For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VLKDDFRLIDLLLDQSLGLALVSDCDPHVPVTGAHTIEIAHPSDWLQPGTVMLTTGLLYGEPDKRGKSAR AFRALVRELVSAGVAALGYGLGVVTDDVPRALVDEANRQHFAVFTVPREVSFMTVIDRVVEQTHSGEPHS LRRVLQMQDHLLDALGATEPEQELISRLSAILRCSVLLYNELGDVVASSGKAPSHLMRSQLRGRSGHLRF SVGKWSVTADSIEPGGEPHWLVVASTRHEIPDALARSTLEVAVRLLNAIERSRYRAAVQNRARQAAFVRE LVAGEIVDQFGAEGHLESLRFGHRPRLRVFAMSPTADYDAGRWATRAPTVLDALEQDALDLARLMRLPVM FAQLDDQLIGVLAADVPAVNGWITNQPEGTVCGLSEPFQDVRTGPERFRNAQRAMRAAQTRNLRHTKFED VGIADWLLTGHHREATVAKATDQLAVLGRHSGYLEFVRTFFANDLDVAATAKALNVHPNTVRHKVKRVEA MFGESLRSPALITAIHLSLEVLALDRSAGDGSGGGPARPH
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3975 | - | - | 100% (530) | regulatory protein, putative |
| M. smegmatis MC2 155 | MSMEG_0579 | - | 9e-13 | 23.47% (490) | helix-turn-helix, Fis-type |
| M. smegmatis MC2 155 | MSMEG_6688 | - | 4e-12 | 21.76% (501) | regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1218c | - | 1e-05 | 39.62% (53) | hypothetical protein Mb1218c |
| M. gilvum PYR-GCK | Mflv_0801 | - | 8e-10 | 29.94% (177) | transcriptional regulator, CdaR |
| M. tuberculosis H37Rv | Rv1186c | - | 1e-05 | 39.62% (53) | hypothetical protein Rv1186c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0825 | - | 2e-15 | 23.18% (522) | peptidase |
| M. marinum M | MMAR_4254 | - | 9e-05 | 35.48% (62) | hypothetical protein MMAR_4254 |
| M. avium 104 | MAV_4933 | - | 3e-07 | 30.95% (168) | hypothetical protein MAV_4933 |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_1854 | - | 3e-19 | 24.95% (517) | purine catabolism PurC domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1218c|M.bovis_AF2122/97 ----MRIAGVGLGQLLLALDATVVS-LVDAPRGLDLPVASTALIDSDDVR
Rv1186c|M.tuberculosis_H37Rv ----MRIAGVGLGQLLLALDATVVS-LVDAPRGLDLPVASTALIDSDDVR
MMAR_4254|M.marinum_M ----MGVAGVGLGQLLLALDATLVS-LVEAPRGLDLPVASAALVDSDDVR
MAB_0825|M.abscessus_ATCC_1997 -MAEYRLTVPITVRDLTQRADLGLV-LSAGEAGAARAIKWAHAIELNDPT
Mvan_1854|M.vanbaalenii_PYR-1 ---------MITARSLCQDENLGLT-LVAGAQAADRPIAWAHAIELADPT
Mflv_0801|M.gilvum_PYR-GCK MSEDRAESAAPTLRDLLEAAQLSLSGPDPADRNLDREVSWVHTTEMRDPS
MAV_4933|M.avium_104 ------------------------------------------MKDFRAPV
MSMEG_3975|M.smegmatis_MC2_155 -----MLKDDFRLIDLLLDQSLGLALVSDCDP--HVPVTGAHTIEIAHPS
:
Mb1218c|M.bovis_AF2122/97 LGLAAAAGSADVFFLIGVTDDEAVR------WVDDQARQRAPVAIFVKHP
Rv1186c|M.tuberculosis_H37Rv LGLAAAAGSADVFFLIGVTDDEAVR------WVDDQARQRAPVAIFVKHP
MMAR_4254|M.marinum_M LGLAAAAGSADIFFLLGVTDHEALR------WIDGQAG--TPVAIFVKQP
MAB_0825|M.abscessus_ATCC_1997 PYLFGGELVMTTGLTVGLSHAEQYE------YAARLSG------------
Mvan_1854|M.vanbaalenii_PYR-1 PYLAGGELVMTTGINIGADAAAQAD------YVARLAA------------
Mflv_0801|M.gilvum_PYR-GCK RYLRGGELVCTVGISL-HSAEDCST------FVDALAG------------
MAV_4933|M.avium_104 NGVDGDSASALVAVPKSQGAQTIRPD-----SVSRLVG------------
MSMEG_3975|M.smegmatis_MC2_155 DWLQPGTVMLTTGLLYGEPDKRGKSARAFRALVRELVS------------
: .
Mb1218c|M.bovis_AF2122/97 SDSVVAGAVRAGSAVVAVEPRARWERLYHLVNHVLEHHGDRADPTDDSGT
Rv1186c|M.tuberculosis_H37Rv SDSVVAGAVRAGSAVVAVEPRARWERLYHLVNHVLEHHGDRADPTDDSGT
MMAR_4254|M.marinum_M SDAVVAKAVRSGAAVVAVEPQARWERLYRLVNHVLEHHGDRT--TDDSGT
MAB_0825|M.abscessus_ATCC_1997 -KNVAALAFDTGTTFSEVPPG------------ILAAG-------DELGL
Mvan_1854|M.vanbaalenii_PYR-1 -AGTAALAVDTGTTLTAVPAG------------VLAAG-------DEHGV
Mflv_0801|M.gilvum_PYR-GCK -AGAAGVCFGVGDGHDDVPAA------------LLDACR-------RAGL
MAV_4933|M.avium_104 -ALLDDHAAVVGRVRSVIRSR----------------------------L
MSMEG_3975|M.smegmatis_MC2_155 -AGVAALGYGLGVVTDDVPRA------------LVDEAN-------RQHF
* :
Mb1218c|M.bovis_AF2122/97 DLFGLAQSLADRIHGMISIEDAQSHVLAYSASNDEADELRRLSILGRAGP
Rv1186c|M.tuberculosis_H37Rv DLFGLAQSLADRIHGMISIEDAQSHVLAYSASNDEADELRRLSILGRAGP
MMAR_4254|M.marinum_M DLFGLAQSLADRIHGMVSIEDAQSHVLAYSASSDEADELRRLSILGRAGP
MAB_0825|M.abscessus_ATCC_1997 PILQVPVSTPFIAITRAVIDELTADELRAVQRVVDQQDVLVRATL-RDGA
Mvan_1854|M.vanbaalenii_PYR-1 PVLRVPASTPFIAIARVVIDAVKADQLESVQRVVDQQEVLARATL-RGGI
Mflv_0801|M.gilvum_PYR-GCK PVLVAPPSVPFSVISRFVAESRLGTEIAVARATNALVPELLLSLRRHDSP
MAV_4933|M.avium_104 PVYRSVADEALEAELEWVLRSAVGGREALHEPQIAGLAAIGEARARDGVP
MSMEG_3975|M.smegmatis_MC2_155 AVFTVPREVSFMTVIDRVVEQTHSGEPHSLRRVLQMQDHLLDALGATEPE
: . . . :
Mb1218c|M.bovis_AF2122/97 PEHLQWIGQWGIFDALRAGREVVRVAER----PELGLRPRLAIGIHQPGV
Rv1186c|M.tuberculosis_H37Rv PEHLQWIGQWGIFDALRPGREVVRVAER----PELGLRPRLAIGIHQPGV
MMAR_4254|M.marinum_M PEHLKWIGQWGIFDALRSGSEVVRVAER----PELGLRPRLAIGIHQPPV
MAB_0825|M.abscessus_ATCC_1997 PGVVSALSRSLAATVIVTATDGTLLAEAGHDAEHLAEITRGAFPNHSRKH
Mvan_1854|M.vanbaalenii_PYR-1 PGVVGALAECLSAVVVAVSTDGRDLAAGGTADPQLISALSEAVG-QARNR
Mflv_0801|M.gilvum_PYR-GCK RRLLDAAGQVLGCYFLLEPEGAAKGDEA---------------------A
MAV_4933|M.avium_104 VDDMLRAWRIGVEVVVECAREAARRLGVD--------------------D
MSMEG_3975|M.smegmatis_MC2_155 QELISRLSAILRCSVLLYNELGDVVASSGKAPSHLMRSQLRGRSGHLRFS
: :
Mb1218c|M.bovis_AF2122/97 GALRPPVFAGTIWVQQGSQPLADDAEEMLRGAAVLAARIMSRLATQPNTH
Rv1186c|M.tuberculosis_H37Rv GALRPPVFAGTIWVQQGSQPLADDAEEMLRGAAVLAARIMSRLATQPNTH
MMAR_4254|M.marinum_M AARRPPVFAGSIWVQQGSQPLAEDADEVLRGAAVLGARIMTRLASRPSTH
MAB_0825|M.abscessus_ATCC_1997 ASRVVADRDGYCTIQTVRAGKAERGYLAVRSEDALTAAQRLLVSHAMALI
Mvan_1854|M.vanbaalenii_PYR-1 GAAVIPDGDALLTIQRLRAAQAVRGYLVVRSAGPLSDSGRLLVSHAVSLI
Mflv_0801|M.gilvum_PYR-GCK VTVPVPGLGALVWMGRGDRPEPALLDLIAR-------------------F
MAV_4933|M.avium_104 ARVLELVQSALAWSDIAMATSAKAHRRTER--------------------
MSMEG_3975|M.smegmatis_MC2_155 VGKWSVTADSIEPGGEPHWLVVASTRHEIPDALARSTLEVAVRLLNAIER
.
Mb1218c|M.bovis_AF2122/97 ALRVQQLLGLAELNATTAPVDVSTIARELGVAAEGNATLIGFDTAENRDT
Rv1186c|M.tuberculosis_H37Rv ALRVQQLLGLAELNATTAPVDVSTIARELGVAAEGNATLIGFDTAENRDT
MMAR_4254|M.marinum_M ARRVQQLLGLADPDPTAAPADVTAIARELGLSADGNAALIGFDTIEADD-
MAB_0825|M.abscessus_ATCC_1997 AIELEKPARVADAEQRLRGAVTRALLADPAAADRSVLRYFGFDP----DT
Mvan_1854|M.vanbaalenii_PYR-1 SIALEKPARVQDAEQRLRSAVTRELLGGRGAVDDGLLRYFGFTP----DG
Mflv_0801|M.gilvum_PYR-GCK VRAAQGERDIEAALTRERVGQLLSLVERRMLLPDALSQLVQWPG------
MAV_4933|M.avium_104 ALALEAEESDAEFVRGALMGSLPAAELRMHAELRGLDPGAEYVA------
MSMEG_3975|M.smegmatis_MC2_155 SRYRAAVQNRARQAAFVRELVAGEIVDQFGAEGHLESLRFGHRPRLRVFA
Mb1218c|M.bovis_AF2122/97 AVRHVRLVDVMALSASAFRHDAQVAANGSRIYVLLPQTTTGRAVTSWVRG
Rv1186c|M.tuberculosis_H37Rv AVRHVRLVDVMALSASAFRHDAQVAANGSRIYVLLPQTTTGRAVTSWVRG
MMAR_4254|M.marinum_M --KQSRLADVLALSASAFRRDAQVGTNGSRIYVVLPQTATARSLTSWVRG
MAB_0825|M.abscessus_ATCC_1997 EVVVVLLCNVGSVLPGELHIDRQLARGGPYLMASVSGEIVVVLAAKN-VG
Mvan_1854|M.vanbaalenii_PYR-1 DVVVSVLHGIGPVLAAEEELSRPLADTGPYLMAATGTEIVIVLPADGSRA
Mflv_0801|M.gilvum_PYR-GCK -------------FAGEIACSAWPAGAGALLSISFPGALIGDAPDLCMML
MAV_4933|M.avium_104 -------------VRARLGGDGPHLRLEQSLGFQDPAHSRRGLCALLDGD
MSMEG_3975|M.smegmatis_MC2_155 MSPTADYDAGRWATRAPTVLDALEQDALDLARLMRLPVMFAQLDDQLIGV
. .
Mb1218c|M.bovis_AF2122/97 TISALRAELGVALRAAIAGPVAGLAEVNPARVEVDRVLESAERHPI-LGQ
Rv1186c|M.tuberculosis_H37Rv TISALRAELGVALRAAIAGPVAGLAEVNPARVEVDRVLESAERHPI-LGQ
MMAR_4254|M.marinum_M TISALRSELGVELRATIAAPVAGLDGLASARVEVDRVLDSAERHPISIGR
MAB_0825|M.abscessus_ATCC_1997 RASELHRSLGTALGRTICAGISRRVRLDEVPLGLHQARSVARAHPDGRIA
Mvan_1854|M.vanbaalenii_PYR-1 RIRTLLRGRGAPGG-----GSSRVVPMADVGTGLEQAR-VAAHSSVGEFT
Mflv_0801|M.gilvum_PYR-GCK TAGAVEMPDDLALP----TGHSAPVTLADLGSAIAQARIALTLAEHRGGR
MAV_4933|M.avium_104 LAGFLIEPPRDVEGVVGFGPPRPLTRLSESYRMAARALVTAEACGLRGAY
MSMEG_3975|M.smegmatis_MC2_155 LAADVPAVNGWITNQPEGTVCGLSEPFQDVRTGPERFRNAQRAMRAAQTR
: . :
Mb1218c|M.bovis_AF2122/97 VT-SLAEARTTVLLDEIVTLVG-TDQRLVDPRIRDLGAQDPVLAQTLRAY
Rv1186c|M.tuberculosis_H37Rv VT-SLAEARTTVLLDEIVTLVG-TDQRLVDPRIRDLGAQDPVLAQTLRAY
MMAR_4254|M.marinum_M VT-SLAEARTTVLLDEIVTLVG-NDARLIDPRIPDLRAKDPVLADTLRVY
MAB_0825|M.abscessus_ATCC_1997 EF-DELDIYGVLLGGRDRGELA-VLAQSVAPLLGTG--ADTTLLDTLESF
Mvan_1854|M.vanbaalenii_PYR-1 EY-ADLGPLAAVLDGRTSRELR-FLAAVLDPLAGN----DEDLIATLAAF
Mflv_0801|M.gilvum_PYR-GCK VGPDQLSTLESLLEQLPLAQLAPFRQLLIDPLTELDTSRGTQHVRTLRTF
MAV_4933|M.avium_104 DIAALGLRTAVAIDADVGELLR---KRYLEPLSVGG--SSRELIATVRTY
MSMEG_3975|M.smegmatis_MC2_155 NLRHTKFEDVGIADWLLTGHHREATVAKATDQLAVLG-RHSGYLEFVRTF
: :
Mb1218c|M.bovis_AF2122/97 LDAFGDIGAAARSLQVHPNTVRYRIRRIEQLLSTSLGDPDVRLLFSLGLR
Rv1186c|M.tuberculosis_H37Rv LDAFGDIGAAARSLQVHPNTVRYRIRRIEQLLSTSLGDPDVRLLFSLGLR
MMAR_4254|M.marinum_M LDSFGDIGLAAQSLQVHPNTVRYRIRRVEKLLSTSFADPDVRLVFSLGLR
MAB_0825|M.abscessus_ATCC_1997 LACNGQMETAALNLGVHRHTMRNRIARIAALLDCDLHSADTRAALWIAIR
Mvan_1854|M.vanbaalenii_PYR-1 LRHNGQMEAAAAELRVHRHTLRNRMRRIHQLLGDDLTSADSRAQLWLALR
Mflv_0801|M.gilvum_PYR-GCK VACNGSLSETAKELFLHTNTVRHRLGRIQEITGRDPLQHNDLTTFVIGMW
MAV_4933|M.avium_104 LACGMHVERTATRLFVHQNTVRYRLARFEELTGASLRDTEVVTEVWWVLE
MSMEG_3975|M.smegmatis_MC2_155 FANDLDVAATAKALNVHPNTVRHKVKRVEAMFGESLRSPALITAIHLSLE
. : :* * :* :*:* :: *. : . . . . :
Mb1218c|M.bovis_AF2122/97 AMERTA--------------
Rv1186c|M.tuberculosis_H37Rv AMERTA--------------
MMAR_4254|M.marinum_M ATDRSS--------------
MAB_0825|M.abscessus_ATCC_1997 ARALLG--------------
Mvan_1854|M.vanbaalenii_PYR-1 AFQLLENRRAPAGRCDS---
Mflv_0801|M.gilvum_PYR-GCK AADRGE--------------
MAV_4933|M.avium_104 LAAMRL--------------
MSMEG_3975|M.smegmatis_MC2_155 VLALDRSAGDGSGGGPARPH