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VADALMALPRLVPPAGALDSPRADVLRGEVRAFLAEQSAAGGFTPSVDAWLSAWDEDFTAALADRGWLGM TVPVEYGGHGRTFLERFVVTEELLAAGAPVAAHWIADRQIVPSLLKYGTELQKSHFLPRIVRGECFFGIG MSEPDSGSDLASVRTRAVRGEGGWLLSGTKVWTSGAHRAHAFIVLARTAPVDPDHRHAGLSQFIVDLRGP GVQTRPIISMNGAHHFNEVILDNACVPDEMVFGAIGNGWTQVTSELSFERSGPERFLSTFVLLAATAESM AEQRFTRDQQLGRLVARIAGLHQMSAAVAGALERNDPADLPAAVVKVLGTSTEGDIAELADLADSHRPRD SEFAALVTAALDQRPGFTLRGGTNEVLRGVIARGLGLR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3511 | - | - | 100% (388) | acyl-CoA dehydrogenase |
| M. marinum M | MMAR_5068 | fadE34 | 8e-42 | 35.01% (337) | acyl-CoA dehydrogenase FadE34 |
| M. marinum M | MMAR_2862 | fadE17 | 1e-39 | 40.73% (248) | acyl-CoA dehydrogenase FadE17 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3604c | fadE34 | 6e-43 | 34.57% (376) | acyl-CoA dehydrogenase FADE34 |
| M. gilvum PYR-GCK | Mflv_5166 | - | 1e-152 | 71.92% (381) | Fis family transcriptional regulator |
| M. tuberculosis H37Rv | Rv3573c | fadE34 | 6e-43 | 34.57% (376) | acyl-CoA dehydrogenase FADE34 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 4e-18 | 29.54% (237) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0615 | - | 1e-41 | 34.31% (341) | putative acyl-CoA dehydrogenase |
| M. avium 104 | MAV_2554 | - | 1e-110 | 55.38% (372) | acyl-CoA dehydrogenase, central region |
| M. smegmatis MC2 155 | MSMEG_2879 | - | 1e-170 | 79.18% (389) | acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3989 | - | 1e-123 | 61.46% (371) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_2757 | - | 0.0 | 96.68% (392) | acyl-CoA dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_3917 | - | 1e-170 | 78.33% (383) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3604c|M.bovis_AF2122/97 MVATVTDEQSAARELVRGWARTAASGAAATAAVRDMEYGFEEGNADAWRP
Rv3573c|M.tuberculosis_H37Rv MVATVTDEQSAARELVRGWARTAASGAAATAAVRDMEYGFEEGNADAWRP
MMAR_3511|M.marinum_M --------------------------------------------------
MUL_2757|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2879|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3917|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5166|M.gilvum_PYR-GCK --------------------------------------------------
TH_3989|M.thermoresistible__bu --------------------------------------------------
MAV_2554|M.avium_104 --------------------------------------------------
MAB_0615|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3604c|M.bovis_AF2122/97 VFAGLAGLGLFGVAVPEDCGGAGGSIEDLCAMVDEAARALVPGPVATTAV
Rv3573c|M.tuberculosis_H37Rv VFAGLAGLGLFGVAVPEDCGGAGGSIEDLCAMVDEAARALVPGPVATTAV
MMAR_3511|M.marinum_M --------------------------------------------------
MUL_2757|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2879|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3917|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5166|M.gilvum_PYR-GCK --------------------------------------------------
TH_3989|M.thermoresistible__bu --------------------------------------------------
MAV_2554|M.avium_104 --------------------------------------------------
MAB_0615|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3604c|M.bovis_AF2122/97 ATLVVSDPKLRSALASGERFAGVAIDGGVQVDPKTSTASGTVGRVLGGAP
Rv3573c|M.tuberculosis_H37Rv ATLVVSDPKLRSALASGERFAGVAIDGGVQVDPKTSTASGTVGRVLGGAP
MMAR_3511|M.marinum_M --------------------------------------------------
MUL_2757|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2879|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3917|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5166|M.gilvum_PYR-GCK --------------------------------------------------
TH_3989|M.thermoresistible__bu --------------------------------------------------
MAV_2554|M.avium_104 --------------------------------------------------
MAB_0615|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3604c|M.bovis_AF2122/97 GGVVLLPADGNWLLVDTACDEVVVEPLRATDFSLPLARMVLTSAPVTVLE
Rv3573c|M.tuberculosis_H37Rv GGVVLLPADGNWLLVDTACDEVVVEPLRATDFSLPLARMVLTSAPVTVLE
MMAR_3511|M.marinum_M --------------------------------------------------
MUL_2757|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2879|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3917|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5166|M.gilvum_PYR-GCK --------------------------------------------------
TH_3989|M.thermoresistible__bu --------------------------------------------------
MAV_2554|M.avium_104 --------------------------------------------------
MAB_0615|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3604c|M.bovis_AF2122/97 VSGERVEDLAATVLAAEAAGVARWTLDTAVAYAKVREQFGKPIGSFQAVK
Rv3573c|M.tuberculosis_H37Rv VSGERVEDLAATVLAAEAAGVARWTLDTAVAYAKVREQFGKPIGSFQAVK
MMAR_3511|M.marinum_M ---------------------------------------------MADAL
MUL_2757|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2879|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3917|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5166|M.gilvum_PYR-GCK --------------------------------------------------
TH_3989|M.thermoresistible__bu --------------------------------------------------
MAV_2554|M.avium_104 --------------------------------------------------
MAB_0615|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 -------------------------------------------------M
Mb3604c|M.bovis_AF2122/97 HLCAQMLCRAEQADVAAADAARAAADSDGTQLSIAAAVAASIGIDAAKAN
Rv3573c|M.tuberculosis_H37Rv HLCAQMLCRAEQADVAAADAARAAADSDGTQLSIAAAVAASIGIDAAKAN
MMAR_3511|M.marinum_M MALPRLVPPAGALDSPRADVLRGEVR------------------------
MUL_2757|M.ulcerans_Agy99 MALPRLVPPAGALDSPRADVLRGEVR------------------------
MSMEG_2879|M.smegmatis_MC2_155 MAIPRLVP-ALDTEPADATALRAEVR------------------------
Mvan_3917|M.vanbaalenii_PYR-1 MAAARLVP-PCTAETSEAHELRAEVR------------------------
Mflv_5166|M.gilvum_PYR-GCK MNTSRLVP-PVADDPHAMDGLRDEVR------------------------
TH_3989|M.thermoresistible__bu MTAVERLP--ASAPVEVAPELRAEVR------------------------
MAV_2554|M.avium_104 --MVNSFD-ALSAREPELVKLRHAVR------------------------
MAB_0615|M.abscessus_ATCC_1997 -----MLIDLTPEQAKLQNDLRHYFS------------------------
MLBr_00737|M.leprae_Br4923 VGWSGNPLFDLFKLPEEHNELRATIR------------------------
*
Mb3604c|M.bovis_AF2122/97 AKDCIQVLGGIGCTWEHDAHLYLRRAHGIGGFLGGSGRWLRRVTALTQAG
Rv3573c|M.tuberculosis_H37Rv AKDCIQVLGGIGCTWEHDAHLYLRRAHGIGGFLGGSGRWLRRVTALTQAG
MMAR_3511|M.marinum_M --------------------AFLAEQSAAGGFTPSVDAWLS---------
MUL_2757|M.ulcerans_Agy99 --------------------AFLAEQSAAGGFTPSVDAWLS---------
MSMEG_2879|M.smegmatis_MC2_155 --------------------AFLDEQRAAGTFTPAVDAWLC---------
Mvan_3917|M.vanbaalenii_PYR-1 --------------------RFLAEQLAAGAFTPTADAWLC---------
Mflv_5166|M.gilvum_PYR-GCK --------------------QFVAEQRDAGRIGRQVDSWLT---------
TH_3989|M.thermoresistible__bu --------------------EFLDEERAAGRFTPRCDAWLV---------
MAV_2554|M.avium_104 --------------------DFLESDRAEFGWQPGVDSWLA---------
MAB_0615|M.abscessus_ATCC_1997 --------------------NLVTAEETREMMIDRHG-------------
MLBr_00737|M.leprae_Br4923 ----------------------ALAEKEIAPHAADVDQRAR---------
.
Mb3604c|M.bovis_AF2122/97 VRRRLGVDLAEVAGLRPEIAAAVAEVAALPEEKRQVALADTGLLAPHWPA
Rv3573c|M.tuberculosis_H37Rv VRRRLGVDLAEVAGLRPEIAAAVAEVAALPEEKRQVALADTGLLAPHWPA
MMAR_3511|M.marinum_M ----------------------------AWDEDFTAALADRGWLGMTVPV
MUL_2757|M.ulcerans_Agy99 ----------------------------AWDEDFTAALADRGWLGMTVPV
MSMEG_2879|M.smegmatis_MC2_155 ----------------------------GWDEKFTTALAARGWLGMTVPK
Mvan_3917|M.vanbaalenii_PYR-1 ----------------------------GWDEDFTAALAERGWLGMTVPV
Mflv_5166|M.gilvum_PYR-GCK ----------------------------GWDEDFSRALAARGWLGMTVPE
TH_3989|M.thermoresistible__bu ----------------------------GWDPEFSRRLAGRGWLGMTLPA
MAV_2554|M.avium_104 ----------------------------GWDEEFSGRLGAAGFTGLTIPQ
MAB_0615|M.abscessus_ATCC_1997 ----------------------------SSYEAVVRRMGQDGWLGVGWPK
MLBr_00737|M.leprae_Br4923 -----------------------------FPEEALAALNASGFNAIHVPE
: * . *
Mb3604c|M.bovis_AF2122/97 PYG-RGASPAEQLLIDQELAAAKVERPDLVIG-WWAAPTILEHGTPEQIE
Rv3573c|M.tuberculosis_H37Rv PYG-RGASPAEQLLIDQELAAAKVERPDLVIG-WWAAPTILEHGTPEQIE
MMAR_3511|M.marinum_M EYGGHGRTFLERFVVTEELLAAGAPVAAHWIADRQIVPSLLKYGTELQKS
MUL_2757|M.ulcerans_Agy99 EYGGHGRTFLERFVVTEELLAVGAPVAAHWIADRQIVPSLLKYGTELQKS
MSMEG_2879|M.smegmatis_MC2_155 EYGGQGRSFLHRFVVTEELLAAGVPVAAHWIADRQIVPSLLKYGTERQKQ
Mvan_3917|M.vanbaalenii_PYR-1 AYGGHGRSFLERFVVTEELLAAGAPVAAHWIADRQIVPSLLKYGTEFQKT
Mflv_5166|M.gilvum_PYR-GCK EYGGHGRSFLERFVVTEELLAAGAPVGAHWIADRQIVPSLLKYGTETQKR
TH_3989|M.thermoresistible__bu RYGGHERSTLERYVVTEELLAAGAPVAAHWIADRQIGPSLLRYGTEAQRN
MAV_2554|M.avium_104 RYGGHGLGHLHRYVVTEELIAAGAPVAAHWTADRQVAPALLTYGNEEQRE
MAB_0615|M.abscessus_ATCC_1997 EYGGHGFGPLEQQIFMNEVMRADVPMP--LVTLQTVGPTLQKYGTEEQKK
MLBr_00737|M.leprae_Br4923 EYGGQGADSVAACIVIEEVARVDASASLIPAVNKLGTMGLILRGSEELKK
** : :. :*: . . : *.
Mb3604c|M.bovis_AF2122/97 RFVPATMRGEFLWCQLFSEPGAGSDLASLRTKAVRADGGWLLTGQKVWTS
Rv3573c|M.tuberculosis_H37Rv RFVPATMRGEFLWCQLFSEPGAGSDLASLRTKAVRADGGWLLTGQKVWTS
MMAR_3511|M.marinum_M HFLPRIVRGECFFGIGMSEPDSGSDLASVRTRAVRGEGGWLLSGTKVWTS
MUL_2757|M.ulcerans_Agy99 HFLPRIVRGECFFGIGMSEPDSGSDLASVRTRAVRGEGGWLLSGTKVWTS
MSMEG_2879|M.smegmatis_MC2_155 EFLPRIAAGQCFFGIGMSEPDSGSDLASVRTRAVQVEGGWRLTGTKVWTS
Mvan_3917|M.vanbaalenii_PYR-1 EFLPKIAGGTCFFGIGMSEPDSGSDLASVRTRAERVDGGWRLTGTKVWTS
Mflv_5166|M.gilvum_PYR-GCK RYLPEIAAGRCYFGIGMSEPDSGSDLASVRTKASPVDGGWSVTGAKVWTS
TH_3989|M.thermoresistible__bu RFLPAIARGECFFGIGMSEPDSGSDLASVRTKATRVDGGWRIDGTKIWTS
MAV_2554|M.avium_104 RLLPKIVAGQLFSSIGMSEHGAGSDLAAVQTKAVRADGGWLLSGSKVWTS
MAB_0615|M.abscessus_ATCC_1997 KFLPGILAGEIHFAIGYTEPEAGTDLASLRTTAVRDGDHYVVNGQKIFTT
MLBr_00737|M.leprae_Br4923 QVLPSLAAEGAMASYALSEREAGSDAASMRTRAKADGDDWILNGFKCWIT
. :* :* :*:* *:::* * . : : * * : :
Mb3604c|M.bovis_AF2122/97 AAHKARWGVCLARTDPDAP---KHKGITYFLVDMTTPGIEIRPLREITGD
Rv3573c|M.tuberculosis_H37Rv AAHKARWGVCLARTDPDAP---KHKGITYFLVDMTTPGIEIRPLREITGD
MMAR_3511|M.marinum_M GAHRAHAFIVLARTAPVDP-DHRHAGLSQFIVDLRGPGVQTRPIISMNGA
MUL_2757|M.ulcerans_Agy99 GAHRAHAFIVLARTAPVDP-DHRHAGLSQFIVDLRGPGVQTRPIISMNGA
MSMEG_2879|M.smegmatis_MC2_155 GAHRAHAFIVLARTAPVDP-AHRHAGLSQFIVRFDGPGVEVRPIISMNGG
Mvan_3917|M.vanbaalenii_PYR-1 GAHLAHAFIALARTAPVDP-AHRHAGLSQFIVDLRGPGVEIRPIVSMNGA
Mflv_5166|M.gilvum_PYR-GCK GAHRADAFICLARTEPVDP-AHRHAGLSQFIVDLRSPGVDIRPIVSMDGR
TH_3989|M.thermoresistible__bu GAHRAHAFFVLARSTPLAESPSRHAGLSQFIVLLDSPGVEIRPIPLLTGE
MAV_2554|M.avium_104 GAHHAHQVVVLARTSPPDP-EHRHAGFSQFLVPCDAEGVRIEPIILMSGA
MAB_0615|M.abscessus_ATCC_1997 GAHQAQYIWLACRTDPSAP---KHKGISILIVDTKDPGYSWTPIITNDGA
MLBr_00737|M.leprae_Br4923 NGGKSTWYTVMAVTDPDKG----ANGISAFIVHKDDEGFSIGPKEKKLGI
. : . : * *:: ::* * * *
Mb3604c|M.bovis_AF2122/97 S--LFNEVFLDNVFVPDEMVVGAVNDGWRLARTTLANER--VAMATGTAL
Rv3573c|M.tuberculosis_H37Rv S--LFNEVFLDNVFVPDEMVVGAVNDGWRLARTTLANER--VAMATGTAL
MMAR_3511|M.marinum_M H--HFNEVILDNACVPDEMVFGAIGNGWTQVTSELSFER--SGPERFLST
MUL_2757|M.ulcerans_Agy99 H--HFNEVILDNAHVPDEMVFGAIGNGWTQVTSELSFER--SGPERFLST
MSMEG_2879|M.smegmatis_MC2_155 H--HFNEVILDDAFVPDDMVFGQIGNGWQQVTSELSFER--SGPERLLST
Mvan_3917|M.vanbaalenii_PYR-1 H--HFNEVLLDGAFVPDEMVFGSIGAGWEQVTSELAFER--SGPERFLST
Mflv_5166|M.gilvum_PYR-GCK H--HFNEVLLDDVFVADDMVFGAIGDGWQQVTSELAFER--SGPERFLST
TH_3989|M.thermoresistible__bu H--HFNEVHLDGVFVPDDMVLGEIGEGWRQVTSELAFER--SGPERFLST
MAV_2554|M.avium_104 H--HFNEVLFEQVFVPDADVLGEVGNGWHQVTSELSFER--SGPERILST
MAB_0615|M.abscessus_ATCC_1997 H--HTNATYYTDVRVPVEMLVGEENAGWKLITTQLNHER--VSLGPSGRI
MLBr_00737|M.leprae_Br4923 KGSPTTELYFDKCRIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIA
. :. :.* . *: : * * .
Mb3604c|M.bovis_AF2122/97 GNPMEELLKVLGDMELDVAQQD-------RLGRLILLAQAGALLDRRIAE
Rv3573c|M.tuberculosis_H37Rv GNPMEELLKVLGDMELDVAQQD-------RLGRLILLAQAGALLDRRIAE
MMAR_3511|M.marinum_M FVLLAATAESMAEQRFTRDQ---------QLGRLVARIAGLHQMSAAVAG
MUL_2757|M.ulcerans_Agy99 FVLLAATAESMAEQRFTRDQ---------QLGRLVARIAGLHQMSAAVAG
MSMEG_2879|M.smegmatis_MC2_155 FVLLAQTTDSMARQQISRDA---------DLGRLVARIAGLHHMSMAVAG
Mvan_3917|M.vanbaalenii_PYR-1 FVLLDACAETIASQRVPRSD---------DLGRLVARVAGLHQMSSAVAG
Mflv_5166|M.gilvum_PYR-GCK FPLLAELAALMNDG-LPRHN---------DLGRYVARVAGLHQMSTAVAG
TH_3989|M.thermoresistible__bu FPLLTTLVDELARRGDRGSGT--------EIGKLIARLWTLRRMSLAIAV
MAV_2554|M.avium_104 GPLLFAAIRTLGRGPVPDDRTA--A----DIGDLMARLISLRQLSLSVAR
MAB_0615|M.abscessus_ATCC_1997 AGMYDRVYEWASKPGPDGVAPLSHE----DVRRVLGEMKAVWRLNELLNW
MLBr_00737|M.leprae_Br4923 QGALDAAIVYTKDRKQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAA
: :
Mb3604c|M.bovis_AF2122/97 LAVGGQD--PGAQSSVRKLIGVRYRQALAEYLMEVSDGG-----------
Rv3573c|M.tuberculosis_H37Rv LAVGGQD--PGAQSSVRKLIGVRYRQALAEYLMEVSDGG-----------
MMAR_3511|M.marinum_M ALERNDP--ADLPAAVVKVLGTSTEGD-IAELADLADS---------HRP
MUL_2757|M.ulcerans_Agy99 ALERNDP--ADLPAAVVKVLGTSTESD-IAELADLADSTDLADSGAPHRP
MSMEG_2879|M.smegmatis_MC2_155 ALERHEP--ADVPAAVVKVLGTTTEGD-IADFADLHRGD--------DGA
Mvan_3917|M.vanbaalenii_PYR-1 ALQRHEP--ADVPAAVVKVLGTTTEGD-IAEYAHLMMDD----------D
Mflv_5166|M.gilvum_PYR-GCK ALERHEP--ADTAAAVVKVLGTSTEGD-IADFADLLTDA--------CAP
TH_3989|M.thermoresistible__bu SLADGVA--QEVPAALVKDLGTRFENE-IVTAAQLLLDLE-------PDP
MAV_2554|M.avium_104 TLTHGGD--AANQAALVKDLGTLFEAESVGLIADLLEAA----------P
MAB_0615|M.abscessus_ATCC_1997 QVASSGDDISMADAAATKILATEWIQKLGRLSEGVVGRYG-----DPADA
MLBr_00737|M.leprae_Br4923 RAERGEPD-LGFISAASKCFASDIAMEVTTDAVQLFGGAG----------
:: * :. :
Mb3604c|M.bovis_AF2122/97 --GLVENRAVYDFLNTRCLTIAGGTEQILLTVAAERLLGLPR---
Rv3573c|M.tuberculosis_H37Rv --GLVENRAVYDFLNTRCLTIAGGTEQILLTVAAERLLGLPR---
MMAR_3511|M.marinum_M RDSEFAALVTAALDQRPGFTLRGGTNEVLRGVIAR-GLGLR----
MUL_2757|M.ulcerans_Agy99 RDPEFAALVTAALDQRPGFTLRGGTNEVLRGVIAR-GLGLR----
MSMEG_2879|M.smegmatis_MC2_155 LPQQARDLITAAVDQRPGFTLRGGTNEVLRGVIAR-GLGLR----
Mvan_3917|M.vanbaalenii_PYR-1 AGQQFSDMANAAVDQRPGFTLRGGTNEVLRGVIAR-GLGIR----
Mflv_5166|M.gilvum_PYR-GCK DHGGYRAMLDDAVVQRPGFTLRGGTNEILRGVIAR-GLGMR----
TH_3989|M.thermoresistible__bu GGEGLPRLLAEAVLQAPGFTIRGGTSEVLRSMVAR-GMGLR----
MAV_2554|M.avium_104 PNSELEAMLNTAWLHKPMFTLRGGTNEVLRGVIAR-GMGLR----
MAB_0615|M.abscessus_ATCC_1997 NTAETLEWLDAQTKRHLVITFGGGVNEVMREMVSTAGLGTPRVPR
MLBr_00737|M.leprae_Br4923 --YTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR------
: *..:: : : :