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VAVVTGGGSGIGRAIVERLAHDGHRVAVLDVNEEAAEKVAARVAADGAHAIAVPTDVAESASVAAAFESV RRALGSVQVLVTSAAITGFKPFAEITIEDWNRHLAVNLTGTFLCLQAALPDMVEAGWGRVVTISSTAAQT GSPRQGHYSASKGGVIALTRTIALEYAAHGITANTVPPFSVDTPMLRAAQEAGNLPPVKYLAKASPVGRL GTGEDIAAACAFLCSDEAGYITGQIIGVNGGEVI
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1395 | - | - | 100% (244) | 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase |
| M. avium 104 | MAV_3962 | - | 5e-73 | 56.56% (244) | NAD-dependent epimerase/dehydratase:Short-chain |
| M. avium 104 | MAV_0942 | - | 7e-65 | 52.92% (240) | 3-oxoacyl-(acyl-carrier-protein) reductase, putative |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0792 | - | 2e-37 | 36.44% (247) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1258 | - | 9e-87 | 61.89% (244) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv0769 | - | 8e-38 | 36.84% (247) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 3e-38 | 38.68% (243) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_2723c | - | 1e-35 | 35.15% (239) | 3-oxoacyl- |
| M. marinum M | MMAR_4715 | - | 4e-61 | 51.25% (240) | 3-oxoacyl- |
| M. smegmatis MC2 155 | MSMEG_0527 | - | 2e-91 | 63.52% (244) | 2-hydroxycyclohexnecarboxyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_2435 | - | 2e-90 | 65.42% (240) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_0315 | fabG2 | 4e-61 | 51.25% (240) | 3-oxoacyl- |
| M. vanbaalenii PYR-1 | Mvan_4185 | - | 1e-72 | 54.51% (244) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1258|M.gilvum_PYR-GCK MVSR-------------------VAVVTGGASGLGEAICAGLAADGHRVA
MSMEG_0527|M.smegmatis_MC2_155 -MSR-------------------VAAVTGAGSGVGRATALQLARDGHRVA
TH_2435|M.thermoresistible__bu --------------------------VTGGASGLGRAIAARLGDDGHRVA
MAV_1395|M.avium_104 -----------------------MAVVTGGGSGIGRAIVERLAHDGHRVA
MMAR_4715|M.marinum_M -MK--------------------TAVVTGGASGIGLAIARRLRADGIDVA
MUL_0315|M.ulcerans_Agy99 -MRPDSS----------PSWCTITSVVTGGASGIGLAIARRLSADGTDVA
Mvan_4185|M.vanbaalenii_PYR-1 -MTR-------------------VAVVTGGASGMGEATCHELGRRGCKVA
MLBr_01807|M.leprae_Br4923 -MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVA
MAB_2723c|M.abscessus_ATCC_199 -MTNA-------------EFVPRSVLVTGGNRGIGLAVAQRLAADGHKVA
Mb0792|M.bovis_AF2122/97 ------------------MFDSKVAIVTGAAQGIGQAYAQALAREGASVV
Rv0769|M.tuberculosis_H37Rv ------------------MFDSKVAIVTGAAQGIGQAYAQALAREGASVV
***. *:* * * * *.
Mflv_1258|M.gilvum_PYR-GCK VLDLDADAANRVAASLRGNGASAVGVAVDVSDEDAVVRAFDAVRTEFGPV
MSMEG_0527|M.smegmatis_MC2_155 VMDLDGQAAEEAAAKIESHGGRALAVAVDVADESAVAAGFEAARQAFGPI
TH_2435|M.thermoresistible__bu VLDIDHAAAEQTAAELRAHGGDAVAVGADVADQDAVHDAFAAIRGSLGPV
MAV_1395|M.avium_104 VLDVNEEAAEKVAARVAADGAHAIAVPTDVAESASVAAAFESVRRALGSV
MMAR_4715|M.marinum_M TLDLKTPDGE-------------LAFSADVTNRSQVDAALTAIRQRLGPV
MUL_0315|M.ulcerans_Agy99 TLDLKTPDGG-------------LAFSADVTNRSQVDAALAAIRQRLGPV
Mvan_4185|M.vanbaalenii_PYR-1 VLDLDGQAAQRVAEELRGDGVPALGVAADVTDRAAVEDAFAKVRTELGPV
MLBr_01807|M.leprae_Br4923 VTHRASVVPDW-----------FFGVECDVTDNDAIGAAFKAVEEHQGPV
MAB_2723c|M.abscessus_ATCC_199 VTHRGSGAPEG-----------LLGVQCDITDNDQIDAAFKEVEEKQGPV
Mb0792|M.bovis_AF2122/97 VADINADGAAAVAKQIVADGGTVIHVPVDVSDEDSAKAMVDRAVGAFGGI
Rv0769|M.tuberculosis_H37Rv VADINADGAAAVAKQIVADGGTAIHVPVDVSDEDSAKAMVDRAVGAFGGI
. . . . *::: . * :
Mflv_1258|M.gilvum_PYR-GCK EILVTSAAIGG---FTRFDKITLDEWNRYLAVNLTGTFLSIRAALSDMVA
MSMEG_0527|M.smegmatis_MC2_155 GIVVTSAAMGG---FTRFDKITLDEWNRYLAVNLTGTFLCIRAALPDMVK
TH_2435|M.thermoresistible__bu HILVTSAAIAG---FTRFDEITLDEWNRYLAVNLTGTFLCVQAALTDMVA
MAV_1395|M.avium_104 QVLVTSAAITG---FKPFAEITIEDWNRHLAVNLTGTFLCLQAALPDMVE
MMAR_4715|M.marinum_M TILVNAAGLDG---FKRFSNITFEDWQRVIDVNLNGVFHTIQAVLPDMVA
MUL_0315|M.ulcerans_Agy99 TILVNAAGLDG---FKRFSNITFEDWQRVIDVNLNGVFHTIQAVLPDMVA
Mvan_4185|M.vanbaalenii_PYR-1 HILVTSAGLVD---FAPFLEISPDRWQRLIEVNLNGTFHCAQVAIPDMLA
MLBr_01807|M.leprae_Br4923 EVLVANAGITS---DMLIMRMSEEQFQKVIDVNLTGVFRVAKLASRNMIK
MAB_2723c|M.abscessus_ATCC_199 EVLVANAGITA---DMLIMRMSEEQFLKVIDANLIGTFRLAKRASRNMIK
Mb0792|M.bovis_AF2122/97 DYLVNNAAIYGGMKLDLLLTVPLDYYKKFMSVNHDGVLVCTRAVYKHMAK
Rv0769|M.tuberculosis_H37Rv DYLVNNAAIYGGMKLDLLLTVPLDYYKKFMSVNHDGVLVCTRAVYKHMAK
:* *.: : :. : : : : .* *.: : . .*
Mflv_1258|M.gilvum_PYR-GCK AQWGRVVTISSAAGQQGAPRQGHYSATKGGVIAMTKTVARDYARHGITAN
MSMEG_0527|M.smegmatis_MC2_155 AQWGRIVTISSAAGQRGAPAQGHYSATKGGVIAMTKTLALDYAAKGITAN
TH_2435|M.thermoresistible__bu DGWGRIVTISSAAGQQGAHRQGHYAATKGGVIALTKTVALDYAAKGITAN
MAV_1395|M.avium_104 AGWGRVVTISSTAAQTGSPRQGHYSASKGGVIALTRTIALEYAAHGITAN
MMAR_4715|M.marinum_M AGWGRIVNISSSSTHSGTPYMTHYVAAKSAVNGLTKALALEYGPSGITVN
MUL_0315|M.ulcerans_Agy99 AGWGRIVNISSSSTHSGTPYMTHYVAAKSAVNGLTKALALEYGPSGITVN
Mvan_4185|M.vanbaalenii_PYR-1 AGWGRIVMISSSSAQRGSPGMAHYAASKGALISFTRSLAREYGPAGITVN
MLBr_01807|M.leprae_Br4923 QRFGRYIFMGSVVGLSGVPGQANYAASKSGLIGMARSLARELGSRSITAN
MAB_2723c|M.abscessus_ATCC_199 KRFGRLIFMGSVAGQIGLPGQANYSASKAGLVGMARALTRELGSRSITAN
Mb0792|M.bovis_AF2122/97 RGGGAIVNQSSTAAWLYSN---FYGLAKVGVNGLTQQLARELGGMKIRIN
Rv0769|M.tuberculosis_H37Rv RGGGAIVNQSSTAAWLYSN---FYGLAKVGVNGLTQQLARELGGMKIRIN
* : .* * :* .: .::: :: : . * *
Mflv_1258|M.gilvum_PYR-GCK SLPPFAIETPMLRRQQSEGKLPPDEFLTQAIPAGRVGAPSDVAAVCSFLC
MSMEG_0527|M.smegmatis_MC2_155 TIPPFVIDTPMLREQQAAGLLPQAEHLTKAIPAGRLGSGDDVAAMCSFLC
TH_2435|M.thermoresistible__bu TVPPFVIDSPMLREQQRRGTLPPAEYLTRAIPMGRLGVAEDVAAVCSFLC
MAV_1395|M.avium_104 TVPPFSVDTPMLRAAQEAGNLPPVKYLAKASPVGRLGTGEDIAAACAFLC
MMAR_4715|M.marinum_M AVPPGFIDTPMLRNAAAQGHLGDIEQNIARTPVRRIGKPEDIAAACAFLV
MUL_0315|M.ulcerans_Agy99 AVPPGFIDTPMLRNAAAQGHLGDIEQNIARTPVRRIGKPEDIAAACAFLV
Mvan_4185|M.vanbaalenii_PYR-1 NVPPSGIETPMQHQSQAAGFLPPNEQMAASIPVGHLGTGDDIAAAVGFLC
MLBr_01807|M.leprae_Br4923 VVAPGFIDTEMTRAMDSK----YQEAALQAIPLGRIGAVEEIAGAVSFLA
MAB_2723c|M.abscessus_ATCC_199 VVAPGFIDTDMTRELGEK----HVETALTAIPMGRIGEPSEVAGVVSWLA
Mb0792|M.bovis_AF2122/97 AIAPGPIDTEATRTVTPA---ELVKNMVQTIPLSRMGTPEDLVGMCLFLL
Rv0769|M.tuberculosis_H37Rv AIAPGPIDTEATRTVTPA---ELVKNMVQTIPLSRMGTPEDLVGMCLFLL
:.* ::: : : * ::* .::.. :*
Mflv_1258|M.gilvum_PYR-GCK SDAAGYVTGQVIGVNGGAVL--
MSMEG_0527|M.smegmatis_MC2_155 SDAAGYVTGQVIGVNGGAVL--
TH_2435|M.thermoresistible__bu SDAAGYLTGQVIGVNGGAIR--
MAV_1395|M.avium_104 SDEAGYITGQIIGVNGGEVI--
MMAR_4715|M.marinum_M SEEAGYITGQILGVNGGRNT--
MUL_0315|M.ulcerans_Agy99 SEEAGYITGQILGVNGGRNT--
Mvan_4185|M.vanbaalenii_PYR-1 SEEAGFITGQTLGVNGGSVMA-
MLBr_01807|M.leprae_Br4923 SEDAGYISGAVIPVDGGLGMGH
MAB_2723c|M.abscessus_ATCC_199 SPDAAYVSGAVIPVDGGLGMGH
Mb0792|M.bovis_AF2122/97 SDSASWITGQIFNVDGGQIIRS
Rv0769|M.tuberculosis_H37Rv SDSASWITGQIFNVDGGQIIRS
* *.:::* : *:**