MAB_4120c|M.abscessus_ATCC_199 SVASSIGATSAQVALAWLLARGDDIVPIP--GTTKVSRVNENVGAVDIEL
MSMEG_2920|M.smegmatis_MC2_155 TVAGELGVQPGQVALAWVLSRGQDVVPIP--GTRHVGFLRENLCAVGIEL
TH_1364|M.thermoresistible__bu LAVFDFELTDDEMNTINGMDNGTRYRPDPXXGEGAAAEHQSADSAAGTAV
. . :: : * * . . . :
MLBr_00458|M.leprae_Br4923 SDDEFEMLSAAGAQ---------------------------
Mvan_2555|M.vanbaalenii_PYR-1 TDAEFETLGNAGAAAS-------------------------
Mflv_1329|M.gilvum_PYR-GCK DDDTRRDLDAAA-----------------------------
MMAR_3520|M.marinum_M SADARAALTEAARAFHPVSARRFLTDTVREKLGRR------
MUL_2745|M.ulcerans_Agy99 SADARAALTEAARAFHPVSARRFLTDTVREKLGRR------
Mb2320|M.bovis_AF2122/97 SAQSRDALTDAARAFRPVSTGRFLTDMVREKVSRR------
Rv2298|M.tuberculosis_H37Rv SAQSRDALTDAARAFRPVSTGRFLTDMVREKVSRR------
MAV_4098|M.avium_104 PAESRDALTDAALAFRPTSAARFLTDLARERIPGRG-----
MAB_4120c|M.abscessus_ATCC_199 LPEHLVRLECLA-AAAGDRYN-AEHLARLEG----------
MSMEG_2920|M.smegmatis_MC2_155 SDDHLRRLEGIAGQVAGHRSARPEHLGTEAPQADSGVQNR-
TH_1364|M.thermoresistible__bu PGHPVRRGGCARRQRRPGTAADHLLHRRSDGLSVEQVDHQR