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MTEPQRAVIARVTADLTAVSAYLNRMAGDLATLDRLVAQQSAAPRPEAVAPQWSPQAPQQPPRQWTPQPV APVAPVAVPARQPDTPPKPRSEGWIGKVLAMAGVAVTLVGVVSLLVLAAQAGILRPEVRVAAGAALAVAL VAVAMWLDRRPGGRVGAVALAATGVAAAYMDVIAVTAIYEWVPAPVGLALAGVVGACGLMLARWWGSEQL GLLVFVPLIALAPVITDGVTLLLIGFMLALSAASLPVQFGRDWFWLHAARTAAVTIPLLVALVSAAIGGR EDLRLALVCALAAVPALVGGVTVSRFSTRPVATTVVSALGTVPLLCVSATADRVPAVLLIAGLAAAALAV AAIGDRLPGIGAPVRRVWAATSAAAALIAVLVAFDGTVAAPVLLAMSIAIAVGGQRDPVGRCAAIGFALI GAMFYLDHAAPAMLVEATPLDGPTVASVVIGSVMLIGAAAANGWTWSRTVSDTEVVRLVWVAVSAVIGYA ATALTVTVGVALGGAEVGFLAGHMAATLSWIVAAALAFGYAARRPGASRSVLIGGGLVLVAAATGKLFLF DLGTLDGMYRVVLFIVGGLVLLGMGAGYARFLAQQSDGRSDAQPGTDHEAHST
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3241 | - | - | 100% (613) | hypothetical protein MSMEG_3241 |
| M. smegmatis MC2 155 | MSMEG_1660 | - | 1e-06 | 36.52% (115) | oxidoreductase, 2-nitropropane dioxygenase family protein |
| M. smegmatis MC2 155 | MSMEG_6718 | - | 6e-06 | 24.59% (362) | transporter, major facilitator family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0086 | - | 5e-06 | 26.14% (329) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_3578 | - | 1e-180 | 57.86% (598) | hypothetical protein Mflv_3578 |
| M. tuberculosis H37Rv | Rv0083 | - | 5e-06 | 26.14% (329) | oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4509c | - | 3e-76 | 37.05% (610) | hypothetical protein MAB_4509c |
| M. marinum M | MMAR_3960 | - | 1e-155 | 49.92% (627) | hypothetical protein MMAR_3960 |
| M. avium 104 | MAV_4391 | - | 7e-07 | 27.68% (383) | hypothetical protein MAV_4391 |
| M. thermoresistible (build 8) | TH_4594 | - | 1e-103 | 50.96% (418) | PUTATIVE putative conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_4170 | - | 2e-07 | 26.58% (365) | integral membrane transport protein |
| M. vanbaalenii PYR-1 | Mvan_2837 | - | 1e-178 | 56.26% (615) | hypothetical protein Mvan_2837 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0086|M.bovis_AF2122/97 -----MTAAPTAGGVVTSGVGVAGVGVGLLGMFGPVRVVHVGWLLPLSGV
Rv0083|M.tuberculosis_H37Rv -----MTAAPTAGGVVTSGVGVAGVGVGLLGMFGPVRVVHVGWLLPLSGV
Mflv_3578|M.gilvum_PYR-GCK MADMTEPHSAVIARLSADFAAISHQLTRVSGDLAALDRILTD-----RAP
Mvan_2837|M.vanbaalenii_PYR-1 ---MTEPHTAVITRLSADFAAISRQLARVSTDLVELDRILAD-----RPQ
MMAR_3960|M.marinum_M ---MTESQHAVISRLSAEFDSLARQMARVSGELSQLDRLISDSVGAPQPA
MSMEG_3241|M.smegmatis_MC2_155 ---MTEPQRAVIARVTADLTAVSAYLNRMAGDLATLDRLVAQ------QS
TH_4594|M.thermoresistible__bu --------------------------------------------------
MAB_4509c|M.abscessus_ATCC_199 ----MFTSHRTASTLRGMSDPQLQQMTATLDELDGRERALRAEVDALRGR
MAV_4391|M.avium_104 --------------------------------------------------
MUL_4170|M.ulcerans_Agy99 --------------------------------------------------
Mb0086|M.bovis_AF2122/97 HIELDRLG-----------------GFFMALTGAVAAPVGCYLIGYVRRE
Rv0083|M.tuberculosis_H37Rv HIELDRLG-----------------GFFMALTGAVAAPVGCYLIGYVRRE
Mflv_3578|M.gilvum_PYR-GCK AAAAPR-------------------PAPQPAAYWPQYP-PQPAPFRPWPQ
Mvan_2837|M.vanbaalenii_PYR-1 SAPAPWPQPVSVP-------SPVPVPSPVPVAQPVPVPSPAPVPQPVAPY
MMAR_3960|M.marinum_M AAAPPQPQPQPVAPYWYPYWQQWAPVAPAPAAAPPRQYAPPPTARPAPQG
MSMEG_3241|M.smegmatis_MC2_155 AAPRPE------------------AVAPQWSPQAPQQPPRQWTPQPVAPV
TH_4594|M.thermoresistible__bu --------------------------------------------------
MAB_4509c|M.abscessus_ATCC_199 MVEWTQAEYLKAQR------------YWDDYRRAQGVAQAVAPAPVVMPP
MAV_4391|M.avium_104 --------------------------------------------------
MUL_4170|M.ulcerans_Agy99 --------------------------------------------------
Mb0086|M.bovis_AF2122/97 HLGRVPMAVVPLFVAAMLLVPAAGSVTTFLLAWELMAIASLILVLSEHAR
Rv0083|M.tuberculosis_H37Rv HLGRVPMAVVPLFVAAMLLVPAAGSVTTFLLAWELMAIASLILVLSEHAR
Mflv_3578|M.gilvum_PYR-GCK APAPAPTQALTPAP---RKERSE-GWIGKLLAVAGVAVTLIGVVLLLVLA
Mvan_2837|M.vanbaalenii_PYR-1 RPAYPAYPAYPPASARVRKERSD-GWIGKLLAVAGVAVTLIGVVLLLVLA
MMAR_3960|M.marinum_M PPAPAPAAAPPVSAPRRPAESTESGWIGKLLAVAGVAVTLTGVALLLVLA
MSMEG_3241|M.smegmatis_MC2_155 APVAVPARQPDTPP----KPRSE-GWIGKVLAMAGVAVTLVGVVSLLVLA
TH_4594|M.thermoresistible__bu --------------------------------------------------
MAB_4509c|M.abscessus_ATCC_199 ARMPVPARAPHPAPPQLEPWWMREGFASKAMALAGAVVTLAGVVMLLVLA
MAV_4391|M.avium_104 ------------------------------MALAVSTTGLCRVSVHWETQ
MUL_4170|M.ulcerans_Agy99 -------MNRGNVRPKLVLGVIVLGSFIASIDLTIVNVALPTLSRALQAS
Mb0086|M.bovis_AF2122/97 PQVRSAGLWYAVMTQLGFIAILVGLVVLAAAGGSDRFAGLGAVCDGVRVA
Rv0083|M.tuberculosis_H37Rv PQVRSAGLWYAVMTQLGFIAILVGLVVLAAAGGSDRFAGLGAVCDGVRAA
Mflv_3578|M.gilvum_PYR-GCK AQAGILRPEFRVSAGGALAAALVGAGWWLNTRPGGRVGAIALVATGVAAA
Mvan_2837|M.vanbaalenii_PYR-1 AQAGILRPEFRVAAGAVLAGALVAAGWWLNGRPGGRVGAIALVATGVAAA
MMAR_3960|M.marinum_M AQAGLLRPEIRVAGGTALSLALVGVAVRLRGRPGGRIGAIALAATGIATA
MSMEG_3241|M.smegmatis_MC2_155 AQAGILRPEVRVAAGAALAVALVAVAMWLDRRPGGRVGAVALAATGVAAA
TH_4594|M.thermoresistible__bu --------------------------------------------------
MAB_4509c|M.abscessus_ATCC_199 AKSGYFGPVPRMVSGAALAGGLVALGIRVYSRPGGRVGGIATAATGFAAA
MAV_4391|M.avium_104 AVDVSLPAEIAVAELIPSLVDMLGAGDGGAGRYRLSAPGAAALDPSTTLA
MUL_4170|M.ulcerans_Agy99 NAELQWIVDSYAIAAAGLLLAAGNLGDRYGRRGWLTIGLVIVGASSAVAA
Mb0086|M.bovis_AF2122/97 VFML-TLVGFGSKAGLVPLHAWLPRAHPEAPSPVSALMSAAMVNLGIYGI
Rv0083|M.tuberculosis_H37Rv VFML-TLVGFGSKAGLVPLHAWLPRAHPEAPSPVSALMSAAMVNLGIYGI
Mflv_3578|M.gilvum_PYR-GCK YMDV-IAVTTIYDWVPAPAGLVLAAVIAGAGLTLARRWDSEHLGLLVLVP
Mvan_2837|M.vanbaalenii_PYR-1 YMDV-IAVTTIYEWTSAPAGLVFASLIAGGGLTLARRWDSEHLGLLVLVP
MMAR_3960|M.marinum_M YLDV-IAATTIYQWVPAPAGLVLAALVGGAGLALARRWDSEHLGLLVLVP
MSMEG_3241|M.smegmatis_MC2_155 YMDV-IAVTAIYEWVPAPVGLALAGVVGACGLMLARWWGSEQLGLLVFVP
TH_4594|M.thermoresistible__bu --------------------------------MLARRWDSEHLGLLVLVP
MAB_4509c|M.abscessus_ATCC_199 FFDV-LALTVIYDRIPVVAGLVLGLGIAGVGLVLARHWNSQPFASGVVAA
MAV_4391|M.avium_104 HNHIGDGAILVLSRIDVPLPAPRYRDIADTVSAALDATARPDVAVRRVAG
MUL_4170|M.ulcerans_Agy99 SAGSAQAVIGARAVMGVGAAIIFPTSLALVTNVFVDSTHR-ARAIGVWSA
Mb0086|M.bovis_AF2122/97 VRFDLQLLGPGPRWWGLALLAVGGTSALYGVLQASVAADLKRLLAYSTTE
Rv0083|M.tuberculosis_H37Rv VRFDLQLLGPGPRWWGLALLAVGGTSALYGVLQASVAADLKRLLAYSTTE
Mflv_3578|M.gilvum_PYR-GCK LIVLAPIVTDG-----VSLLLVG---FMLALAAVSLPVQLGKDWIWLHAA
Mvan_2837|M.vanbaalenii_PYR-1 LIGLAPIVTDG-----ISLLLVG---FMLALAAVSLPVQLGKDWIWLHAA
MMAR_3960|M.marinum_M LIGLAPVLTRG-----ADLLLVS---FMLALSAAALPVQLGKDWVWLHAA
MSMEG_3241|M.smegmatis_MC2_155 LIALAPVITDG-----VTLLLIG---FMLALSAASLPVQFGRDWFWLHAA
TH_4594|M.thermoresistible__bu LVLLAPVITDG-----ITVVLIG---FMLALGAASLPVQLGRDWIWLHAA
MAB_4509c|M.abscessus_ATCC_199 ITVLAPFLTDG-----FTVELAA---FALILLIASLTAQVGRNWPVLHAF
MAV_4391|M.avium_104 AAAAASFVAAG------GLQLVR------NTFSASVVPDSGG-----TVA
MUL_4170|M.ulcerans_Agy99 VTGIAVVIGPILGGWLIEHFSVG---SVFWVNVPIAVVAIVSVNMFVPTS
.: .
Mb0086|M.bovis_AF2122/97 NMGLITLALGAATLFADTG-AYGPASIAAAAAMLHMIAHAAFKSLAFMAA
Rv0083|M.tuberculosis_H37Rv NMGLITLALGAATLFADTG-AYGPASIAAAAAMLHMIAHAAFKSLAFMAA
Mflv_3578|M.gilvum_PYR-GCK RIAAAVLPLLVALAARHID-SREDLWLAG-ACGIAAVIALTAALILLPGT
Mvan_2837|M.vanbaalenii_PYR-1 RIAAAALPVLTALLARHFESARQDLWLAG-ASGIAAAVALVAALILLPGT
MMAR_3960|M.marinum_M RVAAPTVPLLIALVAAGKH---DNTWLLGAACGVAAILAIVSGLIVLPGG
MSMEG_3241|M.smegmatis_MC2_155 RTAAVTIPLLVALVSAAIG-GREDLRLAL-VCALAAVPALVGGVTVSRFS
TH_4594|M.thermoresistible__bu RTASVTLPILGALLGASFA--QDRVPALTAACGIAAVLALAAALLLAPST
MAB_4509c|M.abscessus_ATCC_199 RTVGVSLTLLTAIHVSYTA-----SLALLAMSVMALLVTLVGSLWLLTGE
MAV_4391|M.avium_104 VLVSTTLLTLGAAAVAHRG--YRDPGAALALGAIATVFAGLAGFVAVPG-
MUL_4170|M.ulcerans_Agy99 RNPDRPPLDLPGLLVSTVG------VTVLTYTLIETPNIGWASARTAAGF
. :
Mb0086|M.bovis_AF2122/97 GSVLAATGLRDLDLLGGLARRMPATTVFFGVAALGACGLPLGAGFVSEWL
Rv0083|M.tuberculosis_H37Rv GSVLAATGLRDLDLLGGLARRMPATTVFFGVAALGACGLPLGAGFVSEWL
Mflv_3578|M.gilvum_PYR-GCK GNRVVMALLTVAGIVPVLCVNLAVDRVVAALMAAALAAALLAVALLA---
Mvan_2837|M.vanbaalenii_PYR-1 KNRAAMALLTAAGVLPVLCVSLAVDRVVAALMAATLAAALLAIVLFG---
MMAR_3960|M.marinum_M KNAAALAVLTVVGTLPVLAAAVAVDRVFAALLAGTLAAALLAIVLVG---
MSMEG_3241|M.smegmatis_MC2_155 TRPVATTVVSALGTVPLLCVSATADRVPAVLLIAGLAAAALAVAAIG---
TH_4594|M.thermoresistible__bu RNHTALGLLTAAGTLPVLCVSWAERPAVSALMAAALSAALLAMAAGAGLI
MAB_4509c|M.abscessus_ATCC_199 HDDITSSVMIAVASSPVLYGALFFPVWPLGVLVPVGVAVVMGAVLLLVG-
MAV_4391|M.avium_104 APSLSHVLLAAAAAGLAAVSAIGLSGCGAGLLALACWCLILATAALAG--
MUL_4170|M.ulcerans_Agy99 ALAVVLLAVFLWLERRTWHPILDLSIFANRRFSGGTAAVTTAYLVMCG--
: .
Mb0086|M.bovis_AF2122/97 LVQSLIHAAPGHDPIVALTTPLAVGVVALATGLSVAAMTKAFGIGFLARP
Rv0083|M.tuberculosis_H37Rv LVQSLIHAAPGHDPIVALTTPLAVGVVALATGLSVAAMTKAFGIGFLARP
Mflv_3578|M.gilvum_PYR-GCK DRLPGVDGVVRRVFAVTSAIAALIAVTTAFDGRVGGPVLLAMAVVVAIAV
Mvan_2837|M.vanbaalenii_PYR-1 ERLPGVAGVVRQVFSATSAVAALIAVTVAFDGMIAGPVLLAMAVVVALVG
MMAR_3960|M.marinum_M SELP---TIFTRVLAAWSAISALVAVTVAFDGHVEGPILLALAIVVAIAG
MSMEG_3241|M.smegmatis_MC2_155 DRLPGIGAPVRRVWAATSAAAALIAVLVAFDGTVAAPVLLAMSIAIAVGG
TH_4594|M.thermoresistible__bu RVELVRTGPLRRILSVWAAVAALIAVTVAFDAPVAAPVLLAMATVVAVAG
MAB_4509c|M.abscessus_ATCC_199 ----ALPVHARITVAAVAGVALLQASVDGARDALLAVVLLAIALSCCAIG
MAV_4391|M.avium_104 ----------------VLSGAPLPAVASAAGLVSLCLLGMAARASLALAG
MUL_4170|M.ulcerans_Agy99 ---------------FIFVATQYLQFVAAYRAFDTGVRLVPLAFSYAGLS
. .
Mb0086|M.bovis_AF2122/97 RSTQAEAAREAPASMRAGMAIAAGACLVLAVAPLLVAPMVRRAAATLPAA
Rv0083|M.tuberculosis_H37Rv RSTQAEAAREAPASMRAGMAIAAGACLVLAVAPLLVAPMVRRAAATLPAA
Mflv_3578|M.gilvum_PYR-GCK -------GRDVVGRWVAIGFAVIGAAAHLSYAPLAVLLQPVEVSTATGIS
Mvan_2837|M.vanbaalenii_PYR-1 -------RRDEVARWAAIGFAVVGAGVHLSYSPPSMLLEATRISAAAGIS
MMAR_3960|M.marinum_M -------RHDRMALWAAAGFGIVGLGLYYSYAPLHALLTATVMPTSIAVS
MSMEG_3241|M.smegmatis_MC2_155 -------QRDPVGRCAAIGFALIGAMFYLDHAAPAMLVEATPLDGPTVAS
TH_4594|M.thermoresistible__bu -------RHDRTARWIALGFAVVGGLYYLGVAPPYRVLRPIAVAAPTAVA
MAB_4509c|M.abscessus_ATCC_199 Y-----QLRDRVALVLGQVFGGLGAAVYLAYVRPELLTDSASAVLYAGPL
MAV_4391|M.avium_104 --------LSPRPATAPAGGPEPGEAWVSARARRADRWLTGLLAGLSSSA
MUL_4170|M.ulcerans_Agy99 -------VIAPRIVERVGTTAVVTSGLVMVAVSVACAGGFDAGTPYWLIA
Mb0086|M.bovis_AF2122/97 QAVKFTGLGAVVRLPAMSGSIAPGVIAAAVLAAALAVAVLARWRFRRRPA
Rv0083|M.tuberculosis_H37Rv QAVKFTGLGAVVRLPAMSGSIAPGVIAAAVLAAALAVAVLARWRFRRRPA
Mflv_3578|M.gilvum_PYR-GCK TLVSSLLLATAAVTIVWMWDRT----ETALWVGAAV---VTVYAVTSCTV
Mvan_2837|M.vanbaalenii_PYR-1 TLVSAVLLAAAAVAVVWAWDHTGGATGLAIWIVPAA---VVVYAVTSFTV
MMAR_3960|M.marinum_M TLAASLLSIAFVVAMSRACAGIGGQNRDIRRILAAVGGVLVIYAVTAFTV
MSMEG_3241|M.smegmatis_MC2_155 VVIGSVMLIGAAAANGWTWSRTVSDTEVVRLVWVAVS-AVIGYAATALTV
TH_4594|M.thermoresistible__bu VLIASVLLICCVVAIVWTWRAHVPAAGPLPWLGAAT---VLLYAVTTFTV
MAB_4509c|M.abscessus_ATCC_199 LVIASVLMAATVGMVLATMARVGWASPQSAPTRAVLAGVSMLYSGTAAVV
MAV_4391|M.avium_104 TVGAAVTVLAGAPRLCCLAFGTGTGALLLLRSRGGDGTRALVFAAGGIVT
MUL_4170|M.ulcerans_Agy99 AVMAALGSGLGLTMAPASEAIMGSLSPTAAGVGSAVTGVARQLGACLGVA
.
Mb0086|M.bovis_AF2122/97 PARLPLWACGAADLTVRMQYTATSFAEPLQRVFGDVLRP-DTDIEVTHTA
Rv0083|M.tuberculosis_H37Rv PARLPLWACGAADLTVRMQYTATSFAEPLQRVFGDVLRP-DTDIEVTHTA
Mflv_3578|M.gilvum_PYR-GCK TAGMLVIGGDGGFYAGHMVATILWIAMAAVLFWYAARLP-REDRSVPLGG
Mvan_2837|M.vanbaalenii_PYR-1 TAGMLIGGGDGGFYAGHMAATICWIAMAAALFGYAARLP-REDRSMLIGG
MMAR_3960|M.marinum_M TAGVLIAGTEAGFLAGHMAATICWIAVAAALFVYALRVADRERRTAPIGA
MSMEG_3241|M.smegmatis_MC2_155 TVGVALGGAEVGFLAGHMAATLSWIVAAALAFGYAARRP-GASRSVLIGG
TH_4594|M.thermoresistible__bu TAGVLAGGVGGGFFAGHMAATICWIGLAAALLWYAARRP-RADRAMPLGG
MAB_4509c|M.abscessus_ATCC_199 LSGTALLGNNDGFLLGHGLATVSWMAVSVALLLAGLRRY--RGRSWVTRT
MAV_4391|M.avium_104 TATTFGVAAWSAPLPGPWVAATTATLVAAALYLGCAPRT--------CSP
MUL_4170|M.ulcerans_Agy99 IVGSVFASVYLRSMSSNAALHGLDPAARAAMRQSMAAAKQVLDQLPVGEA
.
Mb0086|M.bovis_AF2122/97 ESRYMAERITYRTAVADAIEQR-LYTPVVGAVAAMAELLRRAHTGSVHRY
Rv0083|M.tuberculosis_H37Rv ESRYMAERITYRTAVADAIEQR-LYTPVVGAVAAMAELLRRAHTGSVHRY
Mflv_3578|M.gilvum_PYR-GCK GLGLVAAAMAKLFLFDLGTLDG-IFRVVVFIVVGLTLLGIGAGYARLLER
Mvan_2837|M.vanbaalenii_PYR-1 GLGLVAAAMAKLFLFDLGTLDG-IFRVAVFIVVGLILLGMGAGYARLLEK
MMAR_3960|M.marinum_M GLALTGAATAKLFLFDLATLDG-IFRVAAFIVVGLVLLAMGTGYARSLAR
MSMEG_3241|M.smegmatis_MC2_155 GLVLVAAATGKLFLFDLGTLDG-MYRVVLFIVGGLVLLGMGAGYARFLAQ
TH_4594|M.thermoresistible__bu GLALVAAAVAKLFLFDLGTLDG-IFRVVVFIVVGLVLLGTGGGYARWLTH
MAB_4509c|M.abscessus_ATCC_199 GFVLAAMAVAKLFLFDLATLDG-VARIGAFIVTGLLLLGGGTLYAREYAT
MAV_4391|M.avium_104 VLSRAADLLEWLALAALVPLTC-WIAGLYGTVRGLTLG------------
MUL_4170|M.ulcerans_Agy99 PAIRHAVESAFLESFGVGCLACAVFAAVGAVVVAFLLPARGEVRDDVAVS
. * .:
Mb0086|M.bovis_AF2122/97 LAYGALGVLIVLVVARCT------
Rv0083|M.tuberculosis_H37Rv LAYGALGVLIVLVVAR--------
Mflv_3578|M.gilvum_PYR-GCK QDKQAATRTFDTT-----------
Mvan_2837|M.vanbaalenii_PYR-1 QDKKL-------------------
MMAR_3960|M.marinum_M ------------------------
MSMEG_3241|M.smegmatis_MC2_155 QSDGRSDAQPGTDHEAHST-----
TH_4594|M.thermoresistible__bu AAGESHPAGESRGTGKHQADNEPV
MAB_4509c|M.abscessus_ATCC_199 RSEEPSAERPVT------------
MAV_4391|M.avium_104 ------------------------
MUL_4170|M.ulcerans_Agy99 VAASAIGPAEGGK-----------