For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VNSFDALSAREPELVKLRHAVRDFLESDRAEFGWQPGVDSWLAGWDEEFSGRLGAAGFTGLTIPQRYGGH GLGHLHRYVVTEELIAAGAPVAAHWTADRQVAPALLTYGNEEQRERLLPKIVAGQLFSSIGMSEHGAGSD LAAVQTKAVRADGGWLLSGSKVWTSGAHHAHQVVVLARTSPPDPEHRHAGFSQFLVPCDAEGVRIEPIIL MSGAHHFNEVLFEQVFVPDADVLGEVGNGWHQVTSELSFERSGPERILSTGPLLFAAIRTLGRGPVPDDR TAADIGDLMARLISLRQLSLSVARTLTHGGDAANQAALVKDLGTLFEAESVGLIADLLEAAPPNSELEAM LNTAWLHKPMFTLRGGTNEVLRGVIARGMGLR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2554 | - | - | 100% (383) | acyl-CoA dehydrogenase, central region |
| M. avium 104 | MAV_1814 | - | 0.0 | 82.72% (382) | putative acyl-CoA dehydrogenase |
| M. avium 104 | MAV_1878 | - | 3e-42 | 33.50% (391) | acyl-CoA dehydrogenase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3592 | fadE31 | 3e-40 | 31.05% (380) | acyl-CoA dehydrogenase FADE31 |
| M. gilvum PYR-GCK | Mflv_5166 | - | 1e-105 | 54.86% (370) | Fis family transcriptional regulator |
| M. tuberculosis H37Rv | Rv3562 | fadE31 | 3e-40 | 31.05% (380) | acyl-CoA dehydrogenase FADE31 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 1e-21 | 30.66% (212) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0595c | - | 2e-39 | 32.74% (336) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_3511 | - | 1e-110 | 55.38% (372) | acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2879 | - | 1e-111 | 54.21% (380) | acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_4559 | - | 1e-170 | 75.65% (382) | PUTATIVE putative acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_2757 | - | 1e-109 | 53.54% (381) | acyl-CoA dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2876 | - | 1e-107 | 53.49% (372) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3592|M.bovis_AF2122/97 --------------MDLNFDDETLAFQAEVREFLAANAASIPTKSYDNAE
Rv3562|M.tuberculosis_H37Rv --------------MDLNFDDETLAFQAEVREFLAANAASIPTKSYDNAE
MAB_0595c|M.abscessus_ATCC_199 --------------MDLLLDDETEAFRAEVREFLVSNVPNPPLPSYDSPE
MAV_2554|M.avium_104 -------MVNSFDALS-AREPELVKLRHAVRDFLESDRAEFGWQPGVDSW
TH_4559|M.thermoresistible__bu --------VSQFDALR-ANEPELADLRASVREFLERDRAEFGWEPDVDSW
MSMEG_2879|M.smegmatis_MC2_155 -----MAIPRLVPALD-TEPADATALRAEVRAFLDEQRAAGTFTPAVDAW
Mvan_2876|M.vanbaalenii_PYR-1 -----MARTRLVPPAG-VDHADTARLRADVRAFLAEQLAAQTFVPSVDSW
MMAR_3511|M.marinum_M MADALMALPRLVPPAGALDSPRADVLRGEVRAFLAEQSAAGGFTPSVDAW
MUL_2757|M.ulcerans_Agy99 -----MALPRLVPPAGALDSPRADVLRGEVRAFLAEQSAAGGFTPSVDAW
Mflv_5166|M.gilvum_PYR-GCK -----MNTSRLVPPVA-DDPHAMDGLRDEVRQFVAEQRDAGRIGRQVDSW
MLBr_00737|M.leprae_Br4923 ----MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRAR
:: :* : : .
Mb3592|M.bovis_AF2122/97 GFAQHRYWDRVLFDAGLSVITWPAKYGGRDAPLLHWIVFEEEYFRAGAPG
Rv3562|M.tuberculosis_H37Rv GFAQHRYWDRVLFDAGLSVITWPAKYGGRDAPLLHWIVFEEEYFRAGAPG
MAB_0595c|M.abscessus_ATCC_199 GAAAHRQWERTLYDAGFSAVSWPKEYGGRDVTPLQWVIFEEEYFKAGAPA
MAV_2554|M.avium_104 LAGWDEEFSGRLGAAGFTGLTIPQRYGGHGLGHLHRYVVTEELIAAGAPV
TH_4559|M.thermoresistible__bu LGQWDEGFSARLAAAGYVGMTIPKEYGGHGLTHLHRYVVTEELLAQGAPV
MSMEG_2879|M.smegmatis_MC2_155 LCGWDEKFTTALAARGWLGMTVPKEYGGQGRSFLHRFVVTEELLAAGVPV
Mvan_2876|M.vanbaalenii_PYR-1 LCGWDEAFTEALAARGYLGMTVPEEYGGHGRSHIERFVVTEELLAAGAPV
MMAR_3511|M.marinum_M LSAWDEDFTAALADRGWLGMTVPVEYGGHGRTFLERFVVTEELLAAGAPV
MUL_2757|M.ulcerans_Agy99 LSAWDEDFTAALADRGWLGMTVPVEYGGHGRTFLERFVVTEELLAVGAPV
Mflv_5166|M.gilvum_PYR-GCK LTGWDEDFSRALAARGWLGMTVPEEYGGHGRSFLERFVVTEELLAAGAPV
MLBr_00737|M.leprae_Br4923 ---FPEEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASA
. * * : * .***:. : :. ** ...
Mb3592|M.bovis_AF2122/97 RASANGTSMLAPTLFAHGTAEQLDRILPKMASGEQIWAQAWSEPESGSDL
Rv3562|M.tuberculosis_H37Rv RASANGTSMLAPTLFAHGTAEQLDRILPKMASGEQIWAQAWSEPESGSDL
MAB_0595c|M.abscessus_ATCC_199 RISQNGMFLLGPTLFAHGSKDQLDRVLPKMANGEEIWAQAWSEPESGSDL
MAV_2554|M.avium_104 AAHWTADRQVAPALLTYGNEEQRERLLPKIVAGQLFSSIGMSEHGAGSDL
TH_4559|M.thermoresistible__bu AAHWVADRQVVPGLLAYGTEEQRQRLLPRIAAGKFFSSIGMSEHGAGSDL
MSMEG_2879|M.smegmatis_MC2_155 AAHWIADRQIVPSLLKYGTERQKQEFLPRIAAGQCFFGIGMSEPDSGSDL
Mvan_2876|M.vanbaalenii_PYR-1 AAHWIADRQIVPALLKHGTDAQKREFLPKIAAGKCFFGIGMSEPDSGSDL
MMAR_3511|M.marinum_M AAHWIADRQIVPSLLKYGTELQKSHFLPRIVRGECFFGIGMSEPDSGSDL
MUL_2757|M.ulcerans_Agy99 AAHWIADRQIVPSLLKYGTELQKSHFLPRIVRGECFFGIGMSEPDSGSDL
Mflv_5166|M.gilvum_PYR-GCK GAHWIADRQIVPSLLKYGTETQKRRYLPEIAAGRCYFGIGMSEPDSGSDL
MLBr_00737|M.leprae_Br4923 SLIPAVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDA
*: *. . ** :. . . ** :***
Mb3592|M.bovis_AF2122/97 ASLRSTASKVDGGWLLNGQKIWSSRAPFADMGFGLFRSDP--AVERHRGL
Rv3562|M.tuberculosis_H37Rv ASLRSTASKVDGGWLLNGQKIWSSRAPFADMGFGLFRSDP--AVERHRGL
MAB_0595c|M.abscessus_ATCC_199 ASLRSPARKVDGGWRLSGQKIWSSRAPFADRAFGLFRSDP--DAQRHQGL
MAV_2554|M.avium_104 AAVQTKAVRADGGWLLSGSKVWTSGAHHAHQVVVLARTSPPDPEHRHAGF
TH_4559|M.thermoresistible__bu AAVQTKAVRTDGGWVLNGTKVWTSGAHKAHQVVVLARTSPPDPQKRHAGF
MSMEG_2879|M.smegmatis_MC2_155 ASVRTRAVQVEGGWRLTGTKVWTSGAHRAHAFIVLARTAPVDPAHRHAGL
Mvan_2876|M.vanbaalenii_PYR-1 ASVRTRATRTDGGWSLSGTKVWTSGAHRAHAFIVLARTAPADPAHRHDGL
MMAR_3511|M.marinum_M ASVRTRAVRGEGGWLLSGTKVWTSGAHRAHAFIVLARTAPVDPDHRHAGL
MUL_2757|M.ulcerans_Agy99 ASVRTRAVRGEGGWLLSGTKVWTSGAHRAHAFIVLARTAPVDPDHRHAGL
Mflv_5166|M.gilvum_PYR-GCK ASVRTKASPVDGGWSVTGAKVWTSGAHRADAFICLARTEPVDPAHRHAGL
MLBr_00737|M.leprae_Br4923 ASMRTRAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDP---DKGANGI
*:::: * ..* :.* * * : . : : : * . *:
Mb3592|M.bovis_AF2122/97 TYFMFDLKAKGVTVRPIAQLGGDTG--FGEIFLDDVFVPDRDVIGAPNDG
Rv3562|M.tuberculosis_H37Rv TYFMFDLKAKGVTVRPIAQLGGDTG--FGEIFLDDVFVPDRDVIGAPNDG
MAB_0595c|M.abscessus_ATCC_199 TYFMFDLKAEGITVRPIPQLDGDPG--FAEIFLDDVFVPDEDVIGAVHDG
MAV_2554|M.avium_104 SQFLVPCDAEGVRIEPIILMSGAHH--FNEVLFEQVFVPDADVLGEVGNG
TH_4559|M.thermoresistible__bu SQFLVPCDAKGVRIEPILLMNGDHH--FNEVSFEDVFIPDADVLGEIGNG
MSMEG_2879|M.smegmatis_MC2_155 SQFIVRFDGPGVEVRPIISMNGGHH--FNEVILDDAFVPDDMVFGQIGNG
Mvan_2876|M.vanbaalenii_PYR-1 SQFIVRFDGPGVEVRPIVSMNGGHH--FNEVILDGAFVPEDMVFGEIGDG
MMAR_3511|M.marinum_M SQFIVDLRGPGVQTRPIISMNGAHH--FNEVILDNACVPDEMVFGAIGNG
MUL_2757|M.ulcerans_Agy99 SQFIVDLRGPGVQTRPIISMNGAHH--FNEVILDNAHVPDEMVFGAIGNG
Mflv_5166|M.gilvum_PYR-GCK SQFIVDLRSPGVDIRPIVSMDGRHH--FNEVLLDDVFVADDMVFGAIGDG
MLBr_00737|M.leprae_Br4923 SAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTG
: *:. *. * * *: :: :. ::* *
Mb3592|M.bovis_AF2122/97 WRAAMSTSSNER--------GMSLRSPARFLASAERLVQLWKDRGSPPEF
Rv3562|M.tuberculosis_H37Rv WRAAMSTSSNER--------GMSLRSPARFLASAERLVQLWKDRGSPPEF
MAB_0595c|M.abscessus_ATCC_199 WRVAMSTSSNER--------GMSLRSPGRFLATADRLVELWKSVPENEFA
MAV_2554|M.avium_104 WHQVTSELSFER--------SGPERILSTGPLLFAAIRTLGRGPVPDDRT
TH_4559|M.thermoresistible__bu WHQVTAELSFER--------SGPERILSTVPLIVAAIRLLGNTPGTDDTT
MSMEG_2879|M.smegmatis_MC2_155 WQQVTSELSFER--------SGPERLLSTFVLLAQTTDSMARQQISRDA-
Mvan_2876|M.vanbaalenii_PYR-1 WSQVTSELSFER--------SGPERLLSTFPLLAATAESMAQHRISYDA-
MMAR_3511|M.marinum_M WTQVTSELSFER--------SGPERFLSTFVLLAATAESMAEQRFTRDQ-
MUL_2757|M.ulcerans_Agy99 WTQVTSELSFER--------SGPERFLSTFVLLAATAESMAEQRFTRDQ-
Mflv_5166|M.gilvum_PYR-GCK WQQVTSELAFER--------SGPERFLSTFPLLAELAALMNDG-LPRHN-
MLBr_00737|M.leprae_Br4923 FKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSI
: . : * . . :
Mb3592|M.bovis_AF2122/97 ADRVADAWIKAQAYRLQTFGTVTRLAAGGE-LGAESSVTKVFWSELDVHL
Rv3562|M.tuberculosis_H37Rv ADRVADAWIKAQAYRLQTFGTVTRLAAGGE-LGAESSVTKVFWSELDVHL
MAB_0595c|M.abscessus_ATCC_199 SERVADAWIAAQAYRLHTFGTVTRLAGGGE-LGAESSITKVFWSELDVAL
MAV_2554|M.avium_104 AADIGDLMARLISLRQLSLSVARTLTHGGD-AANQAALVKDLGTLFEAES
TH_4559|M.thermoresistible__bu ARIVGDLLGRLISLRQLSVWVARTLSEHKD-AANQAALVKDLGTRFEQDS
MSMEG_2879|M.smegmatis_MC2_155 --DLGRLVARIAGLHHMSMAVAGALERHEP-ADVPAAVVKVLGTTTEGD-
Mvan_2876|M.vanbaalenii_PYR-1 --ALGRMVARVAGLHQMSTAVAGALERDEP-ADVPAAVVKLLGTSTEGD-
MMAR_3511|M.marinum_M --QLGRLVARIAGLHQMSAAVAGALERNDP-ADLPAAVVKVLGTSTEGD-
MUL_2757|M.ulcerans_Agy99 --QLGRLVARIAGLHQMSAAVAGALERNDP-ADLPAAVVKVLGTSTESD-
Mflv_5166|M.gilvum_PYR-GCK --DLGRYVARVAGLHQMSTAVAGALERHEP-ADTAAAVVKVLGTSTEGD-
MLBr_00737|M.leprae_Br4923 QFMLADMAMKVEAARLIVYAAAARAERGEPDLGFISAASKCFASDIAMEV
:. . : .. :: * : :
Mb3592|M.bovis_AF2122/97 HQTALDLRGADG-------------ELAGPWTEGLLFALGGPIYAGTNEI
Rv3562|M.tuberculosis_H37Rv HQTALDLRGADG-------------ELAGPWTEGLLFALGGPIYAGTNEI
MAB_0595c|M.abscessus_ATCC_199 HETAIDLRGAEG-------------ELTNAWTDGYLFSLGGPIYAGTNEI
MAV_2554|M.avium_104 VGLIADLLEAA----------PPNSELEAMLNTAWLHKPMFTLRGGTNEV
TH_4559|M.thermoresistible__bu IEVIADVLDRV----------SPTPQIAALTATAILHKPIFTLRGGTNEV
MSMEG_2879|M.smegmatis_MC2_155 IADFADLHRGD--------DGALPQQARDLITAAVDQRPGFTLRGGTNEV
Mvan_2876|M.vanbaalenii_PYR-1 IADFADLHTGD--------ETTTGPGFRDLIAVAVDQRPGFTLRGGTTEV
MMAR_3511|M.marinum_M IAELADLADS---------HRPRDSEFAALVTAALDQRPGFTLRGGTNEV
MUL_2757|M.ulcerans_Agy99 IAELADLADSTDLADSGAPHRPRDPEFAALVTAALDQRPGFTLRGGTNEV
Mflv_5166|M.gilvum_PYR-GCK IADFADLLTDA--------CAPDHGGYRAMLDDAVVQRPGFTLRGGTNEI
MLBr_00737|M.leprae_Br4923 TTDAVQLFGGAG------------YTSDFPVERFMRDAKITQIYEGTNQI
:: : **.::
Mb3592|M.bovis_AF2122/97 QRNIIAERLLGLPREKT---------
Rv3562|M.tuberculosis_H37Rv QRNIIAERLLGLPREKT---------
MAB_0595c|M.abscessus_ATCC_199 QRNIIAERILGLPRESSASARTGGAK
MAV_2554|M.avium_104 LRGVIAR-GMGLR-------------
TH_4559|M.thermoresistible__bu LRGVVAR-GMGLR-------------
MSMEG_2879|M.smegmatis_MC2_155 LRGVIAR-GLGLR-------------
Mvan_2876|M.vanbaalenii_PYR-1 LRGVIAR-GLGMR-------------
MMAR_3511|M.marinum_M LRGVIAR-GLGLR-------------
MUL_2757|M.ulcerans_Agy99 LRGVIAR-GLGLR-------------
Mflv_5166|M.gilvum_PYR-GCK LRGVIAR-GLGMR-------------
MLBr_00737|M.leprae_Br4923 QRVVMSRALLR---------------
* :::. :