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MELRHLRYFLVVVEEGSLGRAAARLHVAQPSLGRQMTDLEHQLGQRLFERAARGMRMTPAARALVAHARE IIRLADASREVVASGVPRERVSLGVGPTVDADWLLAVVEAAKAQSPHLTLRIDEMLSGELVNGVASGELD VAVSSRRPGDQLQSVLLWTEPFGLAISPSGRLKGLDGVAHGDVDHARVLAFAREQTPPEHNEAIREIQTE SPRVRWEFARFSTSAYANARAVDADAILCGEAAARRLPATWRWLPLGRLRTEMHAWLTWRPGSGDGVLQL VELIKGIAPPSGARLGSRAPMT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1799 | - | - | 100% (302) | transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_3840 | - | 5e-21 | 42.28% (149) | LysR-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_1895 | - | 6e-19 | 36.81% (163) | HTH-type transcriptional regulator AlsR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2303c | - | 2e-08 | 38.24% (68) | LysR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1356 | - | 1e-18 | 30.08% (266) | LysR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv2282c | - | 2e-08 | 38.24% (68) | LysR family transcriptional regulator |
| M. leprae Br4923 | MLBr_02041 | oxyR | 5e-13 | 31.98% (172) | putative LysR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_2238 | - | 3e-19 | 36.55% (145) | LysR family transcriptional regulator |
| M. marinum M | MMAR_2756 | oxyR | 4e-12 | 29.44% (180) | hydrogen peroxide-inducible genes activator, OxyR |
| M. avium 104 | MAV_3102 | - | 1e-15 | 31.17% (154) | LysR substrate binding domain-containing protein |
| M. thermoresistible (build 8) | TH_3504 | - | 5e-11 | 27.59% (145) | PUTATIVE putative transcriptional regulator |
| M. ulcerans Agy99 | MUL_2998 | oxyR | 3e-12 | 29.44% (180) | hydrogen peroxide-inducible genes activator, OxyR |
| M. vanbaalenii PYR-1 | Mvan_1027 | - | 9e-19 | 30.04% (233) | LysR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1356|M.gilvum_PYR-GCK MVSAVTGRPTNDPPHTWRHRTIKEPPMELRHLRYFLAVAETCHFGQAAEQ
Mvan_1027|M.vanbaalenii_PYR-1 -------------------------MFSLARLSCFVAVAEELHFGRAAER
MMAR_2756|M.marinum_M -----------MLATILIGMTDKSYQPTLAGLRAFVAVAEKQHFGSAANA
MUL_2998|M.ulcerans_Agy99 ----------------MIGITDKSYQPTLAGLRAFVAVAEKQHFGSAANA
MLBr_02041|M.leprae_Br4923 -------------------MSDKSYQPTIAGLRAFVAVVEKGHFSAAASF
Mb2303c|M.bovis_AF2122/97 -------------------MPLSSRMPGLTCFEIFLAIAEAGSLGGAARE
Rv2282c|M.tuberculosis_H37Rv -------------------MPLSSRMPGLTCFEIFLAIAEAGSLGGAARE
MAB_2238|M.abscessus_ATCC_1997 --------------------------MEIHQLRYLLAVADTSSFTKAAAA
TH_3504|M.thermoresistible__bu ---------------------VPSPKIDLRRLAQFVAVAELGSFTRAAAT
MAV_3102|M.avium_104 --------------------------MDTHRLKYFLRIAEQGSITGAAAS
MSMEG_1799|M.smegmatis_MC2_155 --------------------------MELRHLRYFLVVVEEGSLGRAAAR
: :: :.: : **
Mflv_1356|M.gilvum_PYR-GCK LHIAQPALSYAIRQLENSLDATLFTRTTRHVALTPAGEFLRVEATRILNG
Mvan_1027|M.vanbaalenii_PYR-1 LHMTQPPLSRQVQQLENELGVQLIDRTTRNVTLTPAGAAFLPDARRILQL
MMAR_2756|M.marinum_M LGVSQSTLSQALAALEAGLDLHLVERSTRRVFLTTEGRSLLPHAQAAVEA
MUL_2998|M.ulcerans_Agy99 LGVSQSTLSQALAALEAGLDLHLVERSTRRVFLTTEGRSLLPHAQAAVEA
MLBr_02041|M.leprae_Br4923 LGVRQSTLSQALAALESGLGVQLIERSTRRVFVTTQGRHLLPRAQAAIEA
Mb2303c|M.bovis_AF2122/97 LGLTQQAVSRRLASMEAQIGVRLAIRTTRGSQLTPAGIVVAEWAARLLEV
Rv2282c|M.tuberculosis_H37Rv LGLTQQAVSRRLASMEAQIGVRLAIRTTRGSQLTPAGIVVAEWAARLLEV
MAB_2238|M.abscessus_ATCC_1997 LHVAQPGVSAQIRLLERELGQDLFDRSGRQVRLTDAGKAVIPYARAALAA
TH_3504|M.thermoresistible__bu LHLSQQALSSAVRALENDVGADLFTRDGRRISLTTAGRTLLAEGKPLLAA
MAV_3102|M.avium_104 LGIAQPALSRQIRLLEEDLGVALFRRTRRGVQLTEEGERLRASTAAPLRQ
MSMEG_1799|M.smegmatis_MC2_155 LHVAQPSLGRQMTDLEHQLGQRLFERAARGMRMTPAARALVAHAREIIRL
* : * :. : :* :. * * * :* . . :
Mflv_1356|M.gilvum_PYR-GCK VDAAQRGVRRIAAGRSGLLRLGLTGTAAFSHLPKIARIVR----QELPAV
Mvan_1027|M.vanbaalenii_PYR-1 AEGAAQTVKRIPAGDLGTVVVGFTAASAHAVLPRLLERAR----ERLPDV
MMAR_2756|M.marinum_M VEAFTTAAAGEADPLNGSIRFGIIPTVAPYVLPTVLAGLT----RRLPTL
MUL_2998|M.ulcerans_Agy99 VEAFTTAAAGEADPLNGSIRFGIIPTVAPYVLPTVLAGLT----RRLPTL
MLBr_02041|M.leprae_Br4923 MDAFTAAAAGESDPLRGGMRLGLIPTVAPYVLPTMLTGLT----HRLPTL
Mb2303c|M.bovis_AF2122/97 ADEIDAGLGSLRTEGRQRIRVVASQTIAEQLMPHWMLSLRAADMRRGGTV
Rv2282c|M.tuberculosis_H37Rv ADEIDAGLGSLRTEGRQRIRVVASQTIAEQLMPHWMLSLRAADMRRGGTV
MAB_2238|M.abscessus_ATCC_1997 VDGVREAADEIGGLIRGHIAFGTVTSHGADLSSLLSAFHR-----DHPAI
TH_3504|M.thermoresistible__bu ARTVAEHVRQTEAAAQAHYVIGHTPALSGAEAYALIEPAVT----AYPST
MAV_3102|M.avium_104 LELAMQYAGSPIARLARGVRLGILDTTVDVFAAHLLSSLA----AAFPKV
MSMEG_1799|M.smegmatis_MC2_155 ADASREVVAS--GVPRERVSLGVGPTVDADWLLAVVEAAK----AQSPHL
. :
Mflv_1356|M.gilvum_PYR-GCK ALDIHADLLTPDQCEGLRTGALDVGVLRPPAV-GGDVATRTIAAEPLVLA
Mvan_1027|M.vanbaalenii_PYR-1 KLDLR-EMVTAAQIEGLMTGELDLGMARPPLK-RPGLVSRPLLHEQLLAA
MMAR_2756|M.marinum_M TVRVI-EDQTERLLTALREGSLDTALIALPAD-YGGLTEIPIYEEDFVLA
MUL_2998|M.ulcerans_Agy99 TVRVI-EDQTERLLTALREGSLDTALIALPAD-YGGLTEIPIYEEDFVLA
MLBr_02041|M.leprae_Br4923 TLRVV-EDQTEHLLTALREGALDAAMIALPVE-TAGIAEIPIYDEDFVLA
Mb2303c|M.bovis_AF2122/97 PEVILTATNSEHAIAAVRDGIADLGFIENPCP-PTGLGSVVVARDELVVV
Rv2282c|M.tuberculosis_H37Rv PEVILTATNSEHAIAAVRDGIADLGFIENPCP-PTGLGSVVVARDELVVV
MAB_2238|M.abscessus_ATCC_1997 SITLT-EAGCEELVAGLREGRLDGAIVALGAQRLAGLGLQVIDDQPLVAA
TH_3504|M.thermoresistible__bu SFTLR-QLYPDALTDAVFDGTVQLGLRRGVVP-TPELATAVIGYHRVRVA
MAV_3102|M.avium_104 TFSVE-TGSTDQLVEAMLKGAVDVAVINPVPD--DRIFYRDLLTEDLVVV
MSMEG_1799|M.smegmatis_MC2_155 TLRID-EMLSGELVNGVASGELDVAVSSRRPG--DQLQSVLLWTEPFGLA
: .: * : .. : : . . .
Mflv_1356|M.gilvum_PYR-GCK VSADHRLAAEP-VVSLADLRSEPFIGYT-GQDSAVNDAVTRSCRA---AG
Mvan_1027|M.vanbaalenii_PYR-1 LPEGHPLADMTRELTLIDLDGQDFVMYSPVQARYFNELLISTFTI---AG
MMAR_2756|M.marinum_M LPPGHPMADRH-GVPVAALSELPLLLLD--EGHCLRDQALDVCQN---AG
MUL_2998|M.ulcerans_Agy99 LPPGHPMADRH-GVPVAALSELPLLLLD--EGHCLRDQALDVCQN---AG
MLBr_02041|M.leprae_Br4923 LPPGHPLSGKR-RVPTTALAQLPLLLLD--EGHCLRDQTLDICRK---SG
Mb2303c|M.bovis_AF2122/97 VPPGHKWARRSRVVSARELAQTPLVTRE--PNSGIRDSLTAALRDTLGED
Rv2282c|M.tuberculosis_H37Rv VPPGHKWARRSRVVSARELAQTPLVTRE--PNSGIRDSLTAALRDTLGED
MAB_2238|M.abscessus_ATCC_1997 VAADDLLATRR-TITLQRLCEHTLICLP--TGSGVRSILESECRS---LG
TH_3504|M.thermoresistible__bu FVDSHPLAARE-SVDITELAREQVALWAPPGTSYYSDFLMGACRR---AG
MAV_3102|M.avium_104 GAATSGLDSGQ-MMPFTELVELPLVVPR--SHTGIGNVIENAALR----R
MSMEG_1799|M.smegmatis_MC2_155 ISPSGRLKGLD-GVAHGDVDHARVLAFAREQTPPEHNEAIREIQT-----
: : . .
Mflv_1356|M.gilvum_PYR-GCK FVPHREHS-APGTAVLLALVAADLGVSVVPASVRALPLHGVVFRDL--VD
Mvan_1027|M.vanbaalenii_PYR-1 TTPRYVQY-VTQVHTMLVLVRSGIGIALVPASAATLHPEGVVFRTIGAFR
MMAR_2756|M.marinum_M VRAELADTRAASLATAVQCVNGGLGVTLIPQSAVSVEAARSRVGLAHFAA
MUL_2998|M.ulcerans_Agy99 VRAEHADTRADSLATAVQCVNGGLGVTLIPQSAVSVEAARSRVGLTHFAA
MLBr_02041|M.leprae_Br4923 VQAELANTRAASLATAVQCVTGGLGVTLLPQSAAPVESVRSKLGLAQFAA
Mb2303c|M.bovis_AF2122/97 MQQAPPVLELSSAAAVRAAVLAGAGPAAMSRLAIADDLAFGRLLAVDIPA
Rv2282c|M.tuberculosis_H37Rv MQQAPPVLELSSAAAVRAAVLAGAGPAAMSRLAIADDLAFGRLLAVDIPA
MAB_2238|M.abscessus_ATCC_1997 LSPN-VAFEASSPRALVSLVEQGLGIAVVPAPYVRNRAGVLALDIR----
TH_3504|M.thermoresistible__bu FEPDYVVSRVQGAATVAAPLTTG-GIAFVTAAAGPTMNGRVQVVDLT---
MAV_3102|M.avium_104 KVKISWRIATDSLALTKRLVAAGLVYGVLPLSACLNEIDSNQLRYTPLTE
MSMEG_1799|M.smegmatis_MC2_155 -ESPRVRWEFARFSTSAYANARAVDADAILCGEAAARRLPATWRWLPLGR
:
Mflv_1356|M.gilvum_PYR-GCK GGT-VDLALAWRD------GVDNPVVDAVVAVLAGALTSLDHPALQEQS-
Mvan_1027|M.vanbaalenii_PYR-1 ERP-VELDAVWRG------DSTNP---ALLRVLKDVLPQQEWTT------
MMAR_2756|M.marinum_M PTPGRRIGLVYRA------SSGRDEAYRQLAAIMGESISNEQQVRLVN--
MUL_2998|M.ulcerans_Agy99 PTPGRRIGLVYRA------SSGRDEAYRQLAAIMGESISNEQQVRLVN--
MLBr_02041|M.leprae_Br4923 PCPGRRIGLAFRS------ASGRSASYRQIAKIIGELISTEHHVRLVA--
Mb2303c|M.bovis_AF2122/97 LNLRRQLRAIWVG------GRTPPAG--AIRDLLSHITSRST--------
Rv2282c|M.tuberculosis_H37Rv LNLRRQLRAIWVG------GRTPPAG--AIRDLLSHITSRST--------
MAB_2238|M.abscessus_ATCC_1997 PALRGRLALAWRL------DGPVGPAARAFLERARAVL------------
TH_3504|M.thermoresistible__bu PPLLVPVQALWQR------HTLSAIRDRILEGLG----------------
MAV_3102|M.avium_104 PPLTHRVGVAATSNLELPREVTAKVGNILREETAHLIKTGRWPARLLSPQ
MSMEG_1799|M.smegmatis_MC2_155 LRTEMHAWLTWRP-------GSGDGVLQLVELIKGIAPPSGARLGSRAPM
Mflv_1356|M.gilvum_PYR-GCK -------
Mvan_1027|M.vanbaalenii_PYR-1 -------
MMAR_2756|M.marinum_M -------
MUL_2998|M.ulcerans_Agy99 -------
MLBr_02041|M.leprae_Br4923 -------
Mb2303c|M.bovis_AF2122/97 -------
Rv2282c|M.tuberculosis_H37Rv -------
MAB_2238|M.abscessus_ATCC_1997 -------
TH_3504|M.thermoresistible__bu -------
MAV_3102|M.avium_104 PWDPAVT
MSMEG_1799|M.smegmatis_MC2_155 T------