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MNPPPRLLRPVPDTEHIDGVDGGGDTPSAATSTRPRLAFRTIHGYRRAYRIAGSGPVLLLIHGIGDNSAT WDSVHAQLAEHFTVIAPDLLGHGQSDKPRADYSVAAYANGMRDLLAVLDIERVTVVGHSLGGGVAMQFTY QFPHLVERLILVAPGGVTKDVNIVLRCASLPFIGDALGLLRLPMAMPMLRLGGAVARATFGRASMARDIP DVLRVLADLPEPRASAAFTRTLRAVVDWRGQVVTMLDRCYLTESVPVQLIWGSDDLVIPVSHGHLAHAAM PGSALEIFDKSGHFPFHDDPERFIGIVRQFIASTEPGEYNEDELRRLLRTGVTEHAISGAARTRMAVLDA MGTDERSAT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_3034 | - | - | 100% (359) | hydrolase |
| M. abscessus ATCC 19977 | MAB_4300 | - | 4e-17 | 29.63% (270) | putative hydrolase, alpha/beta fold |
| M. abscessus ATCC 19977 | MAB_0349c | - | 4e-17 | 26.24% (263) | putative hydrolase, alpha/beta fold |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2734 | - | 1e-137 | 71.08% (325) | hydrolase |
| M. gilvum PYR-GCK | Mflv_3952 | - | 1e-135 | 71.69% (325) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv2715 | - | 1e-137 | 71.08% (325) | hydrolase |
| M. leprae Br4923 | MLBr_02603 | - | 9e-09 | 24.65% (284) | hypothetical protein MLBr_02603 |
| M. marinum M | MMAR_1997 | - | 1e-138 | 71.25% (327) | hydrolase |
| M. avium 104 | MAV_3609 | - | 1e-141 | 73.54% (325) | hydrolase |
| M. smegmatis MC2 155 | MSMEG_4867 | - | 2e-22 | 27.78% (270) | 2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase |
| M. thermoresistible (build 8) | TH_4528 | - | 2e-21 | 27.65% (264) | PUTATIVE alpha/beta hydrolase fold |
| M. ulcerans Agy99 | MUL_3358 | - | 1e-137 | 70.95% (327) | hydrolase |
| M. vanbaalenii PYR-1 | Mvan_2445 | - | 1e-138 | 72.92% (325) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2734|M.bovis_AF2122/97 MTERKRN--LRPVR------------------DVAPPTLQFRTVHG----
Rv2715|M.tuberculosis_H37Rv MTERKRN--LRPVR------------------DVAPPTLQFRTVHG----
MMAR_1997|M.marinum_M MTERKRN--LRPVR------------------EVTAPSLQFRTIHG----
MUL_3358|M.ulcerans_Agy99 MTERKRN--LRPVR------------------EVTAPSLQFRTIHG----
MAV_3609|M.avium_104 MTERKRKNTLRPVR------------------EVSAPRLEFRTIHG----
Mflv_3952|M.gilvum_PYR-GCK MTARTPN--LRPVR------------------ELT-PTLRYCTIHG----
Mvan_2445|M.vanbaalenii_PYR-1 MTERKPN--LRPVR------------------ELT-PTLKFCTIHG----
MAB_3034|M.abscessus_ATCC_1997 MNPPPRL--LRPVPDTEHIDGVDGGGDTPSAATSTRPRLAFRTIHG----
MSMEG_4867|M.smegmatis_MC2_155 MTSTAAAGTASAVEFES----------IWSDLQGVAFSQGYLDVPVGDRK
TH_4528|M.thermoresistible__bu ---------------------------VWSDLQGVAFTQGYLDAGG----
MLBr_02603|M.leprae_Br4923 -------------------------------MTITRTERNFYGVGG--VR
:
Mb2734|M.bovis_AF2122/97 YRRAFRIAGS--GPAILLIHGIGDNSTTWNGVHAKLAQR-FTVIAPDLLG
Rv2715|M.tuberculosis_H37Rv YRRAFRIAGS--GPAILLIHGIGDNSTTWNGVHAKLAQR-FTVIAPDLLG
MMAR_1997|M.marinum_M YKRAFRIAGS--GPAILLIHGIGDNSTTWTGIHAKLAQR-FTVIAPDLLG
MUL_3358|M.ulcerans_Agy99 YKRAFRIAGS--GPAILLIHGIGDNSTTWTGIHAKLAQR-FTVIAPDLLG
MAV_3609|M.avium_104 YRRAYRIAGS--GPAILLIHGIGDNSTTWNTVQAKLAQR-FTVIAPDLLG
Mflv_3952|M.gilvum_PYR-GCK YRRAYRIAGS--GPAILLIHGIGDNSTTWAGVQTQLAQR-FTVIAPDLLG
Mvan_2445|M.vanbaalenii_PYR-1 YRRAFRVAGS--GPAILLIHGIGDNSTTWSTVQTQLAQR-FTVIAPDLLG
MAB_3034|M.abscessus_ATCC_1997 YRRAYRIAGS--GPVLLLIHGIGDNSATWDSVHAQLAEH-FTVIAPDLLG
MSMEG_4867|M.smegmatis_MC2_155 IRTRYLHAGNPQAPALLFLHGSGGHAEAYVRNLAAHAEH-FSTWSIDMLG
TH_4528|M.thermoresistible__bu VRTRYLHAGEADKPVLIFLHGSGGHAEAYVRNLEAHAEH-FSTWSIDMLG
MLBr_02603|M.leprae_Br4923 IVYDVWMPDTRPRAVIILAHGFGEHARRYDHVAHYFAAAGLATYALDLRG
.. ..::: ** * :: : * ::. : *: *
Mb2734|M.bovis_AF2122/97 HGQSD-KPRADYSVAAYANGMRDLLSVLDIER----VTIVGHSLGGGVAM
Rv2715|M.tuberculosis_H37Rv HGQSD-KPRADYSVAAYANGMRDLLSVLDIER----VTIVGHSLGGGVAM
MMAR_1997|M.marinum_M HGRSD-KPRADYSIAAYANGMRDLLSVLDIER----VTIIGHSLGGGVAM
MUL_3358|M.ulcerans_Agy99 HGRSD-KPRADYSIAAYANGMRDLLSVLDIER----VTIIGHSLGGGVAM
MAV_3609|M.avium_104 HGQSD-KPRADYSVAAYANGMRDLLAVLDIER----VTIVGHSLGGGVAM
Mflv_3952|M.gilvum_PYR-GCK HGKSD-KPRADYSVAAYANGMRDLLSVLNIDS----ATVVGHSLGGGVAM
Mvan_2445|M.vanbaalenii_PYR-1 HGRSD-KPRADYSVAAYANGMRDLLSVLDIDD----VTVIGHSLGGGVAM
MAB_3034|M.abscessus_ATCC_1997 HGQSD-KPRADYSVAAYANGMRDLLAVLDIER----VTVVGHSLGGGVAM
MSMEG_4867|M.smegmatis_MC2_155 HGYTD-KPGHPLEVAHYVDHVIAFLDTIGAQR----AHISGESLGGWVAA
TH_4528|M.thermoresistible__bu HGYTD-KPGHPLEVRHYVEHLAAVLDAIGADR----AHISGESLGGWVAS
MLBr_02603|M.leprae_Br4923 HGRSAGKRVLVRDLSEYNADFDILVGIATRDHPGLKRIVAGHSMGGAIVF
** : * .: * . .: : : *.*:** :.
Mb2734|M.bovis_AF2122/97 QFAYQFPQLVDRLILVSAGGVTKDVNIVFRLASLPMGSEAMALLRLPLVL
Rv2715|M.tuberculosis_H37Rv QFAYQFPQLVDRLILVSAGGVTKDVNIVFRLASLPMGSEAMALLRLPLVL
MMAR_1997|M.marinum_M QFAYQFPQLVDRLILVGAGGVTKDVNVVFRLASLPMGAEALALLRLPMVL
MUL_3358|M.ulcerans_Agy99 QFAYQFPQLVDRLILVGAGGVTKDVNVVFRLASLPMGAEALALLRLPMVL
MAV_3609|M.avium_104 QFAYQFPHLVERLILVGAGGVTKDVNFVLRWASLPLGSEAIALLRLPLVL
Mflv_3952|M.gilvum_PYR-GCK QFAYQFPQLVDRLILVGAGGVTKDVNIALRAASLPMGTEALALLRLPLLL
Mvan_2445|M.vanbaalenii_PYR-1 QFAYQFPQLVNRLILVGAGGVTKDVNIALRLASLPMGSEALALLRLPLVL
MAB_3034|M.abscessus_ATCC_1997 QFTYQFPHLVERLILVAPGGVTKDVNIVLRCASLPFIGDALGLLRLPMAM
MSMEG_4867|M.smegmatis_MC2_155 RVAVDHPDRVEKLVLNTAGGSQADPEVMKRIITLSMAAAENPTWDTVQAR
TH_4528|M.thermoresistible__bu RFAIDRPDRLDRLVLNTAGGSQADPEVMKRIITLSMAAAENPSWDTVQAR
MLBr_02603|M.leprae_Br4923 AYGVERPDNYDLMVLSGPAVAAQDMVSPLRAVVG----KGLGLVAPGLPV
: *. : ::* .. * *
Mb2734|M.bovis_AF2122/97 PAVQIAGRIVG--KAIGTTSLGHDLPNVLRILDDLPEPTASAAFGRTLRA
Rv2715|M.tuberculosis_H37Rv PAVQIAGRIVG--KAIGTTSLGHDLPNVLRILDDLPEPTASAAFGRTLRA
MMAR_1997|M.marinum_M PTVQLAGKVLG--MALGSTALGQDLPNVLRILDDLPEPTASSAFTRTLRA
MUL_3358|M.ulcerans_Agy99 PTVQLAGKVLG--MALGSTALGQDLPNVLRILDDLPEPTASSAFTRTLRA
MAV_3609|M.avium_104 PAVQLMGRVLG--TALGSTGLGRDLPNVLRILDDLPEPTASAAFSRTLRA
Mflv_3952|M.gilvum_PYR-GCK PTLRLLGRVGG--PLLGNTRIGRDIPNMLRILADLPEPTASSAFARTLRS
Mvan_2445|M.vanbaalenii_PYR-1 PALQVLGRVSG--TVFGSTGVGRDIPDMLRILADLPEPTASSAFARTLRA
MAB_3034|M.abscessus_ATCC_1997 PMLRLGGAVAR--ATFGRASMARDIPDVLRVLADLPEPRASAAFTRTLRA
MSMEG_4867|M.smegmatis_MC2_155 IKWLMADKSKDYDDIVASRQRVYRQPGFVAAMSDIMALQDPQIRARNLLG
TH_4528|M.thermoresistible__bu ITWLMADKSKGYDDIVASRQKIYRQPGFVDAMRNIMALQDPEIRARNLLG
MLBr_02603|M.leprae_Br4923 HQLEVDAISRN--RAVVAAYKDDPLVYHGKVPAGVGRVMLQVGETMTRRA
: . .: . .
Mb2734|M.bovis_AF2122/97 VVDWRGQMVTMLDRCYLTEAIPVQIIWGTKDVVLPVRHAHMAHAAMPGS-
Rv2715|M.tuberculosis_H37Rv VVDWRGQMVTMLDRCYLTEAIPVQIIWGTKDVVLPVRHAHMAHAAMPGS-
MMAR_1997|M.marinum_M VVDWRGQIVTMLDRCYLTQAIPVQIIWGSRDAVVPVRHAEMAHAAMPGS-
MUL_3358|M.ulcerans_Agy99 VVDWRGQIVTMLDRCYLTQAIPVQIIWGSRDAVVPVRHAEMAHAAMPGS-
MAV_3609|M.avium_104 VVDWRGQIVTMLDRCYLTEAIPVQIVWGTKDVVVPVRHAWMAHAAMPGS-
Mflv_3952|M.gilvum_PYR-GCK VVDWRGQVVTMLDRCYLTQSVPVQLIWGSQDSVIPVSHAEMAHTAMPGS-
Mvan_2445|M.vanbaalenii_PYR-1 VVDWRGQVVTMLDRCYLTQSVPVQLIWGDCDAVIPVSHGEMAHAAMPGS-
MAB_3034|M.abscessus_ATCC_1997 VVDWRGQVVTMLDRCYLTESVPVQLIWGSDDLVIPVSHGHLAHAAMPGS-
MSMEG_4867|M.smegmatis_MC2_155 QAEYG------------SITAPTLVVWTSDDPTADVAEGRRIASMIPGA-
TH_4528|M.thermoresistible__bu PEEYG------------AITAPTLVVWTSDDPTADVDEGKRIASMIPGA-
MLBr_02603|M.leprae_Br4923 P----------------VLTTPLLVVHGSEDRLVLVDGSHRLVECVGSTD
: * :: * * . : .:
Mb2734|M.bovis_AF2122/97 -QLEIFEGSGHFPFHD-DPARFIDIVERFMDTTEPAEYDQAALRALLRRG
Rv2715|M.tuberculosis_H37Rv -QLEIFEGSGHFPFHD-DPARFIDIVERFMDTTEPAEYDQAALRALLRRG
MMAR_1997|M.marinum_M -KLEVFEGSGHFPFHD-DPARFIDIVLRFIDSTQPPEYDQAALRELLRTG
MUL_3358|M.ulcerans_Agy99 -KLEVFEGSGHFPFHD-DPARFIDIVLRFIDSTQPPEYDQAALRELLRTG
MAV_3609|M.avium_104 -RLEIFEGSGHFPFHD-DPARFIDVVERFIDSTEPAAYDQEALRRLLRSG
Mflv_3952|M.gilvum_PYR-GCK -RLEIFEGAGHFPFHD-EPDRFVELVEKFIDSTEPAVYDQEYLRTLLRTG
Mvan_2445|M.vanbaalenii_PYR-1 -RLEVFEGSGHFPFHD-DPDRFVEVVEKFIDTSEPAVYDHEYLRGLLRAG
MAB_3034|M.abscessus_ATCC_1997 -ALEIFDKSGHFPFHD-DPERFIGIVRQFIASTEPGEYNEDELRRLLRTG
MSMEG_4867|M.smegmatis_MC2_155 -RFEVMPGCGHWPQYE-DPATFNALHLDFLLGR-----------------
TH_4528|M.thermoresistible__bu -RFEVMPGCGHWPQYE-DPATFNRLHIDFLLGRS----------------
MLBr_02603|M.leprae_Br4923 VELKVYPGLYHEVFNEPERDQVLEDVVCWILKRL----------------
::: * : : . ::
Mb2734|M.bovis_AF2122/97 GGEATVTGSADTRVAVLNAIGSNERSAT
Rv2715|M.tuberculosis_H37Rv GGEATVTGSADTRVAVLNAIGSNERSAT
MMAR_1997|M.marinum_M GGERTVSGPADTRVAVLSAMGSDERSAT
MUL_3358|M.ulcerans_Agy99 GGERTVSDPADTRVAVLSAMGSDERSAT
MAV_3609|M.avium_104 GGAQAVTGPAPTRVAVLSAMGSDERSAT
Mflv_3952|M.gilvum_PYR-GCK TSENTLSGDVDTQVAVLDAIGADERSAT
Mvan_2445|M.vanbaalenii_PYR-1 ISEGTISGPADTRVAVLDAMGADERSAT
MAB_3034|M.abscessus_ATCC_1997 VTEHAISGAARTRMAVLDAMGTDERSAT
MSMEG_4867|M.smegmatis_MC2_155 ----------------------------
TH_4528|M.thermoresistible__bu ----------------------------
MLBr_02603|M.leprae_Br4923 ----------------------------