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NAVAADARGTMRASVLTSVGTVVVEDRPVPTPGPHEVLVEVAAVGVCGSDVHYYRHGRIGDFVVNEPMIL GHELSGRIAAVGEGVDPARVGQRVAVEPQHPCRRCKQCKAGRYNLCPEIKFYATPPIDGAFCRYVTIDDD MAHAVPDSISDDAAALLEPLSVAIATMRKAGVVPGSSILIAGAGPIGVICAQTARAFGAARIVVTDLVAE RRERVLRFGATEVLDPAVDDVAALDPKVDAFVDASGAAPAVVSGIKAVGPAGNVVLVGMGADDVTLPVGY IQNMEINVTGVFRYTDTWPAAIHLVSSGAVDLDALVTGRYDLDHVAEALDSDSDPASLKSIVVPE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3605 | - | - | 100% (346) | sorbitol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3603 | - | 5e-51 | 35.07% (345) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_3094 | - | 4e-45 | 32.07% (343) | oxidoreductase, zinc-binding dehydrogenase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1557 | adh | 6e-27 | 31.47% (340) | alcohol dehydrogenase adh |
| M. gilvum PYR-GCK | Mflv_0660 | - | 2e-43 | 34.46% (325) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv1895 | - | 5e-34 | 31.42% (331) | dehydrogenase |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 5e-23 | 28.00% (350) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_0526c | - | 3e-28 | 26.72% (363) | hypothetical protein MAB_0526c |
| M. marinum M | MMAR_2790 | - | 7e-34 | 29.79% (329) | dehydrogenase |
| M. avium 104 | MAV_2804 | - | 3e-33 | 30.49% (328) | zinc-binding dehydrogenase |
| M. thermoresistible (build 8) | TH_4631 | - | 7e-78 | 61.18% (237) | PUTATIVE Alcohol dehydrogenase GroES domain protein |
| M. ulcerans Agy99 | MUL_2962 | - | 5e-33 | 29.48% (329) | dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0490 | - | 1e-43 | 34.77% (325) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2790|M.marinum_M -----------MRTVVIDGPGSIRVDNRPDPALPGSDGVIVAVSAAGICG
MUL_2962|M.ulcerans_Agy99 -----------MRTVVIDGPGSIRVDNRPDPALPGSDGVIVVVSAAGICG
Rv1895|M.tuberculosis_H37Rv -----------MRAVVIDGAGSVRVNTQPDPALPGPDGVVVAVTAAGICG
MAV_2804|M.avium_104 -----------MRTVVVDGPRSIRVDTRPDPVLPGPDGAIVEVSAAGICG
MSMEG_3605|M.smegmatis_MC2_155 MNAVAADARGTMRASVLTSVGTVVVEDRPVPTP-GPHEVLVEVAAVGVCG
TH_4631|M.thermoresistible__bu --------------------------------------------------
Mflv_0660|M.gilvum_PYR-GCK -----------MEAIVLNGTNDVGLTSVPDPAP-QDGEVIIEVAATGLCG
Mvan_0490|M.vanbaalenii_PYR-1 -----------MEAIVLNGTNDVGLTSVPDPAP-QDGEVIIEVAATGLCG
Mb1557|M.bovis_AF2122/97 -----MSDGAVVRALVLEAPRRLVVRQYR-LPRIGDDDALVRVEACGLCG
MLBr_01784|M.leprae_Br4923 -------MSQTVRGVISRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCH
MAB_0526c|M.abscessus_ATCC_199 -----------MRASVLRN-GSMVYRDDVPSPTPGEGQVLVKVSACGICG
MMAR_2790|M.marinum_M SDLHFYEGEYP----LAEPVALGHEAVGTVVEKGPDVHT---VEVGDQVM
MUL_2962|M.ulcerans_Agy99 SDLHFYEGEYP----LAEPVALGHEAVGTVVEKGPDVHT---VEVGDQVM
Rv1895|M.tuberculosis_H37Rv SDLHFYEGEYP----FTEPVALGHEAVGTIVEAGPQVRT---VGVGDLVM
MAV_2804|M.avium_104 SDLHFYEADFP----MPDPIALGHEAIGTVVEAGPQVRN---VKVGDQVM
MSMEG_3605|M.smegmatis_MC2_155 SDVHYYRHGRIGDFVVNEPMILGHELSGRIAAVGEGVDP---ARVGQRVA
TH_4631|M.thermoresistible__bu ------------------------------------VNG---XXX-----
Mflv_0660|M.gilvum_PYR-GCK TDLHEYVAG---PTFSQPPVVLGHEVSGRIVEVGAGVDQ---SRIGEGAA
Mvan_0490|M.vanbaalenii_PYR-1 TDLHEYVAG---PTFSQPPVVLGHEVSGRIVEVGAGVDQ---SRIGQGAA
Mb1557|M.bovis_AF2122/97 TDHEQYTGELAG----GFAFVPGHETVGTIAAIGPRAEQRWGVSAGDRVA
MLBr_01784|M.leprae_Br4923 TDLTYREGGIN----DRYPFLLGHEAAGTVEVVGPGVTA---VEPGDFVI
MAB_0526c|M.abscessus_ATCC_199 SDLHFAKHGAR-------AIELSKQMVG-MPSLTDGVDLSTDVFMGHEFA
.
MMAR_2790|M.marinum_M VSSVAGCGACAGCATRDPAMCVSG------PQIFGSGALG------GAQA
MUL_2962|M.ulcerans_Agy99 VSSVAGCGACAGCATRDPAMCVSG------PQIFGSGALG------GAQA
Rv1895|M.tuberculosis_H37Rv VSSVAGCGVCPGCETHDPVMCFSG------PMIFGAGVLG------GAQA
MAV_2804|M.avium_104 VSSVAGCGSCAGCATRDPVLCHSG------FQIFGGGVLG------GAQA
MSMEG_3605|M.smegmatis_MC2_155 VEPQHPCRRCKQCKAGRYNLCPE-------IKFYATPPID------GAFC
TH_4631|M.thermoresistible__bu ----------EETRRGRYNLCPH-------MRFYGTPPVD------GALC
Mflv_0660|M.gilvum_PYR-GCK VIPMDFCGSCHYCHRSLYHLCQR-------PGWIG-FTRN------GGLA
Mvan_0490|M.vanbaalenii_PYR-1 VIPMDFCGSCHYCHRSLYHLCQR-------PGWIG-FTRN------GGLA
Mb1557|M.bovis_AF2122/97 VEVFQSCRQCANCRGGEYRRCVRHG----LADMYGFIPVDREPGLWGGYA
MLBr_01784|M.leprae_Br4923 LNWRAVCGQCRACKRGRPSYCFDTFNAQQKMTLIDGTELTPALG-IGAFA
MAB_0526c|M.abscessus_ATCC_199 AEVIEAGPRTQAPASGTAVTSIPIL-----LSAKGLEPIVYSNTTLGGYA
. *. .
MMAR_2790|M.marinum_M DLLAVPAADFQVLKIPAAITTEQALLLTDNLATGW-AAARRADILFGATV
MUL_2962|M.ulcerans_Agy99 DLLAVPATDFQVLKIPAAITTEQALLLTDNLATGW-AAARRADIPFGATV
Rv1895|M.tuberculosis_H37Rv DLLAVPAADFQVLKIPEGITTEQALLLTDNLATGW-AAAQRADISFGSAV
MAV_2804|M.avium_104 DLLAVPAADFQLLKIPEGISTEQALLLTDNLATGW-AAAQRADIPFGGTV
MSMEG_3605|M.smegmatis_MC2_155 RYVTIDDD--MAHAVPDSISDDAAALLEP-LSVAI-ATMRKAGVVPGSSI
TH_4631|M.thermoresistible__bu EYVTIGAA--FAHPVPAEMTDNAAALCEP-LSVAI-ATVDKAAVAGGSRV
Mflv_0660|M.gilvum_PYR-GCK NYVAVPSR--LAVRVPDVVDLEEAALTEP-TAVAF-HAVRRAELLLGETV
Mvan_0490|M.vanbaalenii_PYR-1 NYVAVPSR--LAVRVPDVVDLEEAALTEP-TAVAF-HAVRRAELLLGETV
Mb1557|M.bovis_AF2122/97 EYQYLAPDS-MVLRVAGDLSPEVATLFNPLGAGIR-WGVTIPETKPGDVV
MLBr_01784|M.leprae_Br4923 DKTLVHSG--QCTKVDPAADPAVAGLLGCGVMAGLGAAINTAAVSRDDTV
MAB_0526c|M.abscessus_ATCC_199 EQMLLSAP--LLLPIPNGLDPRHAALTEP-MAVGL-HAVNKSAIQPGTGA
: : * * . .
MMAR_2790|M.marinum_M AVIGLGAVGLCAVRSALAQGAATVFAVDR---VQGRLQRASEWGATAVAS
MUL_2962|M.ulcerans_Agy99 AVIGLGAVGLCAVRSALAQGAATVFAVDR---VQGRLQRAAEWGATAVAS
Rv1895|M.tuberculosis_H37Rv AVIGLGAVGLCALRSAFIHGAATVFAVDR---VKGRLQRAATWGATPIPS
MAV_2804|M.avium_104 AVIGLGAVGLCALRSALFQGAATVFAVDQ---VDGRLARAARWGATPLKA
MSMEG_3605|M.smegmatis_MC2_155 LIAGAGPIGVICAQTARAFGAARIVVTDL---VAERRERVLRFGATEVLD
TH_4631|M.thermoresistible__bu LIAGAGPIGLMTAQVARAYGATDIVVTDL---DPHRRRLAHRFGATTTLD
Mflv_0660|M.gilvum_PYR-GCK MVLGAGALGLTVIQCARAAGAARIFVTEP---SGVRASLARDLGATLVLD
Mvan_0490|M.vanbaalenii_PYR-1 MVLGAGALGLTVIQCARAAGAARIFVTEP---SGVRASLARDLGATLVLD
Mb1557|M.bovis_AF2122/97 AVLGPGIRGLCAAAAAKGAGAGFVMVTGLGPRDADRLALAAQFGADLAVD
MLBr_01784|M.leprae_Br4923 AVIGCGGVGDAAISGAALVGANRIIAVDI---DDTKLEWARTFGATHTVN
MAB_0526c|M.abscessus_ATCC_199 IVIGCGPVGIAVIAALHNLGIEPIVASDY---SSARRDLAQRMGAHQVVD
: * * * * :.. : . **
MMAR_2790|M.marinum_M PAAEAIVAATGGR----GADSVIDAVG-TDASMTDALNAVRAGGTVSVVG
MUL_2962|M.ulcerans_Agy99 PAAEAIVAATSGR----GADSVIDAVD-TDASMTDALNAVRAGGTVSVVG
Rv1895|M.tuberculosis_H37Rv PAAETILAATRGR----GADSVIDAVG-TDASMSDALNAVRPGGTVSVVG
MAV_2804|M.avium_104 PALEAILAATGGR----GADAVIDAVA-TDASLTEALNAVRPGGTVSVVG
MSMEG_3605|M.smegmatis_MC2_155 PAVDDVAALDPK------VDAFVDASG-AAPAVVSGIKAVGPAGNVVLVG
TH_4631|M.thermoresistible__bu PQTDDVTGLR--------VDAFIDASG-APAAVMSGLAAVRPAGRAVLVG
Mflv_0660|M.gilvum_PYR-GCK PHDPGTTACILEETRGVGVDVVFHVAG-SAEAFTQGLDCLRKQGRFMEMS
Mvan_0490|M.vanbaalenii_PYR-1 PHDPGTTACILEETRGVGVDVVFHVAG-SAEAFTQGLDCLRKQGRFMEMS
Mb1557|M.bovis_AF2122/97 VAIDDPVAALTEQTGG-LADVVVDVTAKAPAAFAQAIALARPAGTVVVAG
MLBr_01784|M.leprae_Br4923 ALELEVVKTIQDLTSGFGVDVVIDTVG-RPETWKQAFYARDLAGTVVLVG
MAB_0526c|M.abscessus_ATCC_199 PKIEPTFHAWSRIG--AGAPVIFEAVG-VPGILNEVLRDAPRSARVVVVG
. .... . : . .
MMAR_2790|M.marinum_M VHDLQPFP--LPALTCLLR--SITLRLTIAP-VQRTWSELIPLLESGRLD
MUL_2962|M.ulcerans_Agy99 VHDLQPFP--LPALTCLLR--SITLRLTIAP-VQRTWSELIPLLESGRLD
Rv1895|M.tuberculosis_H37Rv VHDLQPFP--VPALTCLLR--SITLRMTMAP-VQRTWPELIPLLQSGRLD
MAV_2804|M.avium_104 VHDMNPFP--LNALGCLIR--SITLRMTTAP-VQRTWPELIPLLQSGRLD
MSMEG_3605|M.smegmatis_MC2_155 MG-ADDVT--LPVGYIQNM--EINVTGVFRY--TDTWPAAIHLVSSGAVD
TH_4631|M.thermoresistible__bu MG-AETME--LPVQTIQNR--ELILTGVFRY--ANTWPAAIALIRTGRVD
Mflv_0660|M.gilvum_PYR-GCK SW-AGAAS--LDVNRHLLK--EIQLRMVFGYDMFDDFPAVLALIADGKLA
Mvan_0490|M.vanbaalenii_PYR-1 SW-AGAAS--LDVNRHLLK--EIQLRMVFGYDMFDDFPAVLALIADGKLA
Mb1557|M.bovis_AF2122/97 TRGVGSGAPGFSPDVVVFK--ELRVLGALGV-DATAYRAALDLLVSGRYP
MLBr_01784|M.leprae_Br4923 VP-TPDMRLDMPLLDFFSHGGSLKSSWYGDCLPERDFPTLVDLYLQGRLP
MAB_0526c|M.abscessus_ATCC_199 VCMEPDAI---TPYFGIAK--EVAVQFVLAY-EPAEFSETLRRIAHGEID
.: : : *
MMAR_2790|M.marinum_M VDGIFTTSLPLDEAAKGYSIAGSRSGNDVKVLLKV---------------
MUL_2962|M.ulcerans_Agy99 VDGIFTTSLPLDEAAKGYSIAGSRSGNDVKVLLKV---------------
Rv1895|M.tuberculosis_H37Rv VDGIFTTTLPLDEAAKGYATARARSGEELRFCLRPDSRDVLGAHETVDLY
MAV_2804|M.avium_104 VDGIFTTTMPLDEAAIGYATAGSRSGDDVKILLKP---------------
MSMEG_3605|M.smegmatis_MC2_155 LDALVTGRYDLDHVAEALDSDSDPASLKSIVVPE----------------
TH_4631|M.thermoresistible__bu VDALITGRYPLEKTAEALESDRIPGNIKSVVEVGTS--------------
Mflv_0660|M.gilvum_PYR-GCK LAPQITARVPLDRAVKEGLGGLLEGREGLVKVLVKP--------------
Mvan_0490|M.vanbaalenii_PYR-1 LAPQITARVPLDRAVKEGLGGLLEGREGLVKVLVKP--------------
Mb1557|M.bovis_AF2122/97 FASLPRRCVRLEGAEDLLATMAGERDGVPPIHGVLTP-------------
MLBr_01784|M.leprae_Br4923 LGKFVSERIGLGDVEEAFHKIHGGKVLRSVVML-----------------
MAB_0526c|M.abscessus_ATCC_199 VAPLVTGEVGLEDVGSAFADLGDPERHCKILVVP----------------
. * .
MMAR_2790|M.marinum_M ----------------------------
MUL_2962|M.ulcerans_Agy99 ----------------------------
Rv1895|M.tuberculosis_H37Rv VHVRRCQSVADLQLEGAADGVDGPSMLN
MAV_2804|M.avium_104 ----------------------------
MSMEG_3605|M.smegmatis_MC2_155 ----------------------------
TH_4631|M.thermoresistible__bu ----------------------------
Mflv_0660|M.gilvum_PYR-GCK ----------------------------
Mvan_0490|M.vanbaalenii_PYR-1 ----------------------------
Mb1557|M.bovis_AF2122/97 ----------------------------
MLBr_01784|M.leprae_Br4923 ----------------------------
MAB_0526c|M.abscessus_ATCC_199 ----------------------------