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AIPRLVPALDTEPADATALRAEVRAFLDEQRAAGTFTPAVDAWLCGWDEKFTTALAARGWLGMTVPKEYG GQGRSFLHRFVVTEELLAAGVPVAAHWIADRQIVPSLLKYGTERQKQEFLPRIAAGQCFFGIGMSEPDSG SDLASVRTRAVQVEGGWRLTGTKVWTSGAHRAHAFIVLARTAPVDPAHRHAGLSQFIVRFDGPGVEVRPI ISMNGGHHFNEVILDDAFVPDDMVFGQIGNGWQQVTSELSFERSGPERLLSTFVLLAQTTDSMARQQISR DADLGRLVARIAGLHHMSMAVAGALERHEPADVPAAVVKVLGTTTEGDIADFADLHRGDDGALPQQARDL ITAAVDQRPGFTLRGGTNEVLRGVIARGLGLR*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. smegmatis MC2 155 | MSMEG_2879 | - | - | 100% (383) | acyl-CoA dehydrogenase |
M. smegmatis MC2 155 | MSMEG_3392 | - | e-123 | 60.16% (364) | acyl-CoA dehydrogenase domain-containing protein |
M. smegmatis MC2 155 | MSMEG_0603 | - | 2e-44 | 33.50% (394) | putative acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0277c | fadE6 | 6e-43 | 33.16% (392) | acyl-CoA dehydrogenase FADE6 |
M. gilvum PYR-GCK | Mflv_5166 | - | 1e-155 | 72.44% (381) | Fis family transcriptional regulator |
M. tuberculosis H37Rv | Rv0271c | fadE6 | 6e-43 | 33.16% (392) | acyl-CoA dehydrogenase FADE6 |
M. leprae Br4923 | MLBr_00737 | fadE25 | 3e-22 | 30.04% (243) | putative acyl-CoA dehydrogenase |
M. abscessus ATCC 19977 | MAB_4336 | - | 4e-46 | 36.88% (385) | acyl-CoA dehydrogenase FadE |
M. marinum M | MMAR_3511 | - | 1e-170 | 79.18% (389) | acyl-CoA dehydrogenase |
M. avium 104 | MAV_2554 | - | 1e-111 | 54.21% (380) | acyl-CoA dehydrogenase, central region |
M. thermoresistible (build 8) | TH_3989 | - | 1e-129 | 61.79% (390) | PUTATIVE acyl-CoA dehydrogenase domain protein |
M. ulcerans Agy99 | MUL_2757 | - | 1e-170 | 77.92% (394) | acyl-CoA dehydrogenase |
M. vanbaalenii PYR-1 | Mvan_2876 | - | 1e-177 | 79.90% (383) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment Mb0277c|M.bovis_AF2122/97 MSIAITPEHYELADSVRSLVARVAPSEVLHAALESPVENPPPYWQAAAEQ Rv0271c|M.tuberculosis_H37Rv MSIAITPEHYELADSVRSLVARVAPSEVLHAALESPVENPPPYWQAAAEQ MAB_4336|M.abscessus_ATCC_1997 MPIAINSEHVALADSAHAFVERVVPTELLHETLETPLPWPPPFWKSAADQ MSMEG_2879|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_2876|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_3511|M.marinum_M -------------------------------------------------- MUL_2757|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5166|M.gilvum_PYR-GCK -------------------------------------------------- TH_3989|M.thermoresistible__bu -------------------------------------------------- MAV_2554|M.avium_104 -------------------------------------------------- MLBr_00737|M.leprae_Br4923 -------------------------------------------------- Mb0277c|M.bovis_AF2122/97 GLQGVHLAESVGGQGFGILELAVVLAEFGYGAVPGPFVPSAIASALIAAH Rv0271c|M.tuberculosis_H37Rv GLQGVHLAESVGGQGFGILELAVVLAEFGYGAVPGPFVPSAIASALIAAH MAB_4336|M.abscessus_ATCC_1997 GLTSVHLAESVGGQGFGALELAIVVAEFGRGAVPGPFVPSVIASALISAH MSMEG_2879|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_2876|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_3511|M.marinum_M -------------------------------------------------- MUL_2757|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5166|M.gilvum_PYR-GCK -------------------------------------------------- TH_3989|M.thermoresistible__bu -------------------------------------------------- MAV_2554|M.avium_104 -------------------------------------------------- MLBr_00737|M.leprae_Br4923 -------------------------------------------------- Mb0277c|M.bovis_AF2122/97 DPQAKVLAELATGAAIAAYALDSGLTATRHGDVLVIRGEVRAVPAAAQAS Rv0271c|M.tuberculosis_H37Rv DPQAKVLAELATGAAIAAYALDSGLTATRHGDVLVIRGEVRAVPAAAQAS MAB_4336|M.abscessus_ATCC_1997 DPDHPLLSDLASGASIATFSSTSSFTATPAGDGLSVDGQARSVLSATSAT MSMEG_2879|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_2876|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_3511|M.marinum_M -------------------------------------------------- MUL_2757|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5166|M.gilvum_PYR-GCK -------------------------------------------------- TH_3989|M.thermoresistible__bu -------------------------------------------------- MAV_2554|M.avium_104 -------------------------------------------------- MLBr_00737|M.leprae_Br4923 -------------------------------------------------- Mb0277c|M.bovis_AF2122/97 VLVLPVAIESRDEWVVLRNDQLEIEAVKSLDPLRPIAHVRANAVDVSDDA Rv0271c|M.tuberculosis_H37Rv VLVLPVAIESRDEWVVLRNDQLEIEAVKSLDPLRPIAHVRANAVDVSDDA MAB_4336|M.abscessus_ATCC_1997 YVVAPVAIDSDRRWVVLSADDVTLDSQQSVDPLRPVAHVTATAVQVPADR MSMEG_2879|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_2876|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_3511|M.marinum_M -------------------------------------------------- MUL_2757|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5166|M.gilvum_PYR-GCK -------------------------------------------------- TH_3989|M.thermoresistible__bu -------------------------------------------------- MAV_2554|M.avium_104 -------------------------------------------------- MLBr_00737|M.leprae_Br4923 -------------------------------------------------- Mb0277c|M.bovis_AF2122/97 LLSNLTMTTAHALMSTLLSAEAVGVARWATDTASAYAKIREQFGRPIGQF Rv0271c|M.tuberculosis_H37Rv LLSNLTMTTAHALMSTLLSAEAVGVARWATDTASAYAKIREQFGRPIGQF MAB_4336|M.abscessus_ATCC_1997 VLSNLTDARATSIISTIVSAEAVGVARWATDTASEYAKVREQFGRPIGQF MSMEG_2879|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_2876|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_3511|M.marinum_M -------------------------------------------------- MUL_2757|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5166|M.gilvum_PYR-GCK -------------------------------------------------- TH_3989|M.thermoresistible__bu -------------------------------------------------- MAV_2554|M.avium_104 -------------------------------------------------- MLBr_00737|M.leprae_Br4923 -------------------------------------------------- Mb0277c|M.bovis_AF2122/97 QAIKHKCAEMIADTERATAAVWDAARALDDAGESSSDVEFAAAVAATLAP Rv0271c|M.tuberculosis_H37Rv QAIKHKCAEMIADTERATAAVWDAARALDDAGESSSDVEFAAAVAATLAP MAB_4336|M.abscessus_ATCC_1997 QGIKHKCATMAAVTERATAAVWDAARALDDADENPGVVEFAASVAATLAP MSMEG_2879|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_2876|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_3511|M.marinum_M -------------------------------------------------- MUL_2757|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5166|M.gilvum_PYR-GCK -------------------------------------------------- TH_3989|M.thermoresistible__bu -------------------------------------------------- MAV_2554|M.avium_104 -------------------------------------------------- MLBr_00737|M.leprae_Br4923 -------------------------------------------------- Mb0277c|M.bovis_AF2122/97 ATAQRCTQDCIQVHGGIGFTWEHDTNVYYRRALMLAACFGRGSEYPQRVV Rv0271c|M.tuberculosis_H37Rv ATAQRCTQDCIQVHGGIGFTWEHDTNVYYRRALMLAACFGRGSEYPQRVV MAB_4336|M.abscessus_ATCC_1997 AAAQQCAQDCIQVHGGIGYTWEHDAHIYYRRALGLTAALGRSGGAPATVV MSMEG_2879|M.smegmatis_MC2_155 --------------------------------------MAIPRLVPALD- Mvan_2876|M.vanbaalenii_PYR-1 --------------------------------------MARTRLVPPAG- MMAR_3511|M.marinum_M ---------------------------------MADALMALPRLVPPAGA MUL_2757|M.ulcerans_Agy99 --------------------------------------MALPRLVPPAGA Mflv_5166|M.gilvum_PYR-GCK --------------------------------------MNTSRLVPPVA- TH_3989|M.thermoresistible__bu --------------------------------------MTAVERLPASAP MAV_2554|M.avium_104 --------------------------------------MVNSFDALSAR- MLBr_00737|M.leprae_Br4923 -------------------------------------MVGWSGNPLFDLF . Mb0277c|M.bovis_AF2122/97 DTATTAGMRPVDIDLDPSTEKLRAQIRAEVAALKAMPREPRTVAIAEGGW Rv0271c|M.tuberculosis_H37Rv DTATTAGMRPVDIDLDPSTEKLRAQIRAEVAALKAMPREPRTVAIAEGGW MAB_4336|M.abscessus_ATCC_1997 RTAVEHGLRKVDIDLAPETEALRAEIRAEVAALKEIPSGKRNTAIAEGGW MSMEG_2879|M.smegmatis_MC2_155 TEPADATALRAEVRAFLDEQRAAGTFTPAVDAWLCGWDEKFTTALAARGW Mvan_2876|M.vanbaalenii_PYR-1 VDHADTARLRADVRAFLAEQLAAQTFVPSVDSWLCGWDEAFTEALAARGY MMAR_3511|M.marinum_M LDSPRADVLRGEVRAFLAEQSAAGGFTPSVDAWLSAWDEDFTAALADRGW MUL_2757|M.ulcerans_Agy99 LDSPRADVLRGEVRAFLAEQSAAGGFTPSVDAWLSAWDEDFTAALADRGW Mflv_5166|M.gilvum_PYR-GCK DDPHAMDGLRDEVRQFVAEQRDAGRIGRQVDSWLTGWDEDFSRALAARGW TH_3989|M.thermoresistible__bu VEVA--PELRAEVREFLDEERAAGRFTPRCDAWLVGWDPEFSRRLAGRGW MAV_2554|M.avium_104 --EPELVKLRHAVRDFLESDRAEFGWQPGVDSWLAGWDEEFSGRLGAAGF MLBr_00737|M.leprae_Br4923 KLPEEHNELRATIRALAEKEIAPHAADVDQRARFP---EEALAALNASGF : : : : *: Mb0277c|M.bovis_AF2122/97 VLPYLPKPWG-RAASPVEQIIIAQEFTAGRVKRPQIAIAT-WIVPSIVAF Rv0271c|M.tuberculosis_H37Rv VLPYLPKPWG-RAASPVEQIIIAQEFTAGRVKRPQIAIAT-WIVPSIVAF MAB_4336|M.abscessus_ATCC_1997 VLPYLPTPWG-RAASPVEQVIISQEFLTGKVRRPQLGIAT-WLVPSIVAY MSMEG_2879|M.smegmatis_MC2_155 LGMTVPKEYGGQGRSFLHRFVVTEELLAAGVPVAAHWIADRQIVPSLLKY Mvan_2876|M.vanbaalenii_PYR-1 LGMTVPEEYGGHGRSHIERFVVTEELLAAGAPVAAHWIADRQIVPALLKH MMAR_3511|M.marinum_M LGMTVPVEYGGHGRTFLERFVVTEELLAAGAPVAAHWIADRQIVPSLLKY MUL_2757|M.ulcerans_Agy99 LGMTVPVEYGGHGRTFLERFVVTEELLAVGAPVAAHWIADRQIVPSLLKY Mflv_5166|M.gilvum_PYR-GCK LGMTVPEEYGGHGRSFLERFVVTEELLAAGAPVGAHWIADRQIVPSLLKY TH_3989|M.thermoresistible__bu LGMTLPARYGGHERSTLERYVVTEELLAAGAPVAAHWIADRQIGPSLLRY MAV_2554|M.avium_104 TGLTIPQRYGGHGLGHLHRYVVTEELIAAGAPVAAHWTADRQVAPALLTY MLBr_00737|M.leprae_Br4923 NAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIPAVNKLGTMGLILR :* :* : : :: :*. . . .:: Mb0277c|M.bovis_AF2122/97 GTDNQKQRLLPPTFRGDIFWCQLFSEPGAGSDLASLATKATRVDGGWRIT Rv0271c|M.tuberculosis_H37Rv GTDNQKQRLLPPTFRGDIFWCQLFSEPGAGSDLASLATKATRVDGGWRIT MAB_4336|M.abscessus_ATCC_1997 GTEEQKQRFLPPTFRGEMMWCQLFSEPGAGSDLAGLSTKAVKVEGGWRLT MSMEG_2879|M.smegmatis_MC2_155 GTERQKQEFLPRIAAGQCFFGIGMSEPDSGSDLASVRTRAVQVEGGWRLT Mvan_2876|M.vanbaalenii_PYR-1 GTDAQKREFLPKIAAGKCFFGIGMSEPDSGSDLASVRTRATRTDGGWSLS MMAR_3511|M.marinum_M GTELQKSHFLPRIVRGECFFGIGMSEPDSGSDLASVRTRAVRGEGGWLLS MUL_2757|M.ulcerans_Agy99 GTELQKSHFLPRIVRGECFFGIGMSEPDSGSDLASVRTRAVRGEGGWLLS Mflv_5166|M.gilvum_PYR-GCK GTETQKRRYLPEIAAGRCYFGIGMSEPDSGSDLASVRTKASPVDGGWSVT TH_3989|M.thermoresistible__bu GTEAQRNRFLPAIARGECFFGIGMSEPDSGSDLASVRTKATRVDGGWRID MAV_2554|M.avium_104 GNEEQRERLLPKIVAGQLFSSIGMSEHGAGSDLAAVQTKAVRADGGWLLS MLBr_00737|M.leprae_Br4923 GSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRTRAKADGDDWILN *.: : . ** :** :*** *.: *:* ..* : Mb0277c|M.bovis_AF2122/97 GQKIWTTGAQYSQWGALLARTDP---SAPKHNGITYFLLDMKSEGVQVKP Rv0271c|M.tuberculosis_H37Rv GQKIWTTGAQYSQWGALLARTDP---SAPKHNGITYFLLDMKSEGVQVKP MAB_4336|M.abscessus_ATCC_1997 GQKIWTSVAQFADWGACLARTDP---SAPKHNGITYFLVDMKSEGVTVRP MSMEG_2879|M.smegmatis_MC2_155 GTKVWTSGAHRAHAFIVLARTAP-VDPAHRHAGLSQFIVRFDGPGVEVRP Mvan_2876|M.vanbaalenii_PYR-1 GTKVWTSGAHRAHAFIVLARTAP-ADPAHRHDGLSQFIVRFDGPGVEVRP MMAR_3511|M.marinum_M GTKVWTSGAHRAHAFIVLARTAP-VDPDHRHAGLSQFIVDLRGPGVQTRP MUL_2757|M.ulcerans_Agy99 GTKVWTSGAHRAHAFIVLARTAP-VDPDHRHAGLSQFIVDLRGPGVQTRP Mflv_5166|M.gilvum_PYR-GCK GAKVWTSGAHRADAFICLARTEP-VDPAHRHAGLSQFIVDLRSPGVDIRP TH_3989|M.thermoresistible__bu GTKIWTSGAHRAHAFFVLARSTPLAESPSRHAGLSQFIVLLDSPGVEIRP MAV_2554|M.avium_104 GSKVWTSGAHHAHQVVVLARTSP-PDPEHRHAGFSQFLVPCDAEGVRIEP MLBr_00737|M.leprae_Br4923 GFKCWITNGGKSTWYTVMAVTDP----DKGANGISAFIVHKDDEGFSIGP * * * : . : :* : * *:: *:: *. * Mb0277c|M.bovis_AF2122/97 LRELTG--KEFFNTVYLDDVFVPDELVLGEVNRGWEVSRNTLTAERVSI- Rv0271c|M.tuberculosis_H37Rv LRELTG--KEFFNTVYLDDVFVPDELVLGEVNRGWEVSRNTLTAERVSI- MAB_4336|M.abscessus_ATCC_1997 LREMTG--GALFNEVFIDDVFVPDELVVGEVNRGWEVSRNTLTAERVSI- MSMEG_2879|M.smegmatis_MC2_155 IISMNG--GHHFNEVILDDAFVPDDMVFGQIGNGWQQVTSELSFERS--- Mvan_2876|M.vanbaalenii_PYR-1 IVSMNG--GHHFNEVILDGAFVPEDMVFGEIGDGWSQVTSELSFERS--- MMAR_3511|M.marinum_M IISMNG--AHHFNEVILDNACVPDEMVFGAIGNGWTQVTSELSFERS--- MUL_2757|M.ulcerans_Agy99 IISMNG--AHHFNEVILDNAHVPDEMVFGAIGNGWTQVTSELSFERS--- Mflv_5166|M.gilvum_PYR-GCK IVSMDG--RHHFNEVLLDDVFVADDMVFGAIGDGWQQVTSELAFERS--- TH_3989|M.thermoresistible__bu IPLLTG--EHHFNEVHLDGVFVPDDMVLGEIGEGWRQVTSELAFERS--- MAV_2554|M.avium_104 IILMSG--AHHFNEVLFEQVFVPDADVLGEVGNGWHQVTSELSFERS--- MLBr_00737|M.leprae_Br4923 KEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTALATLDHTRPTIG * . : :: :. :.* . *: * * Mb0277c|M.bovis_AF2122/97 ---GGSDSTFLPTLGEFVDFVRDYRFEGQFDQVARHRAGQLIAEGHATKL Rv0271c|M.tuberculosis_H37Rv ---GGSDSTFLPTLGEFVDFVRDYRFEGQFDQVARHRAGQLIAEGHATKL MAB_4336|M.abscessus_ATCC_1997 ---GSSDLPFLASLDDLVAFVGTHDLG----EVARDRAGQLIAEGHGVKL MSMEG_2879|M.smegmatis_MC2_155 -----GPERLLSTFVLLAQTTDSMARQQ---ISRDADLGRLVARIAGLHH Mvan_2876|M.vanbaalenii_PYR-1 -----GPERLLSTFPLLAATAESMAQHR---ISYDAALGRMVARVAGLHQ MMAR_3511|M.marinum_M -----GPERFLSTFVLLAATAESMAEQR---FTRDQQLGRLVARIAGLHQ MUL_2757|M.ulcerans_Agy99 -----GPERFLSTFVLLAATAESMAEQR---FTRDQQLGRLVARIAGLHQ Mflv_5166|M.gilvum_PYR-GCK -----GPERFLSTFPLLAELAALMNDG----LPRHNDLGRYVARVAGLHQ TH_3989|M.thermoresistible__bu -----GPERFLSTFPLLTTLVDELARRGD--RGSGTEIGKLIARLWTLRR MAV_2554|M.avium_104 -----GPERILSTGPLLFAAIRTLGRGPVPDDRTAADIGDLMARLISLRQ MLBr_00737|M.leprae_Br4923 AQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFMLADMAMKVEAARL * : . . : Mb0277c|M.bovis_AF2122/97 LNLRSTLLTLAGGD-PMAPAAISKLLSMRTGQGYAEFAVSSFGTDA---- Rv0271c|M.tuberculosis_H37Rv LNLRSTLLTLAGGD-PMAPAAISKLLSMRTGQGYAEFAVSSFGTDA---- MAB_4336|M.abscessus_ATCC_1997 LNLRSTLLTLAGGD-PMPSAAVSKLLGMRTGQGYAEFVVNHFGQDG---- MSMEG_2879|M.smegmatis_MC2_155 MSMAVAGALERHEP-ADVPAAVVKVLGTTTEGD-IADFADLHRGD----- Mvan_2876|M.vanbaalenii_PYR-1 MSTAVAGALERDEP-ADVPAAVVKLLGTSTEGD-IADFADLHTGD----- MMAR_3511|M.marinum_M MSAAVAGALERNDP-ADLPAAVVKVLGTSTEGD-IAELADLADS------ MUL_2757|M.ulcerans_Agy99 MSAAVAGALERNDP-ADLPAAVVKVLGTSTESD-IAELADLADSTDLADS Mflv_5166|M.gilvum_PYR-GCK MSTAVAGALERHEP-ADTAAAVVKVLGTSTEGD-IADFADLLTDA----- TH_3989|M.thermoresistible__bu MSLAIAVSLADGVA-QEVPAALVKDLGTRFENE-IVTAAQLLLDLE---- MAV_2554|M.avium_104 LSLSVARTLTHGGD-AANQAALVKDLGTLFEAESVGLIADLLEAA----- MLBr_00737|M.leprae_Br4923 IVYAAAARAERGEPDLGFISAASKCFASDIAMEVTTDAVQLFGGAG---- : : :* * :. .. Mb0277c|M.bovis_AF2122/97 ---VIGDTERLPGKWGEYLLASRATTIYGGTSEVQLNIIAERLLGLPRDP Rv0271c|M.tuberculosis_H37Rv ---VIGDTERLPGKWGEYLLASRATTIYGGTSEVQLNIIAERLLGLPRDP MAB_4336|M.abscessus_ATCC_1997 ---AIGDSEQEQGRWADYLLASRATTIYGGTSEVQLNIIAERLLGLPRDP MSMEG_2879|M.smegmatis_MC2_155 ---DGALPQQARDLITAAVDQRPGFTLRGGTNEVLRGVIAR-GLGLR--- Mvan_2876|M.vanbaalenii_PYR-1 ---ETTTGPGFRDLIAVAVDQRPGFTLRGGTTEVLRGVIAR-GLGMR--- MMAR_3511|M.marinum_M ---HRPRDSEFAALVTAALDQRPGFTLRGGTNEVLRGVIAR-GLGLR--- MUL_2757|M.ulcerans_Agy99 GAPHRPRDPEFAALVTAALDQRPGFTLRGGTNEVLRGVIAR-GLGLR--- Mflv_5166|M.gilvum_PYR-GCK ---CAPDHGGYRAMLDDAVVQRPGFTLRGGTNEILRGVIAR-GLGMR--- TH_3989|M.thermoresistible__bu ---PDPGGEGLPRLLAEAVLQAPGFTIRGGTSEVLRSMVAR-GMGLR--- MAV_2554|M.avium_104 -----PPNSELEAMLNTAWLHKPMFTLRGGTNEVLRGVIAR-GMGLR--- MLBr_00737|M.leprae_Br4923 ------YTSDFP--VERFMRDAKITQIYEGTNQIQRVVMSRALLR----- : **.:: :::. :