For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MTERKRNLRPVRDVAPPTLQFRTVHGYRRAFRIAGSGPAILLIHGIGDNSTTWNGVHAKLAQRFTVIAPD LLGHGQSDKPRADYSVAAYANGMRDLLSVLDIERVTIVGHSLGGGVAMQFAYQFPQLVDRLILVSAGGVT KDVNIVFRLASLPMGSEAMALLRLPLVLPAVQIAGRIVGKAIGTTSLGHDLPNVLRILDDLPEPTASAAF GRTLRAVVDWRGQMVTMLDRCYLTEAIPVQIIWGTKDVVLPVRHAHMAHAAMPGSQLEIFEGSGHFPFHD DPARFIDIVERFMDTTEPAEYDQAALRALLRRGGGEATVTGSADTRVAVLNAIGSNERSAT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2715 | - | - | 100% (341) | POSSIBLE HYDROLASE |
| M. tuberculosis H37Rv | Rv3569c | bphD | 4e-19 | 29.02% (255) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. tuberculosis H37Rv | Rv0134 | ephF | 8e-13 | 26.67% (270) | epoxide hydrolase EphF |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2734 | - | 0.0 | 100.00% (341) | hydrolase |
| M. gilvum PYR-GCK | Mflv_3952 | - | 1e-150 | 74.49% (341) | alpha/beta hydrolase fold |
| M. leprae Br4923 | MLBr_00862 | ephD | 1e-08 | 35.48% (93) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3034 | - | 1e-137 | 71.08% (325) | hydrolase |
| M. marinum M | MMAR_1997 | - | 1e-173 | 85.34% (341) | hydrolase |
| M. avium 104 | MAV_3609 | - | 1e-168 | 85.13% (343) | hydrolase |
| M. smegmatis MC2 155 | MSMEG_4867 | - | 4e-20 | 26.10% (249) | 2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase |
| M. thermoresistible (build 8) | TH_4528 | - | 2e-20 | 25.86% (263) | PUTATIVE alpha/beta hydrolase fold |
| M. ulcerans Agy99 | MUL_3358 | - | 1e-172 | 85.04% (341) | hydrolase |
| M. vanbaalenii PYR-1 | Mvan_2445 | - | 1e-154 | 76.83% (341) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3952|M.gilvum_PYR-GCK MTARTPN--LRPVR------------------ELT-PTLRYCTIHG----
Mvan_2445|M.vanbaalenii_PYR-1 MTERKPN--LRPVR------------------ELT-PTLKFCTIHG----
Rv2715|M.tuberculosis_H37Rv MTERKRN--LRPVR------------------DVAPPTLQFRTVHG----
Mb2734|M.bovis_AF2122/97 MTERKRN--LRPVR------------------DVAPPTLQFRTVHG----
MMAR_1997|M.marinum_M MTERKRN--LRPVR------------------EVTAPSLQFRTIHG----
MUL_3358|M.ulcerans_Agy99 MTERKRN--LRPVR------------------EVTAPSLQFRTIHG----
MAV_3609|M.avium_104 MTERKRKNTLRPVR------------------EVSAPRLEFRTIHG----
MAB_3034|M.abscessus_ATCC_1997 MNPPPRL--LRPVPDTEHIDGVDGGGDTPSAATSTRPRLAFRTIHG----
MSMEG_4867|M.smegmatis_MC2_155 MTSTAAAGTASAVEFES----------IWSDLQGVAFSQGYLDVPVGDRK
TH_4528|M.thermoresistible__bu ---------------------------VWSDLQGVAFTQGYLDAGG----
MLBr_00862|M.leprae_Br4923 MPATQS--------------------------IHKVPHQFVESPDG----
Mflv_3952|M.gilvum_PYR-GCK YRRAYRIAGS--GPAILLIHGIGDNSTTWAGVQTQLAQRFTVIAPDLLGH
Mvan_2445|M.vanbaalenii_PYR-1 YRRAFRVAGS--GPAILLIHGIGDNSTTWSTVQTQLAQRFTVIAPDLLGH
Rv2715|M.tuberculosis_H37Rv YRRAFRIAGS--GPAILLIHGIGDNSTTWNGVHAKLAQRFTVIAPDLLGH
Mb2734|M.bovis_AF2122/97 YRRAFRIAGS--GPAILLIHGIGDNSTTWNGVHAKLAQRFTVIAPDLLGH
MMAR_1997|M.marinum_M YKRAFRIAGS--GPAILLIHGIGDNSTTWTGIHAKLAQRFTVIAPDLLGH
MUL_3358|M.ulcerans_Agy99 YKRAFRIAGS--GPAILLIHGIGDNSTTWTGIHAKLAQRFTVIAPDLLGH
MAV_3609|M.avium_104 YRRAYRIAGS--GPAILLIHGIGDNSTTWNTVQAKLAQRFTVIAPDLLGH
MAB_3034|M.abscessus_ATCC_1997 YRRAYRIAGS--GPVLLLIHGIGDNSATWDSVHAQLAEHFTVIAPDLLGH
MSMEG_4867|M.smegmatis_MC2_155 IRTRYLHAGNPQAPALLFLHGSGGHAEAYVRNLAAHAEHFSTWSIDMLGH
TH_4528|M.thermoresistible__bu VRTRYLHAGEADKPVLIFLHGSGGHAEAYVRNLEAHAEHFSTWSIDMLGH
MLBr_00862|M.leprae_Br4923 VRLAIYQSGQPEGPAIVLVHGFPDSHVLWDGVVPLLAKRFRIVRYDNRGV
: :*. *.::::** . : *::* * *
Mflv_3952|M.gilvum_PYR-GCK GKS--DKPRADYSVAAYANGMRDLLSVLNIDS-ATVVGHSLGGGVAMQFA
Mvan_2445|M.vanbaalenii_PYR-1 GRS--DKPRADYSVAAYANGMRDLLSVLDIDD-VTVIGHSLGGGVAMQFA
Rv2715|M.tuberculosis_H37Rv GQS--DKPRADYSVAAYANGMRDLLSVLDIER-VTIVGHSLGGGVAMQFA
Mb2734|M.bovis_AF2122/97 GQS--DKPRADYSVAAYANGMRDLLSVLDIER-VTIVGHSLGGGVAMQFA
MMAR_1997|M.marinum_M GRS--DKPRADYSIAAYANGMRDLLSVLDIER-VTIIGHSLGGGVAMQFA
MUL_3358|M.ulcerans_Agy99 GRS--DKPRADYSIAAYANGMRDLLSVLDIER-VTIIGHSLGGGVAMQFA
MAV_3609|M.avium_104 GQS--DKPRADYSVAAYANGMRDLLAVLDIER-VTIVGHSLGGGVAMQFA
MAB_3034|M.abscessus_ATCC_1997 GQS--DKPRADYSVAAYANGMRDLLAVLDIER-VTVVGHSLGGGVAMQFT
MSMEG_4867|M.smegmatis_MC2_155 GYT--DKPGHPLEVAHYVDHVIAFLDTIGAQR-AHISGESLGGWVAARVA
TH_4528|M.thermoresistible__bu GYT--DKPGHPLEVRHYVEHLAAVLDAIGADR-AHISGESLGGWVASRFA
MLBr_00862|M.leprae_Br4923 GQSSVPKPVSAYTMTRFADDFAAVIDELSPDRPVHVLAHDWGSVGVWEYL
* : ** : :.: . .: :. : . : ... *. . .
Mflv_3952|M.gilvum_PYR-GCK YQFPQLVDRLILVGAGGVTKDVNIALRAASLP-------MGTEALALLRL
Mvan_2445|M.vanbaalenii_PYR-1 YQFPQLVNRLILVGAGGVTKDVNIALRLASLP-------MGSEALALLRL
Rv2715|M.tuberculosis_H37Rv YQFPQLVDRLILVSAGGVTKDVNIVFRLASLP-------MGSEAMALLRL
Mb2734|M.bovis_AF2122/97 YQFPQLVDRLILVSAGGVTKDVNIVFRLASLP-------MGSEAMALLRL
MMAR_1997|M.marinum_M YQFPQLVDRLILVGAGGVTKDVNVVFRLASLP-------MGAEALALLRL
MUL_3358|M.ulcerans_Agy99 YQFPQLVDRLILVGAGGVTKDVNVVFRLASLP-------MGAEALALLRL
MAV_3609|M.avium_104 YQFPHLVERLILVGAGGVTKDVNFVLRWASLP-------LGSEAIALLRL
MAB_3034|M.abscessus_ATCC_1997 YQFPHLVERLILVAPGGVTKDVNIVLRCASLP-------FIGDALGLLRL
MSMEG_4867|M.smegmatis_MC2_155 VDHPDRVEKLVLNTAGGSQADPEVMKRIITLS-------MAAAENPTWDT
TH_4528|M.thermoresistible__bu IDRPDRLDRLVLNTAGGSQADPEVMKRIITLS-------MAAAENPSWDT
MLBr_00862|M.leprae_Br4923 SRSGASDRVASFTSVSGPSQDQLVDYILSGLRRPWRPRTFARAVSQLFRL
: .* * . * :
Mflv_3952|M.gilvum_PYR-GCK PLLLPTLRLLGRVGG--PLLGNTRIGRDIPN--MLRILADLPEPTASSAF
Mvan_2445|M.vanbaalenii_PYR-1 PLVLPALQVLGRVSG--TVFGSTGVGRDIPD--MLRILADLPEPTASSAF
Rv2715|M.tuberculosis_H37Rv PLVLPAVQIAGRIVG--KAIGTTSLGHDLPN--VLRILDDLPEPTASAAF
Mb2734|M.bovis_AF2122/97 PLVLPAVQIAGRIVG--KAIGTTSLGHDLPN--VLRILDDLPEPTASAAF
MMAR_1997|M.marinum_M PMVLPTVQLAGKVLG--MALGSTALGQDLPN--VLRILDDLPEPTASSAF
MUL_3358|M.ulcerans_Agy99 PMVLPTVQLAGKVLG--MALGSTALGQDLPN--VLRILDDLPEPTASSAF
MAV_3609|M.avium_104 PLVLPAVQLMGRVLG--TALGSTGLGRDLPN--VLRILDDLPEPTASAAF
MAB_3034|M.abscessus_ATCC_1997 PMAMPMLRLGGAVAR--ATFGRASMARDIPD--VLRVLADLPEPRASAAF
MSMEG_4867|M.smegmatis_MC2_155 VQARIKWLMADKSKDYDDIVASRQRVYRQPG--FVAAMSDIMALQDPQIR
TH_4528|M.thermoresistible__bu VQARITWLMADKSKGYDDIVASRQKIYRQPG--FVDAMRNIMALQDPEIR
MLBr_00862|M.leprae_Br4923 TYMVLFSIPVLVPMVLWIALSSATIRRTMVDNISTDQIHHSATLARDAAH
.. . : .
Mflv_3952|M.gilvum_PYR-GCK ARTLRSVVDWRGQVVTMLDRCYLTQSVPVQLIWGSQDSVIPVSHAEMAHT
Mvan_2445|M.vanbaalenii_PYR-1 ARTLRAVVDWRGQVVTMLDRCYLTQSVPVQLIWGDCDAVIPVSHGEMAHA
Rv2715|M.tuberculosis_H37Rv GRTLRAVVDWRGQMVTMLDRCYLTEAIPVQIIWGTKDVVLPVRHAHMAHA
Mb2734|M.bovis_AF2122/97 GRTLRAVVDWRGQMVTMLDRCYLTEAIPVQIIWGTKDVVLPVRHAHMAHA
MMAR_1997|M.marinum_M TRTLRAVVDWRGQIVTMLDRCYLTQAIPVQIIWGSRDAVVPVRHAEMAHA
MUL_3358|M.ulcerans_Agy99 TRTLRAVVDWRGQIVTMLDRCYLTQAIPVQIIWGSRDAVVPVRHAEMAHA
MAV_3609|M.avium_104 SRTLRAVVDWRGQIVTMLDRCYLTEAIPVQIVWGTKDVVVPVRHAWMAHA
MAB_3034|M.abscessus_ATCC_1997 TRTLRAVVDWRGQVVTMLDRCYLTESVPVQLIWGSDDLVIPVSHGHLAHA
MSMEG_4867|M.smegmatis_MC2_155 ARNLLGQAEYG------------SITAPTLVVWTSDDPTADVAEGRRIAS
TH_4528|M.thermoresistible__bu ARNLLGPEEYG------------AITAPTLVVWTSDDPTADVDEGKRIAS
MLBr_00862|M.leprae_Br4923 SVKTYPANYFRAFSGRRRGKGVPVVNVPVQLIVNTMDRYVRP-YGYDATA
. : *. :: * . :
Mflv_3952|M.gilvum_PYR-GCK AMPGSRLEIFEGAGHFPFHDEPDRFVELVEKFIDSTEPAVYDQEYLRTLL
Mvan_2445|M.vanbaalenii_PYR-1 AMPGSRLEVFEGSGHFPFHDDPDRFVEVVEKFIDTSEPAVYDHEYLRGLL
Rv2715|M.tuberculosis_H37Rv AMPGSQLEIFEGSGHFPFHDDPARFIDIVERFMDTTEPAEYDQAALRALL
Mb2734|M.bovis_AF2122/97 AMPGSQLEIFEGSGHFPFHDDPARFIDIVERFMDTTEPAEYDQAALRALL
MMAR_1997|M.marinum_M AMPGSKLEVFEGSGHFPFHDDPARFIDIVLRFIDSTQPPEYDQAALRELL
MUL_3358|M.ulcerans_Agy99 AMPGSKLEVFEGSGHFPFHDDPARFIDIVLRFIDSTQPPEYDQAALRELL
MAV_3609|M.avium_104 AMPGSRLEIFEGSGHFPFHDDPARFIDVVERFIDSTEPAAYDQEALRRLL
MAB_3034|M.abscessus_ATCC_1997 AMPGSALEIFDKSGHFPFHDDPERFIGIVRQFIASTEPGEYNEDELRRLL
MSMEG_4867|M.smegmatis_MC2_155 MIPGARFEVMPGCGHWPQYEDPATFNALHLDFLLGR--------------
TH_4528|M.thermoresistible__bu MIPGARFEVMPGCGHWPQYEDPATFNRLHIDFLLGRS-------------
MLBr_00862|M.leprae_Br4923 RWVPRLWRRDIKAGHFSPMSHPQVMAAAVHDLADLVDGKQPSRALLRAQV
. .**:. ..* : :
Mflv_3952|M.gilvum_PYR-GCK RT-----GTSENTLSGD----------------VDTQVAVLDAIGADERS
Mvan_2445|M.vanbaalenii_PYR-1 RA-----GISEGTISGP----------------ADTRVAVLDAMGADERS
Rv2715|M.tuberculosis_H37Rv RR-----GGGEATVTGS----------------ADTRVAVLNAIGSNERS
Mb2734|M.bovis_AF2122/97 RR-----GGGEATVTGS----------------ADTRVAVLNAIGSNERS
MMAR_1997|M.marinum_M RT-----GGGERTVSGP----------------ADTRVAVLSAMGSDERS
MUL_3358|M.ulcerans_Agy99 RT-----GGGERTVSDP----------------ADTRVAVLSAMGSDERS
MAV_3609|M.avium_104 RS-----GGGAQAVTGP----------------APTRVAVLSAMGSDERS
MAB_3034|M.abscessus_ATCC_1997 RT-----GVTEHAISGA----------------ARTRMAVLDAMGTDERS
MSMEG_4867|M.smegmatis_MC2_155 --------------------------------------------------
TH_4528|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GRSRDTFGDTLVSVTGAGSGIGRETALALARRGAEVVVSDIDEAAAKNTA
Mflv_3952|M.gilvum_PYR-GCK AT------------------------------------------------
Mvan_2445|M.vanbaalenii_PYR-1 AT------------------------------------------------
Rv2715|M.tuberculosis_H37Rv AT------------------------------------------------
Mb2734|M.bovis_AF2122/97 AT------------------------------------------------
MMAR_1997|M.marinum_M AT------------------------------------------------
MUL_3358|M.ulcerans_Agy99 AT------------------------------------------------
MAV_3609|M.avium_104 AT------------------------------------------------
MAB_3034|M.abscessus_ATCC_1997 AT------------------------------------------------
MSMEG_4867|M.smegmatis_MC2_155 --------------------------------------------------
TH_4528|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 AQIVASGGVAYAYALDVSDAAAVEAFAEQVSAKHGVPDIVVNNAGIGQAG
Mflv_3952|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2445|M.vanbaalenii_PYR-1 --------------------------------------------------
Rv2715|M.tuberculosis_H37Rv --------------------------------------------------
Mb2734|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1997|M.marinum_M --------------------------------------------------
MUL_3358|M.ulcerans_Agy99 --------------------------------------------------
MAV_3609|M.avium_104 --------------------------------------------------
MAB_3034|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4867|M.smegmatis_MC2_155 --------------------------------------------------
TH_4528|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 RFLDTPPEEFDRVLAVNLGGVVNCCRAFGQRLVERGTGGHIVNVSSMAAY
Mflv_3952|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2445|M.vanbaalenii_PYR-1 --------------------------------------------------
Rv2715|M.tuberculosis_H37Rv --------------------------------------------------
Mb2734|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1997|M.marinum_M --------------------------------------------------
MUL_3358|M.ulcerans_Agy99 --------------------------------------------------
MAV_3609|M.avium_104 --------------------------------------------------
MAB_3034|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4867|M.smegmatis_MC2_155 --------------------------------------------------
TH_4528|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 APLQSLSAYCTSKAATYMFSDCLRAELDAVGVGLTTICPGVIDTNIIQST
Mflv_3952|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2445|M.vanbaalenii_PYR-1 --------------------------------------------------
Rv2715|M.tuberculosis_H37Rv --------------------------------------------------
Mb2734|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1997|M.marinum_M --------------------------------------------------
MUL_3358|M.ulcerans_Agy99 --------------------------------------------------
MAV_3609|M.avium_104 --------------------------------------------------
MAB_3034|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4867|M.smegmatis_MC2_155 --------------------------------------------------
TH_4528|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 RIDTPTAKQERVRDRRGQLDMMFRLRRYGPDKVADTILSAIKKNKPIRPV
Mflv_3952|M.gilvum_PYR-GCK ---------------------------
Mvan_2445|M.vanbaalenii_PYR-1 ---------------------------
Rv2715|M.tuberculosis_H37Rv ---------------------------
Mb2734|M.bovis_AF2122/97 ---------------------------
MMAR_1997|M.marinum_M ---------------------------
MUL_3358|M.ulcerans_Agy99 ---------------------------
MAV_3609|M.avium_104 ---------------------------
MAB_3034|M.abscessus_ATCC_1997 ---------------------------
MSMEG_4867|M.smegmatis_MC2_155 ---------------------------
TH_4528|M.thermoresistible__bu ---------------------------
MLBr_00862|M.leprae_Br4923 APEAYALYGISRVLPQVLRSTARIRVI