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VERPDETTIRYSITGPSEGSTLVLIHGWGCERRYFDDLVAQLPADLRVVAVDLAEHGDSRSSRTVWTMEE FARDVDAVLSAESITRCVVVGHSLGGAVAVEVGRQLPDVVTHVVVLDALHYLGLFPAMDDSKAEAIIRPF HDDFAAAVRALVEGGSPEGFSEELIDSYFSMMVKVRQPAGIRAIEGLVRWNMEHALSETTQPITAFAVRE LLSSEAVERFGDRIDFVPVELGSHHFPVESPEDTAKLLTSVVSV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3336 | - | - | 100% (255) | hydrolase |
| M. smegmatis MC2 155 | MSMEG_1897 | pcaD | 4e-10 | 32.41% (108) | 3-oxoadipate enol-lactonase |
| M. smegmatis MC2 155 | MSMEG_0460 | - | 2e-09 | 29.03% (124) | alpha/beta hydrolase fold |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2734 | - | 7e-12 | 34.00% (100) | hydrolase |
| M. gilvum PYR-GCK | Mflv_0736 | - | 7e-12 | 33.64% (110) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv2715 | - | 8e-12 | 34.00% (100) | hydrolase |
| M. leprae Br4923 | MLBr_02603 | - | 3e-06 | 30.53% (95) | hypothetical protein MLBr_02603 |
| M. abscessus ATCC 19977 | MAB_3034 | - | 1e-12 | 36.79% (106) | hydrolase |
| M. marinum M | MMAR_1388 | hpx | 3e-11 | 37.37% (99) | non-heme haloperoxidase Hpx |
| M. avium 104 | MAV_4567 | - | 2e-12 | 25.30% (249) | dihydrolipoyllysine-residue acetyltransferase component of |
| M. thermoresistible (build 8) | TH_0684 | hpx | 5e-13 | 31.69% (142) | POSSIBLE NON-HEME HALOPEROXIDASE HPX |
| M. ulcerans Agy99 | MUL_2488 | hpx | 2e-11 | 37.37% (99) | non-heme haloperoxidase Hpx |
| M. vanbaalenii PYR-1 | Mvan_2445 | - | 1e-10 | 33.00% (100) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2734|M.bovis_AF2122/97 MTERKRNLRPVRD------------------VAPPTLQFRTVHGYRRAFR
Rv2715|M.tuberculosis_H37Rv MTERKRNLRPVRD------------------VAPPTLQFRTVHGYRRAFR
Mvan_2445|M.vanbaalenii_PYR-1 MTERKPNLRPVRE------------------LTP-TLKFCTIHGYRRAFR
MAB_3034|M.abscessus_ATCC_1997 MNPPPRLLRPVPDTEHIDGVDGGGDTPSAATSTRPRLAFRTIHGYRRAYR
MAV_4567|M.avium_104 MS---------------------------------ELKFLELHGDRVAFR
MMAR_1388|M.marinum_M MSARKATDGKAHTKAP--------AALPDVLPPSRSLTVRAADGTALHTQ
MUL_2488|M.ulcerans_Agy99 MSARKATDGKAHTKAS--------AALPDVLPPSRSLTVRAADGTALHTQ
TH_0684|M.thermoresistible__bu ---------------------------VEQMPPGRVVSVTAPDGVRLHAE
MSMEG_3336|M.smegmatis_MC2_155 -------------------------------------MVERPDETTIRYS
Mflv_0736|M.gilvum_PYR-GCK MFSRSRSVDEAPAWFT------------TALADKPEHSHVDVEGCEIHVR
MLBr_02603|M.leprae_Br4923 -----------------------------MTITRTERNFYGVGGVRIVYD
Mb2734|M.bovis_AF2122/97 IAG----SGPAILLIHGIGDNSTTWNGVHAKLAQR-FTVIAPDLLGHGQS
Rv2715|M.tuberculosis_H37Rv IAG----SGPAILLIHGIGDNSTTWNGVHAKLAQR-FTVIAPDLLGHGQS
Mvan_2445|M.vanbaalenii_PYR-1 VAG----SGPAILLIHGIGDNSTTWSTVQTQLAQR-FTVIAPDLLGHGRS
MAB_3034|M.abscessus_ATCC_1997 IAG----SGPVLLLIHGIGDNSATWDSVHAQLAEH-FTVIAPDLLGHGQS
MAV_4567|M.avium_104 DQG----EGEVLLLIHGMAGSSETWRSVIPPLAKK-FRVIAPDLLGHGES
MMAR_1388|M.marinum_M VFGPA--DGYPIVLTHGFVCSIRAWAYQIADLATD-YRVIAFDHRGHGRS
MUL_2488|M.ulcerans_Agy99 VFGPA--DGYPIVLTHGFVCSIRAWAYQIADLATD-YRVIAFDHRGHGRS
TH_0684|M.thermoresistible__bu VFGPA--DAPPIVLAHGITCAIRVWAHQIAELADD-YRVIAFDHRGHGRS
MSMEG_3336|M.smegmatis_MC2_155 ITGPS--EGSTLVLIHGWGCERRYFDDLVAQLPAD-LRVVAVDLAEHGDS
Mflv_0736|M.gilvum_PYR-GCK VWGAR--ENPPLVLVHGGAAHSGWWDHIAPLLSST-HRIVAPDLSGHGDS
MLBr_02603|M.leprae_Br4923 VWMPDTRPRAVIILAHGFGEHARRYDHVAHYFAAAGLATYALDLRGHGRS
::* ** : :. * * ** *
Mb2734|M.bovis_AF2122/97 DKPRA--DYSVAAYANGMRDLLSVLD----IERVTIVGHSLGGGVAMQFA
Rv2715|M.tuberculosis_H37Rv DKPRA--DYSVAAYANGMRDLLSVLD----IERVTIVGHSLGGGVAMQFA
Mvan_2445|M.vanbaalenii_PYR-1 DKPRA--DYSVAAYANGMRDLLSVLD----IDDVTVIGHSLGGGVAMQFA
MAB_3034|M.abscessus_ATCC_1997 DKPRA--DYSVAAYANGMRDLLAVLD----IERVTVVGHSLGGGVAMQFT
MAV_4567|M.avium_104 AKPRT--DYSLGAFAVWLRDFLDELG----VSRATVVGHSLGGGVAMQFV
MMAR_1388|M.marinum_M GIPRR-GGYTLEHLASDLDSVLDATLA--PHERALIAGHSMGGIAISAWS
MUL_2488|M.ulcerans_Agy99 GIPRR-GGYTLEHLASDLDSVLDATLA--PHERALIAGHSMGGIAISAWS
TH_0684|M.thermoresistible__bu SVPRRRWQYSLDHLASDLDAVLDATLD--PGERAVIAGHSMGGIAISSWA
MSMEG_3336|M.smegmatis_MC2_155 RSSRT--VWTMEEFARDVDAVLSAES----ITRCVVVGHSLGGAVAVEVG
Mflv_0736|M.gilvum_PYR-GCK GTRDS---YDLRRWSREVMAAAAAFS----DGHPTIVGHSLGGWVTATAA
MLBr_02603|M.leprae_Br4923 AGKRV-LVRDLSEYNADFDILVGIATRDHPGLKRIVAGHSMGGAIVFAYG
: . : ***:**
Mb2734|M.bovis_AF2122/97 YQFPQLVDR------LILVSAGGVTKDVNIVFR--LASLPMGSEAMALLR
Rv2715|M.tuberculosis_H37Rv YQFPQLVDR------LILVSAGGVTKDVNIVFR--LASLPMGSEAMALLR
Mvan_2445|M.vanbaalenii_PYR-1 YQFPQLVNR------LILVGAGGVTKDVNIALR--LASLPMGSEALALLR
MAB_3034|M.abscessus_ATCC_1997 YQFPHLVER------LILVAPGGVTKDVNIVLR--CASLPFIGDALGLLR
MAV_4567|M.avium_104 YQHPDYAQR------LILISSGGLGPDVGWVLR--LLSAPG---AELVLP
MMAR_1388|M.marinum_M ERYRHKVHRRADAVALINTATGDLLRKIRMLSVPRELSAARDFAGRGLIN
MUL_2488|M.ulcerans_Agy99 ERYRHKVHRRADAVALINTATGDLLRKIRMLSVPRELSAARDFAGRGLIN
TH_0684|M.thermoresistible__bu ERYPERVSERAAAVALINTTTGDLLHNVQLLPVPDRFAAVRVRTASAVIK
MSMEG_3336|M.smegmatis_MC2_155 RQLPDVVTH------VVVLDALHYLG---------LFPAMDDSKAEAIIR
Mflv_0736|M.gilvum_PYR-GCK SHFGDQINS-------IVVVDSPLRDRAPEERHLSRRTPKAYRSKDEIVG
MLBr_02603|M.leprae_Br4923 VERPDNYDL------MVLSGPAVAAQD--------MVSPLRAVVGKGLGL
. . : . :
Mb2734|M.bovis_AF2122/97 LPLVLPAVQIAGRIVGKAIGTTSLGHDL-PNVLRILDDLPEPTASAAFGR
Rv2715|M.tuberculosis_H37Rv LPLVLPAVQIAGRIVGKAIGTTSLGHDL-PNVLRILDDLPEPTASAAFGR
Mvan_2445|M.vanbaalenii_PYR-1 LPLVLPALQVLGRVSGTVFGSTGVGRDI-PDMLRILADLPEPTASSAFAR
MAB_3034|M.abscessus_ATCC_1997 LPMAMPMLRLGGAVARATFGRASMARDI-PDVLRVLADLPEPRASAAFTR
MAV_4567|M.avium_104 VIAPTPVLSVGNKLRSWLRGAGIQSPRG-AELWNAYSSLSDGETRQSFLK
MMAR_1388|M.marinum_M AFGGFPLPSAVRIPTQYLIAMMAVGADAHPTAARLLYELFAQTSAAGRGG
MUL_2488|M.ulcerans_Agy99 AFGGFPLPSAVRIPTQYLIAMMAVGADAHPTAARLLYELFAQTSAAGRGG
TH_0684|M.thermoresistible__bu TVAGMPARLAA-VPSRYVVSMMAVGRDADPAITNFVHELFTETPPAARDG
MSMEG_3336|M.smegmatis_MC2_155 PFHDDFAAAVRALVEGGSPEGFS------EELIDSYFSMMVKVRQPAGIR
Mflv_0736|M.gilvum_PYR-GCK RFRPVPAQQGVLPYVSAHIASESVRRTLKGWVWKFDPAIFGGHLAEQTPA
MLBr_02603|M.leprae_Br4923 VAPGLPVHQLEVDAISRNRAVVAAYKDD--------PLVYHGKVPAGVGR
:
Mb2734|M.bovis_AF2122/97 TLRAVVDWRGQMVTMLDRCYLTEAIPVQIIWGTKDVVLPVRHAHMAHAAM
Rv2715|M.tuberculosis_H37Rv TLRAVVDWRGQMVTMLDRCYLTEAIPVQIIWGTKDVVLPVRHAHMAHAAM
Mvan_2445|M.vanbaalenii_PYR-1 TLRAVVDWRGQVVTMLDRCYLTQSVPVQLIWGDCDAVIPVSHGEMAHAAM
MAB_3034|M.abscessus_ATCC_1997 TLRAVVDWRGQVVTMLDRCYLTESVPVQLIWGSDDLVIPVSHGHLAHAAM
MAV_4567|M.avium_104 TLRSVVDYRGQAVSALNRLRLREELPVMAIWGERDGIIPVDHAYAAHEAR
MMAR_1388|M.marinum_M CARMLVGEVGSRHISLD----GLTVPTLVIGSERDRLTPISQTRKIASTA
MUL_2488|M.ulcerans_Agy99 CARMLVGEVGSRHISLD----GLTVPTLVIGSERDRLTPISQTRKIASTA
TH_0684|M.thermoresistible__bu WARTLVDAMGPRHIGLH----NLTVPTLVIGSDRDRLLPLVSSRRIAEAA
MSMEG_3336|M.smegmatis_MC2_155 AIEGLVRWNMEHALSET----TQPITAFAVR-------ELLSSEAVERFG
Mflv_0736|M.gilvum_PYR-GCK EREVMEAMMNQMPCRIG-----------YLRCEHGLVPPEMADVVRDILQ
MLBr_02603|M.leprae_Br4923 VMLQVGETMTRRAPVLT-------TPLLVVHGSEDRLVLVDGSHRLVECV
: :
Mb2734|M.bovis_AF2122/97 PGSQLEIFEGSGHFPFHDDPARFIDIVERFMDTTEPAEYDQAALRALLRR
Rv2715|M.tuberculosis_H37Rv PGSQLEIFEGSGHFPFHDDPARFIDIVERFMDTTEPAEYDQAALRALLRR
Mvan_2445|M.vanbaalenii_PYR-1 PGSRLEVFEGSGHFPFHDDPDRFVEVVEKFIDTSEPAVYDHEYLRGLLRA
MAB_3034|M.abscessus_ATCC_1997 PGSALEIFDKSGHFPFHDDPERFIGIVRQFIASTEPGEYNEDELRRLLRT
MAV_4567|M.avium_104 TDARLEVLPDVGHFAQVEAPMRVVELIEDFIATGE-------------RR
MMAR_1388|M.marinum_M PNVFDLVELPGGHCSMLEQHHEVNRHLRTLVDSVG---------------
MUL_2488|M.ulcerans_Agy99 PNVFDLVELPGGHCSMLEQHHEVNRHLRTLVDSVG---------------
TH_0684|M.thermoresistible__bu PNLFDFVELPGGHCAILECPDRVNDHLRALAAAAA---------------
MSMEG_3336|M.smegmatis_MC2_155 DRIDFVPVELGSHHFPVESPEDTAKLLTSVVSV-----------------
Mflv_0736|M.gilvum_PYR-GCK LRGPFVDLVEAGHHPMLDQPLPLVATLRTLLEVWSIT-------------
MLBr_02603|M.leprae_Br4923 GSTDVELKVYPGLYHEVFNEPERDQVLEDVVCWILKRL------------
. : .
Mb2734|M.bovis_AF2122/97 GGGEATVTGSADTRVAVLNAIGSNERSAT
Rv2715|M.tuberculosis_H37Rv GGGEATVTGSADTRVAVLNAIGSNERSAT
Mvan_2445|M.vanbaalenii_PYR-1 GISEGTISGPADTRVAVLDAMGADERSAT
MAB_3034|M.abscessus_ATCC_1997 GVTEHAISGAARTRMAVLDAMGTDERSAT
MAV_4567|M.avium_104 ---DATSPQPG------------------
MMAR_1388|M.marinum_M GRSRARISS--------------------
MUL_2488|M.ulcerans_Agy99 GRSRARISS--------------------
TH_0684|M.thermoresistible__bu DARRATS----------------------
MSMEG_3336|M.smegmatis_MC2_155 -----------------------------
Mflv_0736|M.gilvum_PYR-GCK -----------------------------
MLBr_02603|M.leprae_Br4923 -----------------------------