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MEIGIFLMPAHPPERTLYDATRWDLDVIELADQLGYVEAWVGEHFTVPWEPICAPDLLLAQALLRTQQIK LAPGAHLLPYHHPVELAHRVAYFDHLAQGRFMLGVGASGIPGDWALYDVDGKNGEHREMTREALEIMLRI WTEDEPWEHRGKYWNANGIAPMFEGLMRRHIKPYQKPHPPIGVTGFSAGSETLKLAGERGYIPMSLDLNT EYVATHWDAVEEGALRSGRTPDRRDWRLVREVLVAETDEQAFRYAVDGTMGRAMREYVLPTFRMFGMTKF YKHNPSVPDDEVTPEYLAENTFVVGSVQTVVDKLEATYDQVGGFGHLLILGFDYSDNPGPWKESLRLLAH EVMPRLNARLATKPATAVV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1936 | - | - | 100% (369) | POSSIBLE MONOOXYGENASE |
| M. tuberculosis H37Rv | Rv3618 | - | 1e-42 | 31.75% (378) | monooxygenase |
| M. tuberculosis H37Rv | Rv3520c | - | 3e-11 | 23.60% (267) | coenzyme F420-dependent oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1971 | - | 0.0 | 100.00% (369) | monooxygenase |
| M. gilvum PYR-GCK | Mflv_4429 | - | 7e-36 | 30.50% (377) | luciferase family protein |
| M. leprae Br4923 | MLBr_00348 | - | 3e-12 | 23.44% (273) | putative coenzyme F420-dependent oxidoreductase |
| M. abscessus ATCC 19977 | MAB_0527c | - | 1e-35 | 28.88% (374) | monooxygenase |
| M. marinum M | MMAR_2864 | - | 0.0 | 95.88% (364) | oxygenase |
| M. avium 104 | MAV_0538 | - | 2e-42 | 32.10% (377) | limonene 1,2-monooxygenase |
| M. smegmatis MC2 155 | MSMEG_6107 | - | 1e-42 | 31.30% (377) | limonene 1,2-monooxygenase |
| M. thermoresistible (build 8) | TH_0993 | - | 4e-39 | 30.24% (377) | POSSIBLE MONOOXYGENASE |
| M. ulcerans Agy99 | MUL_2890 | - | 0.0 | 95.33% (364) | oxygenase |
| M. vanbaalenii PYR-1 | Mvan_4004 | - | 0.0 | 90.79% (369) | luciferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6107|M.smegmatis_MC2_155 --MRPLNFGVFITPFHPAGQSPTTALQYDMDRVEALDRLGYDEAWFGEHH
TH_0993|M.thermoresistible__bu -VARPLNFGVFITPFHPVGQSPTLALEYDLERTVALDRLGYDEVWFGEHH
MAV_0538|M.avium_104 -MSAPLRFGVFITPFHPVGQSPTVALEYDLERVVALDRLGFDEAWFGEHH
MAB_0527c|M.abscessus_ATCC_199 MSAPPLRFGAFITPFHPVGQNPTTALEYDLDRVVALDRLGYHEAWFGEHH
Mflv_4429|M.gilvum_PYR-GCK -----MRFGNFMAPFHPVGQNPTLALERDLDLIVAMDRLGFHEAWVGEHH
Rv1936|M.tuberculosis_H37Rv -----MEIGIFLMPAHPPERTLYDATRWDLDVIELADQLGYVEAWVGEHF
Mb1971|M.bovis_AF2122/97 -----MEIGIFLMPAHPPERTLYDATRWDLDVIELADQLGYVEAWVGEHF
MMAR_2864|M.marinum_M -----MEIGIFLMPAHPPERTLYDATQWDLDIIELADQLGYVEAWVGEHF
MUL_2890|M.ulcerans_Agy99 -----MEIGIFLMPAHPPERTLYDAAQWDLDIIELADQLGYVEAWVGEHF
Mvan_4004|M.vanbaalenii_PYR-1 -----MEIGIFLMPAHPPERSLYDATQWDLEIIELADELGYVEAWVGEHF
MLBr_00348|M.leprae_Br4923 ----MVERANAMKLGLQLGYWAAQPPGNAAELVAAAEGAGFDAVFTGEAW
:. . : . : : *: .: **
MSMEG_6107|M.smegmatis_MC2_155 SGGYELIACPEVFIAAAAERTRHIRLGTGVVSLPYHHPLMVADRWVLLDH
TH_0993|M.thermoresistible__bu SGGYELIASPEVFIAAAAERTRHVRLGTGVVSLPYHHPLMVADRWVLLDH
MAV_0538|M.avium_104 SGGYELIACPEVFIATAAERTKHIRLGTGVVSLPYHHPLMVADRWVLLDH
MAB_0527c|M.abscessus_ATCC_199 SGGYELISCPEVFIATAAERTKHIKLGTGVVSLPYHHPLMVVDRWILLDH
Mflv_4429|M.gilvum_PYR-GCK SAGFEIIASPEVFLGVAAERTKHIRLGTGVSSLPYHHPLMLADRMVLLDH
Rv1936|M.tuberculosis_H37Rv TVPWEPICAPDLLLAQALLRTQQIKLAPGAHLLPYHHPVELAHRVAYFDH
Mb1971|M.bovis_AF2122/97 TVPWEPICAPDLLLAQALLRTQQIKLAPGAHLLPYHHPVELAHRVAYFDH
MMAR_2864|M.marinum_M TVPWEPICAPDLLLAQALLRTKQIKLAPGAHLLPYHHPVELAHRVAYFDH
MUL_2890|M.ulcerans_Agy99 TVPWEPICAPDLLLAQALLRTKQIKLAPGAHLLPYHHPVELAHRVAYFDH
Mvan_4004|M.vanbaalenii_PYR-1 TVPWEPICAPDLLLAQALLRTKSIKLAPGAHLLPYHHPVELAHRVAYLDH
MLBr_00348|M.leprae_Br4923 GS------DAYTPLAWWGSSTQRVRLGTSVVQLSARTPTACAMAALTLDH
. :. *: ::*.... *. : * . :**
MSMEG_6107|M.smegmatis_MC2_155 LTRGRVMFGTGPGALPSDAYMMGIDPV--DQRPMMQESLEAILALFRAE-
TH_0993|M.thermoresistible__bu ITRGRVMFGAGPGALPSDAYMMGIDPV--NQRPMMQEALEAILALLRAA-
MAV_0538|M.avium_104 LTRGRVMFGTGPGALPSDAYMMGIDPV--DQRHMMQESLEAILALFRAA-
MAB_0527c|M.abscessus_ATCC_199 ITRGRVIFGTGPGALPTDAYMMGIDPV--DQRRMQEESLEAILALLRAT-
Mflv_4429|M.gilvum_PYR-GCK LTRGRVMLGCGPGQLTSDAHMLGIPAD--EQRPRMEQCLDAIVRLLRG--
Rv1936|M.tuberculosis_H37Rv LAQGRFMLGVGASGIPGDWALYDVDGKNGEHREMTREALEIMLRIWTEDE
Mb1971|M.bovis_AF2122/97 LAQGRFMLGVGASGIPGDWALYDVDGKNGEHREMTREALEIMLRIWTEDE
MMAR_2864|M.marinum_M LAQGRFMLGVGASGIPGDWALYDVDGKNGEHREMTREALEIMLRIWTEDQ
MUL_2890|M.ulcerans_Agy99 LAQGRFMLGVGASGIPGDWALYDVDGKNGEHREMTREALEIMLRIWTEDQ
Mvan_4004|M.vanbaalenii_PYR-1 LAQGRFMLGVGASGIPGDWALFDVDGQNGEHREMTREALEIMLKVWTEDD
MLBr_00348|M.leprae_Br4923 LSGGRHILGLGVSGPQVVEGWYGQPFP--KPLSRTREYIDIVRQVWAREA
:: ** ::* * . . . .: :: : :
MSMEG_6107|M.smegmatis_MC2_155 PGERIDRKTDWFTLR-----DAALHIRPYTWPY-PEISTAAMIS-PSGPR
TH_0993|M.thermoresistible__bu PDERISRETDWFTLR-----DAQLHIRPYTWPY-PEISTAAMIS-PSGPR
MAV_0538|M.avium_104 PTERIDRHSDWFTLR-----DAQLHIRPYTWPY-PEISTAAMIS-PSGPR
MAB_0527c|M.abscessus_ATCC_199 PQERINRETSWFTLR-----DAQLQLRPYTHPY-PEILTAAMFS-PSGPR
Mflv_4429|M.gilvum_PYR-GCK --ETVTMHTDGFTLQ-----DARLQLKPYSEPC-FDIAVAASFS-PTGPR
Rv1936|M.tuberculosis_H37Rv PWEHRGKYWNANGIAPMFEGLMRRHIKPYQKPH-PPIGVTGFSAGSETLK
Mb1971|M.bovis_AF2122/97 PWEHRGKYWNANGIAPMFEGLMRRHIKPYQKPH-PPIGVTGFSAGSETLK
MMAR_2864|M.marinum_M PWEHRGKYWNANGIAPMFEGLMRRHIKPYQKPH-PPIGVTGFSAGSETLK
MUL_2890|M.ulcerans_Agy99 PWEHRGKYWNANGIAPMFEGLMRRHIKPYQKPH-PPIGVTGFSAGSETLK
Mvan_4004|M.vanbaalenii_PYR-1 PWEFRGKYWNANGIAPMFEGLMRRHIKPFQAPH-PPIGVTGFSAGSETLK
MLBr_00348|M.leprae_Br4923 PVVSDGQHYP-LPLTGAGATGLGKALKPITHPLRADIPIMLGAEGPKNVA
: ::* * * .
MSMEG_6107|M.smegmatis_MC2_155 LAGKLGTSLLSLSMSVPGGYAAVETTWNVVRDEAAAAGRPEPDRENWRVL
TH_0993|M.thermoresistible__bu LAGSLGTSLLSLSMSVPGGYAAVENTWDVVVQQAAKAGRPEPDRANWRVL
MAV_0538|M.avium_104 LAGALGTSLLSLSMSVPGGYAALETTWDVVREQAAKAGRDEPDRGDWRVL
MAB_0527c|M.abscessus_ATCC_199 LAGKLGAGLLSLSASIPGGFAALENAWEVVREQAEIHGHPEPDRSSWRVL
Mflv_4429|M.gilvum_PYR-GCK GAGRHGIGMLSIAATARQGMDLLAQHWNTWDEVAREHGH-QADRSKWRLV
Rv1936|M.tuberculosis_H37Rv LAGERGYIPMSLDLNT----EYVATHWDAVEEGALRSGR-TPDRRDWRLV
Mb1971|M.bovis_AF2122/97 LAGERGYIPMSLDLNT----EYVATHWDAVEEGALRSGR-TPDRRDWRLV
MMAR_2864|M.marinum_M LAGERGYLPMSLDLNT----EYVATHWDAVLEGAARSGR-TPDRRDWRLV
MUL_2890|M.ulcerans_Agy99 LAGERGYLPMSLDLNT----EYVATHWDAVLEGAARSGR-TPDRRDWRLV
Mvan_4004|M.vanbaalenii_PYR-1 LAGERGYLPMSLDLNT----DYVATHWDAVLEGAARSGR-TPDRRDWRLV
MLBr_00348|M.leprae_Br4923 LAAEICDGWLPIFFSP-----RMADMYNEWLDEGFARTGARRSREDFEIC
*. :.: . : :: : . .* .:.:
MSMEG_6107|M.smegmatis_MC2_155 GIVHLADTREQAIEDCTYGLQ--DFANYFGAAGFVPLSNQAEGGG---TP
TH_0993|M.thermoresistible__bu GIVHLADTREQALQDCTYGLQ--DFANYFGAAGFVPLANEVAGGQ---SP
MAV_0538|M.avium_104 SIMHIADSREQAIDDCTYGLQ--DFANYFGAAGFVPLANSVEGTQ---TP
MAB_0527c|M.abscessus_ATCC_199 GIMHLAETRDQAIADCTYGLP--DYAHYFGAVGVLPLANSADGADGAIDP
Mflv_4429|M.gilvum_PYR-GCK GPMHLAETREQAERDVEYGIA--EFSRYF--THILPSG-PVQGDT----P
Rv1936|M.tuberculosis_H37Rv REVLVAETDEQAFRYAVDGTMGRAMREYVLPTFRMFGMTKFYKHNPSVPD
Mb1971|M.bovis_AF2122/97 REVLVAETDEQAFRYAVDGTMGRAMREYVLPTFRMFGMTKFYKHNPSVPD
MMAR_2864|M.marinum_M REVLVAETDEQAFRYAVDGTMGRAMREYVLPTFRMFGMTKFYKHNPSVPD
MUL_2890|M.ulcerans_Agy99 REVLVAETDEQAFRYAVDGTMGRAMREYVLPTFRMFGMTKFYKHNPSVPD
Mvan_4004|M.vanbaalenii_PYR-1 REVVVAETDEQAFRYAVDGMMGRNMREYVLPTFRMFGMTKFYKHNPSVPD
MLBr_00348|M.leprae_Br4923 ASAQIVVTEDRAAAFAGIKPFLALYMGGMGAEGTNFHADVYRRMGYAEVV
:. : ::* .
MSMEG_6107|M.smegmatis_MC2_155 YEFVENYASKGNCCIGTPDDAIVYIQDLLDRS-GGFGTFLLLGHDWAP-P
TH_0993|M.thermoresistible__bu REFVEAYAEKGNCCIGTPGDAIVYLSDLLERS-GGFGTFLMLGHDWAS-P
MAV_0538|M.avium_104 HEFVAEYAAKGNCCIGTPEDAIAHIEDLLDRS-GGFGTLLMLGHDWAS-P
MAB_0527c|M.abscessus_ATCC_199 HEFVKAYADEGNCCIGTPEDAIEYIQGLLDTS-GGFGTFLMLGHDWAA-P
Mflv_4429|M.gilvum_PYR-GCK EEIIANNRQSGFAVIGTPDDAIAKISELVEASDGGFGAFLLFDHDWAP-P
Rv1936|M.tuberculosis_H37Rv DEVTPEYLAENTFVVGSVQTVVDKLEATYDQV-GGFGHLLILGFDYSDNP
Mb1971|M.bovis_AF2122/97 DEVTPEYLAENTFVVGSVQTVVDKLEATYDQV-GGFGHLLILGFDYSDNP
MMAR_2864|M.marinum_M DDVTPEYLAENTFVVGSVDTVVDKLEATYDQV-GGFGHLLVLGFDYRENP
MUL_2890|M.ulcerans_Agy99 DDMTPEYLAENTFVVGSVDTVVDKLEATYDQV-GGFGHLLVLGFDYRENP
Mvan_4004|M.vanbaalenii_PYR-1 DDVTPEYLAENTFVVGSVETVVDKLEATYDQV-GGFGHLLILGFDYRDDP
MLBr_00348|M.leprae_Br4923 DEVTALFRSN------QKDKAAEIIPNELVDS-----TMIVGDVDYVCKQ
:. . . : ::: . *:
MSMEG_6107|M.smegmatis_MC2_155 AATFHSYELFAREVIPHFKGQLTAARASHDWAKGMRDQLLGRAGQAIVNA
TH_0993|M.thermoresistible__bu QATYHSYELFAREVIPHFKGQLTAPRASHDWAKQMRGQLLGRAGEAIVKA
MAV_0538|M.avium_104 EATYHCYDLMARKVIPHFKRQLDASRASHDWAKGMRDQLLGRAGEAVVKA
MAB_0527c|M.abscessus_ATCC_199 EATFKSYELFARKVIPHFTGQLTAAQASHDWAQAKRGELLGRAGDAVAKA
Mflv_4429|M.gilvum_PYR-GCK AAKLRSYELFAQYVIPHFTGQLSAPIASRDWVTESGRVFVDQATHAIGRA
Rv1936|M.tuberculosis_H37Rv GPWKESLRLLAHEVMPRLNARLATKP---------ATAVV----------
Mb1971|M.bovis_AF2122/97 GPWKESLRLLAHEVMPRLNARLATKP---------ATAVV----------
MMAR_2864|M.marinum_M GPWKESLRLLAEEVMPRLNARIAKKPGGPHKPPKPEAAIV----------
MUL_2890|M.ulcerans_Agy99 GPWKESLRLLAEEVMPRLNARIANKPGGPHKPPKPEAAIV----------
Mvan_4004|M.vanbaalenii_PYR-1 GPWKESMRLLAEEVMPRLNARIAKKP---------RIALV----------
MLBr_00348|M.leprae_Br4923 IAAWSAAGVTMMMVSASSVEQVRDLAGLF---------------------
. . : * . ::
MSMEG_6107|M.smegmatis_MC2_155 ITEHTQAHPAENEN---
TH_0993|M.thermoresistible__bu IGEHTSEQEQR------
MAV_0538|M.avium_104 ISEHVDEHKDAVH----
MAB_0527c|M.abscessus_ATCC_199 IGEHVAQKASH------
Mflv_4429|M.gilvum_PYR-GCK IESHAAEQQAKQSRTSD
Rv1936|M.tuberculosis_H37Rv -----------------
Mb1971|M.bovis_AF2122/97 -----------------
MMAR_2864|M.marinum_M -----------------
MUL_2890|M.ulcerans_Agy99 -----------------
Mvan_4004|M.vanbaalenii_PYR-1 -----------------
MLBr_00348|M.leprae_Br4923 -----------------