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TTEAPTPTTVVAPTALPASMTAAVMYAPGDIRVEQAPVPRPGPGEVLLKVAACGVCGSDIPRMLRNGGYV MPIICGHEFSGWVVELGDGVEGFDIGELVSVPPLIPCRRCDFCAKGEFGLCENYDYFGSRSDGAYAQYVV SPVGNLLKLPAGIDPRAAAMLDPAAIALHGLWKTGLRAGHRVLVIGAGPIGLFAIQWAKLHGADQVVAVD LSEEKAAMARQAGATDAVQDAEDARAIGGRGFDIVLESAGVPATADMAANLTGPHGHAVFVGIPHAPVTL EKDTFNKFMRLETSLHGSWNSFSAPFPGDEWRTAARMMAAGKLKWEFMITHELGLSELPRMMQQLGDRSI FSSKVLFVPNEV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3094 | - | - | 100% (363) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_3605 | - | 4e-45 | 32.07% (343) | sorbitol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1370 | - | 4e-39 | 31.05% (351) | 2-deoxy-scyllo-inosamine dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2283 | adhE2 | 1e-28 | 28.20% (344) | zinc-dependent alcohol dehydrogenase AdhE2 |
| M. gilvum PYR-GCK | Mflv_0638 | - | 1e-42 | 35.21% (267) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv2259 | adhE2 | 1e-28 | 28.20% (344) | zinc-dependent alcohol dehydrogenase AdhE2 |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 2e-28 | 27.91% (344) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_2084 | - | 9e-32 | 30.23% (344) | zinc-type alcohol dehydrogenase AdhD |
| M. marinum M | MMAR_0343 | - | 1e-33 | 29.53% (342) | zinc-dependent alcohol dehydrogenase |
| M. avium 104 | MAV_2804 | - | 2e-28 | 31.03% (348) | zinc-binding dehydrogenase |
| M. thermoresistible (build 8) | TH_4627 | - | 1e-30 | 28.98% (352) | PUTATIVE Alcohol dehydrogenase, zinc-binding domain protein |
| M. ulcerans Agy99 | MUL_4777 | - | 3e-33 | 29.53% (342) | zinc-dependent alcohol dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0527 | - | 1e-42 | 35.21% (267) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0343|M.marinum_M ----------------MAATMRAERFYADSKTVVLEDVPIPEPGPGEVLV
MUL_4777|M.ulcerans_Agy99 ----------------MAATMRAERFYADSKTVVLEDVPIPEPGPGEVLV
Mb2283|M.bovis_AF2122/97 ----------------MSQTVRGVIARQKGEPVELVNIVVPDPGPGEAVV
Rv2259|M.tuberculosis_H37Rv ----------------MSQTVRGVIARQKGEPVELVNIVVPDPGPGEAVV
MLBr_01784|M.leprae_Br4923 ----------------MSQTVRGVISRKKDEPVELVDIVIPDPGPGEAVV
TH_4627|M.thermoresistible__bu ----------------MSQSVRGVIARKKDEPVEVVDIVIPDPGPGEVVV
MAB_2084|M.abscessus_ATCC_1997 ------------------MKTRAAVLWGLEQKWEVEEVDLDPPGPGEVLV
Mflv_0638|M.gilvum_PYR-GCK --------------------MRAAIYHGREDVRIEELPDPS-PRAGEVVI
Mvan_0527|M.vanbaalenii_PYR-1 --------------------MRAAIYHGREDVRIEELPDPS-PRAGEVVI
MAV_2804|M.avium_104 --------------------MRTVVVDGPRSIRVDTRPDPVLPGPDGAIV
MSMEG_3094|M.smegmatis_MC2_155 MTTEAPTPTTVVAPTALPASMTAAVMYAPG-DIRVEQAPVPRPGPGEVLL
* .. .::
MMAR_0343|M.marinum_M KVAYCGICHSDLSLINGTFPTQAPVVTQGHEASGTIAKLGPEVDGWSEGD
MUL_4777|M.ulcerans_Agy99 KVAYCGICHSDLSLINGTFPTQAPVVTQGHEASGTIVKLGPEVDGWSEGD
Mb2283|M.bovis_AF2122/97 DVTACGVCHTDLTYREGGINDEYPFLLG-HEAAGIIEAVGPGVTAVEPGD
Rv2259|M.tuberculosis_H37Rv DVTACGVCHTDLTYREGGINDEYPFLLG-HEAAGIIEAVGPGVTAVEPGD
MLBr_01784|M.leprae_Br4923 DVTACGVCHTDLTYREGGINDRYPFLLG-HEAAGTVEVVGPGVTAVEPGD
TH_4627|M.thermoresistible__bu KVTACGVCHTDLHYREGGINDEFPFLLG-HEAAGTVESVGSGVTNVEPGD
MAB_2084|M.abscessus_ATCC_1997 RLAATGLCHSDEHLVTGDLPIPLPVVGG-HEGAGTVVECGEGVEDLSEGD
Mflv_0638|M.gilvum_PYR-GCK EVARAGICGTDLHEYIAGPMHAAPGVVIGHEYSGTVVGVGSGVREFTEGD
Mvan_0527|M.vanbaalenii_PYR-1 EVARAGICGTDLHEYIAGPMHAAPGVVIGHEYSGTVVGVGSGVREFTEGD
MAV_2804|M.avium_104 EVSAAGICGSDLHFYEADFPMPDP-IALGHEAIGTVVEAGPQVRNVKVGD
MSMEG_3094|M.smegmatis_MC2_155 KVAACGVCGSDIPRMLRNGGYVMPIICG-HEFSGWVVELGDGVEGFDIGE
:: *:* :* * : ** * : * * *:
MMAR_0343|M.marinum_M RVVVAAGRPCQSCPNCRRGDTVNCLR--------------------IQLM
MUL_4777|M.ulcerans_Agy99 RVVVAAGRPCQSCPNCRRGDTVNCLR--------------------IQLM
Mb2283|M.bovis_AF2122/97 FVILNWRAVCGQCRACKRGRPRYCFDTFNAEQKMTLT-------DGTELT
Rv2259|M.tuberculosis_H37Rv FVILNWRAVCGQCRACKRGRPRYCFDTFNAEQKMTLT-------DGTELT
MLBr_01784|M.leprae_Br4923 FVILNWRAVCGQCRACKRGRPSYCFDTFNAQQKMTLI-------DGTELT
TH_4627|M.thermoresistible__bu FVVLNWRAVCGQCRACKRGRPHLCFDTFNATQKMTLG-------DGTELT
MAB_2084|M.abscessus_ATCC_1997 SVILTFLPSCGRCSYCARGMGNLCELGAALMMGPQIDGTYRFHARGEDVG
Mflv_0638|M.gilvum_PYR-GCK RVCGVGVFGCGECGFCKQGAEALCG--------------------AVGFI
Mvan_0527|M.vanbaalenii_PYR-1 RVCGVGVFGCGECGFCKQGAEALCG--------------------AVGFI
MAV_2804|M.avium_104 QVMVSSVAGCGSCAGCATRDPVLCHSG------------------FQIFG
MSMEG_3094|M.smegmatis_MC2_155 LVSVPPLIPCRRCDFCAKGEFGLCEN--------------------YDYF
* * * * *
MMAR_0343|M.marinum_M AFAYDGAWAEYTVAQAA--GLTRVPDNVSLDQAAILADAVSTPFGAVVRT
MUL_4777|M.ulcerans_Agy99 AFAYDGAWAEYTVAQAA--GLTRVPDNVSLDQAAILADAVSTPFGAVVRT
Mb2283|M.bovis_AF2122/97 AALGIGAFADKTLVHSG--QCTKVDPAADPAVAGLLGCGVMAGLGAAINT
Rv2259|M.tuberculosis_H37Rv AALGIGAFADKTLVHSG--QCTKVDPAADPAVAGLLGCGVMAGLGAAINT
MLBr_01784|M.leprae_Br4923 PALGIGAFADKTLVHSG--QCTKVDPAADPAVAGLLGCGVMAGLGAAINT
TH_4627|M.thermoresistible__bu PALGIGAFAEKTLVHEG--QCTKVDPAADPAVAGLLGCGVMAGVGAAINT
MAB_2084|M.abscessus_ATCC_1997 QMCLLGTFSEYTVVPQA--SVVKIDGGIPLDRAALIGCGVTTGYGSAVRT
Mflv_0638|M.gilvum_PYR-GCK GFAVNGALARYASLPTK--ALFRIPDEISLAEAAVVEP-IASAYHAVRRS
Mvan_0527|M.vanbaalenii_PYR-1 GFAVNGALARYASLPTK--ALFRIPDEISLAEAAVVEP-IASAYHAVRRS
MAV_2804|M.avium_104 GGVLGGAQADLLAVPAADFQLLKIPEGISTEQALLLTDNLATGWAAAQRA
MSMEG_3094|M.smegmatis_MC2_155 GSRSDGAYAQYVVSPVG--NLLKLPAGIDPRAAAMLDPAAIALHGLWKTG
*: : :: * :: :
MMAR_0343|M.marinum_M GKVAVGESVGVWGVGGVGTHIVQLARLVGAVPVIALDINPVVLDRALELG
MUL_4777|M.ulcerans_Agy99 GKVAVGESVGVWGVGGVGTHIVQLARLVGAVPVIALDINPVVLDRALELG
Mb2283|M.bovis_AF2122/97 GGVTRDDTVAVIGCGGVGDAAIAGAALVGAKRIIAVDTDDTKLDWARTFG
Rv2259|M.tuberculosis_H37Rv GGVTRDDTVAVIGCGGVGDAAIAGAALVGAKRIIAVDTDDTKLDWARTFG
MLBr_01784|M.leprae_Br4923 AAVSRDDTVAVIGCGGVGDAAISGAALVGANRIIAVDIDDTKLEWARTFG
TH_4627|M.thermoresistible__bu GAVSRDDTVAVIGCGGVGDAAIAGAALVGAKKIIAVDTDAKKLDWAREFG
MAB_2084|M.abscessus_ATCC_1997 GEVRAGDTVVVVGAGGIGMNAIQGARIAGALAIVAVDPVNFKREQASGFG
Mflv_0638|M.gilvum_PYR-GCK -GLAAGGTVFIAGAGPIGLALVQFSLAQGATQVIVSEVSATRRVAAHRVG
Mvan_0527|M.vanbaalenii_PYR-1 -GLAAGGTVFIAGAGPIGLALVQFSLAQGATQVIVSEVSATRRVAAHRVG
MAV_2804|M.avium_104 -DIPFGGTVAVIGLGAVGLCALRSALFQGAATVFAVDQVDGRLARAARWG
MSMEG_3094|M.smegmatis_MC2_155 --LRAGHRVLVIGAGPIGLFAIQWAKLHGADQVVAVDLSEEKAAMARQAG
: . * : * * :* : : ** :.. : * *
MMAR_0343|M.marinum_M ADYAFDSRDDQLHDKLAEITGGRMLDVAFDAVGLKA--TFEQALGSLTAG
MUL_4777|M.ulcerans_Agy99 ADYAFDSRDDQLHDKLAEITGGRMLDVAFDAVGLKA--TFEQALGSLTAG
Mb2283|M.bovis_AF2122/97 ATHTVNAREVDVVQAIGGLTDGFGADVVIDAVGRPE--TYQQAFYARDLA
Rv2259|M.tuberculosis_H37Rv ATHTVNAREVDVVQAIGGLTDGFGADVVIDAVGRPE--TYQQAFYARDLA
MLBr_01784|M.leprae_Br4923 ATHTVNALELEVVKTIQDLTSGFGVDVVIDTVGRPE--TWKQAFYARDLA
TH_4627|M.thermoresistible__bu ATHTIDASSTDVVEAIQELTDGFGADVVVDAVGRPE--TWEQAFYARDLA
MAB_2084|M.abscessus_ATCC_1997 ATHTA-ASMDEAWSLVSDMTRGKLADVCILTTDVAEGSYTAEALALVGKR
Mflv_0638|M.gilvum_PYR-GCK ATRVIDPLAEDAVEVVRTLTNGNGVDISFDAAGVQP--ALDAALGVLRPR
Mvan_0527|M.vanbaalenii_PYR-1 ATRVIDPLAEDAVEVVRMLTNGNGVDISFDAAGVQP--ALDAALGVLRPR
MAV_2804|M.avium_104 AT----PLKAPALEAILAATGGRGADAVIDAVATDA--SLTEALNAVRPG
MSMEG_3094|M.smegmatis_MC2_155 ATDAVQDAED------ARAIGGRGFDIVLESAGVPA--TADMAANLTGPH
* * * . :. *
MMAR_0343|M.marinum_M GRLVGVGMSAESPT-VGPTSMFGLTHKQVLGHLG--YQN----VDIETLA
MUL_4777|M.ulcerans_Agy99 GRLVGVGTSAESPT-VGPTSMFGLTHKQVLGHLG--YQN----VDIETLA
Mb2283|M.bovis_AF2122/97 GTVVLVGVPTPDMR-LDMPLVDFFSHGGALKSSW--YGDCLPESDFPTLI
Rv2259|M.tuberculosis_H37Rv GTVVLVGVPTPDMR-LDMPLVDFFSHGGALKSSW--YGDCLPESDFPTLI
MLBr_01784|M.leprae_Br4923 GTVVLVGVPTPDMR-LDMPLLDFFSHGGSLKSSW--YGDCLPERDFPTLV
TH_4627|M.thermoresistible__bu GTVVLVGVPTPDMR-IDMPLIDFFSRGGSLKSSW--YGDCLPERDFPTLI
MAB_2084|M.abscessus_ATCC_1997 GRVVVTAIGHPDESSISGSLLEMTLYEKQIRGAL--YGSSNAPHDIPRLV
Mflv_0638|M.gilvum_PYR-GCK GRLMVVAIWEA-PAGIDINRSVMR----EANIGF--SFCYEAQRQVPAIL
Mvan_0527|M.vanbaalenii_PYR-1 GRLMVVAIWEA-PAGIDINRSVMR----EANIGF--SFCYEAQRQVPAIL
MAV_2804|M.avium_104 GTVSVVGVHDMNPFPLNALGCLIR----SITLRM--TTA-PVQRTWPELI
MSMEG_3094|M.smegmatis_MC2_155 GHAVFVGIPHAPVTLEKDTFNKFMRLETSLHGSWNSFSAPFPGDEWRTAA
* ..
MMAR_0343|M.marinum_M KLVSLGRLDLSRSISEIVPLEDLPLG-IEKLERQDGNPIRILVQP---
MUL_4777|M.ulcerans_Agy99 KLVSLGRLDLSRSISEIVPLEDLSLG-IEKLERQDGNPIRILVQP---
Mb2283|M.bovis_AF2122/97 DLYLQGRLPLQRFVSERIGLEDVEEA-FHKMHG--GKVLRSVVML---
Rv2259|M.tuberculosis_H37Rv DLYLQGRLPLQRFVSERIGLEDVEEA-FHKMHG--GKVLRSVVML---
MLBr_01784|M.leprae_Br4923 DLYLQGRLPLGKFVSERIGLGDVEEA-FHKIHG--GKVLRSVVML---
TH_4627|M.thermoresistible__bu NLYLQGRLPLEKFVTERIALDEVEGA-FEKMQR--GEVLRSVVVLK--
MAB_2084|M.abscessus_ATCC_1997 ELYSAGLLKLDELVTREYSLDQINEG-YQDMRS--GRNIRGLVRF---
Mflv_0638|M.gilvum_PYR-GCK DLLATGAINLGELITDEIPLDAVVSQGLEELRVNRDAHVKILIDPSA-
Mvan_0527|M.vanbaalenii_PYR-1 DLLATGAINLGELITDEIPLDAVVSQGLEELRVNRDAHVKILIDPSA-
MAV_2804|M.avium_104 PLLQSGRLDVDGIFTTTMPLDEAAIG-YATAGSRSGDDVKILLKP---
MSMEG_3094|M.smegmatis_MC2_155 RMMAAGKLKWEFMITHELGLSELPRM-MQQLGDRSIFSSKVLFVPNEV
: * : .: * : :.