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QHTGAPEHGVGSVGPTLAEIGAAIGAQIAAPPYDPTVAVQSVMDAERASDAASLDGALVVLDWAPHRPNG PLPNLLTRLEPLLAKRPAAVVITPSRPVNPPRPVVAHARRHGVALLWVMEAAPVDDVRAQIDKLMQMAHT TRAARKGVTVPADLLGAADDLSRLLDELGGALDATVRLLDRPTNGAGTAGFPVVSGGRSAWLEIRRDSAL TPEETELVELLIPVMRLHLRLRDTEHDETTAEAARNLKTILGEDLVAREATLRRSRRLSMFPRHPLVCLV IEPFGVAVTMAGIQQLRSDLEPLARRTDRDAITIVHEGAVVMMVNAAVGLDIMSRGLYRAVRTPLVIGAS DEVTAPRSYPGAFRQAQRAVAVGRRVGGVNRVTRYRDLGILGLLYQLPEHARRGFVTETLGSVADDTPDA LDQRRILRTLRATDCNITESARKLFIHPNTLRARINRIESITGQFLNDPAKRMNIFTALAMFSLDSNPEG E*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4006 | - | - | 100% (492) | transcriptional regulator, CdaR, putative |
| M. smegmatis MC2 155 | MSMEG_6492 | - | 3e-11 | 27.14% (269) | GAF domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_3975 | - | 1e-09 | 30.71% (140) | regulatory protein, putative |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1464 | - | 3e-07 | 31.50% (127) | hypothetical protein Mb1464 |
| M. gilvum PYR-GCK | Mflv_0801 | - | 7e-07 | 31.75% (126) | transcriptional regulator, CdaR |
| M. tuberculosis H37Rv | Rv1429 | - | 3e-07 | 31.50% (127) | hypothetical protein Rv1429 |
| M. leprae Br4923 | MLBr_01052 | - | 1e-07 | 33.61% (119) | hypothetical protein MLBr_01052 |
| M. abscessus ATCC 19977 | MAB_0291 | - | 4e-06 | 22.07% (145) | hypothetical protein MAB_0291 |
| M. marinum M | MMAR_3335 | - | 8e-08 | 27.87% (244) | hypothetical protein MMAR_3335 |
| M. avium 104 | MAV_2195 | - | 3e-06 | 30.46% (174) | hypothetical protein MAV_2195 |
| M. thermoresistible (build 8) | TH_1338 | - | 7e-08 | 28.92% (204) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_1307 | - | 3e-08 | 27.87% (244) | hypothetical protein MUL_1307 |
| M. vanbaalenii PYR-1 | Mvan_4407 | - | 6e-10 | 27.42% (372) | putative GAF sensor protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3335|M.marinum_M --------------------------------------------------
MUL_1307|M.ulcerans_Agy99 --------------------------------------------------
MAV_2195|M.avium_104 --------------------------------------------------
TH_1338|M.thermoresistible__bu --------------------------------------------------
Mb1464|M.bovis_AF2122/97 --------------------------------------------------
Rv1429|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01052|M.leprae_Br4923 --------------------------------------------------
MSMEG_4006|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4407|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0291|M.abscessus_ATCC_1997 MTDIQVGGAREGVPSAGPSALSVLRLLASGTAPDVFEARLKEMARESSPP
Mflv_0801|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_3335|M.marinum_M --------------------------------------------------
MUL_1307|M.ulcerans_Agy99 --------------------------------------------------
MAV_2195|M.avium_104 --------------------------------------------------
TH_1338|M.thermoresistible__bu --------------------------------------------------
Mb1464|M.bovis_AF2122/97 --------------------------------------------------
Rv1429|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01052|M.leprae_Br4923 --------------------------------------------------
MSMEG_4006|M.smegmatis_MC2_155 ------------------------------------------MQHTGAPE
Mvan_4407|M.vanbaalenii_PYR-1 -------------------MSEPRSVIAAQTALIAALRDVVSARSVADVE
MAB_0291|M.abscessus_ATCC_1997 WSAADLHRARGYAERIYGLIEGQNQREARLSNLVGIGIDLLGCHGLDEAS
Mflv_0801|M.gilvum_PYR-GCK --------------------------------------------MSEDRA
MMAR_3335|M.marinum_M -----------------------------------------------MND
MUL_1307|M.ulcerans_Agy99 -----------------------------------------------MNN
MAV_2195|M.avium_104 -----------------------------------------------MND
TH_1338|M.thermoresistible__bu -----------------------------------------------VPD
Mb1464|M.bovis_AF2122/97 ---------------------------------------------MAEAG
Rv1429|M.tuberculosis_H37Rv ---------------------------------------------MAEAG
MLBr_01052|M.leprae_Br4923 ----------------------------------------MARQHPSPRV
MSMEG_4006|M.smegmatis_MC2_155 HGVGSVGPTLAEIGAAIGAQIAA------------PPYDPTVAVQSVMDA
Mvan_4407|M.vanbaalenii_PYR-1 SATLAAVRSLLSADAAFWMDRVD------------DGFAMTALSGLIQPE
MAB_0291|M.abscessus_ATCC_1997 TTLVKRARIMLDADFSFISVRDDSEPETRHHVRYVDGPTTAINHGLYFPI
Mflv_0801|M.gilvum_PYR-GCK ESAAPTLRDLLEA-------------------------AQLSLSGPDPAD
MMAR_3335|M.marinum_M NQFSAIARLGSARSPLELLETVPDS-------------LLRRLK--QYSG
MUL_1307|M.ulcerans_Agy99 NQFSAIARLGSARSPLELLETVPDS-------------LLRRLK--QYSG
MAV_2195|M.avium_104 NPFAGPFAK-HPRSPLETLDTVPES-------------VLRRLK--QYSG
TH_1338|M.thermoresistible__bu NRFVP------PQSTLEVLESVPES-------------VLRRLK--QYSG
Mb1464|M.bovis_AF2122/97 GGPISVIARHMQLIRDDFISELFDK-------------MKAEIRGLDYDA
Rv1429|M.tuberculosis_H37Rv GGPISVIARHMQLIRDDFISELFDK-------------MKAEIRGLDYDA
MLBr_01052|M.leprae_Br4923 RELIREGARIALNPTQEWIDQLDRA-------------TFAANPAIANDP
MSMEG_4006|M.smegmatis_MC2_155 ERASDAASLDGALVVLDWAPHRPNGP---------LPNLLTRLEPLLAKR
Mvan_4407|M.vanbaalenii_PYR-1 SHELSLVPPGAGLAAEIVANDAPASSSDYTVDPRAIPAFAAMFRRENIRS
MAB_0291|M.abscessus_ATCC_1997 GDDVGLVSLYRPGQGPVWTADYPSDTR-----FSRASDGDAAMRSEGVHS
Mflv_0801|M.gilvum_PYR-GCK RNLDREVSWVHTTEMRDPSRYLRGGE------------LVCTVGISLHSA
MMAR_3335|M.marinum_M RLATEAVSAMQERLPFFADLEASQR-ASVALVVQTAVVNFAEWMQNPRSD
MUL_1307|M.ulcerans_Agy99 RLATEAVSAMQERLPFFADLEASQR-ASVALVVQTAVVNFAEWMQNPRSD
MAV_2195|M.avium_104 RLATEAVSVMQDRLPFFADLEASQR-ASVSLVVQTAVVNFAEWMQDPKSN
TH_1338|M.thermoresistible__bu RLATEAVHTMEERLPFFADLEASQR-ASVHLVVQTAVVNFVEWMRDPRSN
Mb1464|M.bovis_AF2122/97 RMADLWRASITENFVTAVHYLDRDT-PQSLVEAPAAALAYARAAAQRDIP
Rv1429|M.tuberculosis_H37Rv RMADLWRASITENFVTAVHYLDRDT-PQSLVEAPAAALAYARAAAQRDIP
MLBr_01052|M.leprae_Br4923 VLAKVVRRASRAHLVHWATANLRDPGAPVPAHLGPEPLTMARDLVRRGRD
MSMEG_4006|M.smegmatis_MC2_155 PAAVVITPSRPVNPPRPVVAHARRHGVALLWVMEAAPVDDVRAQIDKLMQ
Mvan_4407|M.vanbaalenii_PYR-1 TAGAPMRSSEGVVGVLFVFARRSREFTEDEMQLLMSIAGVARALRERLRE
MAB_0291|M.abscessus_ATCC_1997 LMVMPMEHEDQHFGNLYVGSRTVRSFSAAERSLFASLCSFAGIALARASE
Mflv_0801|M.gilvum_PYR-GCK EDCSTFVDALAGAGAAGVCFGVGDGHDDVPAALLDACRRAGLPVLVAPPS
.
MMAR_3335|M.marinum_M ------VSYTAQAFELVPQDLTRRIALRHTVDMVRVTMEFFEEVVP----
MUL_1307|M.ulcerans_Agy99 ------VSYTAQAFELVPQDLTRRIALRHTVDMVRVTMEFFEEVVP----
MAV_2195|M.avium_104 ------VRHTAQAFELVPQDLARRIALRHSVEMVRVTMEFFEEVVP----
TH_1338|M.thermoresistible__bu ------VTYTMQAFEVVPQDLTRRIALRQTVEMVRTTMEFFEQVVP----
Mb1464|M.bovis_AF2122/97 ------LSGLVRAHRLGHARFLEVAMQYVSLLEPADRVSTIIELVN----
Rv1429|M.tuberculosis_H37Rv ------LSGLVRAHRLGHARFLEVAMQYVSLLEPADRVSTIIELVN----
MLBr_01052|M.leprae_Br4923 ------VLALDIYRVGQYTAWRRWMEIAFTLTSDPQELREILNVSA----
MSMEG_4006|M.smegmatis_MC2_155 ------MAHTTRAARKGVTVPADLLGAADDLSRLLDELGGALDATV----
Mvan_4407|M.vanbaalenii_PYR-1 GEFQRELLEQERSRAAAGDRLLRAAETFSSSMLRGQPLAAGLEAASDELG
MAB_0291|M.abscessus_ATCC_1997 FSSNTEQISALERRLELRSILLDTGAGPGGMDGFVLTAGEQLGVAMR---
Mflv_0801|M.gilvum_PYR-GCK ------VPFSVISRFVAESRLGTEIAVARATNALVPELLLSLRRHD----
MMAR_3335|M.marinum_M -LLARS-EEQLTALTVGILKYSRDLAFTAASAYADAAEARGTWDSR----
MUL_1307|M.ulcerans_Agy99 -LLARS-EEQLTALTVGILKYSRDLAFTAASAYADAAEARGTWDSR----
MAV_2195|M.avium_104 -LLARS-EEQLTALTVGVLKYSRDLAFTAATAYADAAEARGTWDSR----
TH_1338|M.thermoresistible__bu -LLARS-EEQVTALTAGILRYSRDLAFAAATAYADAAEARGAWDTR----
Mb1464|M.bovis_AF2122/97 -RSARL-VDLVADQLIVAYEHEHDRWLSRRSGLQQQWVSELLADTP----
Rv1429|M.tuberculosis_H37Rv -RSARL-VDLVADQLIVAYEHEHDRWLSRRSGLQQQWVSELLADTP----
MLBr_01052|M.leprae_Br4923 -QSINEYVAATLEAIATHMQLERDELTRSTHAERLEVVDLILEGAP----
MSMEG_4006|M.smegmatis_MC2_155 -RLLDRPTNGAGTAGFPVVSGGRSAWLEIRRDSALTPEETELVELL----
Mvan_4407|M.vanbaalenii_PYR-1 VRLHVRGLPAPGSPTSHMLPIEDAPTVSSGPEARIPGADLAVLSADGALP
MAB_0291|M.abscessus_ATCC_1997 -VTGHDGSEIASYKWEPDTQNILTTALTVGDDYHGELSVASLDDQPVSVY
Mflv_0801|M.gilvum_PYR-GCK --SPRRLLDAAGQVLGCYFLLEPEGAAKGDEAAVTVPVPGLGALVWMG--
MMAR_3335|M.marinum_M -MEASVVDAVVRGDTGPELLSRAAALNWDTTAPATVVVGTPASARDGSDG
MUL_1307|M.ulcerans_Agy99 -MEASVVDAVVRGDTGPELLSRAAALNWDTTAPATVVVGTPASARDGSDG
MAV_2195|M.avium_104 -MEASVVDAVVRGDTGPELLSRAAALNWDTTAPATVVVGTPAPGRDGSTG
TH_1338|M.thermoresistible__bu -MEANVVDAVVRGAVGPELQSQAAALNWDATAPATVVVGLPRPDR-----
Mb1464|M.bovis_AF2122/97 -VDVPRAERALG--YRLDGVHIAAVVWVDSAVPIGDVVAQFDQVRCLLAG
Rv1429|M.tuberculosis_H37Rv -VDVPRAERALG--YRLDGVHIAAVVWVDSAVPIGDVVAQFDQVRCLLAG
MLBr_01052|M.leprae_Br4923 -VTQERAEARLG--YRLGLTHTAAVIWSDDLDGDHGYLDQAAEAFS----
MSMEG_4006|M.smegmatis_MC2_155 -IPVMRLHLRLR-DTEHDETTAEAARNLKTILGEDLVAREATLRRSRRLS
Mvan_4407|M.vanbaalenii_PYR-1 EMQLALLAQLIGIDFRRQRVELETELALTDQMVHSLLTGDFQELERLWSR
MAB_0291|M.abscessus_ATCC_1997 PLKIEDLATTAAVVMCGDNRMSLSVSQLRNDLLHDVLDYRQRDSRLVQIY
Mflv_0801|M.gilvum_PYR-GCK --RGDRPEPALLDLIARFVRAAQGERDIEAALTRERVGQLLSLVERRMLL
MMAR_3335|M.marinum_M -------------------SERAIQDVRDAAAQHGRAALTDVHGTWLVAI
MUL_1307|M.ulcerans_Agy99 -------------------SERAIQDVRDAAAQHGRAALTDVHGTWLVAI
MAV_2195|M.avium_104 PGD----------------SERASQHVRDIAAQHGRAALTDVHGTWLVAI
TH_1338|M.thermoresistible__bu -------------------LEVVSQDVHHVANRHGRTALSDVHGTWLVTI
Mb1464|M.bovis_AF2122/97 ---------------------ELGPELGPVANSLMVPTDEREARLWFSPA
Rv1429|M.tuberculosis_H37Rv ---------------------ELGPELGPVANSLMVPTDEREARLWFSPA
MLBr_01052|M.leprae_Br4923 -------------------------HVVESTQQLIVVASAATRWVWLADA
MSMEG_4006|M.smegmatis_MC2_155 MFPRHPLVCLVIEPFGVAVTMAGIQQLRSDLEPLARRTDRDAITIVHEGA
Mvan_4407|M.vanbaalenii_PYR-1 TALLGMNPAVPRVLVSIGRDRPVDRMLLDRIRREMRSRISGGYSTTYGGD
MAB_0291|M.abscessus_ATCC_1997 ARRLALDLN--QPHVVVIVRPERGGLDRASLWSASFASRVGGLRATQDEV
Mflv_0801|M.gilvum_PYR-GCK P-----------------DALSQLVQWPGFAGEIACSAWPAGAGALLSIS
MMAR_3335|M.marinum_M VSGHLSPTD--------KVFKDLLEAFSDGPVVIGPTAPMLT--AAYHSA
MUL_1307|M.ulcerans_Agy99 VSGHLSPTD--------KVFKDLLEAFSDGPVVIGPTAPMLT--AAYHSA
MAV_2195|M.avium_104 VSGQLSPTD--------KFLGDLLEAFSDGPVVVGPTAPMLT--AAYHSA
TH_1338|M.thermoresistible__bu VSGALSPTD--------RFLTDLLDVFADGPVVLGPTAPTLS--AAYRSA
Mb1464|M.bovis_AF2122/97 PTRAFAPS---------RIRAAFESAGIRARLACGRVGDGLRGFRASLKQ
Rv1429|M.tuberculosis_H37Rv PTRAFAPS---------RIRAAFESAGIRARLACGRVGDGLRGFRASLKQ
MLBr_01052|M.leprae_Br4923 LALDVPEVQ--------KALLNLSKAR----VAIGTSSAGIEG--FRRSH
MSMEG_4006|M.smegmatis_MC2_155 VVMMVNAAVGL------DIMSRGLYRAVRTPLVIGASDEVTAPRSYPGAF
Mvan_4407|M.vanbaalenii_PYR-1 VVLLCPVPEVEQEAKLVGQVESIVTACRPERLTAGIGPVCRKADDYPLGV
MAB_0291|M.abscessus_ATCC_1997 VVLLIPGSDAG---RIAQTVWDETTAHLRMPVTVSSAGPSERIESIEDTY
Mflv_0801|M.gilvum_PYR-GCK FPGALIGDAP-------DLCMMLTAGAVEMPDDLALPTGHSAPVTLADLG
.
MMAR_3335|M.marinum_M SEAISGMNAVAGWRGAPRPVLARELLPERALMGDA-SAIVA-LHTDVMRP
MUL_1307|M.ulcerans_Agy99 SEAISGMNAVAGWRGASRPVLARELLPERALMGDA-SAIVA-LHTDVMRP
MAV_2195|M.avium_104 SEAISGMNAVGGWRGAPRPVLARELLPERALMGDA-SAIVA-LHTDVMGP
TH_1338|M.thermoresistible__bu TEAIAGMNAVAGWSGAPRPVPARELLPERALLGDQ-TAIAA-LESEVMRP
Mb1464|M.bovis_AF2122/97 AERVKALALAGGARPGGRVMFYDDVAPVALLADDL-EELRR-FVTDVLGD
Rv1429|M.tuberculosis_H37Rv AERVKALALAGGARPGGRVMFYDDVAPVALLADDL-EELRR-FVTDVLGD
MLBr_01052|M.leprae_Br4923 LEALTAQRTLARLKSHQQVAFFADVQLVSLITQNP-EDAKE-FITSTLGD
MSMEG_4006|M.smegmatis_MC2_155 RQAQRAVAVGRRVGGVNRVTRYRDLGILGLLYQLP-EHARRGFVTETLGS
Mvan_4407|M.vanbaalenii_PYR-1 REALFARQVAAQSRTGKAVVSSAELGMYRLFAHVGGTDALLGAVLETLGP
MAB_0291|M.abscessus_ATCC_1997 QDAMRCLDAMSALGALGTAAAAHELGFLGVLLSRH--QDVEGFVRSMVGP
Mflv_0801|M.gilvum_PYR-GCK SAIAQARIALTLAEHRGGRVGPDQLSTLESLLEQLPLAQLAPFRQLLIDP
:: : :
MMAR_3335|M.marinum_M LADAG----PTLIETLDAYLDCGGAIEACARKLFVHPNTIRYRLKRITDF
MUL_1307|M.ulcerans_Agy99 LADAG----PTLIETLDAYLDCGGAIEACARKLFVHPNTIRYRLKRITDF
MAV_2195|M.avium_104 LADAG----PTLIETLDAFLDSGGAIEACARKLFVHPNTVRYRLKRITDF
TH_1338|M.thermoresistible__bu LADAG----PTLTETLDAFLESGGAIEACARRLFVHPNTVRYRLRRIAEI
Mb1464|M.bovis_AF2122/97 LSVDDERN-SWLRETLREFLLRNRSYVATADAMILHRNTIQYRVIQAMEL
Rv1429|M.tuberculosis_H37Rv LSVDDERN-SWLRETLREFLLRNRSYVATADAMILHRNTIQYRVIQAMEL
MLBr_01052|M.leprae_Br4923 FESAS----PALQQTLLTFINEQCNASRAAKRLFTHRNTLLRRIESAEKL
MSMEG_4006|M.smegmatis_MC2_155 VADDTPDA-LDQRRILRTLRATDCNITESARKLFIHPNTLRARINRIESI
Mvan_4407|M.vanbaalenii_PYR-1 LLDADGRDGSDLLNTLHAFLEHDRRIAETARALHLHVNTLRYRVDRIARL
MAB_0291|M.abscessus_ATCC_1997 VIDYDEDRDTDLLQTLDVYFSVGASPTRAAKILHTHPNTVVRRLDRVNEL
Mflv_0801|M.gilvum_PYR-GCK LTELDTSRGTQHVRTLRTFVACNGSLSETAKELFLHTNTVRHRLGRIQEI
. . * * : * **: *: :
MMAR_3335|M.marinum_M TGRDPTQPRDAYVLRVAATVGQLNYPTPPSGAANNTITPVPLPVR---RG
MUL_1307|M.ulcerans_Agy99 TGRDPTQPRDAYVLRVAATVGQLNYPTPPSGAANNTITPVPLPVR---RG
MAV_2195|M.avium_104 TGRDPMQPRDAYVLRVAATVGQLNYPTHPPSAAGAAMPAVPLPVNGAARG
TH_1338|M.thermoresistible__bu TGRDPAVPRDAYVLRVAVSVSRLTRQSYQSSTVNPDLGSTAGWRGQAAGG
Mb1464|M.bovis_AF2122/97 CGQNLDDPDAAFRVQMALEVCRWMAPAVLRAKQ-----------------
Rv1429|M.tuberculosis_H37Rv CGQNLDDPDAAFRVQMALEVCRWMAPAVLRAKQ-----------------
MLBr_01052|M.leprae_Br4923 LPRPLDHTSVHIAVALEALQWRGDQTNTSGPRAGRNDGVPA---------
MSMEG_4006|M.smegmatis_MC2_155 TGQFLNDPAKRMNIFTALAMFSLDSNPEGE--------------------
Mvan_4407|M.vanbaalenii_PYR-1 LKTDLDDPEKRFFILLALRLRGVVGLGPNDSRQAPSSAGENVQ-------
MAB_0291|M.abscessus_ATCC_1997 LGDGWQDAERLLDTQLAIKLWKVRGSLLTRQTG-----------------
Mflv_0801|M.gilvum_PYR-GCK TGRDPLQHNDLTTFVIGMWAADRGE-------------------------
MMAR_3335|M.marinum_M TEGP
MUL_1307|M.ulcerans_Agy99 TEGP
MAV_2195|M.avium_104 QSGG
TH_1338|M.thermoresistible__bu HRAM
Mb1464|M.bovis_AF2122/97 ----
Rv1429|M.tuberculosis_H37Rv ----
MLBr_01052|M.leprae_Br4923 ----
MSMEG_4006|M.smegmatis_MC2_155 ----
Mvan_4407|M.vanbaalenii_PYR-1 ----
MAB_0291|M.abscessus_ATCC_1997 ----
Mflv_0801|M.gilvum_PYR-GCK ----