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MSLTESRSGRVWAFDEFTLDTEGYELRQGDVAIRVEPQVFDVLVKLVDNHHRCVTKEELFDSVWGGRFVG EAALSSRIMAARKALGDDGESQRYIRTVRGRGYQFVGTLSDTAPRDEEPLEIEVPPLRQHIRFCYAADGV RLAYAATGDGPPLVRAANWMTHLGYDIESPVWQHWVRDLSAHHRLIRYDERGCGLSDWSARDFTFEDWVE DLASVVDALELEHFPLLGVSQGGAVAVAYAAKHPDRVSKLVLCGAYARGRAVRAVGEEELRAADLDRELA RVGWGRDDPAFRQVFAAQFLPEGSRADWDAFDQLQRRTTDAQNAVRFLDQFAQIDVLDVAGQVECPTLVM HAQDDLRVPMRFGEELAMLIPQSRFVALPSNNHLLTGTEPAWAIFCHELEAFLAEP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3297 | - | - | 100% (406) | transcriptional regulator, CadC |
| M. smegmatis MC2 155 | MSMEG_3856 | - | e-176 | 72.51% (422) | transcriptional regulator, CadC |
| M. smegmatis MC2 155 | MSMEG_4477 | - | 7e-18 | 28.16% (277) | hydrolase, alpha/beta hydrolase fold family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1935c | lipJ | 6e-14 | 29.64% (253) | lignin peroxidase LIPJ |
| M. gilvum PYR-GCK | Mflv_3121 | - | 1e-170 | 72.32% (401) | transcriptional regulator, CadC |
| M. tuberculosis H37Rv | Rv1900c | lipJ | 3e-13 | 28.97% (252) | lignin peroxidase LIPJ |
| M. leprae Br4923 | MLBr_02269 | - | 8e-11 | 25.79% (252) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_3934c | - | 6e-11 | 27.36% (212) | alpha/beta fold hydrolase |
| M. marinum M | MMAR_3505 | - | 3e-24 | 32.43% (259) | hydrolase |
| M. avium 104 | MAV_4589 | - | 2e-14 | 28.91% (256) | hydrolase, alpha/beta fold family protein |
| M. thermoresistible (build 8) | TH_2963 | - | 1e-11 | 27.20% (250) | PUTATIVE putative 3-oxoadipate enol-lactonase |
| M. ulcerans Agy99 | MUL_4838 | lipJ | 4e-14 | 28.31% (272) | lignin peroxidase LipJ |
| M. vanbaalenii PYR-1 | Mvan_3415 | - | 1e-173 | 74.06% (401) | transcriptional regulator, CadC |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3121|M.gilvum_PYR-GCK ----------------------MTSAD-ALSSSPRVWRWDDYVLDLGRYE
Mvan_3415|M.vanbaalenii_PYR-1 MPPTAGADLAATRGCRHRYCCRVTSADSALSPHRRVWRWDDFVLDVGCYE
MSMEG_3297|M.smegmatis_MC2_155 ----------------------MSLTE---SRSGRVWAFDEFTLDTEGYE
MLBr_02269|M.leprae_Br4923 --------------------------------------------------
MAV_4589|M.avium_104 --------------------------------------------------
MAB_3934c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1935c|M.bovis_AF2122/97 ---MAQAPHIHRTRYAKCGDMDIAYQVLGDGPTDLLVLPGPFVP-IDSID
Rv1900c|M.tuberculosis_H37Rv ---MAQAPHIHRTRYAKCGDMDIAYQVLGDGPTDLLVLPGPFVP-IDSID
MUL_4838|M.ulcerans_Agy99 ---MSQAPRTPRTRYARCGDLDIAYQVIGDHPIDLLVIPGASIP-VDTID
MMAR_3505|M.marinum_M ---MSDD----RVRYARNGDVHLAYRVFGQSGPTVIWVPGWMVSNVDTID
TH_2963|M.thermoresistible__bu --------------------------------------------------
Mflv_3121|M.gilvum_PYR-GCK LRAGDSVIRVEPQVFDVLTQLVSHHDRCVSKEELFDTVWGGRFVGEAALT
Mvan_3415|M.vanbaalenii_PYR-1 LRRGDTMIRVEPQVFDVLAQLVSNHGRFVSKEELFDTVWGGRFVGEAALT
MSMEG_3297|M.smegmatis_MC2_155 LRQGDVAIRVEPQVFDVLVKLVDNHHRCVTKEELFDSVWGGRFVGEAALS
MLBr_02269|M.leprae_Br4923 --------------------------------------------------
MAV_4589|M.avium_104 --------------------------------------------------
MAB_3934c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1935c|M.bovis_AF2122/97 DEPSLYR-FHRRLASFSRVIRLDHRGVGLSSRLAAITTLGPKFWAQDAIA
Rv1900c|M.tuberculosis_H37Rv DEPSLYR-FHRRLASFSRVIRLDHRGVGLSSRLAAITTLGPKFWAQDAIA
MUL_4838|M.ulcerans_Agy99 SEPSMYR-FHRRLASFSRLIRFDHRGVGLSSRVSSPDALGPRFWAEDAIA
MMAR_3505|M.marinum_M EPGSPYAPGIERASQQVRLVVWDRRGTGLSDPATHLLSLDER--LEDLRA
TH_2963|M.thermoresistible__bu --------------------------------------------------
Mflv_3121|M.gilvum_PYR-GCK SRIKA---VRRALGDDGEAQRYIRTVRGRGYRFVGTLHGEDSATPDEASV
Mvan_3415|M.vanbaalenii_PYR-1 SRIKA---VRRALGDDGEAQRYIRTVRGRGYQFVGRLLDDGTAPAPTAAP
MSMEG_3297|M.smegmatis_MC2_155 SRIMA---ARKALGDDGESQRYIRTVRGRGYQFVGTLS--DTAPRDEEPL
MLBr_02269|M.leprae_Br4923 --------------------------------------------------
MAV_4589|M.avium_104 --------------------------------------------------
MAB_3934c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1935c|M.bovis_AF2122/97 VMDAVGCEQATIFAPSFHAMNGLVLAADYPERVRSLIVVNGSARP-LWAP
Rv1900c|M.tuberculosis_H37Rv VMDAVGCEQATIFAPSFHAMNGLVLAADYPERVRSLIVVNGSARP-LWAP
MUL_4838|M.ulcerans_Agy99 VMDAAGCQQATILASGFTATTALVLAADYPERVRSLVLINASART-LHAP
MMAR_3505|M.marinum_M IVDSVGLDRAALWGTSEGGAVSILFAATYPDRVGLLSLFGTAARFSQDLP
TH_2963|M.thermoresistible__bu --------------------------------------------------
Mflv_3121|M.gilvum_PYR-GCK EHV---VRETPRQHIAFARAADGVRLAYAESGDGPPLVKA----ANWMTH
Mvan_3415|M.vanbaalenii_PYR-1 EPAPEPVPEPPRQHIAFTRAADGVRLAYAVSGEGRPLVRA----ANWMTH
MSMEG_3297|M.smegmatis_MC2_155 EIE----VPPLRQHIRFCYAADGVRLAYAATGDGPPLVRA----ANWMTH
MLBr_02269|M.leprae_Br4923 -------------MINLAYEDRG-------TGEPVVFIAG----RGGAGR
MAV_4589|M.avium_104 -------------MINLAYDDRG-------SGEPVVFIAG----HGGAGR
MAB_3934c|M.abscessus_ATCC_199 ------MPLANINGIQISYDDRGP-LALGASGDPVVFISG----RGGAGR
Mb1935c|M.bovis_AF2122/97 DYPVGAQVRRADPFLTVALEPDAVEQGFDVLSIVAPTVAGDDVFRAWWDL
Rv1900c|M.tuberculosis_H37Rv DYPVGAQVRRADPFLTVALEPDAVERGFDVLSIVAPTVAGDDVFRAWWDL
MUL_4838|M.ulcerans_Agy99 DYELGIRSNTAEPFLTLGTDPDAVEQGFDVLRIMAPSVAHDDAFRHWWDL
MMAR_3505|M.marinum_M DFPWGFTPAEVQSQLCAIEDDWGRGALAELFYGQAAEVPG---MRELFGR
TH_2963|M.thermoresistible__bu ------MPRFSRAGTTIDYTDTGAPAG---RLEAPTILFG-----HGLLF
. :
Mflv_3121|M.gilvum_PYR-GCK LGYDSESPVWRHGVREMSLRYRFIRYDERGCGLSDWDVGDFTFDDWVADL
Mvan_3415|M.vanbaalenii_PYR-1 LGYDIESPVWRHWVRDMSLRHKFIRYDERGCGLSDWEVGAFTFDDWVTDL
MSMEG_3297|M.smegmatis_MC2_155 LGYDIESPVWQHWVRDLSAHHRLIRYDERGCGLSDWSARDFTFEDWVEDL
MLBr_02269|M.leprae_Br4923 TWQPHQVPAF------LAAGYRVITFDNRGIG-ATENTEGFTTQTMVADT
MAV_4589|M.avium_104 TWHPYQVPAF------LAAGYRVITFDNRGIG-ATENAQGFTTETMVADT
MAB_3934c|M.abscessus_ATCC_199 SWHLHQVPAF------RAAGYRTITFNNRGIPPTTESADGFTLQDMVDDT
Mb1935c|M.bovis_AF2122/97 AGNRAGPPSMARAVSKVIAEADVRDVLGHIEAPTLILHRVGSTYIPVGHG
Rv1900c|M.tuberculosis_H37Rv AGNRAGPPSIARAVSKVIAEADVRDVLGHIEAPTLILHRVGSTYIPVGHG
MUL_4838|M.ulcerans_Agy99 AGNRAASPSTARAFINAVQASDARDSLPHITAPTLILHRVGTKFVPVEHG
MMAR_3505|M.marinum_M LQRSVSSPSMAKLWWQAFMATDVRAVLGSIRVPTLVLARPGDQLVPLESS
TH_2963|M.thermoresistible__bu SGWQFNLQIY-----ALRRYYRCLAIDWRGQGASSGAARPYDMDTLTEDA
:
Mflv_3121|M.gilvum_PYR-GCK ETVVDAVGLDRFHLMG---VSQGGAVAVAYAARHPDKVSRLVLCGAYARG
Mvan_3415|M.vanbaalenii_PYR-1 ESVVEAVGLERFPLLG---VSQGGAVAVAYAARHPDRVTRLVLCGAYARG
MSMEG_3297|M.smegmatis_MC2_155 ASVVDALELEHFPLLG---VSQGGAVAVAYAAKHPDRVSKLVLCGAYARG
MLBr_02269|M.leprae_Br4923 AVLIESLGAVPARIVG---VSMGSFIAQELMVARPELVRAAVLMATRGRL
MAV_4589|M.avium_104 AALIEGLNAAPARIVG---MSMGAFIAQELMLARPELVSAAVLMGTRGRM
MAB_3934c|M.abscessus_ATCC_199 AALIEQLGAAPARLVG---FSMGALIAQELTLTRPELVTAAVFMGTRGRE
Mb1935c|M.bovis_AF2122/97 RYLAEHIAGSRLVELP-GTDTLYWVGDTGPMLDEIEEFITGVRGGADAER
Rv1900c|M.tuberculosis_H37Rv RYLAEHIAGSRLVELP-GTDTLYWVGDTGPMLDEIEEFITGVRGGADAER
MUL_4838|M.ulcerans_Agy99 RYLAEHIAGSRLVELP-GSDSLYWVGDTAALLDEVEEFITGVRGGFVTER
MMAR_3505|M.marinum_M AALAAAIPNAQFRLLPPGPHTPFDIIDD--LAREVLDFFTGESGAPADER
TH_2963|M.thermoresistible__bu AHLVRSLGVAPAHYVG---LSMGGFVGIRLAARHPELVRSLVLMNTSAGP
: : : : . .
Mflv_3121|M.gilvum_PYR-GCK RAVRALSDDEKRAAALDLELARVGWGRDDPAFRQVFAAQFLPDGTR-ADW
Mvan_3415|M.vanbaalenii_PYR-1 RVVRAMNDDEKRAAALDLDLARVGWGRDDPAFRQVFAAQFLPDGTR-ADW
MSMEG_3297|M.smegmatis_MC2_155 RAVRAVGEEELRAADLDRELARVGWGRDDPAFRQVFAAQFLPEGSR-ADW
MLBr_02269|M.leprae_Br4923 DRTRQFFHAAEAEFHDSGIQLPSGYNAKVRLLENLSRKTLNDDVAV-ADW
MAV_4589|M.avium_104 DRARQFFRDAEAELADGGVALPASYEAKIRLLENFSRKTLNDDTAV-ADW
MAB_3934c|M.abscessus_ATCC_199 DATRSFFRKAELELSASGVEVPAAYQAAMRLLLNFSPKTLNNDAAI-KDW
Mb1935c|M.bovis_AF2122/97 MLATIMFTDIVGSTQHAAALGDDRWRDLLDNHDTIVCHEIQRFGGREVNT
Rv1900c|M.tuberculosis_H37Rv MLATIMFTDIVGSTQHAAALGDDRWRDLLDNHDTIVCHEIQRFGGREVNT
MUL_4838|M.ulcerans_Agy99 VLTAVMFTGIVGSTQRAATVGDLRWRDLLDNHDNLVRHEIQRFGGREVNT
MMAR_3505|M.marinum_M VLKTVLFTDIVSSTEKLSTMGDTAWRHQLNGHDSVVDNLLLRYGGTRAKH
TH_2963|M.thermoresistible__bu EDPAKADRYRTMARIYRFTGIGPLRRAVLPLMFGPAFLADPDSEDVIDEW
.
Mflv_3121|M.gilvum_PYR-GCK AAFDQLQRRTTSPENAVHFLEEFARIDVRDLCARVQCPTLVLHSR-----
Mvan_3415|M.vanbaalenii_PYR-1 AAFDQLQRRTTSPENAVRFLEEFAHIDVRDQCGQVRCPTLILHSR-----
MSMEG_3297|M.smegmatis_MC2_155 DAFDQLQRRTTDAQNAVRFLDQFAQIDVLDVAGQVECPTLVMHAQ-----
MLBr_02269|M.leprae_Br4923 IAMFNMWPIKSTP-GLRCQTDVAPQNNRLPAYRSIAAPVLVIGFA-----
MAV_4589|M.avium_104 IAMFSTWPVKSTP-GMRAQLDVAPYTNRLSAYRSIATPVLVIGFS-----
MAB_3934c|M.abscessus_ATCC_199 IDMFTLWPEPASG-GIDHQRSAIPAPDRPGAYADIKVPSLVIGFT-----
Mb1935c|M.bovis_AF2122/97 AGDGFVATFTSPSAAIACADDIVDAVAALGIEVRIGIHAGEVEVRDASHG
Rv1900c|M.tuberculosis_H37Rv AGDGFVATFTSPSAAIACADDIVDAVAALGIEVRIGIHAGEVEVRDASHG
MUL_4838|M.ulcerans_Agy99 AGDGFVATFSSPSAAINCADAVVDAVAVLGIEVRVGIHAGEVEVR----G
MMAR_3505|M.marinum_M TGDGVFALFDAPTKAARCALQLVPALAALNIAIRAGIHTGECERR----G
TH_2963|M.thermoresistible__bu ERRLRRYPRSSVR---DAVLAVANRAGVEDELAAIDVPTLVIGGA-----
:
Mflv_3121|M.gilvum_PYR-GCK -DDHRVPMRYGEELASLIPDARLVALSSNNHLLTATEPAWQVFCAEVAAF
Mvan_3415|M.vanbaalenii_PYR-1 -DDHRVPMRYGEELAALIPDARLVALSSNNHLLTGAEPAWRVFCDEVETF
MSMEG_3297|M.smegmatis_MC2_155 -DDLRVPMRFGEELAMLIPQSRFVALPSNNHLLTGTEPAWAIFCHELEAF
MLBr_02269|M.leprae_Br4923 -EDVVTPPSLGREVADVLPNGRYLQIPDAGHLGFFERPE-AVNAAALQFF
MAV_4589|M.avium_104 -DDVLTPPYLGREVADALPNGRYVQIPDTGHLGFFERPD-AVNAAMLKFF
MAB_3934c|M.abscessus_ATCC_199 -DDMTLPPYLGKEVADAIPGGQYVEISDAGHLGFIERPD-EVNRVILEFF
Mb1935c|M.bovis_AF2122/97 TDVAGVAVHIGARVCALAGPSEVLVSSTVRDIVAGSRHRFAERGEQELKG
Rv1900c|M.tuberculosis_H37Rv TDVAGVAVHIGARVCALAGPSEVLVSSTVRDIVAGSRHRFAERGEQELKG
MUL_4838|M.ulcerans_Agy99 ADVADLAVHIGARVCALAGSSEVLVSSTVRDIVTGSSHRFAERGEHELKG
MMAR_3505|M.marinum_M QEWSGMAVHIGARIGVLADAGEVFASRTVRDLTAGSGLTFESLGPQQLKG
TH_2963|M.thermoresistible__bu -QDAATPPAHAQALAAGIRGARLEIIDDCGHSSPLERPD--VVTELLRGF
: . . : .. .
Mflv_3121|M.gilvum_PYR-GCK LV-----------------
Mvan_3415|M.vanbaalenii_PYR-1 LAV----------------
MSMEG_3297|M.smegmatis_MC2_155 LAEP---------------
MLBr_02269|M.leprae_Br4923 AGVKGEWP-----------
MAV_4589|M.avium_104 GEQH---------------
MAB_3934c|M.abscessus_ATCC_199 ASTAQTV------------
Mb1935c|M.bovis_AF2122/97 VPGRWRLCVLMRDDATRTR
Rv1900c|M.tuberculosis_H37Rv VPGRWRLCVLMRDDATRTR
MUL_4838|M.ulcerans_Agy99 VPGRWRLCALVREHLTGQR
MMAR_3505|M.marinum_M LPEQIEIYRVSAA------
TH_2963|M.thermoresistible__bu LLEHT--------------