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MHFGIVLQPDPPASRVVELAVAAENRGFDYVWTFDSHLLWQEPYVIHSQILSATRNVMVGPMVTNPLSRD VTVTASTHATLNSMFGNRTVCSIGRGDSAVRTLSGKPSSLATLRAAVKVISDLGNGRPTEINGTTVQIPW ASKSTLDVYVGAYGPRALDLCGQVADGFLLQLADPDITKWMIERVKNAAADAGRNPDDIKVCVGAPAYIG DDLEHQRDQCRWFGGMVGNHVADIVARYGSSGAVPQALTEYIKGRVGYDYNEHGRAGNSHADFVPDEIVD RFCILGPAPAHISKLQELQKLGVDQFAIYLQHDGQDHTLAEYGRAIIPVINRPADAILT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3554 | - | - | 100% (339) | N5,N10-methylene- tetrahydromethanopterin reductase |
| M. smegmatis MC2 155 | MSMEG_4013 | - | e-139 | 69.49% (331) | oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_2456 | - | 1e-38 | 31.39% (309) | 5,10-methylenetetrahydromethanopterin reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3550c | - | 1e-12 | 24.60% (309) | coenzyme F420-dependent oxidoreductase |
| M. gilvum PYR-GCK | Mflv_0211 | - | 7e-11 | 24.76% (206) | luciferase family protein |
| M. tuberculosis H37Rv | Rv3520c | - | 1e-12 | 24.60% (309) | coenzyme F420-dependent oxidoreductase |
| M. leprae Br4923 | MLBr_00269 | - | 4e-12 | 26.70% (206) | putative F420-dependent glucose-6-phosphate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2816c | - | 1e-131 | 65.36% (332) | putative luciferase-like protein |
| M. marinum M | MMAR_0338 | - | 4e-12 | 24.11% (336) | coenzyme F420-dependent oxidoreductase |
| M. avium 104 | MAV_5061 | - | 5e-14 | 26.60% (312) | hypothetical protein MAV_5061 |
| M. thermoresistible (build 8) | TH_2487 | - | 1e-12 | 28.51% (221) | PUTATIVE putative conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_4782 | - | 9e-12 | 24.04% (337) | coenzyme F420-dependent oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_0698 | - | 2e-11 | 25.73% (206) | luciferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0211|M.gilvum_PYR-GCK ----MAELKLGYKASAE-QFAPRELVELAVAAEEHGMDSATVSDHFQPWR
Mvan_0698|M.vanbaalenii_PYR-1 ----MAELKLGYKASAE-QFAPRELVELAVAAEEHGMDSATVSDHFQPWR
MLBr_00269|M.leprae_Br4923 ----MAELRLGYKASAE-QFAPRELVELGVAAEAHGMDSATVSDHFQPWR
Mb3550c|M.bovis_AF2122/97 ---MEAGMKLGLQLGYWGAQPPQNHAELVAAAEDAGFDTVFTAEAWG---
Rv3520c|M.tuberculosis_H37Rv ---MEAGMKLGLQLGYWGAQPPQNHAELVAAAEDAGFDTVFTAEAWG---
MMAR_0338|M.marinum_M ---MRTATTVELSGGKD-SKDGKDVVDFVVEAEKLGLHTCWVAEAWG---
MUL_4782|M.ulcerans_Agy99 ---MRTATTVELSGGK----DGKDTVDFVVEAEKLGLHTCWVAEAWG---
MSMEG_3554|M.smegmatis_MC2_155 -------MHFGIVLQPD--PPASRVVELAVAAENRGFDYVWTFDSHL---
MAB_2816c|M.abscessus_ATCC_199 -------MDFGVVLQCD--PPAVRTVQLAKLAEAHGFSHLWTFDSHL---
TH_2487|M.thermoresistible__bu MTDYGHDLLFGTFVTPS-NHPPHHPVEQAVVADRAGLDLVTFQDHPY---
MAV_5061|M.avium_104 ---MVSHLPADRVDETG-ARTVAQGIEDGVAAERLGFANVYLSERWN---
: *: *: :
Mflv_0211|M.gilvum_PYR-GCK HEGGHAPFSLAWMTAVGERTTRLQLGTSVLTPTFRYNPAVIAQAFATMGC
Mvan_0698|M.vanbaalenii_PYR-1 HEGGHAPFSLAWMTAVGERTKRLQLGTSVLTPTFRYNPAVIAQAFATMGC
MLBr_00269|M.leprae_Br4923 HQGGHASFSLSWMTAVGERTNRILLGTSVLTPTFRYNPAVIGQAFATMGC
Mb3550c|M.bovis_AF2122/97 ---SDAYTPLAWWGSS---TQRVRLGTSVIQLSART-PTACAMAALTLDH
Rv3520c|M.tuberculosis_H37Rv ---SDAYTPLAWWGSS---TQRVRLGTSVIQLSART-PTACAMAALTLDH
MMAR_0338|M.marinum_M ---SDAPSALGYIAAR---TERMQLGSGVLQVGTRS-PVLVAQTAITLSN
MUL_4782|M.ulcerans_Agy99 ---SDAPSALGYIAAR---TERMQLGSGVLQVGTRS-PVLVAQTAITLSN
MSMEG_3554|M.smegmatis_MC2_155 ----LWQEPYVIHSQILSATRNVMVGPMVTNPLSRD-VTVTASTHATLNS
MAB_2816c|M.abscessus_ATCC_199 ----LWQEPYVLYSQILHETRRIVVGPMVTNPATRD-WTVTASLYATLND
TH_2487|M.thermoresistible__bu --VAKYHDTWTLMSYAAARTQRVRLSANVANLPLRP-PAVLARSAAGLDL
MAV_5061|M.avium_104 -----LKEAGVVLGAIGARTTRVGLGTGLVSPARRH-VLHMAALGATIHA
. * .: :.. : * . :
Mflv_0211|M.gilvum_PYR-GCK LYPDRIFLGVGTGEALNEIATGYEGEWPEFKERYARLRESVRLMRELWLG
Mvan_0698|M.vanbaalenii_PYR-1 LYPGRIFLGVGTGEALNEIATGYEGDWPEFKERYARLRESVRLMRDLWLG
MLBr_00269|M.leprae_Br4923 LYPNRVFLGVGTGEALNEVATGYQGAWPEFKERFARLRESVRLMRELWRG
Mb3550c|M.bovis_AF2122/97 LSGGRHILGLGVSGPQ--VVEGWYG--QRFPKPLARTREYIDIVRQVWAR
Rv3520c|M.tuberculosis_H37Rv LSGGRHILGLGVSGPQ--VVEGWYG--QRFPKPLARTREYIDIVRQVWAR
MMAR_0338|M.marinum_M LSCGRFLLGLGASGPQ--VIEGLHG--VAFDRPLARLKETVEIVRQVFAG
MUL_4782|M.ulcerans_Agy99 LSCGRFLLGLGASGPR--VIEGLHG--VAFDRPLARLKETVEIVRQVFAG
MSMEG_3554|M.smegmatis_MC2_155 MFGNRTVCSIGRGDSAVRTLSGKPS-------SLATLRAAVKVISDLGNG
MAB_2816c|M.abscessus_ATCC_199 MYGNRTICGIGRGDSAVRVTGGTPT-------TLATLRESIHVIRELANS
TH_2487|M.thermoresistible__bu LSGGRVELGLG-AGAFWDGVVAMGGERRSPGAAIKALEEAIAVIRGIWDV
MAV_5061|M.avium_104 AVGPRFLLGLGRGDHAYLRHEGLKT------AGFAAVVDYVKIMRRLWDG
* .:* . . : :: :
Mflv_0211|M.gilvum_PYR-GCK ---DRVDFEGEYYKT-------KGASIYDVP-----EGGIPIYIAAGGPQ
Mvan_0698|M.vanbaalenii_PYR-1 ---DRVDFEGEYYKT-------KGASIYDVP-----EGGIPIYIAAGGPQ
MLBr_00269|M.leprae_Br4923 ---DRVDFDGDYYQL-------KGASIYDVP-----EGGVPIYIAAGGPE
Mb3550c|M.bovis_AF2122/97 E--SPVTSAGPHYRLPLTGEGTTGLGKALKPITHPLRADIPIMLGAEGPK
Rv3520c|M.tuberculosis_H37Rv E--SPVTSAGPHYRLPLTGEGTTGLGKALKPITHPLRADIPIMLGAEGPK
MMAR_0338|M.marinum_M ---GKVTYSGSEFQIPRRGGEARPMRLSTRP-----EYDIPIYLAALSPA
MUL_4782|M.ulcerans_Agy99 ---GKVTYSGSEFQIPRRGGEARPMRLSTRP-----EYDIPIYLAALSPA
MSMEG_3554|M.smegmatis_MC2_155 ---RPTEINGTTVQIP-----------WASK------STLDVYVGAYGPR
MAB_2816c|M.abscessus_ATCC_199 ---RPVEYHGATMQFP-----------WSRG------SELDVWVAAYGPK
TH_2487|M.thermoresistible__bu DAAGVLDVDGAHYRIR-------GAKRGPAP-----AHRISIWIGGYGPR
MAV_5061|M.avium_104 ---EAVTYDGPAGNYRN----IKLGDIYQGP------APQVLYGTFGMPK
* . : *
Mflv_0211|M.gilvum_PYR-GCK VAKYAGRAGDGFICTSGKGE--ELYKEKLIPAMREGAEAAG--KNPDDVD
Mvan_0698|M.vanbaalenii_PYR-1 VAKYAGRAGDGFICTSGKGE--ELYKDKLIPAMREGAEAAG--KNPDDID
MLBr_00269|M.leprae_Br4923 VAKYAGRAGEGFVCTSGKGE--ELYTEKLIPAVLEGAAVAG--RDADDID
Mb3550c|M.bovis_AF2122/97 NVALAAEICDGWLPIFYSP---RMAG-MYNEWLDEGFARPGARRSREDFE
Rv3520c|M.tuberculosis_H37Rv NVALAAEICDGWLPIFYSP---RMAG-MYNEWLDEGFARPGARRSREDFE
MMAR_0338|M.marinum_M MLRLTGRIADGWLGTSFVP---EGAGDAYFTHLDAGLAAAG--RSRADID
MUL_4782|M.ulcerans_Agy99 MLRLTGRIADGWLGTSFVP---EGAGDAYFTHLDAGLAAAG--RSRADID
MSMEG_3554|M.smegmatis_MC2_155 ALDLCGQVADGFLLQLADP----DITKWMIERVKNAAADAG--RNPDDIK
MAB_2816c|M.abscessus_ATCC_199 ALALAGQVADGFILQLADI----DIARWMIGAVREAAVAAG--RDPAAVR
TH_2487|M.thermoresistible__bu MLGLVGRLADGWLPSLQYLSGGVSDLTAMNQRIDDAAVAAG--RDPRQIR
MAV_5061|M.avium_104 AAAAVAEAFDGVILPPMMSP---SATTASVGRLRRACEAIGRDPATLRVV
.. :* : : . * .
Mflv_0211|M.gilvum_PYR-GCK RMIEIKISYD---TDPELALENTRFWAPLSLTAEQKHSIDDPMEMEKAAD
Mvan_0698|M.vanbaalenii_PYR-1 RMIEIKISYD---TDPELALENTRFWAPLSLTAEQKHSIDDPIEMEKAAD
MLBr_00269|M.leprae_Br4923 KMIEIKMSYD---PDPEQALSNIRFWAPLSLAAEQKHSIDDPIEMEKVAD
Mb3550c|M.bovis_AF2122/97 ICATAQVVIT---DDRAAAFAGIKPFLALYMGGMGAEETNFHADVYRRMG
Rv3520c|M.tuberculosis_H37Rv ICATAQVVIT---DDRAAAFAGIKPFLALYMGGMGAEETNFHADVYRRMG
MMAR_0338|M.marinum_M FCQGAEVAFASGVEELRDMVAARKTELAFSLGGMGSASTNYYNQAYSRQG
MUL_4782|M.ulcerans_Agy99 FCQGAEVAFASGVEELRDMVAARKTELAFSLGGMGSASTNYYNQAYSRQG
MSMEG_3554|M.smegmatis_MC2_155 VCVGAPAYIGDDLEHQRDQCRWFGGMVGNHVADIVARYGSSGAVPQALTE
MAB_2816c|M.abscessus_ATCC_199 ICVAAPMYVGSDRTHMRAQCRWFGGMVGNHVADIVARYGSQGDVPQTLTA
TH_2487|M.thermoresistible__bu RLLNVGGQPS---ADELADIALSHGISAFILASDDTATTER--------F
MAV_5061|M.avium_104 QCVVTAPDLSVDETRALAHARAVTYLQAPEYGAALARVNGWSLAPVERLR
Mflv_0211|M.gilvum_PYR-GCK ELPIEQV------AKRWIVASDPDEAVAKVADYVDYG----------LNH
Mvan_0698|M.vanbaalenii_PYR-1 ALPIEQV------AKRWIVASDPDEAVAKVKDYVDWG----------LNH
MLBr_00269|M.leprae_Br4923 ALPIEQV------AKRWIVVSDPDEAVARVGQYVTWG----------LNH
Mb3550c|M.bovis_AF2122/97 YTQVVDE------VTKLFRSGRKDEAAEIIPDELVDDAVIVGDIDHVRKQ
Rv3520c|M.tuberculosis_H37Rv YTQVVDE------VTKLFRSGRKDEAAEIIPDELVDDAVIVGDIDHVRKQ
MMAR_0338|M.marinum_M WSEVAAA------VRERWQRGDREGAARLVTDEMVLATTLIGTEEMVRSR
MUL_4782|M.ulcerans_Agy99 WSEVAAA------VRERWQRGDREGAARLVTDEMVLATTLIGTEEMVRSR
MSMEG_3554|M.smegmatis_MC2_155 YIKGRVG------YDYNEHGRAGNSHADFVPDEIVDRFCILGPAPAHISK
MAB_2816c|M.abscessus_ATCC_199 YIAGRDG------YDYNQHGRAGNTHAEFVSDDIVDRFCVLGTADEHIAK
TH_2487|M.thermoresistible__bu AAEVAPA------VRELVTAQR----------------------------
MAV_5061|M.avium_104 AAVAKVKSAGDELVDTAFHRIQLMDLADMVPDEWMEASCAFGTAAQCARK
Mflv_0211|M.gilvum_PYR-GCK LVFHAPGHDQRRFLELFQRDLEPRLRKLG----------------
Mvan_0698|M.vanbaalenii_PYR-1 LVFHAPGHDQRRFLELFRRDLEPRLRKLG----------------
MLBr_00269|M.leprae_Br4923 LVFHAPGHNQRRFLELFEKDLAPRLRRLG----------------
Mb3550c|M.bovis_AF2122/97 MAVWEAAGVTMMVVTAGSAEQVRDLAALV----------------
Rv3520c|M.tuberculosis_H37Rv MAVWEAAGVTMMVVTAGSAEQVRDLAALV----------------
MMAR_0338|M.marinum_M LVAWRDAGVNTVRLYPAGDTMDAKLSTLGRAIELVRAVR------
MUL_4782|M.ulcerans_Agy99 LVAWRDAGVNTVRLYPAGDTMDAKLSTLGRAIELVRAVR------
MSMEG_3554|M.smegmatis_MC2_155 LQELQKLGVDQFAIYLQHDGQDHTLAEYGRAIIPVINRPADAILT
MAB_2816c|M.abscessus_ATCC_199 LSELKALGVDQFAGYLQHDNKEETLRVYGETVIPALSQHITAKSG
TH_2487|M.thermoresistible__bu ---------------------------------------------
MAV_5061|M.avium_104 LQEFKRAGADEIATYGSTPSQNAGVLAAWSDAFAGDMR-------