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KHLEVDGIGNVSRIGLGTWQFGSREWGYGDRYASGAARDIVARACALGVTLFDTAEVYGLGKSERILGEA LGDERAEVVVASKIMPVAPFPAVVKQRERASARRLQLDRIPLYQIHQPNPVVPDSVIMPGIRELLDIGRI GAAGVSNYSLARWKKADAALGRPVVSNQVHFSLAHPGPLDDLVPFAERENRIIIAYSPLAQGLLGGKYGV DNRPAGVRAVNPLFGTENLRRIEPLLQTLRAVAIDVDAKPAQVALAWLISLPGVVAIPGASSVEQLEFNV AAADIELSADARAALTEAARAFHPVSARRFLTDTVREKLGRR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2745 | - | - | 100% (323) | hypothetical protein MUL_2745 |
| M. ulcerans Agy99 | MUL_1987 | - | 1e-11 | 29.00% (269) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2320 | - | 1e-161 | 87.31% (323) | hypothetical protein Mb2320 |
| M. gilvum PYR-GCK | Mflv_4697 | - | 2e-11 | 25.00% (296) | 2,5-didehydrogluconate reductase |
| M. tuberculosis H37Rv | Rv2298 | - | 1e-161 | 87.31% (323) | hypothetical protein Rv2298 |
| M. leprae Br4923 | MLBr_00458 | - | 1e-21 | 31.56% (301) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_4120c | - | 8e-32 | 33.00% (303) | aldo/keto reductase |
| M. marinum M | MMAR_3520 | - | 1e-179 | 98.76% (323) | hypothetical protein MMAR_3520 |
| M. avium 104 | MAV_4098 | - | 1e-150 | 82.04% (323) | aldo/keto reductase |
| M. smegmatis MC2 155 | MSMEG_2920 | - | 2e-31 | 34.13% (293) | aldo/keto reductase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_2555 | - | 1e-19 | 31.06% (293) | aldo/keto reductase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_2745|M.ulcerans_Agy99 ----------------------MKHLEVDGIGNVSRIGLGTWQFGSRE--
MMAR_3520|M.marinum_M ----------------------MKHLEVDGIGNVSRIGLGTWQFGSRE--
Mb2320|M.bovis_AF2122/97 ----------------------MKYLDVDGIGQVSRIGLGTWQFGSRE--
Rv2298|M.tuberculosis_H37Rv ----------------------MKYLDVDGIGQVSRIGLGTWQFGSRE--
MAV_4098|M.avium_104 ----------------------MKYVDVDGVGRLSRIGLGTWQFGSRE--
MLBr_00458|M.leprae_Br4923 MRRFWRTVVEVTSQNSQALAQASGAFTLGGDLKVNRLGFGAMRLTGK---
Mvan_2555|M.vanbaalenii_PYR-1 ----------MTSGSS----RTAPTFLLGGELPVNRLGFGAMRLTGP---
MAB_4120c|M.abscessus_ATCC_199 -----------------------MKHTWLGELSVSRIGLGAMSMSAY---
MSMEG_2920|M.smegmatis_MC2_155 -----------------------MTVAPL-RTDRRRLGSGGPEVSAIGLG
Mflv_4697|M.gilvum_PYR-GCK -------------------MTHVPAIELNDGASIPQLGFGVYQISPED--
::* * .
MUL_2745|M.ulcerans_Agy99 ----WGYGDRYASGAARDIVARACALGVTLFDTAEVYGLGKSERILGEAL
MMAR_3520|M.marinum_M ----WGYGDRYASGAARDIVARARALGVTLFDTAEVYGLGKSERILGEAL
Mb2320|M.bovis_AF2122/97 ----WGYGDRYATGAARDIVKRARALGVTLFDTAEIYGLGKSERILGEAL
Rv2298|M.tuberculosis_H37Rv ----WGYGDRYATGAARDIVKRARALGVTLFDTAEIYGLGKSERILGEAL
MAV_4098|M.avium_104 ----WGYGDSYAAGAAGDIVRRALALGVTLFDTAEIYGFGKSERILGDAL
MLBr_00458|M.leprae_Br4923 ----GVWGPPVDRYEAVRVLRRAVELGVNFIDTADSYGPYVSEEIIAEAL
Mvan_2555|M.vanbaalenii_PYR-1 ----GVWGPPADRDECLRVLRRAVDLGVDFIDTADSYGPYISEDLIREAL
MAB_4120c|M.abscessus_ATCC_199 YRAIGSESGPD-EATSIDTLRRALDLGVSLIDTAEIYGPFVNEELVGRAI
MSMEG_2920|M.smegmatis_MC2_155 FMSFRAGSGPDDEKQAKDIVDAAIDLGVTLFDTADIYGPEHSEVLLGKAI
Mflv_4697|M.gilvum_PYR-GCK ---------------TADVVRQALEVGYRHIDTAQMYQNEKGVGQGIRNS
: * :* :***: * .
MUL_2745|M.ulcerans_Agy99 GDERAEVVVASKIMP------------VAPFPAVVKQRERASARRLQLDR
MMAR_3520|M.marinum_M GDERAEVVVASKIMP------------VAPFPAVVKQRERASARRLQLDR
Mb2320|M.bovis_AF2122/97 GDDRTEVVVASKVFP------------VAPFPAVIKNRERASARRLQLNR
Rv2298|M.tuberculosis_H37Rv GDDRTEVVVASKVFP------------VAPFPAVIKNRERASARRLQLNR
MAV_4098|M.avium_104 GEQRAEVAVASKIMP------------VAPFPAVVRQRARASARRLGLDR
MLBr_00458|M.leprae_Br4923 HP-YKGLVIATKAG---LLRTGRDVWIPLGNPSYLRQELEMSLRRLNVDT
Mvan_2555|M.vanbaalenii_PYR-1 HP-YDGVVIATKAG---LLRTAPDVWEPLGFPAYLRQECEMSLRRLGTDT
MAB_4120c|M.abscessus_ATCC_199 AGRRDEVVLATKFG-LVSHGNGAS-QVLDSTPGNISTAVEGSLRRLGVDH
MSMEG_2920|M.smegmatis_MC2_155 RGRRDSLVIATKFGNRLDRGTSTDGRALDGRPEYVRSAIEGSLRRLGVDH
Mflv_4697|M.gilvum_PYR-GCK GIDRGDVFVTSKLNN------------GFHTPEDARRAFDETLKALEFDY
: :::* * : : * :
MUL_2745|M.ulcerans_Agy99 IPLYQIHQPNPVVPDSVIMP---GIRELLDIGRIGAAGVSNYSLARWKKA
MMAR_3520|M.marinum_M IPLYQIHQPNPVVPDSVIMP---GMRELLDTGRIGAAGVSNYSLARWKKA
Mb2320|M.bovis_AF2122/97 IPLYQIHQPNPVVPDSVIMP---GMRDLLDSGDIGAAGVSNYSLARWRKA
Rv2298|M.tuberculosis_H37Rv IPLYQIHQPNPVVPDSVIMP---GMRDLLDSGDIGAAGVSNYSLARWRKA
MAV_4098|M.avium_104 IPLYQVHQPNPVFPDSVIMP---GMRDLLDSGEIGAAGVSNYSLQRWRKA
MLBr_00458|M.leprae_Br4923 IDLFQLHRIDPNFPLADQVG---ELFTLKNEGKIRHIGLSEINLDQLTAA
Mvan_2555|M.vanbaalenii_PYR-1 IDLFQLHRIAPKFPAEDQIG---ELAKLQQEGKVRHIGLSEVSVDQLTAA
MAB_4120c|M.abscessus_ATCC_199 IDLYYQHRVDPNVAIEDTIG---AVAELVQQGKVRYIGLSEAAAGTIRRA
MSMEG_2920|M.smegmatis_MC2_155 VDLYYQHRVDPQVPIEDTVG---ALAELVQAGKVRHIGLSEPGPQTLRRA
Mflv_4697|M.gilvum_PYR-GCK VDLFLIHWPLPTLYDGDFVSTWKTLEEFTKDGRARSIGVSNFQVAHLQRL
: *: * * . : : : . * *:*:
MUL_2745|M.ulcerans_Agy99 DAALGRPVVSNQVHFSLAHPGPLDDLVPFAERENRIIIAYSPLAQGLLGG
MMAR_3520|M.marinum_M DAALGRPVVSNQVHFSLAHPGPLDDLVPFAERENRIIIAYSPLAQGLLGG
Mb2320|M.bovis_AF2122/97 DAALGRPVVSNQVHFSLAHPDALEDLVPFAELENRIVIAYSPLAQGLLGG
Rv2298|M.tuberculosis_H37Rv DAALGRPVVSNQVHFSLAHPDALEDLVPFAELENRIVIAYSPLAQGLLGG
MAV_4098|M.avium_104 DAALGRPVISNQVHFSLAYPKALKNLVPFAERENRIVIAYSPLEQGLLGG
MLBr_00458|M.leprae_Br4923 QQIT--EIVSVQNMYNLSAR-AAEPLLDAVTSRGIGFIPWSPLAAGPLAA
Mvan_2555|M.vanbaalenii_PYR-1 RAVA--PIVSVQNMYNLTMR-AAEPVLDACEADGIAFIPWFPLAAGPLAA
MAB_4120c|M.abscessus_ATCC_199 HAVH--PITALQNEYSLWTRDIEDEILPTIRELGIGLVAYSPLGRGFLTG
MSMEG_2920|M.smegmatis_MC2_155 HAVH--PVAAIQNEWSLFTRDIEDETVPIARELGIGIVPYSPLGRGWLTG
Mflv_4697|M.gilvum_PYR-GCK ADET--DTVPAVNQIEVHPYFANDEVRAYGTEHGIATEAWSPIAQGKVLD
. .: . . .: *: * :
MUL_2745|M.ulcerans_Agy99 KYGVDNRPAG--VRAVNPLFGTENLRRIEPLLQTLRAVAIDVDAKPAQVA
MMAR_3520|M.marinum_M KYGVDNRPAG--VRAVNPLFGTENLRRIEPLLQTLRAVATDVDAKPAQVA
Mb2320|M.bovis_AF2122/97 KYGLENRPGG--VRALNPLFGTENLRRIEPLLATLRAIAVDVDAKPAQVA
Rv2298|M.tuberculosis_H37Rv KYGLENRPGG--VRALNPLFGTENLRRIEPLLATLRAIAVDVDAKPAQVA
MAV_4098|M.avium_104 KYGVDNRPGG--VRAVNALFGTENLRRIEPLLQLLRDVAAQVDAKPAQVA
MLBr_00458|M.leprae_Br4923 PDGP------------------------------LQRIAVNHHATPSQLA
Mvan_2555|M.vanbaalenii_PYR-1 ADGP------------------------------LHRIAAEHHATPSQLA
MAB_4120c|M.abscessus_ATCC_199 AIGSRDQLAEGDFRREQPRFSAENFDANLALVEEVRSVASSIGATSAQVA
MSMEG_2920|M.smegmatis_MC2_155 RVQSRDNISG--THRDHPRFSDEAFDRNRALADTVVTVAGELGVQPGQVA
Mflv_4697|M.gilvum_PYR-GCK -------------------------------DPVVTRIAEATGKTPAQVV
: :* ..*:.
MUL_2745|M.ulcerans_Agy99 LAWLISLPG-VVAIPGASSVEQLEFNVAAADIELSADARAALTEAARAFH
MMAR_3520|M.marinum_M LAWLISLPG-VVAIPGASSVEQLEFNVAAADIELSADARAALTEAARAFH
Mb2320|M.bovis_AF2122/97 LAWLISLPG-VVAIPGASSVEQLEFNVAAADIELSAQSRDALTDAARAFR
Rv2298|M.tuberculosis_H37Rv LAWLISLPG-VVAIPGASSVEQLEFNVAAADIELSAQSRDALTDAARAFR
MAV_4098|M.avium_104 LAWLISYPG-VVAIPGASSVEQLEFNVAAADIELPAESRDALTDAALAFR
MLBr_00458|M.leprae_Br4923 LAWLLKRSPVMLPIPGTSRVAHLEENVAAAEISLSDDEFEMLSAAGAQ--
Mvan_2555|M.vanbaalenii_PYR-1 LAWLLKRSPVMLPIPGTSKVAHLEENVAAAQIDLTDAEFETLGNAGAAAS
MAB_4120c|M.abscessus_ATCC_199 LAWLLARGDDIVPIPGTTKVSRVNENVGAVDIELLPEHLVRLECLA-AAA
MSMEG_2920|M.smegmatis_MC2_155 LAWVLSRGQDVVPIPGTRHVGFLRENLCAVGIELSDDHLRRLEGIAGQVA
Mflv_4697|M.gilvum_PYR-GCK LRWHIQRGD--IVFPKSVTLQRIKDNFALFDFELGAEDFDAVSGLDKGEA
* * : : :* : : :. *. :.* :
MUL_2745|M.ulcerans_Agy99 PVSARRFLTDTVREKLGRR-----
MMAR_3520|M.marinum_M PVSARRFLTDTVREKLGRR-----
Mb2320|M.bovis_AF2122/97 PVSTGRFLTDMVREKVSRR-----
Rv2298|M.tuberculosis_H37Rv PVSTGRFLTDMVREKVSRR-----
MAV_4098|M.avium_104 PTSAARFLTDLARERIPGRG----
MLBr_00458|M.leprae_Br4923 ------------------------
Mvan_2555|M.vanbaalenii_PYR-1 ------------------------
MAB_4120c|M.abscessus_ATCC_199 GDRYN-AEHLARLEG---------
MSMEG_2920|M.smegmatis_MC2_155 GHRSARPEHLGTEAPQADSGVQNR
Mflv_4697|M.gilvum_PYR-GCK GRIGPNPDTFDYVPS---------