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TGLHLNISLMTPGHFRHAWRLPHADPLAYLDIDHFARLTRIAEAATMDAVFLGDSPALRGEIEEAPGTGL DPLVLLGHLAAITTNIGVVITSSTTYNTPYNLARRFQALDHVTKGRVAVNIVTTGTPAAAENFGLSDHPD RDTRYRRAWEFLDVVTRLWDSWEPGWLVADKQSGRYADMSKIHRIDHQGEFFSVAGPLPVAAGPQHRPVL VQAGGSDGGLKLAGDFADVVFTVAQTRAGAADFRNDIRRRAVAAGRQPDDIKLSLGVVVLVAATEAEARA RAEQLFATLPIERLTTQLLANLGLPHGEFGPDDPISVSDLPDTIPAVAFSAGFSTSLRALIAEHPCTPRE LIHRSAGGSGHRLLVGSAEQIADDLESWYRAGTADGFTIMPAETAIDLENFATLVVPILQERGLFRRGYP APTLRERFGLRFPDAEVTGHRTA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4091 | ssuD | - | 100% (444) | nitrilotriacetate monooxygenase component A |
| M. smegmatis MC2 155 | MSMEG_1162 | - | 2e-90 | 42.56% (430) | nitrilotriacetate monooxygenase component A |
| M. smegmatis MC2 155 | MSMEG_2842 | ssuD | 4e-85 | 42.00% (431) | nitrilotriacetate monooxygenase component A |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1971 | - | 5e-09 | 23.42% (333) | monooxygenase |
| M. gilvum PYR-GCK | Mflv_0250 | - | 6e-50 | 31.02% (403) | hypothetical protein Mflv_0250 |
| M. tuberculosis H37Rv | Rv1936 | - | 5e-09 | 23.42% (333) | monooxygenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4125 | - | 6e-62 | 38.35% (425) | putative nitrilotriacetate monooxygenase |
| M. marinum M | MMAR_0703 | - | 3e-57 | 33.65% (425) | FMNH2-utilizing oxygenase |
| M. avium 104 | MAV_3425 | - | 1e-79 | 41.53% (431) | nitrilotriacetate monooxygenase component A |
| M. thermoresistible (build 8) | TH_4079 | - | 1e-91 | 44.08% (431) | PUTATIVE nitrilotriacetate monooxygenase component A |
| M. ulcerans Agy99 | MUL_4507 | fgd2 | 2e-07 | 26.34% (262) | F420-dependent glucose-6-phosphate dehydrogenase Fgd2 |
| M. vanbaalenii PYR-1 | Mvan_6020 | - | 1e-69 | 35.47% (437) | xenobiotic compound DszA family monooxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_4091|M.smegmatis_MC2_155 -------MTGLHLNISLMTPGHFRHAWRLPHADP-LAYLDIDHFARLTRI
TH_4079|M.thermoresistible__bu ----------------------------LPETRL-SGITDIDHYLELARI
MAV_3425|M.avium_104 ---MSRRERGLTLNVNVLNLGIHTASWRRSAEPP-TAFTDPGYYVRMARI
Mvan_6020|M.vanbaalenii_PYR-1 ---------MMHLITWLMGNSYHAAGWRHQLAWE-RTAMRLDVLIEIAKI
MAB_4125|M.abscessus_ATCC_1997 ----MSSRNGRQLHLLAFGNVRAGGAWRLPGVRN-GPANQLNTLVATAKA
Mflv_0250|M.gilvum_PYR-GCK MTDSAKRKAHLLGFVQHGVMNHASTMWAHPRDKVGYHWSRPEYWRDLGRT
MMAR_0703|M.marinum_M ---MIRKPVHLAAHFPG---VNNTTVWADPGAGSQIEFES---FVHLART
Mb1971|M.bovis_AF2122/97 --------------------MEIGIFLMPAHPPERTLYDATRWDLDVIEL
Rv1936|M.tuberculosis_H37Rv --------------------MEIGIFLMPAHPPERTLYDATRWDLDVIEL
MUL_4507|M.ulcerans_Agy99 ------MALLFHWFLPTYGDSRGLVAGGHGLPMSGNRPATLRYLNQIAAA
MSMEG_4091|M.smegmatis_MC2_155 AEAATMDAVFLGDSPALR---------GEIEEAPGTGLDPLVLLGHLAAI
TH_4079|M.thermoresistible__bu AERGKLDAIFFADHPVLK---------GKTEFRPFDALDPVTLVTALSTA
MAV_3425|M.avium_104 AERGTLDALFLADGPAVR---------DHPALRPSQALEPSVILAAVAAE
Mvan_6020|M.vanbaalenii_PYR-1 AEEAKLDALFVADGNGVRNMDKVGLFEANTPSARPTVYDPVTLMAAISQH
MAB_4125|M.abscessus_ATCC_1997 AEAAKFDAVFFADGLNFG-------PKATWAHKSTEDFEPLTATSYLAAV
Mflv_0250|M.gilvum_PYR-GCK MERGLFDAMFIADELAPYTTYKGSSDPVVKFAGQCPVHEPASVVPIVGAF
MMAR_0703|M.marinum_M AERGLFDFFFLAEGLRLREHRGRIHDLDVVGR-----PDTFTLLAALAGV
Mb1971|M.bovis_AF2122/97 ADQLGYVEAWVGEHFTVP---------------WEPICAPDLLLAQALLR
Rv1936|M.tuberculosis_H37Rv ADQLGYVEAWVGEHFTVP---------------WEPICAPDLLLAQALLR
MUL_4507|M.ulcerans_Agy99 AESNGFEAVLTPAGLWCE--------------------DAWLTTAMLVGT
: .
MSMEG_4091|M.smegmatis_MC2_155 TTNIGVVITSSTT-YNTPYNLARRFQALDHVTKGRVAVNIVTTGTPAAAE
TH_4079|M.thermoresistible__bu TTHIGLVATASTT-YTEPYGLARRFATLDHVSRGRAGWNIVTTANAAAAA
MAV_3425|M.avium_104 TEHLGLIGTFSST-FNDPVELAHRLLSLDQLSGGRLAWNIVTTYSEAAGG
Mvan_6020|M.vanbaalenii_PYR-1 TKHIGLVGTASTT-YESPWVVARRFASLDHLSNGRASWNVVTGSNPGDSE
MAB_4125|M.abscessus_ATCC_1997 TERLGLVVTGSST-FQPPYHLARQLLSLDHLSSGRAGWNLVTSFAQAAAA
Mflv_0250|M.gilvum_PYR-GCK TKHLGIGITLSTS-FVPPYMMARQLSTLDHLTGGRVGWNIVTSYSKSEFQ
MMAR_0703|M.marinum_M TDRIGLTGTINTT-FNEPFEVARQFATLDHLSEGRAGWNIVTSSDAFTGA
Mb1971|M.bovis_AF2122/97 TQQIKLAPGAHLLPYHHPVELAHRVAYFDHLAQGRFMLGVGASGIPGDWA
Rv1936|M.tuberculosis_H37Rv TQQIKLAPGAHLLPYHHPVELAHRVAYFDHLAQGRFMLGVGASGIPGDWA
MUL_4507|M.ulcerans_Agy99 TKTLKFLVALRPG-LVSPTLAAQMATTFQQQSGGRLLVNVVTGGEAHEQR
* : . * *: ::: : ** .: :
MSMEG_4091|M.smegmatis_MC2_155 NFGLSDHPDRDTRYRRAWEFLDVVTRLWDSWEPGWLVADKQSGRYADMSK
TH_4079|M.thermoresistible__bu NFGRPAHPDPEHRYSRADEFLQVALRLWDSWEDDAIVGDKQAPRFVDPDK
MAV_3425|M.avium_104 NFGLADLPDRSTRYRRAAEFVDVALALWR-----------------DAAT
Mvan_6020|M.vanbaalenii_PYR-1 NFGLAHHPDRDSRYARAEEFVSACKALWNSWDEDAFVERKDTGQYLNARK
MAB_4125|M.abscessus_ATCC_1997 NFGERGFLPHDERYRLAEETLQVVKSLWHSLEPDTVIEDRAAGIYSDINK
Mflv_0250|M.gilvum_PYR-GCK AMGKENLTPRDKRYEVVEEYMQLLYQLWDSWDDDAIVYDRDNGVFADPAK
MMAR_0703|M.marinum_M NFRRGGYLDHADRYQRAEEFLTVARKFWDSWAPGAVLADIENGDYVDPER
Mb1971|M.bovis_AF2122/97 LYDVDGK--NGEHREMTREALEIMLRIWTEDEP-----------WEHRGK
Rv1936|M.tuberculosis_H37Rv LYDVDGK--NGEHREMTREALEIMLRIWTEDEP-----------WEHRGK
MUL_4507|M.ulcerans_Agy99 AYG--DFLDKQQRYRRTGEFLHVVRQLWASGQP-----------------
: . * : :*
MSMEG_4091|M.smegmatis_MC2_155 IHRIDHQGEFFSVAGPLPVAAGPQHRPVLVQAGGSD--GGLKLAGDFADV
TH_4079|M.thermoresistible__bu IHAIDHRGEHFSVAGPLEVPRSPQGHPVLFQAGSSE--PGKQLAAKYAEA
MAV_3425|M.avium_104 GGGVDHRGEFFAVTGSLPQGPSPQGHPLLVQAGGSP--QGRELAGRVADA
Mvan_6020|M.vanbaalenii_PYR-1 VRVPDYKGRHLSVKGPLNVSRSPQGRPVLFHAGQSE--GGRRLAARHADC
MAB_4125|M.abscessus_ATCC_1997 IHVANHDGEFHKVKGPLGVTPSRQGHPVIFQAGSST--TGRAFAARHAEV
Mflv_0250|M.gilvum_PYR-GCK VREVNFQGEFFQSRGRHFVAPSPQKRPVLWQAGSSA--QGREFASRHAES
MMAR_0703|M.marinum_M IRSVEHSGPQFEVRGFATLPAGPQGHPVLLQAGDSE--QGRAFGARHADA
Mb1971|M.bovis_AF2122/97 YWNANGIAPMFEGLMRRHIKPYQKPHPPIGVTGFSAGSETLKLAGERGYI
Rv1936|M.tuberculosis_H37Rv YWNANGIAPMFEGLMRRHIKPYQKPHPPIGVTGFSAGSETLKLAGERGYI
MUL_4507|M.ulcerans_Agy99 ---VTFEGEHIHVH-QAQLGRLPDPPPPVFFGGSSE--SAGAVAARYADT
. . * : * * ... .
MSMEG_4091|M.smegmatis_MC2_155 VFTVAQTRAGAADFRNDIRRRAVAAGRQPDDIKLSLGVVVLVAATEAEAR
TH_4079|M.thermoresistible__bu IFTAQPTVEEARQFYADVKARVRQHGRDPDRVHILPGLSAIIGGTEEEAR
MAV_3425|M.avium_104 VFSAELDLDAAIEHYRYVKDAAVAHGRGRDAVRILPGLITTIGSSRAEAQ
Mvan_6020|M.vanbaalenii_PYR-1 IFEAAASVEAAREFYADLKRRRVEIGGEPDHLRIIVSVAVYLGRTESEAV
MAB_4125|M.abscessus_ATCC_1997 VFTGQTDVERAKNFYRQLHQEARAAGR-TFAPLVTPSLGVVVGSTEAEAL
Mflv_0250|M.gilvum_PYR-GCK VFGIFPTPKSMRAYATDIRTRASDAGRDPESVKLIYGLQTIIDRDKGRAN
MMAR_0703|M.marinum_M MFTLHSSLRDGQRYYADVKGRARSYGRDPDQLKVFPAATFVIGDTPDQAG
Mb1971|M.bovis_AF2122/97 PMSLDLNTEYVATHWDAVEEGALRSGRTPDRRDWRLVREVLVAETDEQAF
Rv1936|M.tuberculosis_H37Rv PMSLDLNTEYVATHWDAVEEGALRSGRTPDRRDWRLVREVLVAETDEQAF
MUL_4507|M.ulcerans_Agy99 YLTWGEPLSAVGKKIDWIRGLAADHGR---ALSYGLRIHVITRDTAEEAW
: :. * .*
MSMEG_4091|M.smegmatis_MC2_155 ARAEQL-FATLPIERLTTQLLANLGLPHGEFGPDDPISVSDL---PDTIP
TH_4079|M.thermoresistible__bu RIQRRL-EDLTVPDYGLEQLSRIVGYRVGRDDLDRRLQFG-----SDDPP
MAV_3425|M.avium_104 RRYEEQ-NALLPAGHDVERLSQTLGADLSGLPLDEPIPARLLGS-VPDPS
Mvan_6020|M.vanbaalenii_PYR-1 ELYSEL-NSLISPDLGVDFLAKAVSEDLTGYPVDGPMPDLS--------A
MAB_4125|M.abscessus_ATCC_1997 AAESTI-YEHFIPEYQAGWLLE-VDVNVVGADLDGPVPASAF------PD
Mflv_0250|M.gilvum_PYR-GCK DRYAEF-VENVQIESALGILSGHTGFDFSTLGLDDNVVDAD-------VQ
MMAR_0703|M.marinum_M EKARQISYQQVSGATAIAMLEQVWGRDLSDYDPDGPLPDIDPIADAAISQ
Mb1971|M.bovis_AF2122/97 RYAVDG---TMGRAMREYVLPTFRMFGMTKFYKHNPSVPDD---------
Rv1936|M.tuberculosis_H37Rv RYAVDG---TMGRAMREYVLPTFRMFGMTKFYKHNPSVPDD---------
MUL_4507|M.ulcerans_Agy99 RVADRL-------------LAGIDPADIERMQANLARSESE---------
* .
MSMEG_4091|M.smegmatis_MC2_155 AVAFSAGFSTSLRALIAEHPCTPRELIHR-SAGGSGHRLLVGSAEQIADD
TH_4079|M.thermoresistible__bu AIHMQSRY-ALVRRLVSTENLTVRELLLR-LSGGRGHRVFAGTPEQVADT
MAV_3425|M.avium_104 KFVGSLGFRESVVRLVVSGGLTLRQTLRA-FSG-SGHRVIVGSPVDVADT
Mvan_6020|M.vanbaalenii_PYR-1 PVVGGNSIRGQLDAIAKAEQLTVRQMYER-VVPTMGNTALIGTATQIADV
MAB_4125|M.abscessus_ATCC_1997 STETHQTALAGYKHLATVGNPTVREFLYR-TLNAFGTR-FVGSAEQVADQ
Mflv_0250|M.gilvum_PYR-GCK GIRGLFDAILEAKDGAPVTVREAAQIYGV-SMGAP---VAVGTPADVADQ
MMAR_0703|M.marinum_M GRVRHADPVAVARRYRERSQAENLSIREL-VIAVTSRQQFVGTPSHIADE
Mb1971|M.bovis_AF2122/97 --EVTPEYLAENTFVVGSVQTVVDKLEAT-YDQVGGFGHLLILGFDYSDN
Rv1936|M.tuberculosis_H37Rv --EVTPEYLAENTFVVGSVQTVVDKLEAT-YDQVGGFGHLLILGFDYSDN
MUL_4507|M.ulcerans_Agy99 ---GQRRMAELHGGVLDQLEIAPNLWAGVGLVRGGAGTALVGSHQEVAER
. ::
MSMEG_4091|M.smegmatis_MC2_155 LESWYRAGTADGFTIMPAETAIDLENFATLVVPILQERGLFRRGYPAPTL
TH_4079|M.thermoresistible__bu IEEWFTTGAADGFNLIPPALPSSLTAFVDHVVPELQRRGLFRTEYTGTTL
MAV_3425|M.avium_104 IEQWFGAGAADGFNLMPDVFPDGLEVFVDEVVPILRSRGLFRASYAEATL
Mvan_6020|M.vanbaalenii_PYR-1 MEEWYTTGACDGFVLGASISPFTLLLIRDELVPELQRRGLFRRHYTGSTL
MAB_4125|M.abscessus_ATCC_1997 IELWFSEGAADGFILSTSGLPGQFELFTEHVVPILVRRGLFRAEYTGSTL
Mflv_0250|M.gilvum_PYR-GCK MEQYLDEGDCNGFMMLATDTPGCFNDMTELLVPELQKRGRFRTRYPGTTL
MMAR_0703|M.marinum_M IDRYVQADACDGFILVPHLTPHGLDEFVDRVVPLLQERGAFRTAYTGQTL
Mb1971|M.bovis_AF2122/97 PGPWKES----------------LRLLAHEVMPRLNARLATKPATAVV--
Rv1936|M.tuberculosis_H37Rv PGPWKES----------------LRLLAHEVMPRLNARLATKPATAVV--
MUL_4507|M.ulcerans_Agy99 IIEYARLG-ISHFILSGYPHLEEAYWFGEGVLPILERKRLWHRPHGSSPH
: : ::* * : :
MSMEG_4091|M.smegmatis_MC2_155 RERFGLRFPDAEVTGHRTA----
TH_4079|M.thermoresistible__bu RDHLGLPRPRNRFTTGRPVAAAS
MAV_3425|M.avium_104 RERL---------TGDRHVVAA-
Mvan_6020|M.vanbaalenii_PYR-1 RENLGLP------PVDNSPFAT-
MAB_4125|M.abscessus_ATCC_1997 REHLALPWP---VPARPPALLA-
Mflv_0250|M.gilvum_PYR-GCK RESLREY----------------
MMAR_0703|M.marinum_M RDHLGLAGLPS------------
Mb1971|M.bovis_AF2122/97 -----------------------
Rv1936|M.tuberculosis_H37Rv -----------------------
MUL_4507|M.ulcerans_Agy99 SAALPVAHSSVN-----------