For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MTAPTMSAVVPDPAWRDLRQQVRSFLADQLAAHRFEPGIDGWLTGWSDTFSRSLAQQGWVGMTIPRQYGG HGRSHFERFVVTEELLIAGAPVAAHWIADRQVAPSLLRYGTEEQKKELLPEIAAARCTFAIGMSEPDSGS DLASVRTRAVPVDGGWLLNGTKVWTSGAHHAAKILVLARTSGSHGDRHRGLSQLVVDLRAPGVEIVPIES LDGGHHFNEVVFTDCFVPAEGLLGAEGQGWKQVTAELGFERSGPERFLSTALVVRLLIEHVTRGEISPEP VLGQFLARLHGLHQMSLSVAAALDRGENADAAAAMVKMLGTATEGDLVQAADYLTGSISGPLRDAVAWAT VQRPGFTLRGGTNEVLAGVVARGLGLR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3392 | - | - | 100% (377) | acyl-CoA dehydrogenase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_2879 | - | e-123 | 60.16% (364) | acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5906 | - | 7e-41 | 31.79% (390) | putative acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3534 | fadE26 | 1e-39 | 32.57% (393) | acyl-CoA dehydrogenase FADE26 |
| M. gilvum PYR-GCK | Mflv_5166 | - | 1e-124 | 60.37% (381) | Fis family transcriptional regulator |
| M. tuberculosis H37Rv | Rv3504 | fadE26 | 1e-39 | 32.57% (393) | acyl-CoA dehydrogenase FADE26 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 2e-21 | 28.69% (237) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0615 | - | 1e-45 | 35.07% (345) | putative acyl-CoA dehydrogenase |
| M. marinum M | MMAR_3511 | - | 1e-120 | 60.11% (366) | acyl-CoA dehydrogenase |
| M. avium 104 | MAV_2554 | - | 1e-101 | 52.69% (372) | acyl-CoA dehydrogenase, central region |
| M. thermoresistible (build 8) | TH_3989 | - | 1e-109 | 55.41% (379) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_2757 | - | 1e-119 | 58.71% (373) | acyl-CoA dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2876 | - | 1e-125 | 60.99% (364) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3534|M.bovis_AF2122/97 ----------MRISYTPQQEELRRELRSYFATLMTPERREALSSVQGEYG
Rv3504|M.tuberculosis_H37Rv ----------MRISYTPQQEELRRELRSYFATLMTPERREALSSVQGEYG
MAB_0615|M.abscessus_ATCC_1997 ----------MLIDLTPEQAKLQNDLRHYFSNLVTAEETREMMIDR----
MMAR_3511|M.marinum_M MADALMALPRLVPPAGALDSPRADVLRGEVRAFLAEQSAAGGFTPSVDAW
MUL_2757|M.ulcerans_Agy99 -----MALPRLVPPAGALDSPRADVLRGEVRAFLAEQSAAGGFTPSVDAW
Mvan_2876|M.vanbaalenii_PYR-1 -----MARTRLVPPAG-VDHADTARLRADVRAFLAEQLAAQTFVPSVDSW
Mflv_5166|M.gilvum_PYR-GCK -----MNTSRLVPPVA-DDPHAMDGLRDEVRQFVAEQRDAGRIGRQVDSW
TH_3989|M.thermoresistible__bu -----MTAVERLPASAPVEVA--PELRAEVREFLDEERAAGRFTPRCDAW
MSMEG_3392|M.smegmatis_MC2_155 -----MTAPTMS---AVVPDPAWRDLRQQVRSFLADQLAAHRFEPGIDGW
MAV_2554|M.avium_104 -----MVNSFDALSAR---EPELVKLRHAVRDFLESDRAEFGWQPGVDSW
MLBr_00737|M.leprae_Br4923 ----MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQR--
** . : :
Mb3534|M.bovis_AF2122/97 VGNVYRETIAQMGRDGWLALGWPKEYGGQGRSAMDQLIFTDEAAIAGAPV
Rv3504|M.tuberculosis_H37Rv VGNVYRETIAQMGRDGWLALGWPKEYGGQGRSAMDQLIFTDEAAIAGAPV
MAB_0615|M.abscessus_ATCC_1997 HGSSYEAVVRRMGQDGWLGVGWPKEYGGHGFGPLEQQIFMNEVMRADVPM
MMAR_3511|M.marinum_M LSAWDEDFTAALADRGWLGMTVPVEYGGHGRTFLERFVVTEELLAAGAPV
MUL_2757|M.ulcerans_Agy99 LSAWDEDFTAALADRGWLGMTVPVEYGGHGRTFLERFVVTEELLAVGAPV
Mvan_2876|M.vanbaalenii_PYR-1 LCGWDEAFTEALAARGYLGMTVPEEYGGHGRSHIERFVVTEELLAAGAPV
Mflv_5166|M.gilvum_PYR-GCK LTGWDEDFSRALAARGWLGMTVPEEYGGHGRSFLERFVVTEELLAAGAPV
TH_3989|M.thermoresistible__bu LVGWDPEFSRRLAGRGWLGMTLPARYGGHERSTLERYVVTEELLAAGAPV
MSMEG_3392|M.smegmatis_MC2_155 LTGWSDTFSRSLAQQGWVGMTIPRQYGGHGRSHFERFVVTEELLIAGAPV
MAV_2554|M.avium_104 LAGWDEEFSGRLGAAGFTGLTIPQRYGGHGLGHLHRYVVTEELIAAGAPV
MLBr_00737|M.leprae_Br4923 -ARFPEEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASA
: *: .: * .***: . :. :* ....
Mb3534|M.bovis_AF2122/97 PFLTINS--VAPTIMAYGTDEQKRFFLPRIAAGDLHFSIGYSEPGAGTDL
Rv3504|M.tuberculosis_H37Rv PFLTINS--VAPTIMAYGTDEQKRFFLPRIAAGDLHFSIGYSEPGAGTDL
MAB_0615|M.abscessus_ATCC_1997 PLVTLQT--VGPTLQKYGTEEQKKKFLPGILAGEIHFAIGYTEPEAGTDL
MMAR_3511|M.marinum_M AAHWIADRQIVPSLLKYGTELQKSHFLPRIVRGECFFGIGMSEPDSGSDL
MUL_2757|M.ulcerans_Agy99 AAHWIADRQIVPSLLKYGTELQKSHFLPRIVRGECFFGIGMSEPDSGSDL
Mvan_2876|M.vanbaalenii_PYR-1 AAHWIADRQIVPALLKHGTDAQKREFLPKIAAGKCFFGIGMSEPDSGSDL
Mflv_5166|M.gilvum_PYR-GCK GAHWIADRQIVPSLLKYGTETQKRRYLPEIAAGRCYFGIGMSEPDSGSDL
TH_3989|M.thermoresistible__bu AAHWIADRQIGPSLLRYGTEAQRNRFLPAIARGECFFGIGMSEPDSGSDL
MSMEG_3392|M.smegmatis_MC2_155 AAHWIADRQVAPSLLRYGTEEQKKELLPEIAAARCTFAIGMSEPDSGSDL
MAV_2554|M.avium_104 AAHWTADRQVAPALLTYGNEEQRERLLPKIVAGQLFSSIGMSEHGAGSDL
MLBr_00737|M.leprae_Br4923 SLIPAVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDA
: *.: : ** : . . :* :*:*
Mb3534|M.bovis_AF2122/97 ANLRTTAVRDGDDYVVNGQKMWTSLIQYADYVWLAVRTNPESSGAKKHRG
Rv3504|M.tuberculosis_H37Rv ANLRTTAVRDGDDYVVNGQKMWTSLIQYADYVWLAVRTNPESSGAKKHRG
MAB_0615|M.abscessus_ATCC_1997 ASLRTTAVRDGDHYVVNGQKIFTTGAHQAQYIWLACRTDP---SAPKHKG
MMAR_3511|M.marinum_M ASVRTRAVRGEGGWLLSGTKVWTSGAHRAHAFIVLARTAP-VDPDHRHAG
MUL_2757|M.ulcerans_Agy99 ASVRTRAVRGEGGWLLSGTKVWTSGAHRAHAFIVLARTAP-VDPDHRHAG
Mvan_2876|M.vanbaalenii_PYR-1 ASVRTRATRTDGGWSLSGTKVWTSGAHRAHAFIVLARTAP-ADPAHRHDG
Mflv_5166|M.gilvum_PYR-GCK ASVRTKASPVDGGWSVTGAKVWTSGAHRADAFICLARTEP-VDPAHRHAG
TH_3989|M.thermoresistible__bu ASVRTKATRVDGGWRIDGTKIWTSGAHRAHAFFVLARSTPLAESPSRHAG
MSMEG_3392|M.smegmatis_MC2_155 ASVRTRAVPVDGGWLLNGTKVWTSGAHHAAKILVLARTSG--SHGDRHRG
MAV_2554|M.avium_104 AAVQTKAVRADGGWLLSGSKVWTSGAHHAHQVVVLARTSP-PDPEHRHAG
MLBr_00737|M.leprae_Br4923 ASMRTRAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDP----DKGANG
* ::* * . : : * * : : : : *
Mb3534|M.bovis_AF2122/97 ISVLIVPTTAEGFSWTPVHTMAGP---DTSATYYSDVRVPVANRVGEENA
Rv3504|M.tuberculosis_H37Rv ISVLIVPTTAEGFSWTPVHTMAGP---DTSATYYSDVRVPVANRVGEENA
MAB_0615|M.abscessus_ATCC_1997 ISILIVDTKDPGYSWTPIITNDGAH--HTNATYYTDVRVPVEMLVGEENA
MMAR_3511|M.marinum_M LSQFIVDLRGPGVQTRPIISMNGAH--HFNEVILDNACVPDEMVFGAIGN
MUL_2757|M.ulcerans_Agy99 LSQFIVDLRGPGVQTRPIISMNGAH--HFNEVILDNAHVPDEMVFGAIGN
Mvan_2876|M.vanbaalenii_PYR-1 LSQFIVRFDGPGVEVRPIVSMNGGH--HFNEVILDGAFVPEDMVFGEIGD
Mflv_5166|M.gilvum_PYR-GCK LSQFIVDLRSPGVDIRPIVSMDGRH--HFNEVLLDDVFVADDMVFGAIGD
TH_3989|M.thermoresistible__bu LSQFIVLLDSPGVEIRPIPLLTGEH--HFNEVHLDGVFVPDDMVLGEIGE
MSMEG_3392|M.smegmatis_MC2_155 LSQLVVDLRAPGVEIVPIESLDGGH--HFNEVVFTDCFVPAEGLLGAEGQ
MAV_2554|M.avium_104 FSQFLVPCDAEGVRIEPIILMSGAH--HFNEVLFEQVFVPDADVLGEVGN
MLBr_00737|M.leprae_Br4923 ISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGT
:* ::* * * * . :. .* .
Mb3534|M.bovis_AF2122/97 GWKLVTNQLNHERVALVSPAPIFGCLREVREWAQNTKDAGG-TRLIDSEW
Rv3504|M.tuberculosis_H37Rv GWKLVTNQLNHERVALVSPAPIFGCLREVREWAQNTKDAGG-TRLIDSEW
MAB_0615|M.abscessus_ATCC_1997 GWKLITTQLNHERVSLGPSGRIAGMYDRVYEWAS-KPGPDG-VAPLSHED
MMAR_3511|M.marinum_M GWTQVTSELSFERS---GPERFLSTFVLLAATAESMAEQR----FTRDQQ
MUL_2757|M.ulcerans_Agy99 GWTQVTSELSFERS---GPERFLSTFVLLAATAESMAEQR----FTRDQQ
Mvan_2876|M.vanbaalenii_PYR-1 GWSQVTSELSFERS---GPERLLSTFPLLAATAESMAQHR----ISYDAA
Mflv_5166|M.gilvum_PYR-GCK GWQQVTSELAFERS---GPERFLSTFPLLAELAALMNDG-----LPRHND
TH_3989|M.thermoresistible__bu GWRQVTSELAFERS---GPERFLSTFPLLTTLVDELARRGD---RGSGTE
MSMEG_3392|M.smegmatis_MC2_155 GWKQVTAELGFERS---GPERFLSTALVVRLLIEHVTRGE----ISPEPV
MAV_2554|M.avium_104 GWHQVTSELSFERS---GPERILSTGPLLFAAIRTLGRGPV-PDDRTAAD
MLBr_00737|M.leprae_Br4923 GFKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQS
*: * . * .
Mb3534|M.bovis_AF2122/97 VQLNLARVHAKAEVLKLINWELASSQSGPKDAGPSPADASAAKVFGTELA
Rv3504|M.tuberculosis_H37Rv VQLNLARVHAKAEVLKLINWELASSQSGPKDAGPSPADASAAKVFGTELA
MAB_0615|M.abscessus_ATCC_1997 VRRVLGEMKAVWRLNELLNWQVASS-----GDDISMADAAATKILATEWI
MMAR_3511|M.marinum_M LGRLVARIAGLHQMSAAVAGALERN-------DPADLPAAVVKVLGTSTE
MUL_2757|M.ulcerans_Agy99 LGRLVARIAGLHQMSAAVAGALERN-------DPADLPAAVVKVLGTSTE
Mvan_2876|M.vanbaalenii_PYR-1 LGRMVARVAGLHQMSTAVAGALERD-------EPADVPAAVVKLLGTSTE
Mflv_5166|M.gilvum_PYR-GCK LGRYVARVAGLHQMSTAVAGALERH-------EPADTAAAVVKVLGTSTE
TH_3989|M.thermoresistible__bu IGKLIARLWTLRRMSLAIAVSLADG-------VAQEVPAALVKDLGTRFE
MSMEG_3392|M.smegmatis_MC2_155 LGQFLARLHGLHQMSLSVAAALDRG-------ENADAAAAMVKMLGTATE
MAV_2554|M.avium_104 IGDLMARLISLRQLSLSVARTLTHG-------GDAANQAALVKDLGTLFE
MLBr_00737|M.leprae_Br4923 IQFMLADMAMKVEAARLIVYAAAARAE--RGEPDLGFISAASKCFASDIA
: :. : . : :: * :.:
Mb3534|M.bovis_AF2122/97 TEAYRLLMEVLGT----AATLRQNSPGALLRGRVERMHRACLILTFGGGT
Rv3504|M.tuberculosis_H37Rv TEAYRLLMEVLGT----AATLRQNSPGALLRGRVERMHRACLILTFGGGT
MAB_0615|M.abscessus_ATCC_1997 QKLGRLSEGVVGR----YGDPADANTAETLE-WLDAQTKRHLVITFGGGV
MMAR_3511|M.marinum_M GD-IAELADLADS---------HRPRDSEFAALVTAALDQRPGFTLRGGT
MUL_2757|M.ulcerans_Agy99 SD-IAELADLADSTDLADSGAPHRPRDPEFAALVTAALDQRPGFTLRGGT
Mvan_2876|M.vanbaalenii_PYR-1 GD-IADFADLHTG--------DETTTGPGFRDLIAVAVDQRPGFTLRGGT
Mflv_5166|M.gilvum_PYR-GCK GD-IADFADLLTD--------ACAPDHGGYRAMLDDAVVQRPGFTLRGGT
TH_3989|M.thermoresistible__bu NE-IVTAAQLLLD-------LEPDPGGEGLPRLLAEAVLQAPGFTIRGGT
MSMEG_3392|M.smegmatis_MC2_155 GD-LVQAADYLTG-----------SISGPLRDAVAWATVQRPGFTLRGGT
MAV_2554|M.avium_104 AESVGLIADLLEA----------APPNSELEAMLNTAWLHKPMFTLRGGT
MLBr_00737|M.leprae_Br4923 MEVTTDAVQLFGG------------AGYTSDFPVERFMRDAKITQIYEGT
. : : *.
Mb3534|M.bovis_AF2122/97 NEVQRDIIGMVALGLPRANR
Rv3504|M.tuberculosis_H37Rv NEVQRDIIGMVALGLPRANR
MAB_0615|M.abscessus_ATCC_1997 NEVMREMVSTAGLGTPRVPR
MMAR_3511|M.marinum_M NEVLRGVIARG-LGLR----
MUL_2757|M.ulcerans_Agy99 NEVLRGVIARG-LGLR----
Mvan_2876|M.vanbaalenii_PYR-1 TEVLRGVIARG-LGMR----
Mflv_5166|M.gilvum_PYR-GCK NEILRGVIARG-LGMR----
TH_3989|M.thermoresistible__bu SEVLRSMVARG-MGLR----
MSMEG_3392|M.smegmatis_MC2_155 NEVLAGVVARG-LGLR----
MAV_2554|M.avium_104 NEVLRGVIARG-MGLR----
MLBr_00737|M.leprae_Br4923 NQIQRVVMSRALLR------
.:: ::. :