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MKAVLYEAPKTWSVTDVPTPQPGKGEVRIRVAQVGVCGTDLHIHDGEFGAVFPLIPGHELVGVVDAVGEG VTRFGIGEQVTVNPNVYCGQCPYCLAGRLGQCAAMLGYGSNFPGFFAEYAIADHTLVFSTEGLPLDTAVF SEPTACAMHGLESLQMRPGGSALVLGAGPTGLLLAQLIAAGGASSVTVAGPTQAKLDTASALGIDRTVRI SRDDPEGNIAALMAASPHGDGYDAVVEATGSPAVGDICVPLARRGGTVLIYGVTREDDLVRFHPFDVFRR EITIKGSFAEMTSFGAAIDALRGGRVRTDGIITHRFALDDYGRALEALRSDPAVHKVVIVP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1370 | - | - | 100% (341) | 2-deoxy-scyllo-inosamine dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3094 | - | 3e-39 | 31.05% (351) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_3605 | - | 1e-37 | 31.70% (347) | sorbitol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3113 | adhD | 6e-31 | 29.03% (372) | zinc-type alcohol dehydrogenase AdhD |
| M. gilvum PYR-GCK | Mflv_0125 | - | 6e-34 | 32.12% (358) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv3086 | adhD | 6e-31 | 29.03% (372) | zinc-type alcohol dehydrogenase AdhD |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 4e-24 | 25.79% (349) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_0983c | - | 6e-30 | 29.79% (376) | zinc-containing alcohol dehydrogenase |
| M. marinum M | MMAR_0127 | adhD_1 | 1e-30 | 29.76% (373) | zinc-containing alcohol dehydrogenase NAD- dependent, |
| M. avium 104 | MAV_4173 | - | 5e-29 | 29.59% (338) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. thermoresistible (build 8) | TH_4627 | - | 6e-31 | 28.37% (349) | PUTATIVE Alcohol dehydrogenase, zinc-binding domain protein |
| M. ulcerans Agy99 | MUL_1292 | adhE2 | 3e-27 | 27.79% (349) | zinc-dependent alcohol dehydrogenase AdhE2 |
| M. vanbaalenii PYR-1 | Mvan_0788 | - | 2e-35 | 32.12% (358) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3113|M.bovis_AF2122/97 -MKTTAAVLFEA--------GKPFELMELDLDGPGPGEVLVKYTAAGLCH
Rv3086|M.tuberculosis_H37Rv -MKTTAAVLFEA--------GKPFELMELDLDGPGPGEVLVKYTAAGLCH
MMAR_0127|M.marinum_M -MKTTAAVLLEA--------GKPFEIMELELDGPRVGEVLIKYTAAGLCH
MAB_0983c|M.abscessus_ATCC_199 -MRIRSAVLHAAPIERPYRDTHPLKVIELELDPPGPGEVLVRIEAAGLCH
MLBr_01784|M.leprae_Br4923 MSQTVRGVISRK-------KDEPVELVDIVIPDPGPGEAVVDVTACGVCH
MUL_1292|M.ulcerans_Agy99 MSQTVRGVISRK-------KGEPVELVDIVVPDPGPGEAVVDISACGVCH
TH_4627|M.thermoresistible__bu MSQSVRGVIARK-------KDEPVEVVDIVIPDPGPGEVVVKVTACGVCH
Mflv_0125|M.gilvum_PYR-GCK ---MRAAVYYGP---------NKLEVDDVPEPEARPGTVKLKVGFNGICG
Mvan_0788|M.vanbaalenii_PYR-1 ---MRAAVYYGP---------NKLEVDDVAEPEPGPGTVKLKVGFNGICG
MSMEG_1370|M.smegmatis_MC2_155 ----MKAVLYEAP--------KTWSVTDVPTPQPGKGEVRIRVAQVGVCG
MAV_4173|M.avium_104 -------MVTSP---------DRAEVIDVERPGVGPRDVLVRMRACGICG
: . .: :: . : *:*
Mb3113|M.bovis_AF2122/97 SDLHLTDGD-----------LPPRFPIVGGHEGSGVIEEVGAGVTRVKPG
Rv3086|M.tuberculosis_H37Rv SDLHLTDGD-----------LPPRFPIVGGHEGSGVIEEVGAGVTRVKPG
MMAR_0127|M.marinum_M SDLHLTDGD-----------LPPRYPIVGGHEGSGVIEEVGPGVSKVKPG
MAB_0983c|M.abscessus_ATCC_199 SDLSVVDGN-----------RIRPVPMALGHEAAGVIAAVGPGVRDVSPG
MLBr_01784|M.leprae_Br4923 TDLTYREGG-----------INDRYPFLLGHEAAGTVEVVGPGVTAVEPG
MUL_1292|M.ulcerans_Agy99 TDLTYREGG-----------INDEYPFLLGHEAAGTVEAVGPGVTNVEPG
TH_4627|M.thermoresistible__bu TDLHYREGG-----------INDEFPFLLGHEAAGTVESVGSGVTNVEPG
Mflv_0125|M.gilvum_PYR-GCK TDLHEYYAGPIFVPTAPHPLTGAQLPLTMGHEFSGTITAVGDGVTGWQEG
Mvan_0788|M.vanbaalenii_PYR-1 TDLHEYYAGPIFVPTEPHPLTGQQLPLTMGHEFSGTIAAVGDGVTGWSEG
MSMEG_1370|M.smegmatis_MC2_155 TDLHIHDGE-----------FGAVFPLIPGHELVGVVDAVGEGVTRFGIG
MAV_4173|M.avium_104 SDAFYISIGG---------VPPRQGHTPLGHEPAGEVVEVGAEVTGLAVG
:* *** * : ** * *
Mb3113|M.bovis_AF2122/97 DHVVCSFIPNCGTCRYCCTGRQNLC-DMGATILEGCMPDGSFRFHS-QGT
Rv3086|M.tuberculosis_H37Rv DHVVCSFIPNCGTCRYCCTGRQNLC-DMGATILEGCMPDGSFRFHS-QGT
MMAR_0127|M.marinum_M DHVVCSFIPNCGTCRYCSTGRQNLC-DMGATILEGCMSDGSFRFHR-KGV
MAB_0983c|M.abscessus_ATCC_199 DHVVLVYVPSCGACRYCSSGRPALCPDAAAANGRGDLIRGGTRLHDLDGT
MLBr_01784|M.leprae_Br4923 DFVILNWRAVCGQCRACKRGRPSYCFDTFNAQQKMTLIDG---------T
MUL_1292|M.ulcerans_Agy99 DFVILNWRAVCGQCRACKRGRPSYCFDTFNAEQKMTLTDG---------T
TH_4627|M.thermoresistible__bu DFVVLNWRAVCGQCRACKRGRPHLCFDTFNATQKMTLGDG---------T
Mflv_0125|M.gilvum_PYR-GCK DRVAVEPIYKCDQCGPCRAGNYNVCQQIGFHG------------------
Mvan_0788|M.vanbaalenii_PYR-1 DRVAVEPIYKCGHCGPCRAGNYNVCQQIGFHG------------------
MSMEG_1370|M.smegmatis_MC2_155 EQVTVNPNVYCGQCPYCLAGRLGQCAAMLGYG------------------
MAV_4173|M.avium_104 DHVVINPMAAPSGIIGNGGASGALADYLLIEN------------------
: * . . .
Mb3113|M.bovis_AF2122/97 DFGAMCMLGTFAERATVSQHSVVKVDDWLPLETAVLVGCGVPSGWGTAVN
Rv3086|M.tuberculosis_H37Rv DFGAMCMLGTFAERATVSQHSVVKVDDWLPLETAVLVGCGVPSGWGTAVN
MMAR_0127|M.marinum_M DFGAMCMLGTFSERATISQHSVVKIDDWLPLTTAVLVGCGVPTGWGTSVY
MAB_0983c|M.abscessus_ATCC_199 EVRHHLGVSGFADHAVVDRNSVVVIDENVPLDTAALFGCAMLTGFGAVTH
MLBr_01784|M.leprae_Br4923 ELTPALGIGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAIN
MUL_1292|M.ulcerans_Agy99 ELTPALGIGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAVN
TH_4627|M.thermoresistible__bu ELTPALGIGAFAEKTLVHEGQCTKVDPAADPAVAGLLGCGVMAGVGAAIN
Mflv_0125|M.gilvum_PYR-GCK ----LMSDGGMAEYTVVPTGMLHRLPDTVSLELGALVEP--MSVAYHAAT
Mvan_0788|M.vanbaalenii_PYR-1 ----LMSDGGMAEYTVVPTSMLHKLPDNVSLELGALVEP--MSVAYHAAT
MSMEG_1370|M.smegmatis_MC2_155 -----SNFPGFFAEYAIADHTLVFSTEGLPLDTAVFSEP--TACAMHGLE
MAV_4173|M.avium_104 ---------------AVRGTSLEVIPDHIPWEVAALNEP--MAVARHGVN
: . : :
Mb3113|M.bovis_AF2122/97 AGNLRAGDTAVIYGVGGLGINAVQGATAAGCKYVVVVDPVAFKRETALKF
Rv3086|M.tuberculosis_H37Rv AGNLRAGDTAVIYGVGGLGINAVQGATAAGCKYVVVVDPVAFKRETALKF
MMAR_0127|M.marinum_M AGGVRPGDTTVIYGAGGLGINAVQGAVSAGAKHVVVVDPVAFKRDTALKF
MAB_0983c|M.abscessus_ATCC_199 TASVRPGDSVAVLGLGGVGLAVVMSAAAAGAGEVLAIDPVPAKRELALEL
MLBr_01784|M.leprae_Br4923 TAAVSRDDTVAVIGCGGVGDAAISGAALVGANRIIAVDIDDTKLEWARTF
MUL_1292|M.ulcerans_Agy99 TGGVTRDDTVAVIGCGGVGDAAIAGAALVGAKKIIAVDTDNTKLEWARAF
TH_4627|M.thermoresistible__bu TGAVSRDDTVAVIGCGGVGDAAIAGAALVGAKKIIAVDTDAKKLDWAREF
Mflv_0125|M.gilvum_PYR-GCK LGEVSAGDTAMVFGAGPIGIGLWFALRGKGLDDVFVVEPSPTRRTAIEAL
Mvan_0788|M.vanbaalenii_PYR-1 LGDVSPGDTAMVFGAGPIGIGLWFALRGKGLDDVFVVEPSPTRRAAIEVL
MSMEG_1370|M.smegmatis_MC2_155 SLQMRPGGSALVLGAGPTGLLLAQLIAAGGASSVTVAGPTQAKLDTASAL
MAV_4173|M.avium_104 RCQPRPTDKVVVFGAGPIGLGATLAFKSLGVQHIVVIDLIPGRLDKAVRI
... : * * * * : . : :
Mb3113|M.bovis_AF2122/97 GATHAF-----ADAASAAAKVDELTW--------GQGADAALILVGTVDD
Rv3086|M.tuberculosis_H37Rv GATHAF-----ADAASAAAKVDELTW--------GQGADAALILVGTVDD
MMAR_0127|M.marinum_M GATHAF-----PDAASAAAKVNEITW--------GQGADQALILVGTVDT
MAB_0983c|M.abscessus_ATCC_199 GATSAC-----APDEAPG------------------GHDWVFEVVG--SA
MLBr_01784|M.leprae_Br4923 GATHTVN----ALELEVVKTIQDLTS--------GFGVDVVIDTVG--RP
MUL_1292|M.ulcerans_Agy99 GATHTVN----ARELDVVETIQDLTG--------GFGVDVVIDAVG--RP
TH_4627|M.thermoresistible__bu GATHTID----ASSTDVVEAIQELTD--------GFGADVVVDAVG--RP
Mflv_0125|M.gilvum_PYR-GCK GARTLD-----PTADDVPAFIADHTG--------GDGADAVFDAAG--VT
Mvan_0788|M.vanbaalenii_PYR-1 GARTLD-----PTSADVPAFIADHTR--------GDGADAVFDAAG--VT
MSMEG_1370|M.smegmatis_MC2_155 GIDRTVRISRDDPEGNIAALMAASPH--------GDGYDAVVEATG--SP
MAV_4173|M.avium_104 GADAVVN----SAEEDVAARLVELHGPGESMFPGKAGTDIYLDAAG--AP
* * * . .*
Mb3113|M.bovis_AF2122/97 EVVSAATAVIGKGGTVVITGLADPAKLTVHVSGTDLTLHEKTIKGSLFGS
Rv3086|M.tuberculosis_H37Rv EVVSAATAVIGKGGTVVITGLADPAKLTVHVSGTDLTLHEKTIKGSLFGS
MMAR_0127|M.marinum_M EVVSAAAAVIGKGGTVVITGLANPEKLTVQLSGLDLTLNEKTIKGTLFGS
MAB_0983c|M.abscessus_ATCC_199 AVLEQAYALTGRGGGTVSVGLPHP-DARISLPALNIVAEGRSILGSYMGS
MLBr_01784|M.leprae_Br4923 ETWKQAFYARDLAGTVVLVGVPTP-DMRLDMPLLDFFSHGGSLKSSWYGD
MUL_1292|M.ulcerans_Agy99 ETWKQAFYARDLAGTVVLVGVPTP-DMRLDMPLVDFFSRGGALKSSWYGD
TH_4627|M.thermoresistible__bu ETWEQAFYARDLAGTVVLVGVPTP-DMRIDMPLIDFFSRGGSLKSSWYGD
Mflv_0125|M.gilvum_PYR-GCK PAVATALGCVGSRKPMISVAIYEK---PLETPLLNLVMNESRIQG---SL
Mvan_0788|M.vanbaalenii_PYR-1 PAVSTALACVGSRKPMISVAIYEK---PLETPLLNLVMNESRIQG---SL
MSMEG_1370|M.smegmatis_MC2_155 AVGDICVPLARRGGTVLIYGVTRE-DDLVRFHPFDVFRREITIKG----S
MAV_4173|M.avium_104 AVVSTALAAAKKGATLGIVGVHKE---PVPVDLINVMSNEITIVG----S
. . .: : :. . : .
Mb3113|M.bovis_AF2122/97 CNPQYDIVRLLRLYDAGQLMLDELVTTTYNLEQVNQGYQDLRDGKNIRGV
Rv3086|M.tuberculosis_H37Rv CNPQYDIVRLLRLYDAGQLMLDELVTTTYNLEQVNQGYQDLRDGKNIRGV
MMAR_0127|M.marinum_M ANPQYDIVRLLRLYDAGQLKLDELITTQYRLEDVNQGYQDLRDGKNIRGV
MAB_0983c|M.abscessus_ATCC_199 AQPQQDIPAMLALWRAGRLPVEKLKSDDLPLSDINIALDALAEGQAVRQI
MLBr_01784|M.leprae_Br4923 CLPERDFPTLVDLYLQGRLPLGKFVSERIGLGDVEEAFHKIHGGKVLRSV
MUL_1292|M.ulcerans_Agy99 CLPERDFPTLIDLYLQGRLPLDKFVSEQIGLGGIEEAFEKMHAGKVLRSV
TH_4627|M.thermoresistible__bu CLPERDFPTLINLYLQGRLPLEKFVTERIALDEVEGAFEKMQRGEVLRSV
Mflv_0125|M.gilvum_PYR-GCK CYTGADFESVIALMADGRYDTTGWVTRIPIDDVVDEGFEALHAGTKMKVL
Mvan_0788|M.vanbaalenii_PYR-1 CYTGADFEAVIALMGQGKYDTTGWVTRIPIDDVVDEGFEALHAGTKMKVL
MSMEG_1370|M.smegmatis_MC2_155 FAEMTSFGAAIDALRGGRVRTDGIITHRFALDDYGRALEALRSDPAVHKV
MAV_4173|M.avium_104 MGYPDEIFEVTGDLVRNWEKYALIVSHTIPFDRVGEALELARTPGAADKV
.: . : . . :
Mb3113|M.bovis_AF2122/97 IVH----
Rv3086|M.tuberculosis_H37Rv IVH----
MMAR_0127|M.marinum_M IVHD---
MAB_0983c|M.abscessus_ATCC_199 LRPGVSA
MLBr_01784|M.leprae_Br4923 VML----
MUL_1292|M.ulcerans_Agy99 VVL----
TH_4627|M.thermoresistible__bu VVLK---
Mflv_0125|M.gilvum_PYR-GCK VDPNGAQ
Mvan_0788|M.vanbaalenii_PYR-1 VDPNGA-
MSMEG_1370|M.smegmatis_MC2_155 VIVP---
MAV_4173|M.avium_104 VVTFC--
: