For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
KTTDTSDLARTRNLLSRLEAGDRVDYDFIVCGAGTTGSVVARRLAEGLGASVLLLEAGGDDDVESIMDPQ RWPANLGTERDWGFVAEENVHLNNRALPMSMGKVLGGGSSINVMCWARGHKADWNFFAAEAGDPAWGYDN VLEIYRSVENWTGTPDPVRRGTRGPIHVEPIPDPQPCAVATIEAAKSLGLPAYDSPNGAMMEGPGGAAML EVLTKDGRRQSIYRAYVVPVLGRVDLTVLTGAVVQRIVVVGRRATAVEVKIAGTVHEITARSEVIVSLGA INTPKVLLQSGIGDERQLRYFGIPVNAHLPGVGRNLQDHLAFPVEWEFPPGWGPDARGQACIYWSSESGL AAPDQYACFTGIPFGTPETAERFPLPASAWFLYGTVARPQSRGTVTLTGSHPCDPVQVHANSLAHPEDVA KSRQCVEFLREFGNAAELRPYVRRPVMPGDLAGRDLDEFLRNAGGSFWHPTWLKLVCTVGADLDEDCS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3432 | - | - | 100% (489) | choline dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0281 | - | e-144 | 55.73% (445) | choline dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3444 | - | 8e-48 | 31.91% (467) | choline dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1310 | - | 1e-49 | 31.89% (486) | dehydrogenase FAD flavoprotein GMC oxidoreductase |
| M. gilvum PYR-GCK | Mflv_1255 | - | 3e-44 | 30.30% (495) | glucose-methanol-choline oxidoreductase |
| M. tuberculosis H37Rv | Rv1279 | - | 1e-49 | 31.89% (486) | dehydrogenase FAD flavoprotein GMC oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0250 | - | 8e-50 | 31.96% (485) | GMC-type oxidoreductase |
| M. marinum M | MMAR_4427 | - | 1e-142 | 53.03% (445) | dehydrogenase fad flavoprotein GMC oxidoreductase |
| M. avium 104 | MAV_4980 | - | 4e-41 | 32.38% (383) | choline dehydrogenase |
| M. thermoresistible (build 8) | TH_3275 | - | 2e-50 | 34.12% (510) | PUTATIVE putative oxidoreductase, GMC family protein |
| M. ulcerans Agy99 | MUL_4004 | - | 6e-52 | 31.91% (492) | dehydrogenase fad flavoprotein GMC oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_1606 | - | 1e-146 | 53.85% (468) | glucose-methanol-choline oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1310|M.bovis_AF2122/97 -----------------------MDTQSDYVVVGTGSAGAVVASRLSTDP
Rv1279|M.tuberculosis_H37Rv -----------------------MDTQSDYVVVGTGSAGAVVASRLSTDP
MUL_4004|M.ulcerans_Agy99 -----------------------MDIECDYVVVGTGSAGAAVVNRLSADS
MAB_0250|M.abscessus_ATCC_1997 ---------------------MVEDLAADFVIVGAGSAGAPLATRLSERT
Mflv_1255|M.gilvum_PYR-GCK ----------------------MAVTGYDYIVVGAGSAGCVLANRLSADP
MAV_4980|M.avium_104 --------------------------------------------------
TH_3275|M.thermoresistible__bu ---------------MGVVMMGRRSNLHDYIVVGAGSSGCTVAGRLAEGK
MMAR_4427|M.marinum_M ------------------MCSDPIAARYDFVVCGSGSAGSVVARRLSENS
Mvan_1606|M.vanbaalenii_PYR-1 MGDHGHTDLAERIRLNQNRLRQNLRPQYDFIVCGAGSAGSVIARRLAENP
MSMEG_3432|M.smegmatis_MC2_155 MKTTDTSDLAR-TRNLLSRLEAGDRVDYDFIVCGAGTTGSVVARRLAEGL
Mb1310|M.bovis_AF2122/97 ATTVVALEAGPRDKNRFIGVPAAFSKLFRSEID-WDYLTEPQPELDGREI
Rv1279|M.tuberculosis_H37Rv ATTVVALEAGPRDKNRFIGVPAAFSKLFRSEID-WDYLTEPQPELDGREI
MUL_4004|M.ulcerans_Agy99 GTSVVALEAGPSDKNRFIGIPAAFPKLFRSEVD-WDYTTEPEPQLGGREI
MAB_0250|M.abscessus_ATCC_1997 NDQVLVLEAGPKDKDMGIHIPAAFSKLFRSDVD-WDYLTEPQPQLNNRQI
Mflv_1255|M.gilvum_PYR-GCK AIRVLLLEAGRGDRNLWLHIPKGAGKLFDSERHMWHYETTPFG-PDAHVE
MAV_4980|M.avium_104 -------------------MQTAIG----------------------RAV
TH_3275|M.thermoresistible__bu RHSVLVLEAGGSDLSPFIRIPAGLMR--VNPRNYWHFRLEPDPTRNGAVD
MMAR_4427|M.marinum_M NVAVLLLEAGGTDDVAEVMDPAQWPVNLGSARD-WGFASAPSAHLNGRSI
Mvan_1606|M.vanbaalenii_PYR-1 DVSVLLLEAGGDDDDESVVRADQWPLNLGTSRD-WNFVAEASPHVNGRSL
MSMEG_3432|M.smegmatis_MC2_155 GASVLLLEAGGDDDVESIMDPQRWPANLGTERD-WGFVAEENVHLNNRAL
Mb1310|M.bovis_AF2122/97 YWPRGKVLGGSSSMNAMMWVRGFASDYDEWAARAG-PRWSYADVLGYFRR
Rv1279|M.tuberculosis_H37Rv YWPRGKVLGGSSSMNAMMWVRGFASDYDEWAARAG-PRWSYADVLGYFRR
MUL_4004|M.ulcerans_Agy99 YWPRDKVLGGSSSMNAMMWVRGFAADYDEWARLAG-SHWSYGELLGYFRQ
MAB_0250|M.abscessus_ATCC_1997 YWPRGKTLGGSSSMNAMMWVRGFAADYDDWAQVAG-EQWSFANIAPYFKR
Mflv_1255|M.gilvum_PYR-GCK QWMRGKVIGGSSAVNGMIYNRGHRADYDALEQMGN-KGWGWDEILPIFKG
MAV_4980|M.avium_104 PFARGRGIGGSSTINAMVFARGHRDSYSRWRDNGA-AGWSFDELLPYFKR
TH_3275|M.thermoresistible__bu TWAAGRVVGGGSSVNAMLWVRGNRADFDTWAKLGA-QGWDYESLLPAMRS
MMAR_4427|M.marinum_M PLSMGKVLGGGSSINVMAWARGHRNDWAHFAAEAGDPSWGYESVLDVYRR
Mvan_1606|M.vanbaalenii_PYR-1 PMNMGKVLGGGSSINVMMWSRGHRSDWDFFAAEASDPGWGYDAVLDIYRR
MSMEG_3432|M.smegmatis_MC2_155 PMSMGKVLGGGSSINVMCWARGHKADWNFFAAEAGDPAWGYDNVLEIYRS
.: :**.*::* * : ** .: . *.: : :
Mb1310|M.bovis_AF2122/97 IENVTAAWHFVSGDDSGVTGPLHISRQRSPRSVTAAWLAAARECGFAAAR
Rv1279|M.tuberculosis_H37Rv IENVTAAWHFVSGDDSGVTGPLHISRQRSPRSVTAAWLAAARECGFAAAR
MUL_4004|M.ulcerans_Agy99 IEDVTAAWHFVNGDDSGVTGPLQISRQRSPSPLTAAWLAATRDCGFAPVQ
MAB_0250|M.abscessus_ATCC_1997 IEAVEG----ATESDEGTDGALKISKQRSPRSSTAAWLEAVKEAGFDVER
Mflv_1255|M.gilvum_PYR-GCK FEDHEFG----PSATRGTGGPLHISVPRDPDPLCEDMIEAATGAGMWRVR
MAV_4980|M.avium_104 SESTCGK----DPSLRGQDGPMAVAPAAHPNPVLVACLCAAIQQGYPRAA
TH_3275|M.thermoresistible__bu LETWEGG----ADRYRGGTGPQHVSRIRLHHPLVQKWLTGAAQTGMPILA
MMAR_4427|M.marinum_M IEDWHGR---CDGDRRGVGGPVFVQTAPDPNPIATAVVDGAGAIGIPVYD
Mvan_1606|M.vanbaalenii_PYR-1 IEDWHGS---PDPDYRGSGGEVFVQPAPDPNPVAPAAVDAAAAVGIPTFD
MSMEG_3432|M.smegmatis_MC2_155 VENWTGT---PDPVRRGTRGPIHVEPIPDPQPCAVATIEAAKSLGLPAYD
* * * : . : .. *
Mb1310|M.bovis_AF2122/97 -PNSPRPEG---FCETVVTQRRGARFSTADAYLKPAMRRKNLRVLTGATA
Rv1279|M.tuberculosis_H37Rv -PNSPRPEG---FCETVVTQRRGARFSTADAYLKPAMRRKNLRVLTGATA
MUL_4004|M.ulcerans_Agy99 -PNSAEPEG---FCETIVTQRRGSRWSTVDAYLRPAMGRRNLSILTGATA
MAB_0250|M.abscessus_ATCC_1997 -ANTPEPKG---FSETMVCQHGGRRWSTADGYLKPGLRRRNLNVVTDAQA
Mflv_1255|M.gilvum_PYR-GCK DINESDGER---IGYATSTIRGGRRVSAATAFLKPVLHRPNLTVRTGATV
MAV_4980|M.avium_104 DISGGLEVG---FGFTDLNIVDGKRQSAADAYLLPALDRPNLEFHSGATV
TH_3275|M.thermoresistible__bu DYNGESQFG---AAWSQLSQKNGLRHSAAQAFLAPARRRGEVDVESHAVV
MMAR_4427|M.marinum_M SNNGIMMEGPGGASLLDLQLRNRLRESVFRSYVHPYLQQRNLTVLTGATV
Mvan_1606|M.vanbaalenii_PYR-1 HPNGKMMEGCGGAAISDMRVRDGLRESVFRSYTYPYLDRPNLTVLTGAVV
MSMEG_3432|M.smegmatis_MC2_155 SPNGAMMEGPGGAAMLEVLTKDGRRQSIYRAYVVPVLGRVDLTVLTGAVV
. * * .: * : :: . : * .
Mb1310|M.bovis_AF2122/97 TRVVIDGDRAVGVEYQSDGQTRIVYARREVVLCAGAVNSPQLLMLSGIGD
Rv1279|M.tuberculosis_H37Rv TRVVIDGDRAVGVEYQSDGQTRIVYARREVVLCAGAVNSPQLLMLSGIGD
MUL_4004|M.ulcerans_Agy99 TRIVIHGTRATGVEYQREGQHCTVHARREVVLCGGAVNSPQLLMLSGIGD
MAB_0250|M.abscessus_ATCC_1997 RRVLFDGIRAVGVEYVRDGITHTVHARREVILSGGAINSPQLLMLSGIGE
Mflv_1255|M.gilvum_PYR-GCK RRVLFDGERADGVEIATGAGTEQVRAAREVVLSLGSLNSPKLLQLSGIGP
MAV_4980|M.avium_104 HRLRIRGSRCTGVEYTTAEGRQVTAAAREIILCAGAIGSPHLLLASGIGP
TH_3275|M.thermoresistible__bu DKVIIENGRAVGVEYVRRGTRKVAYAAKEVILSAGALCSPLILLRSGIGP
MMAR_4427|M.marinum_M RRLTFSGSRVTGVEFSHANAIRTVSATQEVVVSLGAVNTPKVLMQSGIGD
Mvan_1606|M.vanbaalenii_PYR-1 TRVPVHMQRATGVEFEMAGTTHRIDAGVETVLCLGAIHTPKVLMHSGIGD
MSMEG_3432|M.smegmatis_MC2_155 QRIVVVGRRATAVEVKIAGTVHEITARSEVIVSLGAINTPKVLLQSGIGD
:: . * .** * * ::. *:: :* :* ****
Mb1310|M.bovis_AF2122/97 RDHLAEHDIDTVYHAPEVGCNLLDHLVTVLGFDVEKDS-----LFAAEK-
Rv1279|M.tuberculosis_H37Rv RDHLAEHDIDTVYHAPEVGCNLLDHLVTVLGFDVEKDS-----LFAAEK-
MUL_4004|M.ulcerans_Agy99 RSHLADHGIETVYHAPEVGQNLLDHLITPLGFDVAGDS-----LAAAEK-
MAB_0250|M.abscessus_ATCC_1997 ATRLGELGIPVVHDAPQVGQNLLDHLCCPVGYAVKSDS-----LFGAEK-
Mflv_1255|M.gilvum_PYR-GCK SDVLGAAGVPVLVERDNVGRRMREHRCATLRYRLKEDLGY-NKLLATNVG
MAV_4980|M.avium_104 PNHLRSFRVDVALELPGVGANLQDHPIVPLVYRAARPVPAGR--------
TH_3275|M.thermoresistible__bu AEELRDHGIDVIADLPGVGRNLQEHPAITMTFTVTDRTLN---QELTPLS
MMAR_4427|M.marinum_M ANDLRGFGIPVVTHLRGVGHNYQDHPRIDCVWESHEALAPR---------
Mvan_1606|M.vanbaalenii_PYR-1 AAELHRLGIAPVQHLPGVGANLQDHPGFGCVWEYRDPLPPR---------
MSMEG_3432|M.smegmatis_MC2_155 ERQLRYFGIPVNAHLPGVGRNLQDHLAFPVEWEFPPGWGP----------
* : . ** . :* :
Mb1310|M.bovis_AF2122/97 -PGQLISYLLRRRGMLTSNVGEAYGFVRSRPELKLPDLELIFAP------
Rv1279|M.tuberculosis_H37Rv -PGQLISYLLRRRGMLTSNVGEAYGFVRSRPELKLPDLELIFAP------
MUL_4004|M.ulcerans_Agy99 -PMQLINYLLRRRGMLTSNVGEAYGFVRSRPGLDLPDLELIFAP------
MAB_0250|M.abscessus_ATCC_1997 -PLQLANYFLRHRGMLTSNVGEAYGFLRSHPNLTLPDLELIFAP------
Mflv_1255|M.gilvum_PYR-GCK QALTGMKYLATRKGPLAAPSFDVVGFVKDRPDSERPLGQVMMGPW-----
MAV_4980|M.avium_104 -----------------YNHGELLGLIRRHATGGPPEIQIFGVD------
TH_3275|M.thermoresistible__bu ILKGAFDFVLRRRGPATAPLSHAMLFGPPLEPEGWPQYHVLMAPLGTEQE
MMAR_4427|M.marinum_M -----------------NNGAEVTVFWKSHPKLATPDLQICVAEFP----
Mvan_1606|M.vanbaalenii_PYR-1 -----------------NTASEATYFWKSDPQLPTPDLQTCQVEVP----
MSMEG_3432|M.smegmatis_MC2_155 -----------------DARGQACIYWSSESGLAAPDQYACFTGIP----
. *
Mb1310|M.bovis_AF2122/97 ----------APFYDEALVP-PAGHGVVFGPILVAPQSRGQITLRSADPH
Rv1279|M.tuberculosis_H37Rv ----------APFYDEALVP-PAGHGVVFGPILVAPQSRGQITLRSADPH
MUL_4004|M.ulcerans_Agy99 ----------APFYDEGLPAHPPGHGVVFGPILVAPQSRGQITLRSADPH
MAB_0250|M.abscessus_ATCC_1997 ----------APFFDEGIGV-ATEHAIVMGPILLKPESSGEITLTSPDPL
Mflv_1255|M.gilvum_PYR-GCK --------TLPPYNTGEPVVIEREPGISCLGMVLRPTSQGYVEITSADPG
MAV_4980|M.avium_104 --------------SADVPGLGGADGYVLGVSVMQPVSRGRVGLSGPTIQ
TH_3275|M.thermoresistible__bu KPHATQEEAEQNRYDKQNVSLSRNSIVSAFMSPLHPRGRGTVRLGSPDVD
MMAR_4427|M.marinum_M ----------LSSPENAARYGLPAHGWTMCVGVVRPQSRGRVRLTGAHPG
Mvan_1606|M.vanbaalenii_PYR-1 ----------LTSAENAARFGVPQAGWTMFAGVVRPASRGRVWLSSAQPS
MSMEG_3432|M.smegmatis_MC2_155 ----------FGTPETAERFPLPASAWFLYGTVARPQSRGTVTLTGSHPC
* . * : : ..
Mb1310|M.bovis_AF2122/97 AKPVIEPRYLSDLGGVDRAAMMAGLRICARIAQARPLRDLLGSIARPRNS
Rv1279|M.tuberculosis_H37Rv AKPVIEPRYLSDLGGVDRAAMMAGLRICARIAQARPLRDLLGSIARPRNS
MUL_4004|M.ulcerans_Agy99 AKPIIEARYLSDPGGVDRAAMMEGLRICARIAQAPALRGLLGPVARPHNS
MAB_0250|M.abscessus_ATCC_1997 AKPRIDPRYLSDPAGRDRAAMMFGLRTTARIAETPSMRAVLGKILRPRNP
Mflv_1255|M.gilvum_PYR-GCK AALRITPNYLTT--EHDRTATAALVRRMRSIFEQSPIAERISHETYPGPR
MAV_4980|M.avium_104 EPPAIDPNYLSD--DRDMGLMIEGLRIGRKIGMSQALDPWRAEELAPGDD
TH_3275|M.thermoresistible__bu ATPVIEHPMLAD--ERDVVDLTAAGRKVREIFQSPAMRPHVIAENAPSRG
MMAR_4427|M.marinum_M APVLIEAEMLAHP--DDMKAAAAGVQLCREIGNSAPLRPFAKREVMPG--
Mvan_1606|M.vanbaalenii_PYR-1 DPVHIDTGMLSDP--ADVAAAVAAVELCREIGNAAPLRPFTKREVMPG--
MSMEG_3432|M.smegmatis_MC2_155 DPVQVHANSLAHP--EDVAKSRQCVEFLREFGNAAELRPYVRRPVMPG--
: *: * . : : *
Mb1310|M.bovis_AF2122/97 TELDEATLELALATCSHTLYHPMGTCRMGSD--EASVVDPQLRVRGVDGL
Rv1279|M.tuberculosis_H37Rv TELDEATLELALATCSHTLYHPMGTCRMGSD--EASVVDPQLRVRGVDGL
MUL_4004|M.ulcerans_Agy99 SELDEATLELALTTCSHTLYHPLGTCRMGSD--EASVVDRQLRVRGVDGL
MAB_0250|M.abscessus_ATCC_1997 SDDLEETLVAALENNSHTLYHPVGTCRMGAD--DASVVTPDLTVRGVQGL
Mflv_1255|M.gilvum_PYR-GCK VDSDEELVDAALEG-GYCGYHAVGTCAMGPD--DDDVVDSHLRVRGVDGL
MAV_4980|M.avium_104 -AVDDAALRSYIQRSVASYFHPVGTCAMGTG--PESVVDNQLRLHGIDNL
TH_3275|M.thermoresistible__bu VETDD-EWAEFIRNHCFGGSHWVGTARMGADSDPDAVVDPQLRVRGVSGL
MMAR_4427|M.marinum_M -GLAGAELERFVRDGASTYWHQSGTAKMGRD--DMSVVDAKLKVHGMENL
Mvan_1606|M.vanbaalenii_PYR-1 -NLRGPALEEFVRNAASTYWHPTGTAKMGRD--DMSVVDGALRVYGVAGL
MSMEG_3432|M.smegmatis_MC2_155 -DLAGRDLDEFLRNAGGSFWHPT-----------------WLKLVCTVGA
: * * : .
Mb1310|M.bovis_AF2122/97 RVADASVMPSTVRGHTHAPSVLIGEKAADLIRS-------
Rv1279|M.tuberculosis_H37Rv RVADASVMPSTVRGHTHAPSVLIGEKAADLIRS-------
MUL_4004|M.ulcerans_Agy99 RVADASVMPSTVRGHTHAPSVLIGAKAADLIRN-------
MAB_0250|M.abscessus_ATCC_1997 RVVDASVIPSLIRGHTHAPSVLLGEKAADLILSPQP----
Mflv_1255|M.gilvum_PYR-GCK RVVDCSVMPTIVAGNLNGPIMAMAWRAADFILHGR-----
MAV_4980|M.avium_104 RVIDASVMPSLPSNNTAATVYAIAERGADLVRLG------
TH_3275|M.thermoresistible__bu RVADASVMPTLTSGNTNAPCVLIGEKAAELIRGR------
MMAR_4427|M.marinum_M RVADSSIMPRITTGNTMAPCVVIGERAAEIVKADHGL---
Mvan_1606|M.vanbaalenii_PYR-1 RVADGSIMPRVSTGNTMAPCVVIGERAAALLGATHGLRAA
MSMEG_3432|M.smegmatis_MC2_155 DLDEDCS---------------------------------
: : .