For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
ALPRLVPPAGALDSPRADVLRGEVRAFLAEQSAAGGFTPSVDAWLSAWDEDFTAALADRGWLGMTVPVEY GGHGRTFLERFVVTEELLAVGAPVAAHWIADRQIVPSLLKYGTELQKSHFLPRIVRGECFFGIGMSEPDS GSDLASVRTRAVRGEGGWLLSGTKVWTSGAHRAHAFIVLARTAPVDPDHRHAGLSQFIVDLRGPGVQTRP IISMNGAHHFNEVILDNAHVPDEMVFGAIGNGWTQVTSELSFERSGPERFLSTFVLLAATAESMAEQRFT RDQQLGRLVARIAGLHQMSAAVAGALERNDPADLPAAVVKVLGTSTESDIAELADLADSTDLADSGAPHR PRDPEFAALVTAALDQRPGFTLRGGTNEVLRGVIARGLGLR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2757 | - | - | 100% (392) | acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_4144 | fadE34 | 1e-42 | 34.59% (344) | acyl-CoA dehydrogenase FadE34 |
| M. ulcerans Agy99 | MUL_4125 | fadE30 | 3e-37 | 34.65% (355) | acyl-CoA dehydrogenase FadE30 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3604c | fadE34 | 2e-43 | 34.20% (383) | acyl-CoA dehydrogenase FADE34 |
| M. gilvum PYR-GCK | Mflv_5166 | - | 1e-150 | 69.92% (389) | Fis family transcriptional regulator |
| M. tuberculosis H37Rv | Rv3573c | fadE34 | 2e-43 | 34.20% (383) | acyl-CoA dehydrogenase FADE34 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 4e-19 | 26.94% (386) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0597 | - | 2e-41 | 33.83% (405) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_3511 | - | 0.0 | 96.68% (392) | acyl-CoA dehydrogenase |
| M. avium 104 | MAV_2554 | - | 1e-109 | 53.54% (381) | acyl-CoA dehydrogenase, central region |
| M. smegmatis MC2 155 | MSMEG_2879 | - | 1e-170 | 77.92% (394) | acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3989 | - | 1e-123 | 60.85% (378) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. vanbaalenii PYR-1 | Mvan_3917 | - | 1e-169 | 76.28% (392) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3604c|M.bovis_AF2122/97 MVATVTDEQSAARELVRGWARTAASGAAATAAVRDMEYGFEEGNADAWRP
Rv3573c|M.tuberculosis_H37Rv MVATVTDEQSAARELVRGWARTAASGAAATAAVRDMEYGFEEGNADAWRP
MUL_2757|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3511|M.marinum_M --------------------------------------------------
MSMEG_2879|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3917|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5166|M.gilvum_PYR-GCK --------------------------------------------------
TH_3989|M.thermoresistible__bu --------------------------------------------------
MAV_2554|M.avium_104 --------------------------------------------------
MAB_0597|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3604c|M.bovis_AF2122/97 VFAGLAGLGLFGVAVPEDCGGAGGSIEDLCAMVDEAARALVPGPVATTAV
Rv3573c|M.tuberculosis_H37Rv VFAGLAGLGLFGVAVPEDCGGAGGSIEDLCAMVDEAARALVPGPVATTAV
MUL_2757|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3511|M.marinum_M --------------------------------------------------
MSMEG_2879|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3917|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5166|M.gilvum_PYR-GCK --------------------------------------------------
TH_3989|M.thermoresistible__bu --------------------------------------------------
MAV_2554|M.avium_104 --------------------------------------------------
MAB_0597|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3604c|M.bovis_AF2122/97 ATLVVSDPKLRSALASGERFAGVAIDGGVQVDPKTSTASGTVGRVLGGAP
Rv3573c|M.tuberculosis_H37Rv ATLVVSDPKLRSALASGERFAGVAIDGGVQVDPKTSTASGTVGRVLGGAP
MUL_2757|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3511|M.marinum_M --------------------------------------------------
MSMEG_2879|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3917|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5166|M.gilvum_PYR-GCK --------------------------------------------------
TH_3989|M.thermoresistible__bu --------------------------------------------------
MAV_2554|M.avium_104 --------------------------------------------------
MAB_0597|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3604c|M.bovis_AF2122/97 GGVVLLPADGNWLLVDTACDEVVVEPLRATDFSLPLARMVLTSAPVTVLE
Rv3573c|M.tuberculosis_H37Rv GGVVLLPADGNWLLVDTACDEVVVEPLRATDFSLPLARMVLTSAPVTVLE
MUL_2757|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3511|M.marinum_M --------------------------------------------------
MSMEG_2879|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3917|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5166|M.gilvum_PYR-GCK --------------------------------------------------
TH_3989|M.thermoresistible__bu --------------------------------------------------
MAV_2554|M.avium_104 --------------------------------------------------
MAB_0597|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3604c|M.bovis_AF2122/97 VSGERVEDLAATVLAAEAAGVARWTLDTAVAYAKVREQFGKPIGSFQAVK
Rv3573c|M.tuberculosis_H37Rv VSGERVEDLAATVLAAEAAGVARWTLDTAVAYAKVREQFGKPIGSFQAVK
MUL_2757|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3511|M.marinum_M ---------------------------------------------MADAL
MSMEG_2879|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3917|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5166|M.gilvum_PYR-GCK --------------------------------------------------
TH_3989|M.thermoresistible__bu --------------------------------------------------
MAV_2554|M.avium_104 --------------------------------------------------
MAB_0597|M.abscessus_ATCC_1997 ------------------------------------------------MV
MLBr_00737|M.leprae_Br4923 -------------------------------------------------M
Mb3604c|M.bovis_AF2122/97 HLCAQMLCRAEQADVAAADAARAAADSDGTQLSIAAAVAASIGIDAAKAN
Rv3573c|M.tuberculosis_H37Rv HLCAQMLCRAEQADVAAADAARAAADSDGTQLSIAAAVAASIGIDAAKAN
MUL_2757|M.ulcerans_Agy99 MALPRLVPPAGALDSPRADVLRGEVR------------------------
MMAR_3511|M.marinum_M MALPRLVPPAGALDSPRADVLRGEVR------------------------
MSMEG_2879|M.smegmatis_MC2_155 MAIPRLVP-ALDTEPADATALRAEVR------------------------
Mvan_3917|M.vanbaalenii_PYR-1 MAAARLVP-PCTAETSEAHELRAEVR------------------------
Mflv_5166|M.gilvum_PYR-GCK MNTSRLVP-PVADDPHAMDGLRDEVR------------------------
TH_3989|M.thermoresistible__bu MTAVERLP--ASAPVEVAPELRAEVR------------------------
MAV_2554|M.avium_104 --MVNSFD-ALSAREPELVKLRHAVR------------------------
MAB_0597|M.abscessus_ATCC_1997 ESQVSPAPAGEPMSEMSDDQVRTEIREWLAEN------------------
MLBr_00737|M.leprae_Br4923 VGWSGNPLFDLFKLPEEHNELRATIR------------------------
*
Mb3604c|M.bovis_AF2122/97 AKDCIQVLGGIGCTWEHDAHLYLRRAHGIGGFLGGSGRWLRRVTALTQAG
Rv3573c|M.tuberculosis_H37Rv AKDCIQVLGGIGCTWEHDAHLYLRRAHGIGGFLGGSGRWLRRVTALTQAG
MUL_2757|M.ulcerans_Agy99 --------------------AFLAEQSAAGGFTPSVDAWLS---------
MMAR_3511|M.marinum_M --------------------AFLAEQSAAGGFTPSVDAWLS---------
MSMEG_2879|M.smegmatis_MC2_155 --------------------AFLDEQRAAGTFTPAVDAWLC---------
Mvan_3917|M.vanbaalenii_PYR-1 --------------------RFLAEQLAAGAFTPTADAWLC---------
Mflv_5166|M.gilvum_PYR-GCK --------------------QFVAEQRDAGRIGRQVDSWLT---------
TH_3989|M.thermoresistible__bu --------------------EFLDEERAAGRFTPRCDAWLV---------
MAV_2554|M.avium_104 --------------------DFLESDRAEFGWQPGVDSWLA---------
MAB_0597|M.abscessus_ATCC_1997 ------------------LVGEFAELKGLGGPGSEHEAFEER--------
MLBr_00737|M.leprae_Br4923 ----------------------ALAEKEIAPHAADVDQRAR---------
Mb3604c|M.bovis_AF2122/97 VRRRLGVDLAEVAGLRPEIAAAVAEVAALPEEKRQVALADTGLLAPHWPA
Rv3573c|M.tuberculosis_H37Rv VRRRLGVDLAEVAGLRPEIAAAVAEVAALPEEKRQVALADTGLLAPHWPA
MUL_2757|M.ulcerans_Agy99 ----------------------------AWDEDFTAALADRGWLGMTVPV
MMAR_3511|M.marinum_M ----------------------------AWDEDFTAALADRGWLGMTVPV
MSMEG_2879|M.smegmatis_MC2_155 ----------------------------GWDEKFTTALAARGWLGMTVPK
Mvan_3917|M.vanbaalenii_PYR-1 ----------------------------GWDEDFTAALAERGWLGMTVPV
Mflv_5166|M.gilvum_PYR-GCK ----------------------------GWDEDFSRALAARGWLGMTVPE
TH_3989|M.thermoresistible__bu ----------------------------GWDPEFSRRLAGRGWLGMTLPA
MAV_2554|M.avium_104 ----------------------------GWDEEFSGRLGAAGFTGLTIPQ
MAB_0597|M.abscessus_ATCC_1997 -------------------------------LAWNRHLAAAGWTCLGWPV
MLBr_00737|M.leprae_Br4923 -----------------------------FPEEALAALNASGFNAIHVPE
* * *
Mb3604c|M.bovis_AF2122/97 PYG-RGASPAEQLLIDQELAAAKVERPDLVIG-WWAAPTILEHGTPEQIE
Rv3573c|M.tuberculosis_H37Rv PYG-RGASPAEQLLIDQELAAAKVERPDLVIG-WWAAPTILEHGTPEQIE
MUL_2757|M.ulcerans_Agy99 EYGGHGRTFLERFVVTEELLAVGAPVAAHWIADRQIVPSLLKYGTELQKS
MMAR_3511|M.marinum_M EYGGHGRTFLERFVVTEELLAAGAPVAAHWIADRQIVPSLLKYGTELQKS
MSMEG_2879|M.smegmatis_MC2_155 EYGGQGRSFLHRFVVTEELLAAGVPVAAHWIADRQIVPSLLKYGTERQKQ
Mvan_3917|M.vanbaalenii_PYR-1 AYGGHGRSFLERFVVTEELLAAGAPVAAHWIADRQIVPSLLKYGTEFQKT
Mflv_5166|M.gilvum_PYR-GCK EYGGHGRSFLERFVVTEELLAAGAPVGAHWIADRQIVPSLLKYGTETQKR
TH_3989|M.thermoresistible__bu RYGGHERSTLERYVVTEELLAAGAPVAAHWIADRQIGPSLLRYGTEAQRN
MAV_2554|M.avium_104 RYGGHGLGHLHRYVVTEELIAAGAPVAAHWTADRQVAPALLTYGNEEQRE
MAB_0597|M.abscessus_ATCC_1997 EHGGRGATVSQRVIFYEEYARAEAPHKVNHLGEELLGPTLIAYGTPEQQQ
MLBr_00737|M.leprae_Br4923 EYGGQGADSVAACIVIEEVARVDASASLIPAVNKLGTMGLILRGSEELKK
:* : :. :* . . :: *.
Mb3604c|M.bovis_AF2122/97 RFVPATMRGEFLWCQLFSEPGAGSDLASLRTKAVRADGGWLLTGQKVWTS
Rv3573c|M.tuberculosis_H37Rv RFVPATMRGEFLWCQLFSEPGAGSDLASLRTKAVRADGGWLLTGQKVWTS
MUL_2757|M.ulcerans_Agy99 HFLPRIVRGECFFGIGMSEPDSGSDLASVRTRAVRGEGGWLLSGTKVWTS
MMAR_3511|M.marinum_M HFLPRIVRGECFFGIGMSEPDSGSDLASVRTRAVRGEGGWLLSGTKVWTS
MSMEG_2879|M.smegmatis_MC2_155 EFLPRIAAGQCFFGIGMSEPDSGSDLASVRTRAVQVEGGWRLTGTKVWTS
Mvan_3917|M.vanbaalenii_PYR-1 EFLPKIAGGTCFFGIGMSEPDSGSDLASVRTRAERVDGGWRLTGTKVWTS
Mflv_5166|M.gilvum_PYR-GCK RYLPEIAAGRCYFGIGMSEPDSGSDLASVRTKASPVDGGWSVTGAKVWTS
TH_3989|M.thermoresistible__bu RFLPAIARGECFFGIGMSEPDSGSDLASVRTKATRVDGGWRIDGTKIWTS
MAV_2554|M.avium_104 RLLPKIVAGQLFSSIGMSEHGAGSDLAAVQTKAVRADGGWLLSGSKVWTS
MAB_0597|M.abscessus_ATCC_1997 RFLPAIRDVTELWCQGYSEPGAGSDLANVSTSAVLDGGDWVINGQKVWTS
MLBr_00737|M.leprae_Br4923 QVLPSLAAEGAMASYALSEREAGSDAASMRTRAKADGDDWILNGFKCWIT
. :* ** :*** * : * * ..* : * * * :
Mb3604c|M.bovis_AF2122/97 AAHKARWGVCLARTDPDAP---KHKGITYFLVDMTTPGIEIRPLREITGD
Rv3573c|M.tuberculosis_H37Rv AAHKARWGVCLARTDPDAP---KHKGITYFLVDMTTPGIEIRPLREITGD
MUL_2757|M.ulcerans_Agy99 GAHRAHAFIVLARTAPVDP-DHRHAGLSQFIVDLRGPGVQTRPIISMNGA
MMAR_3511|M.marinum_M GAHRAHAFIVLARTAPVDP-DHRHAGLSQFIVDLRGPGVQTRPIISMNGA
MSMEG_2879|M.smegmatis_MC2_155 GAHRAHAFIVLARTAPVDP-AHRHAGLSQFIVRFDGPGVEVRPIISMNGG
Mvan_3917|M.vanbaalenii_PYR-1 GAHLAHAFIALARTAPVDP-AHRHAGLSQFIVDLRGPGVEIRPIVSMNGA
Mflv_5166|M.gilvum_PYR-GCK GAHRADAFICLARTEPVDP-AHRHAGLSQFIVDLRSPGVDIRPIVSMDGR
TH_3989|M.thermoresistible__bu GAHRAHAFFVLARSTPLAESPSRHAGLSQFIVLLDSPGVEIRPIPLLTGE
MAV_2554|M.avium_104 GAHHAHQVVVLARTSPPDP-EHRHAGFSQFLVPCDAEGVRIEPIILMSGA
MAB_0597|M.abscessus_ATCC_1997 LALQSQWCFVVARTEPGSS---RHKGLSYLLVPLDQPGVEIRPIIQLTGT
MLBr_00737|M.leprae_Br4923 NGGKSTWYTVMAVTDPDKG----ANGISAFIVHKDDEGFSIGPKEKKLGI
. : :* : * *:: ::* *. * *
Mb3604c|M.bovis_AF2122/97 --SLFNEVFLDNVFVPDEMVVGAVNDGWRLARTTLANERVAM--------
Rv3573c|M.tuberculosis_H37Rv --SLFNEVFLDNVFVPDEMVVGAVNDGWRLARTTLANERVAM--------
MUL_2757|M.ulcerans_Agy99 --HHFNEVILDNAHVPDEMVFGAIGNGWTQVTSELSFERSGP--------
MMAR_3511|M.marinum_M --HHFNEVILDNACVPDEMVFGAIGNGWTQVTSELSFERSGP--------
MSMEG_2879|M.smegmatis_MC2_155 --HHFNEVILDDAFVPDDMVFGQIGNGWQQVTSELSFERSGP--------
Mvan_3917|M.vanbaalenii_PYR-1 --HHFNEVLLDGAFVPDEMVFGSIGAGWEQVTSELAFERSGP--------
Mflv_5166|M.gilvum_PYR-GCK --HHFNEVLLDDVFVADDMVFGAIGDGWQQVTSELAFERSGP--------
TH_3989|M.thermoresistible__bu --HHFNEVHLDGVFVPDDMVLGEIGEGWRQVTSELAFERSGP--------
MAV_2554|M.avium_104 --HHFNEVLFEQVFVPDADVLGEVGNGWHQVTSELSFERSGP--------
MAB_0597|M.abscessus_ATCC_1997 --SEFNEVFFDNARTSADLVVGEPGDGWRVAMGTLTFERG----------
MLBr_00737|M.leprae_Br4923 KGSPTTELYFDKCRIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIA
.*: :: . :.* . *: . * *
Mb3604c|M.bovis_AF2122/97 ATGTALGNPMEELLKVLGDMELDVAQQD-RLGRLILLAQAGALLDRRIAE
Rv3573c|M.tuberculosis_H37Rv ATGTALGNPMEELLKVLGDMELDVAQQD-RLGRLILLAQAGALLDRRIAE
MUL_2757|M.ulcerans_Agy99 ERFLSTFVLLAATAESMAEQRFTRDQ---QLGRLVARIAGLHQMSAAVAG
MMAR_3511|M.marinum_M ERFLSTFVLLAATAESMAEQRFTRDQ---QLGRLVARIAGLHQMSAAVAG
MSMEG_2879|M.smegmatis_MC2_155 ERLLSTFVLLAQTTDSMARQQISRDA---DLGRLVARIAGLHHMSMAVAG
Mvan_3917|M.vanbaalenii_PYR-1 ERFLSTFVLLDACAETIASQRVPRSD---DLGRLVARVAGLHQMSSAVAG
Mflv_5166|M.gilvum_PYR-GCK ERFLSTFPLLAELAALMNDG-LPRHN---DLGRYVARVAGLHQMSTAVAG
TH_3989|M.thermoresistible__bu ERFLSTFPLLTTLVDELARRGDRGSGT--EIGKLIARLWTLRRMSLAIAV
MAV_2554|M.avium_104 ERILSTGPLLFAAIRTLGRGPVPDDRTAADIGDLMARLISLRQLSLSVAR
MAB_0597|M.abscessus_ATCC_1997 VSTLGNQITYARELSRLAELAKSNGAADDPAIRERLAQAYVGMRTMRAYA
MLBr_00737|M.leprae_Br4923 QGALDAAIVYTKDRKQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAA
:
Mb3604c|M.bovis_AF2122/97 LAVGGQD-PGAQSSVRKLIGVRYRQALAEYLMEVSDGG------------
Rv3573c|M.tuberculosis_H37Rv LAVGGQD-PGAQSSVRKLIGVRYRQALAEYLMEVSDGG------------
MUL_2757|M.ulcerans_Agy99 ALERNDP-ADLPAAVVKVLGTSTESD-IAELADLADSTDLADSGAPHRPR
MMAR_3511|M.marinum_M ALERNDP-ADLPAAVVKVLGTSTEGD-IAELADLADS---------HRPR
MSMEG_2879|M.smegmatis_MC2_155 ALERHEP-ADVPAAVVKVLGTTTEGD-IADFADLHRGD--------DGAL
Mvan_3917|M.vanbaalenii_PYR-1 ALQRHEP-ADVPAAVVKVLGTTTEGD-IAEYAHLMMDD----------DA
Mflv_5166|M.gilvum_PYR-GCK ALERHEP-ADTAAAVVKVLGTSTEGD-IADFADLLTDA--------CAPD
TH_3989|M.thermoresistible__bu SLADGVA-QEVPAALVKDLGTRFENE-IVTAAQLLLDLE-------PDPG
MAV_2554|M.avium_104 TLTHGGD-AANQAALVKDLGTLFEAESVGLIADLLEAA----------PP
MAB_0597|M.abscessus_ATCC_1997 LATMDEE-RPGQDNVSKLLWANWHRDLGELAMEIIGTS--------TLLT
MLBr_00737|M.leprae_Br4923 RAERGEPDLGFISAASKCFASDIAMEVTTDAVQLFGGAG-----------
* : .:
Mb3604c|M.bovis_AF2122/97 -GLVENRAVYDFLNTRCLTIAGGTEQILLTVAAERLLGLPR---
Rv3573c|M.tuberculosis_H37Rv -GLVENRAVYDFLNTRCLTIAGGTEQILLTVAAERLLGLPR---
MUL_2757|M.ulcerans_Agy99 DPEFAALVTAALDQRPGFTLRGGTNEVLRGVIAR-GLGLR----
MMAR_3511|M.marinum_M DSEFAALVTAALDQRPGFTLRGGTNEVLRGVIAR-GLGLR----
MSMEG_2879|M.smegmatis_MC2_155 PQQARDLITAAVDQRPGFTLRGGTNEVLRGVIAR-GLGLR----
Mvan_3917|M.vanbaalenii_PYR-1 GQQFSDMANAAVDQRPGFTLRGGTNEVLRGVIAR-GLGIR----
Mflv_5166|M.gilvum_PYR-GCK HGGYRAMLDDAVVQRPGFTLRGGTNEILRGVIAR-GLGMR----
TH_3989|M.thermoresistible__bu GEGLPRLLAEAVLQAPGFTIRGGTSEVLRSMVAR-GMGLR----
MAV_2554|M.avium_104 NSELEAMLNTAWLHKPMFTLRGGTNEVLRGVIAR-GMGLR----
MAB_0597|M.abscessus_ATCC_1997 NAGEMDEWQRLFLFSRADTIYGGSNEIQRNIISERVLGLPREAR
MLBr_00737|M.leprae_Br4923 -YTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR------
: *:.:: : :. :