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RHADEVSPLFQRQRPTPSDPPEGTPEWFTAALEHRPQHSTIDFEGCRIHLRTWGDPENPPLVFVHGGAAH SGWWDHIAPFFTRTHRVIAPDVSGHGDSGTRSHYSLTKWAREVLAVAAAEGPAARPTIVGHSMGGWVTAT AAMKYGADIDSILIIDSPLRERAPEEGRLRNRRSDHPGYPSREEILARFRAVPAQDVTLPFIDRHIASES VRQTDTGWVWKFDPAIFSGSLQGQTPAEQEILENTFAQIPCRVGYLRCENGLVPPDMAEQIRSTLQLRGP FVELALAGHHPMLDQPLPLVATIRTLLEFWSIT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0460 | - | - | 100% (314) | alpha/beta hydrolase fold |
| M. smegmatis MC2 155 | MSMEG_2036 | - | 3e-14 | 28.37% (289) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_3336 | - | 2e-09 | 29.03% (124) | hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2734 | - | 2e-09 | 33.01% (103) | hydrolase |
| M. gilvum PYR-GCK | Mflv_0736 | - | 1e-116 | 63.61% (305) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv0134 | ephF | 2e-09 | 30.00% (140) | epoxide hydrolase EphF |
| M. leprae Br4923 | MLBr_00862 | ephD | 1e-07 | 27.62% (105) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3034 | - | 7e-11 | 31.33% (150) | hydrolase |
| M. marinum M | MMAR_4837 | - | 2e-09 | 23.66% (186) | hydrolase |
| M. avium 104 | MAV_0093 | - | 1e-121 | 66.02% (309) | alpha/beta hydrolase fold |
| M. thermoresistible (build 8) | TH_0684 | hpx | 2e-10 | 36.79% (106) | POSSIBLE NON-HEME HALOPEROXIDASE HPX |
| M. ulcerans Agy99 | MUL_3358 | - | 6e-09 | 33.66% (101) | hydrolase |
| M. vanbaalenii PYR-1 | Mvan_2912 | - | 1e-12 | 28.11% (281) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2734|M.bovis_AF2122/97 -----MTERKRNLRPVRD------------------VAPPTLQFRTVHGY
MUL_3358|M.ulcerans_Agy99 -----MTERKRNLRPVRE------------------VTAPSLQFRTIHGY
MAB_3034|M.abscessus_ATCC_1997 -----MNPPPRLLRPVPDTEHIDGVDGGGDTPSAATSTRPRLAFRTIHGY
Mvan_2912|M.vanbaalenii_PYR-1 -------------------------------------MHDDVKYLDLHGD
MSMEG_0460|M.smegmatis_MC2_155 ---MRHADEVSPLFQRQRPTPSDPPEGTPEWFTAALEHRPQHSTIDFEGC
MAV_0093|M.avium_104 MLSCMANREGQKLFSRSRQMP-----ATPSWFTAALDQKPERCDVEVDGC
Mflv_0736|M.gilvum_PYR-GCK ------------MFSRSRSVD-----EAPAWFTTALADKPEHSHVDVEGC
TH_0684|M.thermoresistible__bu --------------------------------VEQMPPGRVVSVTAPDGV
Rv0134|M.tuberculosis_H37Rv -----------------------------MIALPALEGVEHRHVDVAEGV
MLBr_00862|M.leprae_Br4923 -----------------------------MPATQSIHKVPHQFVESPDGV
MMAR_4837|M.marinum_M -------------------MAATETPDSQRLTTSDHMTISQGRIRTSDGI
.*
Mb2734|M.bovis_AF2122/97 RRAFRIAGS---GPAILLIHGIGDNSTTWNGVHAKLAQR-FTVIAPDLLG
MUL_3358|M.ulcerans_Agy99 KRAFRIAGS---GPAILLIHGIGDNSTTWTGIHAKLAQR-FTVIAPDLLG
MAB_3034|M.abscessus_ATCC_1997 RRAYRIAGS---GPVLLLIHGIGDNSATWDSVHAQLAEH-FTVIAPDLLG
Mvan_2912|M.vanbaalenii_PYR-1 RVAYREAGQ---GPAVLLIHGMGGSSLTWKALLPHLATR-YRVIAPDLLG
MSMEG_0460|M.smegmatis_MC2_155 RIHLRTWGDPE-NPPLVFVHGGAAHSGWWDHIAPFFTRT-HRVIAPDVSG
MAV_0093|M.avium_104 RIRMRVWGAAD-QPPVVLVHGGGAHSGWWDHIAPFFSHT-HRVIAPDLSG
Mflv_0736|M.gilvum_PYR-GCK EIHVRVWGARE-NPPLVLVHGGAAHSGWWDHIAPLLSST-HRIVAPDLSG
TH_0684|M.thermoresistible__bu RLHAEVFGPAD-APPIVLAHGITCAIRVWAHQIAELADD-YRVIAFDHRG
Rv0134|M.tuberculosis_H37Rv RIHVADAGPAD-GPAVMLVHGFPQNWWEWRDLIGPLAADGNRVLCPDLRG
MLBr_00862|M.leprae_Br4923 RLAIYQSGQPE-GPAIVLVHGFPDSHVLWDGVVPLLAKR-FRIVRYDNRG
MMAR_4837|M.marinum_M TLVADCYRHAATRPVVLLLHGGGQNRHAWATTARRLHSHGYTVVAYDTRG
* ::: ** * : :: * *
Mb2734|M.bovis_AF2122/97 HGQSDKPRA--DYSVAAYANGMRDLLSVLD--IERVTIVGHSLGGGVAMQ
MUL_3358|M.ulcerans_Agy99 HGRSDKPRA--DYSIAAYANGMRDLLSVLD--IERVTIIGHSLGGGVAMQ
MAB_3034|M.abscessus_ATCC_1997 HGQSDKPRA--DYSVAAYANGMRDLLAVLD--IERVTVVGHSLGGGVAMQ
Mvan_2912|M.vanbaalenii_PYR-1 HGQSDKPRG--DYSLGAFAVWLRDLLDLLG--IARVTLVGHSLGGGVAMQ
MSMEG_0460|M.smegmatis_MC2_155 HGDSG-TRS--HYSLTKWAREVLAVAAAEGP-AARPTIVGHSMGGWVTAT
MAV_0093|M.avium_104 HGDSD-PRD--SYDLRIWAGEVMAAAAAAGP-AGRPTIVGHSMGGWVVST
Mflv_0736|M.gilvum_PYR-GCK HGDSG-TRD--SYDLRRWSREVMAAAAAFS--DGHPTIVGHSLGGWVTAT
TH_0684|M.thermoresistible__bu HGRSSVPRRRWQYSLDHLASDLDAVLDATLDPGERAVIAGHSMGGIAISS
Rv0134|M.tuberculosis_H37Rv AGWSSAPRS--RYTKTEMADDLAAVLDGLG--VAKVKLVAHDWGGPVAFI
MLBr_00862|M.leprae_Br4923 VGQSSVPKPVSAYTMTRFADDFAAVIDELSP-DRPVHVLAHDWGSVGVWE
MMAR_4837|M.marinum_M HGDSDWDPS-GQYDVERFVSDLISVRDHVSP-DSPPAVVGASLGGLIILA
* *. * . : . . *.
Mb2734|M.bovis_AF2122/97 FAYQFPQLVDR----LILVSA---GGVTKDVNIVFRLASLPMGSEAMALL
MUL_3358|M.ulcerans_Agy99 FAYQFPQLVDR----LILVGA---GGVTKDVNVVFRLASLPMGAEALALL
MAB_3034|M.abscessus_ATCC_1997 FTYQFPHLVER----LILVAP---GGVTKDVNIVLRCASLPFIGDALGLL
Mvan_2912|M.vanbaalenii_PYR-1 FVHQHPDYCER----LVLISS---GGLGPELGRSLRLLSTPG----IELL
MSMEG_0460|M.smegmatis_MC2_155 AAMKYGADIDS----ILIIDSPLRERAPEEGRLRNRRSDHPGYPSREEIL
MAV_0093|M.avium_104 AAMHYSSKINS----MLVIDSPLWERAPEEGRLRRRK--HTEYRTRDEIL
Mflv_0736|M.gilvum_PYR-GCK AASHFGDQINS----IVVVDSPLRDRAPEERHLSRRT--PKAYRSKDEIV
TH_0684|M.thermoresistible__bu WAERYPERVSERAAAVALINTTTGDLLHNVQLLPVPDRFAAVRVRTASAV
Rv0134|M.tuberculosis_H37Rv MMLRHPEKVTG----FFGVNTVAPWVKRDLGMLRNMWRFWYQIPMSLPVI
MLBr_00862|M.leprae_Br4923 YLSRSGASDRVASFTSVSGPSQDQLVDYILSGLRRPWRPRTFARAVSQLF
MMAR_4837|M.marinum_M THLLAPPDLWA---AVVLVDITPRMEFDGAHRIVSFMAAHPDGFGTLDDA
Mb2734|M.bovis_AF2122/97 RLPLVLPAVQIAGRIVGKAIGTTSLG-HDLPNVLRILDDLPEPTASAAFG
MUL_3358|M.ulcerans_Agy99 RLPMVLPTVQLAGKVLGMALGSTALG-QDLPNVLRILDDLPEPTASSAFT
MAB_3034|M.abscessus_ATCC_1997 RLPMAMPMLRLGGAVARATFGRASMA-RDIPDVLRVLADLPEPRASAAFT
Mvan_2912|M.vanbaalenii_PYR-1 LPVAAAPSVVAVGERVRSWLGARGLASPEVGETWNAYASLSDPQTRTAFL
MSMEG_0460|M.smegmatis_MC2_155 ARFRAVPAQDVTLPFIDRHIASESVR--------QTDTGWVWKFDPAIFS
MAV_0093|M.avium_104 ARFTAVPSQELILPYVREHIAAESIR--------KTSAGWVWKFDPAIFG
Mflv_0736|M.gilvum_PYR-GCK GRFRPVPAQQGVLPYVSAHIASESVR--------RTLKGWVWKFDPAIFG
TH_0684|M.thermoresistible__bu IKTVAGMPARLAAVPSRYVVSMMAVGRDADPAITNFVHELFTETPPAARD
Rv0134|M.tuberculosis_H37Rv GPRVISDPKGRYFRLLTGWVGGGFRVPDD--DVRLYLDCMREPGHAEAGS
MLBr_00862|M.leprae_Br4923 RLTYMVLFSIPVLVPMVLWIALSSATIRRTMVDNISTDQIHHSATLARDA
MMAR_4837|M.marinum_M ADVIAEYNPRRARPENLDGLHKVLRQRSDGRWIWRWDPAFISSNFDVLQG
.
Mb2734|M.bovis_AF2122/97 RTLRAVVDWRGQ---MVTMLDRCYLTEAIPVQIIWGTKDVVLPVRHAHMA
MUL_3358|M.ulcerans_Agy99 RTLRAVVDWRGQ---IVTMLDRCYLTQAIPVQIIWGSRDAVVPVRHAEMA
MAB_3034|M.abscessus_ATCC_1997 RTLRAVVDWRGQ---VVTMLDRCYLTESVPVQLIWGSDDLVIPVSHGHLA
Mvan_2912|M.vanbaalenii_PYR-1 RTLRSVVDAQGQ---AVSALNRLHFTLGLPTLLIWGDQDRLIPPAHGEAA
MSMEG_0460|M.smegmatis_MC2_155 GSLQGQTPAE------QEILENTFAQIPCRVGYLRCENGLVPPDMAEQIR
MAV_0093|M.avium_104 GEFLQPTPAD------EESLESMLTAMRCRVGYLRCEAGLVPPAMAERIR
Mflv_0736|M.gilvum_PYR-GCK GHLAEQTPAE------REVMEAMMNQMPCRIGYLRCEHGLVPPEMADVVR
TH_0684|M.thermoresistible__bu GWARTLVDAMG-------PRHIGLHNLTVPTLVIGSDRDRLLPLVSSRRI
Rv0134|M.tuberculosis_H37Rv RWYRTFQTREML---RWLRGEYNDARVDVPVRWLHGTGDPVITPDLLDGY
MLBr_00862|M.leprae_Br4923 AHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQLIVNTMDRYVRPYGYDAT
MMAR_4837|M.marinum_M NLMTGSEEFDAIS----GFLADAARRITAPTLLVRGALSDVVSQDTVNEF
: .
Mb2734|M.bovis_AF2122/97 HAAMPGSQLEIFEGSGHFPFHDDPARFIDIVERFMDTTEPAEYDQAALRA
MUL_3358|M.ulcerans_Agy99 HAAMPGSKLEVFEGSGHFPFHDDPARFIDIVLRFIDSTQPPEYDQAALRE
MAB_3034|M.abscessus_ATCC_1997 HAAMPGSALEIFDKSGHFPFHDDPERFIGIVRQFIASTEPGEYNEDELRR
Mvan_2912|M.vanbaalenii_PYR-1 HAALPGSRLVILPAVGHFPQVEAPLAVADTLDDFIANSSP----------
MSMEG_0460|M.smegmatis_MC2_155 STLQLRGPFVELALAGHHPMLDQPLPLVATIRTLLEFWSIT---------
MAV_0093|M.avium_104 SLLQLRGPFVELAQAGHHPMLDQPLPLVATLRTLLEFWSIT---------
Mflv_0736|M.gilvum_PYR-GCK DILQLRGPFVDLVEAGHHPMLDQPLPLVATLRTLLEVWSIT---------
TH_0684|M.thermoresistible__bu AEAAPNLFDFVELPGGHCAILECPDRVNDHLRALAAAAADARRATS----
Rv0134|M.tuberculosis_H37Rv AERASDFEVELVDGVGHWIVEQRPELVLDRVRAFLAAGTEQRD-------
MLBr_00862|M.leprae_Br4923 ARWVPR-LWRRDIKAGHFSPMSHPQVMAAAVHDLADLVDGKQPSRALLRA
MMAR_4837|M.marinum_M LQLVPHAETTDVTGTGHMVAGDNNDAFTAAVTDFLDRTMGMT--------
** . . : :
Mb2734|M.bovis_AF2122/97 LLRRGGGEATVTGSADTRVAVLNAIGSNERSAT-----------------
MUL_3358|M.ulcerans_Agy99 LLRTGGGERTVSDPADTRVAVLSAMGSDERSAT-----------------
MAB_3034|M.abscessus_ATCC_1997 LLRTGVTEHAISGAARTRMAVLDAMGTDERSAT-----------------
Mvan_2912|M.vanbaalenii_PYR-1 --WHGPPRHADHAEAD----------------------------------
MSMEG_0460|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0093|M.avium_104 --------------------------------------------------
Mflv_0736|M.gilvum_PYR-GCK --------------------------------------------------
TH_0684|M.thermoresistible__bu --------------------------------------------------
Rv0134|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00862|M.leprae_Br4923 QVGRSRDTFGDTLVSVTGAGSGIGRETALALARRGAEVVVSDIDEAAAKN
MMAR_4837|M.marinum_M --------------------------------------------------
Mb2734|M.bovis_AF2122/97 --------------------------------------------------
MUL_3358|M.ulcerans_Agy99 --------------------------------------------------
MAB_3034|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2912|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0460|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0093|M.avium_104 --------------------------------------------------
Mflv_0736|M.gilvum_PYR-GCK --------------------------------------------------
TH_0684|M.thermoresistible__bu --------------------------------------------------
Rv0134|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00862|M.leprae_Br4923 TAAQIVASGGVAYAYALDVSDAAAVEAFAEQVSAKHGVPDIVVNNAGIGQ
MMAR_4837|M.marinum_M --------------------------------------------------
Mb2734|M.bovis_AF2122/97 --------------------------------------------------
MUL_3358|M.ulcerans_Agy99 --------------------------------------------------
MAB_3034|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2912|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0460|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0093|M.avium_104 --------------------------------------------------
Mflv_0736|M.gilvum_PYR-GCK --------------------------------------------------
TH_0684|M.thermoresistible__bu --------------------------------------------------
Rv0134|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00862|M.leprae_Br4923 AGRFLDTPPEEFDRVLAVNLGGVVNCCRAFGQRLVERGTGGHIVNVSSMA
MMAR_4837|M.marinum_M --------------------------------------------------
Mb2734|M.bovis_AF2122/97 --------------------------------------------------
MUL_3358|M.ulcerans_Agy99 --------------------------------------------------
MAB_3034|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2912|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0460|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0093|M.avium_104 --------------------------------------------------
Mflv_0736|M.gilvum_PYR-GCK --------------------------------------------------
TH_0684|M.thermoresistible__bu --------------------------------------------------
Rv0134|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00862|M.leprae_Br4923 AYAPLQSLSAYCTSKAATYMFSDCLRAELDAVGVGLTTICPGVIDTNIIQ
MMAR_4837|M.marinum_M --------------------------------------------------
Mb2734|M.bovis_AF2122/97 --------------------------------------------------
MUL_3358|M.ulcerans_Agy99 --------------------------------------------------
MAB_3034|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2912|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0460|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0093|M.avium_104 --------------------------------------------------
Mflv_0736|M.gilvum_PYR-GCK --------------------------------------------------
TH_0684|M.thermoresistible__bu --------------------------------------------------
Rv0134|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00862|M.leprae_Br4923 STRIDTPTAKQERVRDRRGQLDMMFRLRRYGPDKVADTILSAIKKNKPIR
MMAR_4837|M.marinum_M --------------------------------------------------
Mb2734|M.bovis_AF2122/97 -----------------------------
MUL_3358|M.ulcerans_Agy99 -----------------------------
MAB_3034|M.abscessus_ATCC_1997 -----------------------------
Mvan_2912|M.vanbaalenii_PYR-1 -----------------------------
MSMEG_0460|M.smegmatis_MC2_155 -----------------------------
MAV_0093|M.avium_104 -----------------------------
Mflv_0736|M.gilvum_PYR-GCK -----------------------------
TH_0684|M.thermoresistible__bu -----------------------------
Rv0134|M.tuberculosis_H37Rv -----------------------------
MLBr_00862|M.leprae_Br4923 PVAPEAYALYGISRVLPQVLRSTARIRVI
MMAR_4837|M.marinum_M -----------------------------