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MVLSKGVGLFPTEPVGAMREYVGLCESLGYDNVWFGDSQNIWRESSTVMGAAAVGTERIVFGTGVTNAVT RHTSLLASTWATLAEFTGGRVALGIGTGDSSLRTMGLKPQRLAELEKSVSDLRALFRGEKVAEATSGAEY HLNYLSEPVDIPIYIAASAPKILRMSGRIADGVIVLVGTAPHFIEAALETIAAGAAESGRTLDDLHIVLW TPTAIDDDRTKARDLVRAHVSRVAIRPLPAKVAPELEEAIDRIRKSYNYYEHMNTEASHADLVPDELVDL FALAGTPAECGQRLKEIEALGVDQVSIVPFVRPGESRAPTIRTFADLVGGHG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2456 | - | - | 100% (332) | 5,10-methylenetetrahydromethanopterin reductase |
| M. smegmatis MC2 155 | MSMEG_3554 | - | 1e-38 | 31.39% (309) | N5,N10-methylene- tetrahydromethanopterin reductase |
| M. smegmatis MC2 155 | MSMEG_4013 | - | 2e-35 | 30.48% (315) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0415 | fgd1 | 4e-14 | 28.24% (262) | F420-dependent glucose-6-phosphate dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4328 | - | 2e-18 | 26.23% (305) | luciferase family protein |
| M. tuberculosis H37Rv | Rv0407 | fgd1 | 4e-14 | 28.24% (262) | F420-dependent glucose-6-phosphate dehydrogenase |
| M. leprae Br4923 | MLBr_00269 | - | 2e-16 | 28.68% (258) | putative F420-dependent glucose-6-phosphate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2816c | - | 1e-32 | 30.97% (310) | putative luciferase-like protein |
| M. marinum M | MMAR_0338 | - | 1e-18 | 27.74% (328) | coenzyme F420-dependent oxidoreductase |
| M. avium 104 | MAV_5061 | - | 2e-20 | 28.05% (303) | hypothetical protein MAV_5061 |
| M. thermoresistible (build 8) | TH_1627 | - | 1e-20 | 26.54% (324) | conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_4782 | - | 1e-18 | 27.74% (328) | coenzyme F420-dependent oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_2018 | - | 9e-18 | 26.23% (305) | luciferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4328|M.gilvum_PYR-GCK MTEAKMDELGYYLLAGAGGEGPATLMDEARRGEELGFGTGFISERWN---
Mvan_2018|M.vanbaalenii_PYR-1 MTR-VLDELGFYLLAGAGGEGPATLMDEARRGEELGFGTGFISERWN---
TH_1627|M.thermoresistible__bu MNR-PLDELGYYLLAGAGGEGPATLMDEARRGEELGFGTAFISERWN---
Mb0415|M.bovis_AF2122/97 -----MAELKLGYKASAEQFAPRELVELAVAAEAHGMDSATVSDHFQPWR
Rv0407|M.tuberculosis_H37Rv -----MAELKLGYKASAEQFAPRELVELAVAAEAHGMDSATVSDHFQPWR
MLBr_00269|M.leprae_Br4923 -----MAELRLGYKASAEQFAPRELVELGVAAEAHGMDSATVSDHFQPWR
MMAR_0338|M.marinum_M ----MRTATTVELSGGKDSKDGKDVVDFVVEAEKLGLHTCWVAEAWG---
MUL_4782|M.ulcerans_Agy99 ----MRTATTVELSGGK---DGKDTVDFVVEAEKLGLHTCWVAEAWG---
MAV_5061|M.avium_104 ----MVSHLPADRVDETGARTVAQGIEDGVAAERLGFANVYLSERWN---
MSMEG_2456|M.smegmatis_MC2_155 ----MVLSKGVGLFPTEPVGAMREYVGLC---ESLGYDNVWFGDSQN---
MAB_2816c|M.abscessus_ATCC_199 ------MDFGVVLQCDPP---AVRTVQLAKLAEAHGFSHLWTFDSHL---
: * * :
Mflv_4328|M.gilvum_PYR-GCK -----VKEASSLTGAALAVTSRMQIATAATNHNTRH-PLITGSWATTMHR
Mvan_2018|M.vanbaalenii_PYR-1 -----VKEASSLTGAALAVTSRMQIATAATNHNTRH-PLITGSWATTMHR
TH_1627|M.thermoresistible__bu -----VKEASSLVGAACAVTERMQIATAATNHNTRH-PLITGSWATTMHR
Mb0415|M.bovis_AF2122/97 HQGGHAPFSLSWMTAVGERTNRLLLGTSVLTPTFRYNPAVIAQAFATMGC
Rv0407|M.tuberculosis_H37Rv HQGGHAPFSLSWMTAVGERTNRLLLGTSVLTPTFRYNPAVIAQAFATMGC
MLBr_00269|M.leprae_Br4923 HQGGHASFSLSWMTAVGERTNRILLGTSVLTPTFRYNPAVIGQAFATMGC
MMAR_0338|M.marinum_M ---SDAPSALGYIAAR---TERMQLGSGVLQVGTRS-PVLVAQTAITLSN
MUL_4782|M.ulcerans_Agy99 ---SDAPSALGYIAAR---TERMQLGSGVLQVGTRS-PVLVAQTAITLSN
MAV_5061|M.avium_104 -----LKEAGVVLGAIGARTTRVGLGTGLVSPARRH-VLHMAALGATIHA
MSMEG_2456|M.smegmatis_MC2_155 ----IWRESSTVMGAAAVGTERIVFGTGVTNAVTRH-TSLLASTWATLAE
MAB_2816c|M.abscessus_ATCC_199 ----LWQEPYVLYSQILHETRRIVVGPMVTNPATRD-WTVTASLYATLND
. * *: ... * . *:
Mflv_4328|M.gilvum_PYR-GCK LSGGRFTLGIGRGIGAIYNAFGIPT------VTTAQMEDFAQVMRKLWHG
Mvan_2018|M.vanbaalenii_PYR-1 LSGGRFTLGIGRGIGAIYNAFGIPT------VTTAQMEDFAQVMRKLWHG
TH_1627|M.thermoresistible__bu LSGGRFTLGIGRGVAAMYAAFGIPP------VTTAQMEDFAQVMRRLWRG
Mb0415|M.bovis_AF2122/97 LYPNRVFLGVGTGEALNEIATGYEGAWPEFKERFARLRESVGLMRQLWSG
Rv0407|M.tuberculosis_H37Rv LYPNRVFLGVGTGEALNEIATGYEGAWPEFKERFARLRESVGLMRQLWSG
MLBr_00269|M.leprae_Br4923 LYPNRVFLGVGTGEALNEVATGYQGAWPEFKERFARLRESVRLMRELWRG
MMAR_0338|M.marinum_M LSCGRFLLGLGASGPQ--VIEGLHG--VAFDRPLARLKETVEIVRQVFAG
MUL_4782|M.ulcerans_Agy99 LSCGRFLLGLGASGPR--VIEGLHG--VAFDRPLARLKETVEIVRQVFAG
MAV_5061|M.avium_104 AVGPRFLLGLGRGDHAYLRHEGLKT------AGFAAVVDYVKIMRRLWDG
MSMEG_2456|M.smegmatis_MC2_155 FTGGRVALGIGTGDSS-LRTMGLKP------QRLAELEKSVSDLRALFRG
MAB_2816c|M.abscessus_ATCC_199 MYGNRTICGIGRGDSAVRVTGGTPT-------TLATLRESIHVIRELANS
* *:* . * * : . :* : .
Mflv_4328|M.gilvum_PYR-GCK ELIFNHDGPLGKYQ------VLFLDPDFREDIRLAIVAFG--PQTLALGG
Mvan_2018|M.vanbaalenii_PYR-1 ELIFNHDGPLGKYQ------VLFLDPDFREDIRLAIVAFG--PQTLALGG
TH_1627|M.thermoresistible__bu EVIFDHDGPIGRYQ------VLFLDPDFNEDIRLAIVAFG--PQTLALGG
Mb0415|M.bovis_AF2122/97 DRVDFDGDYYRLKG-------ASIYDVPDGGVPVYIAAGG--PAVAKYAG
Rv0407|M.tuberculosis_H37Rv DRVDFDGDYYRLKG-------ASIYDVPDGGVPVYIAAGG--PAVAKYAG
MLBr_00269|M.leprae_Br4923 DRVDFDGDYYQLKG-------ASIYDVPEGGVPIYIAAGG--PEVAKYAG
MMAR_0338|M.marinum_M GKVTYSGSEFQIPRRGGEARPMRLSTRPEYDIPIYLAALS--PAMLRLTG
MUL_4782|M.ulcerans_Agy99 GKVTYSGSEFQIPRRGGEARPMRLSTRPEYDIPIYLAALS--PAMLRLTG
MAV_5061|M.avium_104 EAVTYDGPAGNYRN-------IKLGDIYQGPAPQVLYGTFGMPKAAAAVA
MSMEG_2456|M.smegmatis_MC2_155 EKVAEATSGAEYHLN---------YLSEPVDIPIYIAASA--PKILRMSG
MAB_2816c|M.abscessus_ATCC_199 RPVEYHGATMQFPWS------------RGSELDVWVAAYG--PKALALAG
: : . * .
Mflv_4328|M.gilvum_PYR-GCK REFDDVILHTYFTPETLQRAVKTVKDAAEQAGRDPASVRVWS----CFAT
Mvan_2018|M.vanbaalenii_PYR-1 REFDDVILHTYFTPETLQRAVRTVKDAAEQAGRDPASVRVWS----CFAT
TH_1627|M.thermoresistible__bu RMFDDVILHTYFTPETLQRAVKTVKDAAEQAGRDPAEVRVWS----CFAT
Mb0415|M.bovis_AF2122/97 RAGDGFICTS----GKGEELYTEKLMPAVREGAAAADRS---------VD
Rv0407|M.tuberculosis_H37Rv RAGDGFICTS----GKGEELYTEKLMPAVREGAAAADRS---------VD
MLBr_00269|M.leprae_Br4923 RAGEGFVCTS----GKGEELYTEKLIPAVLEGAAVAGRD---------AD
MMAR_0338|M.marinum_M RIADGWLGTSFVPEGAGDAYFTHLDAGLAAAGRSRADIDFCQGAEVAFAS
MUL_4782|M.ulcerans_Agy99 RIADGWLGTSFVPEGAGDAYFTHLDAGLAAAGRSRADIDFCQGAEVAFAS
MAV_5061|M.avium_104 EAFDGVILPPMMSPSATTASVGRLRRACEAIGRDPATLRVVQ----CVVT
MSMEG_2456|M.smegmatis_MC2_155 RIADGVIVLVGTAPHFIEAALETIAAGAAESGRTLDDLHIVLWTPTAIDD
MAB_2816c|M.abscessus_ATCC_199 QVADGFILQLAD-IDIARWMIGAVREAAVAAGRDPAAVRICVAAPMYVGS
. :. : *
Mflv_4328|M.gilvum_PYR-GCK VGDHLPEELRLKKTVARLATYLQG-----YGDLLVNTNGWDPAVLQRFRD
Mvan_2018|M.vanbaalenii_PYR-1 VGDHLPEELRLKKTVARLATYLQG-----YGDLLVNTNGWDPAVLQRFRD
TH_1627|M.thermoresistible__bu VGDHLPEELRLKKTVARLATYLQG-----YGDLLVETNGWDPAVLRKFRD
Mb0415|M.bovis_AF2122/97 GIDKMIEIKISYDPDPELALN--------------NTRFWAPLSLTAEQK
Rv0407|M.tuberculosis_H37Rv GIDKMIEIKISYDPDPELALN--------------NTRFWAPLSLTAEQK
MLBr_00269|M.leprae_Br4923 DIDKMIEIKMSYDPDPEQALS--------------NIRFWAPLSLAAEQK
MMAR_0338|M.marinum_M GVEELRDMVAARKTELAFSLGGMGSASTNYYNQAYSRQGWSEVAAAVRER
MUL_4782|M.ulcerans_Agy99 GVEELRDMVAARKTELAFSLGGMGSASTNYYNQAYSRQGWSEVAAAVRER
MAV_5061|M.avium_104 APDLSVDETRALAHARAVTYLQAP----EYGAALARVNGWSLAPVERLRA
MSMEG_2456|M.smegmatis_MC2_155 DRTKARDLVRAHVSRVAIRPLP------------AKVAPELEEAIDRIRK
MAB_2816c|M.abscessus_ATCC_199 DRTHMRAQCRWFGGMVGNHVADIVAR--------YGSQGDVPQTLTAYIA
Mflv_4328|M.gilvum_PYR-GCK D-KVVQSIG-GGIDHKATAEQIEHIATLIPDEWLEP-SATGSPQQCADRV
Mvan_2018|M.vanbaalenii_PYR-1 D-KVVQSVG-GGIDHKATAEQIEHIATLIPDEWLAP-SATGSPQQCADRV
TH_1627|M.thermoresistible__bu D-PVVQSIP-GGIDHKATPEQIEHIATLIPDEWLEP-AATGSARQCVERI
Mb0415|M.bovis_AF2122/97 H-SIDDPIEMEKAADALPIEQIAKRWIVASDPDEAV-EKVGQYVTWGLNH
Rv0407|M.tuberculosis_H37Rv H-SIDDPIEMEKAADALPIEQIAKRWIVASDPDEAV-EKVGQYVTWGLNH
MLBr_00269|M.leprae_Br4923 H-SIDDPIEMEKVADALPIEQVAKRWIVVSDPDEAV-ARVGQYVTWGLNH
MMAR_0338|M.marinum_M W-QRGD----REGAARLVTDEMVLATTLIGTEEMVR-SRLVAWRDAGVNT
MUL_4782|M.ulcerans_Agy99 W-QRGD----REGAARLVTDEMVLATTLIGTEEMVR-SRLVAWRDAGVNT
MAV_5061|M.avium_104 AVAKVKSAGDELVDTAFHRIQLMDLADMVPDEWMEASCAFGTAAQCARKL
MSMEG_2456|M.smegmatis_MC2_155 S-----------YNYYEHMNTEASHADLVPDELVDLFALAGTPAECGQRL
MAB_2816c|M.abscessus_ATCC_199 G--------RDGYDYNQHGRAGNTHAEFVSDDIVDRFCVLGTADEHIAKL
. .
Mflv_4328|M.gilvum_PYR-GCK RKEFDYGADAVIMHGATP--DELEPIVAAYRAGQS------------
Mvan_2018|M.vanbaalenii_PYR-1 RQELDYGADAVIMHGATP--DELEPIVAAYRAGRS------------
TH_1627|M.thermoresistible__bu RKEFDYGADAVIMHGATP--DELEPIVAEYRAVVG------------
Mb0415|M.bovis_AF2122/97 LVFHAPGHDQRRFLELFQ--SDLAPRLRRLG----------------
Rv0407|M.tuberculosis_H37Rv LVFHAPGHDQRRFLELFQ--SDLAPRLRRLG----------------
MLBr_00269|M.leprae_Br4923 LVFHAPGHNQRRFLELFE--KDLAPRLRRLG----------------
MMAR_0338|M.marinum_M VRLYPAGDTMDAKLSTLG--RAIELVRAVR-----------------
MUL_4782|M.ulcerans_Agy99 VRLYPAGDTMDAKLSTLG--RAIELVRAVR-----------------
MAV_5061|M.avium_104 QEFKRAGADEIATYGSTP--SQNAGVLAAWSDAFAGDMR--------
MSMEG_2456|M.smegmatis_MC2_155 KEIEALGVDQVSIVPFVRPGESRAPTIRTFADLVGGHG---------
MAB_2816c|M.abscessus_ATCC_199 SELKALGVDQFAGYLQHD---NKEETLRVYGETVIPALSQHITAKSG
*