For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MDFGVVLQCNPPASRVVSLAAEAEDRGFSHVWTFDSHVLWQEPYVIYSQILAATRNVIVGPMVTNPLTRD DTVTASTFATLNSMFGNRTVCGIGRGDSAVRVISGKPSTVTHLRESIEVIRALGNGGSATINGATVQFPW AARSRLPVYGAGYGPKVLDLIGRHADGFILQLADPAIVQWTVGRVRKAAEQAGRDPRDVTIVVASPAYVG DNLAHQRDQCRWFGGMVGNHVADLVDRYGGDGTQVPAALTDYIRDRQGYDYNEHGRAGNAHTEFVPDEIV DRFCVLGPAEDHVRRLRELADLGVDQFAVYLQHDGKDETLAQYGEAVIPALQPTVAARS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4013 | - | - | 100% (339) | oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_3554 | - | e-139 | 69.49% (331) | N5,N10-methylene- tetrahydromethanopterin reductase |
| M. smegmatis MC2 155 | MSMEG_2456 | - | 2e-35 | 30.48% (315) | 5,10-methylenetetrahydromethanopterin reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0137c | fgd2 | 6e-12 | 27.43% (226) | putative f420-dependant glucose-6-phosphate dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4328 | - | 2e-11 | 32.02% (178) | luciferase family protein |
| M. tuberculosis H37Rv | Rv0132c | fgd2 | 4e-12 | 27.43% (226) | putative f420-dependent glucose-6-phosphate dehydrogenase |
| M. leprae Br4923 | MLBr_00131 | - | 2e-11 | 29.48% (173) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_2816c | - | 1e-130 | 66.37% (339) | putative luciferase-like protein |
| M. marinum M | MMAR_0338 | - | 3e-12 | 24.63% (341) | coenzyme F420-dependent oxidoreductase |
| M. avium 104 | MAV_5061 | - | 4e-15 | 27.42% (310) | hypothetical protein MAV_5061 |
| M. thermoresistible (build 8) | TH_2487 | - | 6e-13 | 30.23% (215) | PUTATIVE putative conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_4782 | - | 2e-12 | 24.71% (340) | coenzyme F420-dependent oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_2018 | - | 2e-11 | 32.02% (178) | luciferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_4013|M.smegmatis_MC2_155 -----------------------------------------MDFGVVLQC
MAB_2816c|M.abscessus_ATCC_199 -----------------------------------------MDFGVVLQC
Mb0137c|M.bovis_AF2122/97 MTGISRRTFGLAAGFGAIGAGGLGGGCSTRSGPTPTPEPASRGVGVVLSH
Rv0132c|M.tuberculosis_H37Rv MTGISRRTFGLAAGFGAIGAGGLGGGCSTRSGPTPTPEPASRGVGVVLSH
Mflv_4328|M.gilvum_PYR-GCK ---------------------------------MTEAKMDELGYYLLAGA
Mvan_2018|M.vanbaalenii_PYR-1 ---------------------------------MTR-VLDELGFYLLAGA
MMAR_0338|M.marinum_M -------------------------------------MRTATTVELSGGK
MUL_4782|M.ulcerans_Agy99 -------------------------------------MRTATTVELSGGK
MAV_5061|M.avium_104 -------------------------------------MVSHLPADRVDET
TH_2487|M.thermoresistible__bu ----------------------------------MTDYGHDLLFGTFVTP
MLBr_00131|M.leprae_Br4923 ---------------MAGFRFGFVDALVHTLFPPSLPARASIVSGAVLGA
MSMEG_4013|M.smegmatis_MC2_155 NPP-ASRVVSLAAEAEDRGFSHVWTFDSHVLWQE-------PYVIYSQIL
MAB_2816c|M.abscessus_ATCC_199 DPP-AVRTVQLAKLAEAHGFSHLWTFDSHLLWQE-------PYVLYSQIL
Mb0137c|M.bovis_AF2122/97 EQFRTDRLVAHAQAAEQAGFRYVWASDHLQPWQDNEGHSMFPWLTLALVG
Rv0132c|M.tuberculosis_H37Rv EQFRTDRLVAHAQAAEQAGFRYVWASDHLQPWQDNEGHSMFPWLTLALVG
Mflv_4328|M.gilvum_PYR-GCK GGEGPATLMDEARRGEELGFGTGFISERWNVKEAS--------SLTGAAL
Mvan_2018|M.vanbaalenii_PYR-1 GGEGPATLMDEARRGEELGFGTGFISERWNVKEAS--------SLTGAAL
MMAR_0338|M.marinum_M DSKDGKDVVDFVVEAEKLGLHTCWVAEAWGSDAPS--------ALG-YIA
MUL_4782|M.ulcerans_Agy99 ---DGKDTVDFVVEAEKLGLHTCWVAEAWGSDAPS--------ALG-YIA
MAV_5061|M.avium_104 GARTVAQGIEDGVAAERLGFANVYLSERWNLKEAG--------VVLGAIG
TH_2487|M.thermoresistible__bu SNHPPHHPVEQAVVADRAGLDLVTFQDHPYVAKYHD-----TWTLMSYAA
MLBr_00131|M.leprae_Br4923 DSYWVGDHLNALVPRSVATPKYLGVAAKVVPKIDAN---YEPWTMLGNLA
: .
MSMEG_4013|M.smegmatis_MC2_155 AATRN--VIVGPMVTNPLTR-DDTVTASTFATLNSMFGNRTVCGIGRGD-
MAB_2816c|M.abscessus_ATCC_199 HETRR--IVVGPMVTNPATR-DWTVTASLYATLNDMYGNRTICGIGRGD-
Mb0137c|M.bovis_AF2122/97 NSTSS--ILFGTGVTCPIYRYHPATVAQAFASLAILNPGRVFLGLGTGKR
Rv0132c|M.tuberculosis_H37Rv NSTSS--ILFGTGVTCPIYRYHPATVAQAFASLAILNPGRVFLGLGTGER
Mflv_4328|M.gilvum_PYR-GCK AVTSR--MQIATAATNHNTR-HPLITGSWATTMHRLSGGRFTLGIGR-GI
Mvan_2018|M.vanbaalenii_PYR-1 AVTSR--MQIATAATNHNTR-HPLITGSWATTMHRLSGGRFTLGIGR-GI
MMAR_0338|M.marinum_M ARTER--MQLGSGVLQVGTR-SPVLVAQTAITLSNLSCGRFLLGLGASGP
MUL_4782|M.ulcerans_Agy99 ARTER--MQLGSGVLQVGTR-SPVLVAQTAITLSNLSCGRFLLGLGASGP
MAV_5061|M.avium_104 ARTTR--VGLGTGLVSPARR-HVLHMAALGATIHAAVGPRFLLGLGRGD-
TH_2487|M.thermoresistible__bu ARTQR--VRLSANVANLPLR-PPAVLARSAAGLDLLSGGRVELGLGAGAF
MLBr_00131|M.leprae_Br4923 AGNRLNGLRLGVCVTDAGRR-NPAVTAQAAATLHLLTRGKAMLGIGVGE-
. : .. * . : : *:*
MSMEG_4013|M.smegmatis_MC2_155 ----SAVRVISGK-PSTVTHLRESIEVIRALGNG-------GSATING--
MAB_2816c|M.abscessus_ATCC_199 ----SAVRVTGGT-PTTLATLRESIHVIRELANS-------RPVEYHG--
Mb0137c|M.bovis_AF2122/97 LNEQAATDTFGNY-RERHDRLIEAIVLIRQLWSG-------ERISFTGHY
Rv0132c|M.tuberculosis_H37Rv LNEQAATDTFGNY-RERHDRLIEAIVLIRQLWSG-------ERISFTGHY
Mflv_4328|M.gilvum_PYR-GCK GAIYNAFGIP----TVTTAQMEDFAQVMRKLWHG------ELIFNHDGPL
Mvan_2018|M.vanbaalenii_PYR-1 GAIYNAFGIP----TVTTAQMEDFAQVMRKLWHG------ELIFNHDGPL
MMAR_0338|M.marinum_M QVIEGLHGVAF---DRPLARLKETVEIVRQVFAGGKVTYSGSEFQIPRRG
MUL_4782|M.ulcerans_Agy99 RVIEGLHGVAF---DRPLARLKETVEIVRQVFAGGKVTYSGSEFQIPRRG
MAV_5061|M.avium_104 ---HAYLRHEGLK-TAGFAAVVDYVKIMRRLWDG-------EAVTYDGPA
TH_2487|M.thermoresistible__bu WDGVVAMGGERRSPGAAIKALEEAIAVIRGIWDVD----AAGVLDVDGAH
MLBr_00131|M.leprae_Br4923 ---REGNEPYGVEWTKPVARFQEALATIRALWDSN-----GELVSRESQF
. : :* :
MSMEG_4013|M.smegmatis_MC2_155 ---ATVQFPWAARS--RLPVYGAGYG--PKVLDLIGR-HADGFILQLADP
MAB_2816c|M.abscessus_ATCC_199 ---ATMQFPWSRGS--ELDVWVAAYG--PKALALAGQ-VADGFILQLADI
Mb0137c|M.bovis_AF2122/97 FRTDELKLYDTPAM--PPPIFVAASG--PQSATLAGR-YGDGWIAQARDI
Rv0132c|M.tuberculosis_H37Rv FRTDELKLYDTPAM--PPPIFVAASG--PQSATLAGR-YGDGWIAQARDI
Mflv_4328|M.gilvum_PYR-GCK GKYQVLFLDPDFRE--DIRLAIVAFG--PQTLALGGREFDDVILHTYFTP
Mvan_2018|M.vanbaalenii_PYR-1 GKYQVLFLDPDFRE--DIRLAIVAFG--PQTLALGGREFDDVILHTYFTP
MMAR_0338|M.marinum_M GEARPMRLSTRPEY--DIPIYLAALS--PAMLRLTGR-IADGWLGTSFVP
MUL_4782|M.ulcerans_Agy99 GEARPMRLSTRPEY--DIPIYLAALS--PAMLRLTGR-IADGWLGTSFVP
MAV_5061|M.avium_104 GNYRNIKLGDIYQG--PAPQVLYGTFGMPKAAAAVAEAFDGVILPPMMSP
TH_2487|M.thermoresistible__bu YRIRGAKRGPAPAH--RISIWIGGYG--PRMLGLVGR-LADGWLPSLQYL
MLBr_00131|M.leprae_Br4923 FPLHNALFDLPPYRGKWPEIWVAAHG--PRMLQATGR-YADAWIPIVLVR
. * .. . :
MSMEG_4013|M.smegmatis_MC2_155 AIVQWTVGRVRKA----AEQAGRDPRDVTIVVASPAYVGDNLAHQR---D
MAB_2816c|M.abscessus_ATCC_199 DIARWMIGAVREA----AVAAGRDPAAVRICVAAPMYVGSDRTHMR---A
Mb0137c|M.bovis_AF2122/97 NDAKLLA-AFAAG----AQAAGRDPTTLGKRAELFAVVGDDKAAAR---A
Rv0132c|M.tuberculosis_H37Rv NDAKLLA-AFAAG----AQAAGRDPTTLGKRAELFAVVGDDKAAAR---A
Mflv_4328|M.gilvum_PYR-GCK ETLQRAVKTVKDA----AEQAGRDPASVRVWSCFATVGDHLPEELRLKKT
Mvan_2018|M.vanbaalenii_PYR-1 ETLQRAVRTVKDA----AEQAGRDPASVRVWSCFATVGDHLPEELRLKKT
MMAR_0338|M.marinum_M EGAGDAYFTHLDAG---LAAAGRSRADIDFCQGAEVAFASGVEELR-DMV
MUL_4782|M.ulcerans_Agy99 EGAGDAYFTHLDAG---LAAAGRSRADIDFCQGAEVAFASGVEELR-DMV
MAV_5061|M.avium_104 SATTASVGRLRRA----CEAIGRDPATLRVVQCVVTAPDLSVDETR-ALA
TH_2487|M.thermoresistible__bu SGGVSDLTAMNQRIDDAAVAAGRDPRQIRRLLNVGGQPSAD---------
MLBr_00131|M.leprae_Br4923 PTDYSCALEVVRT---AASDAGRDPMSITPAAVRGIITGRTRDDVDEALD
**. :
MSMEG_4013|M.smegmatis_MC2_155 QCRWFGGMVGNHVADLVDRYGGDGTQVPAALTDYIRDRQGYDYNEHGRAG
MAB_2816c|M.abscessus_ATCC_199 QCRWFGGMVGNHVADIVARYGSQG-DVPQTLTAYIAGRDGYDYNQHGRAG
Mb0137c|M.bovis_AF2122/97 ADLWR----------------------------FTAG--AVDQPNPVEIQ
Rv0132c|M.tuberculosis_H37Rv ADLWR----------------------------FTAG--AVDQPNPVEIQ
Mflv_4328|M.gilvum_PYR-GCK VARLATYLQGYGDLLVNTNGWDPAVLQRFRDDKVVQSIGGGIDHKATAEQ
Mvan_2018|M.vanbaalenii_PYR-1 VARLATYLQGYGDLLVNTNGWDPAVLQRFRDDKVVQSVGGGIDHKATAEQ
MMAR_0338|M.marinum_M AARKTELAFSLGGMGSASTNYYNQAYSRQGWSEVAAAVR---ERWQRGDR
MUL_4782|M.ulcerans_Agy99 AARKTELAFSLGGMGSASTNYYNQAYSRQGWSEVAAAVR---ERWQRGDR
MAV_5061|M.avium_104 HARAVTYLQAPEYGAALARVNGWSLAPVERLRAAVAKVKSAGDELVDTAF
TH_2487|M.thermoresistible__bu --------------------------------------------------
MLBr_00131|M.leprae_Br4923 SVLVRMIALGVPG----------EAWARHGVEHPMGADFAGVQDIIPQTI
MSMEG_4013|M.smegmatis_MC2_155 N-----AHTEFVPDEIVDRFCVLGPAEDHVRRLRELADLGVDQFAVYLQH
MAB_2816c|M.abscessus_ATCC_199 N-----THAEFVSDDIVDRFCVLGTADEHIAKLSELKALGVDQFAGYLQH
Mb0137c|M.bovis_AF2122/97 R-----AAESNPIEKVLANWAVGTDPGVHIGAVQAVLDAGAVPFLHFPQD
Rv0132c|M.tuberculosis_H37Rv R-----AAESNPIEKVLANWAVGTDPGVHIGAVQAVLDAGAVPFLHFPQD
Mflv_4328|M.gilvum_PYR-GCK I-----EHIATLIPDEWLEPSATGSPQQCADRVRKEFDYGADAVIMHGAT
Mvan_2018|M.vanbaalenii_PYR-1 I-----EHIATLIPDEWLAPSATGSPQQCADRVRQELDYGADAVIMHGAT
MMAR_0338|M.marinum_M E-----GAARLVTDEMVLATTLIGTEEMVRSRLVAWRDAGVNTVRLYPAG
MUL_4782|M.ulcerans_Agy99 E-----GAARLVTDEMVLATTLIGTEEMVRSRLVAWRDAGVNTVRLYPAG
MAV_5061|M.avium_104 HRIQLMDLADMVPDEWMEASCAFGTAAQCARKLQEFKRAGADEIATYGST
TH_2487|M.thermoresistible__bu ------ELADIALSHGISAFILASDDTATTERFAAEVAPAVRELVTAQR-
MLBr_00131|M.leprae_Br4923 DEETVVSYAAKVPAALMKEVLFSGTPEEVIDQVAEWRDHGLKYLVVINGS
. . .
MSMEG_4013|M.smegmatis_MC2_155 DGKDETLAQYGEAVIPALQPTVAARS-
MAB_2816c|M.abscessus_ATCC_199 DNKEETLRVYGETVIPALSQHITAKSG
Mb0137c|M.bovis_AF2122/97 D-PITAIDFYRTNVLPELR--------
Rv0132c|M.tuberculosis_H37Rv D-PITAIDFYRTNVLPELR--------
Mflv_4328|M.gilvum_PYR-GCK PDELEPIVAAYRAGQS-----------
Mvan_2018|M.vanbaalenii_PYR-1 PDELEPIVAAYRAGRS-----------
MMAR_0338|M.marinum_M -DTMDAKLSTLGRAIELVRAVR-----
MUL_4782|M.ulcerans_Agy99 -DTMDAKLSTLGRAIELVRAVR-----
MAV_5061|M.avium_104 PSQNAGVLAAWSDAFAGDMR-------
TH_2487|M.thermoresistible__bu ---------------------------
MLBr_00131|M.leprae_Br4923 -LVNSSLRKTVSALLPHARVLRGLKKL