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MSSVAVHHVVTGRSDGPAVVFSNSLGSTHRMWDPQLAAFEERFRVVRYDTRGHGQSPVPEGPYTIDDLAD DVVALLDTLGIERAHVVGLSLGGMTAMRLSARNPQRVDRIALLCTATHLPPSSAWTERAAAVRTHGSAAV AESVVGRWFTPGFLAADPGRKAAYQQMIAATPAEGYAGCCEAIAALDLRADLARITAPTLAIAGTDDPAT PPDRLAEITAAVRGARLVQVTPGAHLANVEQADAITPTLLEHLGTEQS
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. smegmatis MC2 155 | MSMEG_1897 | pcaD | - | 100% (258) | 3-oxoadipate enol-lactonase |
M. smegmatis MC2 155 | MSMEG_4707 | - | 9e-20 | 28.15% (270) | non-heme bromoperoxidase BPO-A2 |
M. smegmatis MC2 155 | MSMEG_1352 | - | 5e-18 | 28.46% (260) | hydrolase, alpha/beta fold family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3196c | hpx | 3e-15 | 28.26% (276) | non-Heme haloperoxidase Hpx |
M. gilvum PYR-GCK | Mflv_1348 | - | 7e-95 | 66.01% (253) | 3-oxoadipate enol-lactonase |
M. tuberculosis H37Rv | Rv3171c | hpx | 5e-16 | 28.62% (276) | non-Heme haloperoxidase Hpx |
M. leprae Br4923 | MLBr_01899 | lipG | 1e-16 | 30.50% (259) | putative hydrolase |
M. abscessus ATCC 19977 | MAB_0349c | - | 3e-20 | 30.04% (253) | putative hydrolase, alpha/beta fold |
M. marinum M | MMAR_1388 | hpx | 4e-17 | 28.21% (280) | non-heme haloperoxidase Hpx |
M. avium 104 | MAV_4589 | - | 7e-17 | 28.02% (257) | hydrolase, alpha/beta fold family protein |
M. thermoresistible (build 8) | TH_2963 | - | 2e-27 | 32.41% (253) | PUTATIVE putative 3-oxoadipate enol-lactonase |
M. ulcerans Agy99 | MUL_2488 | hpx | 3e-17 | 28.21% (280) | non-heme haloperoxidase Hpx |
M. vanbaalenii PYR-1 | Mvan_0563 | - | 8e-39 | 35.83% (254) | 4-carboxymuconolactone decarboxylase |
CLUSTAL 2.0.9 multiple sequence alignment MSMEG_1897|M.smegmatis_MC2_155 ---------------------------------MSSVAVHHVVTGRSD-G Mflv_1348|M.gilvum_PYR-GCK ---------------------------------MSAVDVHVIESGLPD-G Mvan_0563|M.vanbaalenii_PYR-1 ---------------------------------MSNPPLTAIHLGGPDDG Mb3196c|M.bovis_AF2122/97 ----------------------------MTVRAADGTPLHTQVFGPPHGY Rv3171c|M.tuberculosis_H37Rv ----------------------------MTVRAADGTPLHTQVFGPPHGY MMAR_1388|M.marinum_M MSARKATDGKAHTKAPAALPDVLPPSRSLTVRAADGTALHTQVFGPADGY MUL_2488|M.ulcerans_Agy99 MSARKATDGKAHTKASAALPDVLPPSRSLTVRAADGTALHTQVFGPADGY MAB_0349c|M.abscessus_ATCC_199 ------------------------MGSAALQDRYLQSCLGGLHVRIGGEG MAV_4589|M.avium_104 -------------------------------------MINLAYDDRGSGE TH_2963|M.thermoresistible__bu ----------------------------MPRFSRAGTTIDYTDTGAPAGR MLBr_01899|M.leprae_Br4923 ------------------------MEVRSGYATSGDLKLYYEDMGNVDDP : MSMEG_1897|M.smegmatis_MC2_155 PAVVFSNSLG-STHRMWD--PQLAAFEERFRVVRYDTRGHGQSPVP---- Mflv_1348|M.gilvum_PYR-GCK PAVVLSNSLG-ATHRMWD--AQLDALERRFRVLRYDTRGHGASPVP---- Mvan_0563|M.vanbaalenii_PYR-1 PLLLLGPSLGTTTATLWT--GVAQRLVDHVRVVGWDLPGHGRGRR----- Mb3196c|M.bovis_AF2122/97 PIVLTHGFVC--AIRAWA--YQIADLAGDYRVIAFDHRGHGRSGVPR--- Rv3171c|M.tuberculosis_H37Rv PIVLTHGFVC--AIRAWA--YQIADLAGDYRVIAFDHRGHGRSGVPR--- MMAR_1388|M.marinum_M PIVLTHGFVC--SIRAWA--YQIADLATDYRVIAFDHRGHGRSGIPR--- MUL_2488|M.ulcerans_Agy99 PIVLTHGFVC--SIRAWA--YQIADLATDYRVIAFDHRGHGRSGIPR--- MAB_0349c|M.abscessus_ATCC_199 PVILFWPSLL-MTGSMWA--AQAEYFADRYTVILVDPPGHG-DSQSL--- MAV_4589|M.avium_104 PVVFIAGHGG--AGRTWHPYQVPAFLAAGYRVITFDNRGIGATEN----- TH_2963|M.thermoresistible__bu LEAPTILFGHGLLFSGWQFNLQIYALRRYYRCLAIDWRGQGASSG-A--- MLBr_01899|M.leprae_Br4923 PVLLIMGLGA--QLVLWRTAFCEKLVAQGLRVVRYDNRDVGLSSRTDSTE * . : * . * MSMEG_1897|M.smegmatis_MC2_155 ---------------------EGPYTIDDLADDVVALLDT--LGIERAHV Mflv_1348|M.gilvum_PYR-GCK ---------------------DGPYSIDDLADDVVGILDR--RGIDTAHL Mvan_0563|M.vanbaalenii_PYR-1 ---------------------AHPFTIADLAAAVLVIADD--LNVETFHY Mb3196c|M.bovis_AF2122/97 ---------------------RGAYSLNHLAADLDSVLDATLAPRERAVV Rv3171c|M.tuberculosis_H37Rv ---------------------RGAYSLNHLAADLDSVLDATLAPRERAVV MMAR_1388|M.marinum_M ---------------------RGGYTLEHLASDLDSVLDATLAPHERALI MUL_2488|M.ulcerans_Agy99 ---------------------RGGYTLEHLASDLDSVLDATLAPHERALI MAB_0349c|M.abscessus_ATCC_199 ---------------------TRMFRFEDCAHAITQILDS--LGIERAHV MAV_4589|M.avium_104 ---------------------AQGFTTETMVADTAALIEG--LNAAPARI TH_2963|M.thermoresistible__bu ---------------------ARPYDMDTLTEDAAHLVRS--LGVAPAHY MLBr_01899|M.leprae_Br4923 QPCPSQPLTARLIRFWLGQRNACAYTLEDMTDDAVALLDH--LSIERAHI : . : MSMEG_1897|M.smegmatis_MC2_155 VGLSLGGMTAMRLSARNPQRVDR------------------IALLCTATH Mflv_1348|M.gilvum_PYR-GCK VGLSLGGMTAMRVAARNPDRVNR------------------MVLLCTAAE Mvan_0563|M.vanbaalenii_PYR-1 AGDSVGGCVGLQLLLDAPQRVSS------------------ATLLCTGAA Mb3196c|M.bovis_AF2122/97 AGHSMGGITIAAWSDRYRHKVRRRTDAVALINTTTGDLVRKVKLLSVPRE Rv3171c|M.tuberculosis_H37Rv AGHSMGGITIAAWSDRYRHKVRRRTDAVALINTTTGDLVRKVKLLSVPRE MMAR_1388|M.marinum_M AGHSMGGIAISAWSERYRHKVHRRADAVALINTATGDLLRKIRMLSVPRE MUL_2488|M.ulcerans_Agy99 AGHSMGGIAISAWSERYRHKVHRRADAVALINTATGDLLRKIRMLSVPRE MAB_0349c|M.abscessus_ATCC_199 VGNSWGGMIGGTFTAMYPHRAGAS---------------VLMNATASRAS MAV_4589|M.avium_104 VGMSMGAFIAQELMLARPELVSA------------------AVLMGTRGR TH_2963|M.thermoresistible__bu VGLSMGGFVGIRLAARHPELVRS---------------LVLMNTSAGPED MLBr_01899|M.leprae_Br4923 VGASMGGMIAQIFAARFPTRTRS------------------LAVFFSSNN .* * *. . MSMEG_1897|M.smegmatis_MC2_155 LPPSSAWTERAAAVRTHG--SAAVAESVVGRWFTPGFLAA----DPGRKA Mflv_1348|M.gilvum_PYR-GCK LAPAQAWTDRAAAVRAGG--AESVAPAVIARWFTLSHLET----HPAERA Mvan_0563|M.vanbaalenii_PYR-1 IGTPDGWLARAATVRAGG--VDTMLAGAAERWFAPGFVDR----EPGTAS Mb3196c|M.bovis_AF2122/97 LSPVRVLAGRSLVNTFGG--FPLPGAARALSRHVISTLAVAADADPSATR Rv3171c|M.tuberculosis_H37Rv LSPVRVLAGRSLVNTFGG--FPLPGAARALSRHVISTLAVAADADPSATR MMAR_1388|M.marinum_M LSAARDFAGRGLINAFGG--FPLPSAVRIPTQYLIAMMAVGADAHPTAAR MUL_2488|M.ulcerans_Agy99 LSAARDFAGRGLINAFGG--FPLPSAVRIPTQYLIAMMAVGADAHPTAAR MAB_0349c|M.abscessus_ATCC_199 MRQRVEFRLLTEIVRILGR-FREPLTTRAVKAFVGPTIMR---ERPHVEQ MAV_4589|M.avium_104 MDRARQFFRDAEAELADG--GVALPASYEAKIRLLENFSRKTLNDDTAVA TH_2963|M.thermoresistible__bu PAKADRYRTMARIYRFTG--IGPLRRAVLPLMFGPAFLADP--DSEDVID MLBr_01899|M.leprae_Br4923 RPFLPPPAPRALLALLTGPPTGSRRDVVVDNVVRVTKITGSPLYRMPEEQ * . MSMEG_1897|M.smegmatis_MC2_155 AYQQMIAATPAEGYAG--CCEAIAALD--LRADLAR-ITAPTLAIAGTDD Mflv_1348|M.gilvum_PYR-GCK EWVDMIAATPAEGYAS--CCEAIAELD--LREQLPT-ITAPTLAIAGADD Mvan_0563|M.vanbaalenii_PYR-1 ALLDALSHTDAESYAQ--VCEALAVFD--VTNQLSE-IVTPVLAVAGSVD Mb3196c|M.bovis_AF2122/97 LVYELFTQMSAAGRGG--CAKMLVEEVGSAHLNLDG-LTVPTLVIGGVRD Rv3171c|M.tuberculosis_H37Rv LVYELFTQTSAAGRGG--CAKMLVEEVGSAHLNLDG-LTVPTLVIGGVRD MMAR_1388|M.marinum_M LLYELFAQTSAAGRGG--CARMLVGEVGSRHISLDG-LTVPTLVIGSERD MUL_2488|M.ulcerans_Agy99 LLYELFAQTSAAGRGG--CARMLVGEVGSRHISLDG-LTVPTLVIGSERD MAB_0349c|M.abscessus_ATCC_199 SIRAELRDLRVDSVYW--AVNSVVPARPDQRELLGR-ITTPILVIAGRED MAV_4589|M.avium_104 DWIAMFSTWPVKSTPG--MRAQLDVAPYTNRLSAYRSIATPVLVIGFSDD TH_2963|M.thermoresistible__bu EWERRLRRYPRSSVRD--AVLAVANRAG-VEDELAA-IDVPTLVIGGAQD MLBr_01899|M.leprae_Br4923 VRTNAAEIYDRSFYPLGVSRQFSAILGSGSLLHYNQRIIAPTVVIHGRAD : .* :.: * MSMEG_1897|M.smegmatis_MC2_155 PATPPDRLAEITAAVRGARLVQVTPGAHLANVEQADAITPTLLEHLGTEQ Mflv_1348|M.gilvum_PYR-GCK PATPPAKLEQIVSAIPGARLLVVDGAAHLANAEQPEQITPAIIEHL--EQ Mvan_0563|M.vanbaalenii_PYR-1 VPTPPESLRRIASDVKDGDLVVLEGVGHLAPAEAPQRVAGLIAEIVGVPQ Mb3196c|M.bovis_AF2122/97 RLTPISQSRRIARTAPNVVGLVELPGGHCSMLERHQEVNSHLRALAESVT Rv3171c|M.tuberculosis_H37Rv RLTPISQSRRIARTAPNVVGLVELPGGHCSMLERHQEVNSHLRALAESVT MMAR_1388|M.marinum_M RLTPISQTRKIASTAPNVFDLVELPGGHCSMLEQHHEVNRHLRTLVDSVG MUL_2488|M.ulcerans_Agy99 RLTPISQTRKIASTAPNVFDLVELPGGHCSMLEQHHEVNRHLRTLVDSVG MAB_0349c|M.abscessus_ATCC_199 PTFPVAETELMAEAIPGAELVIMENTGHLAALERPEEVNALIDDFLKRHP MAV_4589|M.avium_104 VLTPPYLGREVADALPNGRYVQIPDTGHLGFFERPDAVNAAMLKFFGEQH TH_2963|M.thermoresistible__bu AATPPAHAQALAAGIRGARLEIIDDCGHSSPLERPDVVTELLRGFLLEHT MLBr_01899|M.leprae_Br4923 KLVRPSSGRAVARAITGARLVLFDGMGHDLPQQLWDQAVGVLMSNFAKAS :. . .* : . : MSMEG_1897|M.smegmatis_MC2_155 S------------------------------------------------- Mflv_1348|M.gilvum_PYR-GCK R------------------------------------------------- Mvan_0563|M.vanbaalenii_PYR-1 PPSKTLEDVHRAGMAVRREVLGEAHVDRAVAGTTDLTADFQHMITQYAWG Mb3196c|M.bovis_AF2122/97 RHVRDRRISS---------------------------------------- Rv3171c|M.tuberculosis_H37Rv RHVRDRRISS---------------------------------------- MMAR_1388|M.marinum_M GRSRAR-ISS---------------------------------------- MUL_2488|M.ulcerans_Agy99 GRSRAR-ISS---------------------------------------- MAB_0349c|M.abscessus_ATCC_199 IED----------------------------------------------- MAV_4589|M.avium_104 -------------------------------------------------- TH_2963|M.thermoresistible__bu -------------------------------------------------- MLBr_01899|M.leprae_Br4923 -------------------------------------------------- MSMEG_1897|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_1348|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0563|M.vanbaalenii_PYR-1 TIWTRPGLDLRSRSMITLTALVARGHHEELAMHLRAARRNGLSNDEIKEL Mb3196c|M.bovis_AF2122/97 -------------------------------------------------- Rv3171c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_1388|M.marinum_M -------------------------------------------------- MUL_2488|M.ulcerans_Agy99 -------------------------------------------------- MAB_0349c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4589|M.avium_104 -------------------------------------------------- TH_2963|M.thermoresistible__bu -------------------------------------------------- MLBr_01899|M.leprae_Br4923 -------------------------------------------------- MSMEG_1897|M.smegmatis_MC2_155 ----------------------------------- Mflv_1348|M.gilvum_PYR-GCK ----------------------------------- Mvan_0563|M.vanbaalenii_PYR-1 LMQTAIYCGVPDANSAFRIAAEVLPEFDEHPGAPS Mb3196c|M.bovis_AF2122/97 ----------------------------------- Rv3171c|M.tuberculosis_H37Rv ----------------------------------- MMAR_1388|M.marinum_M ----------------------------------- MUL_2488|M.ulcerans_Agy99 ----------------------------------- MAB_0349c|M.abscessus_ATCC_199 ----------------------------------- MAV_4589|M.avium_104 ----------------------------------- TH_2963|M.thermoresistible__bu ----------------------------------- MLBr_01899|M.leprae_Br4923 -----------------------------------