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ARTRLVPPAGVDHADTARLRADVRAFLAEQLAAQTFVPSVDSWLCGWDEAFTEALAARGYLGMTVPEEYG GHGRSHIERFVVTEELLAAGAPVAAHWIADRQIVPALLKHGTDAQKREFLPKIAAGKCFFGIGMSEPDSG SDLASVRTRATRTDGGWSLSGTKVWTSGAHRAHAFIVLARTAPADPAHRHDGLSQFIVRFDGPGVEVRPI VSMNGGHHFNEVILDGAFVPEDMVFGEIGDGWSQVTSELSFERSGPERLLSTFPLLAATAESMAQHRISY DAALGRMVARVAGLHQMSTAVAGALERDEPADVPAAVVKLLGTSTEGDIADFADLHTGDETTTGPGFRDL IAVAVDQRPGFTLRGGTTEVLRGVIARGLGMR*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. vanbaalenii PYR-1 | Mvan_2876 | - | - | 100% (383) | acyl-CoA dehydrogenase domain-containing protein |
M. vanbaalenii PYR-1 | Mvan_3917 | - | e-165 | 75.46% (383) | acyl-CoA dehydrogenase domain-containing protein |
M. vanbaalenii PYR-1 | Mvan_4958 | - | 5e-41 | 37.67% (292) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3604c | fadE34 | 5e-42 | 32.98% (382) | acyl-CoA dehydrogenase FADE34 |
M. gilvum PYR-GCK | Mflv_5166 | - | 1e-152 | 72.11% (380) | Fis family transcriptional regulator |
M. tuberculosis H37Rv | Rv3573c | fadE34 | 5e-42 | 32.98% (382) | acyl-CoA dehydrogenase FADE34 |
M. leprae Br4923 | MLBr_00737 | fadE25 | 1e-24 | 30.60% (268) | putative acyl-CoA dehydrogenase |
M. abscessus ATCC 19977 | MAB_0597 | - | 5e-41 | 32.56% (387) | acyl-CoA dehydrogenase FadE |
M. marinum M | MMAR_3511 | - | 1e-163 | 75.26% (384) | acyl-CoA dehydrogenase |
M. avium 104 | MAV_2554 | - | 1e-108 | 53.49% (372) | acyl-CoA dehydrogenase, central region |
M. smegmatis MC2 155 | MSMEG_2879 | - | 1e-177 | 79.90% (383) | acyl-CoA dehydrogenase |
M. thermoresistible (build 8) | TH_3989 | - | 1e-126 | 60.85% (378) | PUTATIVE acyl-CoA dehydrogenase domain protein |
M. ulcerans Agy99 | MUL_2757 | - | 1e-162 | 73.47% (392) | acyl-CoA dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment Mb3604c|M.bovis_AF2122/97 MVATVTDEQSAARELVRGWARTAASGAAATAAVRDMEYGFEEGNADAWRP Rv3573c|M.tuberculosis_H37Rv MVATVTDEQSAARELVRGWARTAASGAAATAAVRDMEYGFEEGNADAWRP Mvan_2876|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2879|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_3511|M.marinum_M -------------------------------------------------- MUL_2757|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5166|M.gilvum_PYR-GCK -------------------------------------------------- TH_3989|M.thermoresistible__bu -------------------------------------------------- MAV_2554|M.avium_104 -------------------------------------------------- MAB_0597|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_00737|M.leprae_Br4923 -------------------------------------------------- Mb3604c|M.bovis_AF2122/97 VFAGLAGLGLFGVAVPEDCGGAGGSIEDLCAMVDEAARALVPGPVATTAV Rv3573c|M.tuberculosis_H37Rv VFAGLAGLGLFGVAVPEDCGGAGGSIEDLCAMVDEAARALVPGPVATTAV Mvan_2876|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2879|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_3511|M.marinum_M -------------------------------------------------- MUL_2757|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5166|M.gilvum_PYR-GCK -------------------------------------------------- TH_3989|M.thermoresistible__bu -------------------------------------------------- MAV_2554|M.avium_104 -------------------------------------------------- MAB_0597|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_00737|M.leprae_Br4923 -------------------------------------------------- Mb3604c|M.bovis_AF2122/97 ATLVVSDPKLRSALASGERFAGVAIDGGVQVDPKTSTASGTVGRVLGGAP Rv3573c|M.tuberculosis_H37Rv ATLVVSDPKLRSALASGERFAGVAIDGGVQVDPKTSTASGTVGRVLGGAP Mvan_2876|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2879|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_3511|M.marinum_M -------------------------------------------------- MUL_2757|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5166|M.gilvum_PYR-GCK -------------------------------------------------- TH_3989|M.thermoresistible__bu -------------------------------------------------- MAV_2554|M.avium_104 -------------------------------------------------- MAB_0597|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_00737|M.leprae_Br4923 -------------------------------------------------- Mb3604c|M.bovis_AF2122/97 GGVVLLPADGNWLLVDTACDEVVVEPLRATDFSLPLARMVLTSAPVTVLE Rv3573c|M.tuberculosis_H37Rv GGVVLLPADGNWLLVDTACDEVVVEPLRATDFSLPLARMVLTSAPVTVLE Mvan_2876|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2879|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_3511|M.marinum_M -------------------------------------------------- MUL_2757|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5166|M.gilvum_PYR-GCK -------------------------------------------------- TH_3989|M.thermoresistible__bu -------------------------------------------------- MAV_2554|M.avium_104 -------------------------------------------------- MAB_0597|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_00737|M.leprae_Br4923 -------------------------------------------------- Mb3604c|M.bovis_AF2122/97 VSGERVEDLAATVLAAEAAGVARWTLDTAVAYAKVREQFGKPIGSFQAVK Rv3573c|M.tuberculosis_H37Rv VSGERVEDLAATVLAAEAAGVARWTLDTAVAYAKVREQFGKPIGSFQAVK Mvan_2876|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2879|M.smegmatis_MC2_155 -------------------------------------------------- MMAR_3511|M.marinum_M -------------------------------------------------- MUL_2757|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5166|M.gilvum_PYR-GCK -------------------------------------------------- TH_3989|M.thermoresistible__bu -------------------------------------------------- MAV_2554|M.avium_104 -------------------------------------------------- MAB_0597|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_00737|M.leprae_Br4923 -------------------------------------------------- Mb3604c|M.bovis_AF2122/97 HLCAQMLCRAEQADVAAADAARAAADSDGTQLSIAAAVAASIGIDAAKAN Rv3573c|M.tuberculosis_H37Rv HLCAQMLCRAEQADVAAADAARAAADSDGTQLSIAAAVAASIGIDAAKAN Mvan_2876|M.vanbaalenii_PYR-1 -------------------------------MARTRLVPPAG-VDHADT- MSMEG_2879|M.smegmatis_MC2_155 -------------------------------MAIPRLVPALD-TEPADA- MMAR_3511|M.marinum_M --------------------------MADALMALPRLVPPAGALDSPRA- MUL_2757|M.ulcerans_Agy99 -------------------------------MALPRLVPPAGALDSPRA- Mflv_5166|M.gilvum_PYR-GCK -------------------------------MNTSRLVPPVA-DDPHAM- TH_3989|M.thermoresistible__bu -------------------------------MTAVERLPASAPVEVA--- MAV_2554|M.avium_104 -------------------------------MVNSFDALSAR---EPEL- MAB_0597|M.abscessus_ATCC_1997 -------------------------------MVESQVSPAPAGEPMSEMS MLBr_00737|M.leprae_Br4923 -------------------------------MVGWSGNPLFDLFKLPEEH : Mb3604c|M.bovis_AF2122/97 AKDCIQVLGGIGCTWEHDAHLYLRR--------AHGIGGFLGGSGRWLRR Rv3573c|M.tuberculosis_H37Rv AKDCIQVLGGIGCTWEHDAHLYLRR--------AHGIGGFLGGSGRWLRR Mvan_2876|M.vanbaalenii_PYR-1 ------------ARLRADVRAFLAE--------QLAAQTFVPSVDSWLC- MSMEG_2879|M.smegmatis_MC2_155 ------------TALRAEVRAFLDE--------QRAAGTFTPAVDAWLC- MMAR_3511|M.marinum_M ------------DVLRGEVRAFLAE--------QSAAGGFTPSVDAWLS- MUL_2757|M.ulcerans_Agy99 ------------DVLRGEVRAFLAE--------QSAAGGFTPSVDAWLS- Mflv_5166|M.gilvum_PYR-GCK ------------DGLRDEVRQFVAE--------QRDAGRIGRQVDSWLT- TH_3989|M.thermoresistible__bu ------------PELRAEVREFLDE--------ERAAGRFTPRCDAWLV- MAV_2554|M.avium_104 ------------VKLRHAVRDFLES--------DRAEFGWQPGVDSWLA- MAB_0597|M.abscessus_ATCC_1997 -----------DDQVRTEIREWLAENLVGEFAELKGLGGPGSEHEAFEER MLBr_00737|M.leprae_Br4923 ------------NELRATIRALAEK----------EIAPHAADVDQRAR- . : Mb3604c|M.bovis_AF2122/97 VTALTQAGVRRRLGVDLAEVAGLRPEIAAAVAEVAALPEEKRQVALADTG Rv3573c|M.tuberculosis_H37Rv VTALTQAGVRRRLGVDLAEVAGLRPEIAAAVAEVAALPEEKRQVALADTG Mvan_2876|M.vanbaalenii_PYR-1 ------------------------------------GWDEAFTEALAARG MSMEG_2879|M.smegmatis_MC2_155 ------------------------------------GWDEKFTTALAARG MMAR_3511|M.marinum_M ------------------------------------AWDEDFTAALADRG MUL_2757|M.ulcerans_Agy99 ------------------------------------AWDEDFTAALADRG Mflv_5166|M.gilvum_PYR-GCK ------------------------------------GWDEDFSRALAARG TH_3989|M.thermoresistible__bu ------------------------------------GWDPEFSRRLAGRG MAV_2554|M.avium_104 ------------------------------------GWDEEFSGRLGAAG MAB_0597|M.abscessus_ATCC_1997 ---------------------------------------LAWNRHLAAAG MLBr_00737|M.leprae_Br4923 -------------------------------------FPEEALAALNASG * * Mb3604c|M.bovis_AF2122/97 LLAPHWPAPYG-RGASPAEQLLIDQELAAAKVERPDLVIG-WWAAPTILE Rv3573c|M.tuberculosis_H37Rv LLAPHWPAPYG-RGASPAEQLLIDQELAAAKVERPDLVIG-WWAAPTILE Mvan_2876|M.vanbaalenii_PYR-1 YLGMTVPEEYGGHGRSHIERFVVTEELLAAGAPVAAHWIADRQIVPALLK MSMEG_2879|M.smegmatis_MC2_155 WLGMTVPKEYGGQGRSFLHRFVVTEELLAAGVPVAAHWIADRQIVPSLLK MMAR_3511|M.marinum_M WLGMTVPVEYGGHGRTFLERFVVTEELLAAGAPVAAHWIADRQIVPSLLK MUL_2757|M.ulcerans_Agy99 WLGMTVPVEYGGHGRTFLERFVVTEELLAVGAPVAAHWIADRQIVPSLLK Mflv_5166|M.gilvum_PYR-GCK WLGMTVPEEYGGHGRSFLERFVVTEELLAAGAPVGAHWIADRQIVPSLLK TH_3989|M.thermoresistible__bu WLGMTLPARYGGHERSTLERYVVTEELLAAGAPVAAHWIADRQIGPSLLR MAV_2554|M.avium_104 FTGLTIPQRYGGHGLGHLHRYVVTEELIAAGAPVAAHWTADRQVAPALLT MAB_0597|M.abscessus_ATCC_1997 WTCLGWPVEHGGRGATVSQRVIFYEEYARAEAPHKVNHLGEELLGPTLIA MLBr_00737|M.leprae_Br4923 FNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIPAVNKLGTMGLIL * :* : :. :* . . :: Mb3604c|M.bovis_AF2122/97 HGTPEQIERFVPATMRGEFLWCQLFSEPGAGSDLASLRTKAVRADGGWLL Rv3573c|M.tuberculosis_H37Rv HGTPEQIERFVPATMRGEFLWCQLFSEPGAGSDLASLRTKAVRADGGWLL Mvan_2876|M.vanbaalenii_PYR-1 HGTDAQKREFLPKIAAGKCFFGIGMSEPDSGSDLASVRTRATRTDGGWSL MSMEG_2879|M.smegmatis_MC2_155 YGTERQKQEFLPRIAAGQCFFGIGMSEPDSGSDLASVRTRAVQVEGGWRL MMAR_3511|M.marinum_M YGTELQKSHFLPRIVRGECFFGIGMSEPDSGSDLASVRTRAVRGEGGWLL MUL_2757|M.ulcerans_Agy99 YGTELQKSHFLPRIVRGECFFGIGMSEPDSGSDLASVRTRAVRGEGGWLL Mflv_5166|M.gilvum_PYR-GCK YGTETQKRRYLPEIAAGRCYFGIGMSEPDSGSDLASVRTKASPVDGGWSV TH_3989|M.thermoresistible__bu YGTEAQRNRFLPAIARGECFFGIGMSEPDSGSDLASVRTKATRVDGGWRI MAV_2554|M.avium_104 YGNEEQRERLLPKIVAGQLFSSIGMSEHGAGSDLAAVQTKAVRADGGWLL MAB_0597|M.abscessus_ATCC_1997 YGTPEQQQRFLPAIRDVTELWCQGYSEPGAGSDLANVSTSAVLDGGDWVI MLBr_00737|M.leprae_Br4923 RGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRTRAKADGDDWIL *. . :* ** :*** * : * * ..* : Mb3604c|M.bovis_AF2122/97 TGQKVWTSAAHKARWGVCLARTDP---DAPKHKGITYFLVDMTTPGIEIR Rv3573c|M.tuberculosis_H37Rv TGQKVWTSAAHKARWGVCLARTDP---DAPKHKGITYFLVDMTTPGIEIR Mvan_2876|M.vanbaalenii_PYR-1 SGTKVWTSGAHRAHAFIVLARTAP-ADPAHRHDGLSQFIVRFDGPGVEVR MSMEG_2879|M.smegmatis_MC2_155 TGTKVWTSGAHRAHAFIVLARTAP-VDPAHRHAGLSQFIVRFDGPGVEVR MMAR_3511|M.marinum_M SGTKVWTSGAHRAHAFIVLARTAP-VDPDHRHAGLSQFIVDLRGPGVQTR MUL_2757|M.ulcerans_Agy99 SGTKVWTSGAHRAHAFIVLARTAP-VDPDHRHAGLSQFIVDLRGPGVQTR Mflv_5166|M.gilvum_PYR-GCK TGAKVWTSGAHRADAFICLARTEP-VDPAHRHAGLSQFIVDLRSPGVDIR TH_3989|M.thermoresistible__bu DGTKIWTSGAHRAHAFFVLARSTPLAESPSRHAGLSQFIVLLDSPGVEIR MAV_2554|M.avium_104 SGSKVWTSGAHHAHQVVVLARTSP-PDPEHRHAGFSQFLVPCDAEGVRIE MAB_0597|M.abscessus_ATCC_1997 NGQKVWTSLALQSQWCFVVARTEP---GSSRHKGLSYLLVPLDQPGVEIR MLBr_00737|M.leprae_Br4923 NGFKCWITNGGKSTWYTVMAVTDP----DKGANGISAFIVHKDDEGFSIG * * * : . :: :* : * *:: ::* *. Mb3604c|M.bovis_AF2122/97 PLREITGD--SLFNEVFLDNVFVPDEMVVGAVNDGWRLARTTLANERVAM Rv3573c|M.tuberculosis_H37Rv PLREITGD--SLFNEVFLDNVFVPDEMVVGAVNDGWRLARTTLANERVAM Mvan_2876|M.vanbaalenii_PYR-1 PIVSMNGG--HHFNEVILDGAFVPEDMVFGEIGDGWSQVTSELSFERSGP MSMEG_2879|M.smegmatis_MC2_155 PIISMNGG--HHFNEVILDDAFVPDDMVFGQIGNGWQQVTSELSFERSGP MMAR_3511|M.marinum_M PIISMNGA--HHFNEVILDNACVPDEMVFGAIGNGWTQVTSELSFERSGP MUL_2757|M.ulcerans_Agy99 PIISMNGA--HHFNEVILDNAHVPDEMVFGAIGNGWTQVTSELSFERSGP Mflv_5166|M.gilvum_PYR-GCK PIVSMDGR--HHFNEVLLDDVFVADDMVFGAIGDGWQQVTSELAFERSGP TH_3989|M.thermoresistible__bu PIPLLTGE--HHFNEVHLDGVFVPDDMVLGEIGEGWRQVTSELAFERSGP MAV_2554|M.avium_104 PIILMSGA--HHFNEVLFEQVFVPDADVLGEVGNGWHQVTSELSFERSGP MAB_0597|M.abscessus_ATCC_1997 PIIQLTGT--SEFNEVFFDNARTSADLVVGEPGDGWRVAMGTLTFERG-- MLBr_00737|M.leprae_Br4923 PKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTALATLDHTRPTI * * .*: :: . :.* . *: . * * Mb3604c|M.bovis_AF2122/97 --------ATGTALGNPMEELLKVLGDMELD-VAQQDRLGRLILLAQAGA Rv3573c|M.tuberculosis_H37Rv --------ATGTALGNPMEELLKVLGDMELD-VAQQDRLGRLILLAQAGA Mvan_2876|M.vanbaalenii_PYR-1 --------ERLLSTFPLLAATAESMAQHR---ISYDAALGRMVARVAGLH MSMEG_2879|M.smegmatis_MC2_155 --------ERLLSTFVLLAQTTDSMARQQ---ISRDADLGRLVARIAGLH MMAR_3511|M.marinum_M --------ERFLSTFVLLAATAESMAEQR---FTRDQQLGRLVARIAGLH MUL_2757|M.ulcerans_Agy99 --------ERFLSTFVLLAATAESMAEQR---FTRDQQLGRLVARIAGLH Mflv_5166|M.gilvum_PYR-GCK --------ERFLSTFPLLAELAALMNDG----LPRHNDLGRYVARVAGLH TH_3989|M.thermoresistible__bu --------ERFLSTFPLLTTLVDELARRGD--RGSGTEIGKLIARLWTLR MAV_2554|M.avium_104 --------ERILSTGPLLFAAIRTLGRGPVPDDRTAADIGDLMARLISLR MAB_0597|M.abscessus_ATCC_1997 --------VSTLGNQITYARELSRLAELAKSNGAADDPAIRERLAQAYVG MLBr_00737|M.leprae_Br4923 GAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFMLADMAMKVEAAR : Mb3604c|M.bovis_AF2122/97 LLDRRIAELAVGGQD-PGAQSSVRKLIGVRYRQALAEYLMEVSDGG---- Rv3573c|M.tuberculosis_H37Rv LLDRRIAELAVGGQD-PGAQSSVRKLIGVRYRQALAEYLMEVSDGG---- Mvan_2876|M.vanbaalenii_PYR-1 QMSTAVAGALERDEP-ADVPAAVVKLLGTSTEGD-IADFADLHTGD---- MSMEG_2879|M.smegmatis_MC2_155 HMSMAVAGALERHEP-ADVPAAVVKVLGTTTEGD-IADFADLHRGD---- MMAR_3511|M.marinum_M QMSAAVAGALERNDP-ADLPAAVVKVLGTSTEGD-IAELADLADS----- MUL_2757|M.ulcerans_Agy99 QMSAAVAGALERNDP-ADLPAAVVKVLGTSTESD-IAELADLADSTDLAD Mflv_5166|M.gilvum_PYR-GCK QMSTAVAGALERHEP-ADTAAAVVKVLGTSTEGD-IADFADLLTDA---- TH_3989|M.thermoresistible__bu RMSLAIAVSLADGVA-QEVPAALVKDLGTRFENE-IVTAAQLLLDLE--- MAV_2554|M.avium_104 QLSLSVARTLTHGGD-AANQAALVKDLGTLFEAESVGLIADLLEAA---- MAB_0597|M.abscessus_ATCC_1997 MRTMRAYALATMDEE-RPGQDNVSKLLWANWHRDLGELAMEIIGTS---- MLBr_00737|M.leprae_Br4923 LIVYAAAARAERGEPDLGFISAASKCFASDIAMEVTTDAVQLFGGAG--- * : :: Mb3604c|M.bovis_AF2122/97 ---------GLVENRAVYDFLNTRCLTIAGGTEQILLTVAAERLLGLPR- Rv3573c|M.tuberculosis_H37Rv ---------GLVENRAVYDFLNTRCLTIAGGTEQILLTVAAERLLGLPR- Mvan_2876|M.vanbaalenii_PYR-1 ----ETTTGPGFRDLIAVAVDQRPGFTLRGGTTEVLRGVIAR-GLGMR-- MSMEG_2879|M.smegmatis_MC2_155 ----DGALPQQARDLITAAVDQRPGFTLRGGTNEVLRGVIAR-GLGLR-- MMAR_3511|M.marinum_M ----HRPRDSEFAALVTAALDQRPGFTLRGGTNEVLRGVIAR-GLGLR-- MUL_2757|M.ulcerans_Agy99 SGAPHRPRDPEFAALVTAALDQRPGFTLRGGTNEVLRGVIAR-GLGLR-- Mflv_5166|M.gilvum_PYR-GCK ----CAPDHGGYRAMLDDAVVQRPGFTLRGGTNEILRGVIAR-GLGMR-- TH_3989|M.thermoresistible__bu ----PDPGGEGLPRLLAEAVLQAPGFTIRGGTSEVLRSMVAR-GMGLR-- MAV_2554|M.avium_104 ------PPNSELEAMLNTAWLHKPMFTLRGGTNEVLRGVIAR-GMGLR-- MAB_0597|M.abscessus_ATCC_1997 ----TLLTNAGEMDEWQRLFLFSRADTIYGGSNEIQRNIISERVLGLPRE MLBr_00737|M.leprae_Br4923 ---------YTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR---- : *: :: : :. : Mb3604c|M.bovis_AF2122/97 -- Rv3573c|M.tuberculosis_H37Rv -- Mvan_2876|M.vanbaalenii_PYR-1 -- MSMEG_2879|M.smegmatis_MC2_155 -- MMAR_3511|M.marinum_M -- MUL_2757|M.ulcerans_Agy99 -- Mflv_5166|M.gilvum_PYR-GCK -- TH_3989|M.thermoresistible__bu -- MAV_2554|M.avium_104 -- MAB_0597|M.abscessus_ATCC_1997 AR MLBr_00737|M.leprae_Br4923 --