For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MFSRSRSVDEAPAWFTTALADKPEHSHVDVEGCEIHVRVWGARENPPLVLVHGGAAHSGWWDHIAPLLSS THRIVAPDLSGHGDSGTRDSYDLRRWSREVMAAAAAFSDGHPTIVGHSLGGWVTATAASHFGDQINSIVV VDSPLRDRAPEERHLSRRTPKAYRSKDEIVGRFRPVPAQQGVLPYVSAHIASESVRRTLKGWVWKFDPAI FGGHLAEQTPAEREVMEAMMNQMPCRIGYLRCEHGLVPPEMADVVRDILQLRGPFVDLVEAGHHPMLDQP LPLVATLRTLLEVWSIT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0736 | - | - | 100% (297) | alpha/beta hydrolase fold |
| M. gilvum PYR-GCK | Mflv_3026 | - | 1e-09 | 29.12% (182) | alpha/beta hydrolase fold |
| M. gilvum PYR-GCK | Mflv_4502 | - | 2e-09 | 33.07% (127) | alpha/beta hydrolase fold |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2734 | - | 2e-09 | 30.10% (103) | hydrolase |
| M. tuberculosis H37Rv | Rv0134 | ephF | 1e-09 | 35.92% (103) | epoxide hydrolase EphF |
| M. leprae Br4923 | MLBr_00862 | ephD | 5e-07 | 28.89% (135) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4522c | - | 1e-11 | 31.75% (126) | epoxide hydrolase EphF |
| M. marinum M | MMAR_1355 | lipV | 3e-09 | 29.36% (109) | lipase LipV |
| M. avium 104 | MAV_0093 | - | 1e-120 | 66.11% (298) | alpha/beta hydrolase fold |
| M. smegmatis MC2 155 | MSMEG_0460 | - | 1e-116 | 63.61% (305) | alpha/beta hydrolase fold |
| M. thermoresistible (build 8) | TH_0992 | ephA | 1e-08 | 26.53% (147) | PROBABLE EPOXIDE HYDROLASE EPHA (EPOXIDE HYDRATASE) |
| M. ulcerans Agy99 | MUL_2524 | lipV | 1e-09 | 29.36% (109) | lipase LipV |
| M. vanbaalenii PYR-1 | Mvan_2912 | - | 4e-11 | 25.45% (275) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2734|M.bovis_AF2122/97 -----------------------MTERKRNLRPVRDVAPPTLQFRTVHGY
Mvan_2912|M.vanbaalenii_PYR-1 -----------------------MHD--------------DVKYLDLHGD
Mflv_0736|M.gilvum_PYR-GCK ------------MFSRSR-----SVDEAPAWFTTALADKPEHSHVDVEGC
MSMEG_0460|M.smegmatis_MC2_155 ---MRHADEVSPLFQRQRPTPSDPPEGTPEWFTAALEHRPQHSTIDFEGC
MAV_0093|M.avium_104 MLSCMANREGQKLFSRSR-----QMPATPSWFTAALDQKPERCDVEVDGC
MMAR_1355|M.marinum_M -----------------------------------------------MST
MUL_2524|M.ulcerans_Agy99 -----------------------------------------------MST
Rv0134|M.tuberculosis_H37Rv -----------------------------MIALPALEGVEHRHVDVAEGV
MAB_4522c|M.abscessus_ATCC_199 ---------------------------MTQRSMPVLDGVEHQYVQAGD-V
MLBr_00862|M.leprae_Br4923 -----------------------------MPATQSIHKVPHQFVESPDGV
TH_0992|M.thermoresistible__bu ------------------------------------VITPSERSVETNGV
Mb2734|M.bovis_AF2122/97 RRAFRIAG--SGPAILLIHGIGDNSTTWNGVHA-KLAQRFTVIAPDLLGH
Mvan_2912|M.vanbaalenii_PYR-1 RVAYREAG--QGPAVLLIHGMGGSSLTWKALLP-HLATRYRVIAPDLLGH
Mflv_0736|M.gilvum_PYR-GCK EIHVRVWGARENPPLVLVHGGAAHSGWWDHIAP-LLSSTHRIVAPDLSGH
MSMEG_0460|M.smegmatis_MC2_155 RIHLRTWGDPENPPLVFVHGGAAHSGWWDHIAP-FFTRTHRVIAPDVSGH
MAV_0093|M.avium_104 RIRMRVWGAADQPPVVLVHGGGAHSGWWDHIAP-FFSHTHRVIAPDLSGH
MMAR_1355|M.marinum_M DLHVHRYGPEEPVRVLTIHGVTEHGQSWEYLAG-YLPEVS-IAAPDLLGH
MUL_2524|M.ulcerans_Agy99 DLHVHRYGPEEPVRVLTIHGVTEHGQSWEYLAG-YLPEVN-IAAPDLLGH
Rv0134|M.tuberculosis_H37Rv RIHVADAGPADGPAVMLVHGFPQNWWEWRDLIGPLAADGNRVLCPDLRGA
MAB_4522c|M.abscessus_ATCC_199 KIHVAVAGPQDGRAVVLLHGWPENWWMWHKVIPALAAAGYRVHAMDLRGA
MLBr_00862|M.leprae_Br4923 RLAIYQSGQPEGPAIVLVHGFPDSHVLWDGVVP-LLAKRFRIVRYDNRGV
TH_0992|M.thermoresistible__bu RLRLVEAGERGDPLVVLAHGFPELAYSWRHQIPALVDAGYHVMAPDQRGY
* :: ** * : * *
Mb2734|M.bovis_AF2122/97 GQSDK--PRADYSVAAY-ANGMRDLLSVLDIERVTIVGHSLG--------
Mvan_2912|M.vanbaalenii_PYR-1 GQSDK--PRGDYSLGAF-AVWLRDLLDLLGIARVTLVGHSLG--------
Mflv_0736|M.gilvum_PYR-GCK GDSG---TRDSYDLRRWSREVMAAAAAFS-DGHPTIVGHSLG--------
MSMEG_0460|M.smegmatis_MC2_155 GDSG---TRSHYSLTKWAREVLAVAAAEGPAARPTIVGHSMG--------
MAV_0093|M.avium_104 GDSD---PRDSYDLRIWAGEVMAAAAAAGPAGRPTIVGHSMG--------
MMAR_1355|M.marinum_M GRSS---WAAPWSIDAN-VSALAALLKDQADGPVVVVGHSFG--------
MUL_2524|M.ulcerans_Agy99 GRSS---WAAPWSIDAN-VSALAALLKDQADGPVVVVGHSFG--------
Rv0134|M.tuberculosis_H37Rv GWSSA--PRSRYTKTEM-ADDLAAVLDGLGVAKVKLVAHDWG--------
MAB_4522c|M.abscessus_ATCC_199 GWSEV--APAGYEKEQF-ASDVLAAADALGLESFDLVGHDWG--------
MLBr_00862|M.leprae_Br4923 GQSSVPKPVSAYTMTRFADDFAAVIDELSPDRPVHVLAHDWGSVGVWEYL
TH_0992|M.thermoresistible__bu GGSSAPEAIEAYDITRL-TADLMGLLDDIGAEKAAFIGHDWG--------
* * : .:.*. *
Mb2734|M.bovis_AF2122/97 ---GGVAMQFAYQFPQLVDRLILVSA---GGVTKDVNIVFRLASLPMGSE
Mvan_2912|M.vanbaalenii_PYR-1 ---GGVAMQFVHQHPDYCERLVLISS---GGLGPELGRSLRLLSTPG---
Mflv_0736|M.gilvum_PYR-GCK ---GWVTATAASHFGDQINSIVVVDSPLRDRAPEERHLSRRTP--KAYRS
MSMEG_0460|M.smegmatis_MC2_155 ---GWVTATAAMKYGADIDSILIIDSPLRERAPEEGRLRNRRSDHPGYPS
MAV_0093|M.avium_104 ---GWVVSTAAMHYSSKINSMLVIDSPLWERAPEEGRLRRRKH--TEYRT
MMAR_1355|M.marinum_M ---GAVALQLAAAHPDLVAALILLDPAIGLNGSRVREVVDAMVAFPDYTD
MUL_2524|M.ulcerans_Agy99 ---GAVALQLAAAHPDLVAALILLDPAIGLDGSRVREVVDAMVAFPDYTD
Rv0134|M.tuberculosis_H37Rv ---GPVAFIMMLRHPEKVTGFFGVNTVAPWVKRDLGMLRNMWRFWYQIPM
MAB_4522c|M.abscessus_ATCC_199 ---GWTAQLVALKAQSRIRRLVVLNIPPVWQQPGR-VARYAHKLAYQLVV
MLBr_00862|M.leprae_Br4923 SRSGASDRVASFTSVSGPSQDQLVDYILSGLRRPWRPRTFARAVSQLFRL
TH_0992|M.thermoresistible__bu ---ALVVWNAALLYPDRVAAVAGLSVPPVPRSLTRPTEAFRALVGEDNFF
. :.
Mb2734|M.bovis_AF2122/97 AMALLRLPLVLPAVQI--AGRIVGKAIGTTSLG-HDLPNVLRILDDLPEP
Mvan_2912|M.vanbaalenii_PYR-1 -IELLLPVAAAPSVVA--VGERVRSWLGARGLASPEVGETWNAYASLSDP
Mflv_0736|M.gilvum_PYR-GCK KDEIVGRFRPVPAQQG--VLPYVSAHIASESVRRTLKGWVWKFDPAIFGG
MSMEG_0460|M.smegmatis_MC2_155 REEILARFRAVPAQDV--TLPFIDRHIASESVRQTDTGWVWKFDPAIFSG
MAV_0093|M.avium_104 RDEILARFTAVPSQEL--ILPYVREHIAAESIRKTSAGWVWKFDPAIFGG
MMAR_1355|M.marinum_M PAEARMERAYGAWADV--DPAVLDAELDEHLITLPNGRYSWRIS---LPA
MUL_2524|M.ulcerans_Agy99 PAEARMERAYGAWADV--DPAVLDAELDEHLITLPNGRYSWRIS---LPA
Rv0134|M.tuberculosis_H37Rv SLPVIGPRVISDPKGR--YFRLLTGWVGGGFRVPDDDVRLYLDCMREPGH
MAB_4522c|M.abscessus_ATCC_199 GAPVVGPLSHLSPTLW--WFIRRSG-------MPKESVDFFRSCFRDRDR
MLBr_00862|M.leprae_Br4923 TYMVLFSIPVLVPMVL--WIALSSATIRRTMVDNISTDQIHHSATLARDA
TH_0992|M.thermoresistible__bu YILYFQEPGVADAELDGDPARTMRRMFGGLTSDPDAAHRMLQPGPAGFID
Mb2734|M.bovis_AF2122/97 TASAAFGRTLRAVVDWRGQMVTMLDRCYLT--------------------
Mvan_2912|M.vanbaalenii_PYR-1 QTRTAFLRTLRSVVDAQGQAVSALNRLHFT--------------------
Mflv_0736|M.gilvum_PYR-GCK HLAEQTPAEREVMEAMMNQMPCRIG-------------------------
MSMEG_0460|M.smegmatis_MC2_155 SLQGQTPAEQEILENTFAQIPCRVG-------------------------
MAV_0093|M.avium_104 EFLQPTPADEESLESMLTAMRCRVG-------------------------
MMAR_1355|M.marinum_M MVCYWSELARDAALPPPGIATTLVR-------------------------
MUL_2524|M.ulcerans_Agy99 MVCYWSELARDAALPPPGIATTLVR-------------------------
Rv0134|M.tuberculosis_H37Rv AEAGSRWYRTFQTREMLRWLRGEYNDA--R--------------------
MAB_4522c|M.abscessus_ATCC_199 RVAGSKIYRSMVGKEFANLARGPYDDQ--K--------------------
MLBr_00862|M.leprae_Br4923 AHSVKTYPANYFRAFSGRRRGKGVPVVN----------------------
TH_0992|M.thermoresistible__bu RLPEPEALPDWLTAEELDHYIAEFTRTGFTGGLNWYRNMDRNWELTEHLA
Mb2734|M.bovis_AF2122/97 ---EAIPVQIIWGTKDVVLPVRHAHMAHAAMPG-SQLEIFEGSGHFPFHD
Mvan_2912|M.vanbaalenii_PYR-1 ---LGLPTLLIWGDQDRLIPPAHGEAAHAALPG-SRLVILPAVGHFPQVE
Mflv_0736|M.gilvum_PYR-GCK ---------YLRCEHGLVPPEMADVVRDILQLR-GPFVDLVEAGHHPMLD
MSMEG_0460|M.smegmatis_MC2_155 ---------YLRCENGLVPPDMAEQIRSTLQLR-GPFVELALAGHHPMLD
MAV_0093|M.avium_104 ---------YLRCEAGLVPPAMAERIRSLLQLR-GPFVELAQAGHHPMLD
MMAR_1355|M.marinum_M ---------AVRADPQYVSDELIAALRERLGAD-FALREFECG-HMVPQA
MUL_2524|M.ulcerans_Agy99 ---------AVRADPQYVSDELIAALRERLGAD-FALREFECG-HMVPQA
Rv0134|M.tuberculosis_H37Rv ---VDVPVRWLHGTGDPVITPDLLDGYAERASD-FEVELVDGVGHWIVEQ
MAB_4522c|M.abscessus_ATCC_199 ---LTMPVRVLFGLDDVAVHPSLLDGFKDHADD-LNITEVPNCGHFIVDE
MLBr_00862|M.leprae_Br4923 -----VPVQLIVNTMDRYVRPYGYDATARWVPR-LWRRDIKAG-HFSPMS
TH_0992|M.thermoresistible__bu GATITAPALFLAGAADPVLGFMRPERATEVAVGPYRQVLLDGAGHWVQQE
: . *
Mb2734|M.bovis_AF2122/97 DPARFIDIVERFMDTTEPAEYDQAALRALLRRGGGEATVTGSADTRVAVL
Mvan_2912|M.vanbaalenii_PYR-1 APLAVADTLDDFIANSSP------------WHGPPRHADHAEAD------
Mflv_0736|M.gilvum_PYR-GCK QPLPLVATLRTLLEVWSIT-------------------------------
MSMEG_0460|M.smegmatis_MC2_155 QPLPLVATIRTLLEFWSIT-------------------------------
MAV_0093|M.avium_104 QPLPLVATLRTLLEFWSIT-------------------------------
MMAR_1355|M.marinum_M KPTEVATLIREQLKTP----------------------------------
MUL_2524|M.ulcerans_Agy99 KPTEVATLIREQLKTP----------------------------------
Rv0134|M.tuberculosis_H37Rv RPELVLDRVRAFLAAGTEQRD-----------------------------
MAB_4522c|M.abscessus_ATCC_199 QPELVVKWLSEVLAEPAP--------------------------------
MLBr_00862|M.leprae_Br4923 HPQVMAAAVHDLADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSG
TH_0992|M.thermoresistible__bu RPQEVNAALIDFLRGLELQ-------------------------------
* . :
Mb2734|M.bovis_AF2122/97 NAIGSNERSAT---------------------------------------
Mvan_2912|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0736|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0460|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0093|M.avium_104 --------------------------------------------------
MMAR_1355|M.marinum_M --------------------------------------------------
MUL_2524|M.ulcerans_Agy99 --------------------------------------------------
Rv0134|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4522c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 IGRETALALARRGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDA
TH_0992|M.thermoresistible__bu --------------------------------------------------
Mb2734|M.bovis_AF2122/97 --------------------------------------------------
Mvan_2912|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0736|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0460|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0093|M.avium_104 --------------------------------------------------
MMAR_1355|M.marinum_M --------------------------------------------------
MUL_2524|M.ulcerans_Agy99 --------------------------------------------------
Rv0134|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4522c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 AAVEAFAEQVSAKHGVPDIVVNNAGIGQAGRFLDTPPEEFDRVLAVNLGG
TH_0992|M.thermoresistible__bu --------------------------------------------------
Mb2734|M.bovis_AF2122/97 --------------------------------------------------
Mvan_2912|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0736|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0460|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0093|M.avium_104 --------------------------------------------------
MMAR_1355|M.marinum_M --------------------------------------------------
MUL_2524|M.ulcerans_Agy99 --------------------------------------------------
Rv0134|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4522c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 VVNCCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFS
TH_0992|M.thermoresistible__bu --------------------------------------------------
Mb2734|M.bovis_AF2122/97 --------------------------------------------------
Mvan_2912|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0736|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0460|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0093|M.avium_104 --------------------------------------------------
MMAR_1355|M.marinum_M --------------------------------------------------
MUL_2524|M.ulcerans_Agy99 --------------------------------------------------
Rv0134|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4522c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DCLRAELDAVGVGLTTICPGVIDTNIIQSTRIDTPTAKQERVRDRRGQLD
TH_0992|M.thermoresistible__bu --------------------------------------------------
Mb2734|M.bovis_AF2122/97 --------------------------------------------------
Mvan_2912|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0736|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0460|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0093|M.avium_104 --------------------------------------------------
MMAR_1355|M.marinum_M --------------------------------------------------
MUL_2524|M.ulcerans_Agy99 --------------------------------------------------
Rv0134|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4522c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 MMFRLRRYGPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRS
TH_0992|M.thermoresistible__bu --------------------------------------------------
Mb2734|M.bovis_AF2122/97 -------
Mvan_2912|M.vanbaalenii_PYR-1 -------
Mflv_0736|M.gilvum_PYR-GCK -------
MSMEG_0460|M.smegmatis_MC2_155 -------
MAV_0093|M.avium_104 -------
MMAR_1355|M.marinum_M -------
MUL_2524|M.ulcerans_Agy99 -------
Rv0134|M.tuberculosis_H37Rv -------
MAB_4522c|M.abscessus_ATCC_199 -------
MLBr_00862|M.leprae_Br4923 TARIRVI
TH_0992|M.thermoresistible__bu -------