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RIAVAGAGSIGCYVGGRLQAAGHQVVYIGRPSLGRAIAEHGLSLSDYLGWSAAIPASECAFSEDIDTVRS ADIVLVTVKSAATAQMAESLAGRLEPGAVVVSLQNGIRNPAQLSRYIKQHNVITGIVGFNVAQVGAAHFH QGTQGKLSLSTGAESLAGALTHGGLLTTVRDDMAAVQWGKLVVNLNNSVNALSGLPLKAELGDRDYRLVL AAAQREALGLLRRAGQPVVSPLAAPLSLMPWVLTMPNPIFTRAARQMVAMDPQARSSMLDDITLGRPTEI DYINGEVVELAKRLGAKAPVNAALVSLIRDVTSSHEITRWPGPKLRREINHRAAASHMLS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2908c | - | - | 100% (341) | 2-dehydropantoate 2-reductase |
| M. abscessus ATCC 19977 | MAB_3554 | - | 2e-15 | 26.37% (311) | ketopantoate reductase ApbA/PanE |
| M. abscessus ATCC 19977 | MAB_3288c | - | 2e-06 | 31.39% (137) | glycerol-3-phosphate dehydrogenase, NAD-dependent |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2603 | - | 3e-08 | 24.38% (242) | 2-dehydropantoate 2-reductase |
| M. gilvum PYR-GCK | Mflv_0533 | - | 3e-17 | 24.77% (331) | ketopantoate reductase ApbA/PanE |
| M. tuberculosis H37Rv | Rv2573 | - | 3e-08 | 24.38% (242) | 2-dehydropantoate 2-reductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_0863 | apbA | 8e-22 | 29.57% (328) | ketopantoate reductase, ApbA |
| M. avium 104 | MAV_4625 | panE | 8e-25 | 28.48% (323) | 2-dehydropantoate 2-reductase |
| M. smegmatis MC2 155 | MSMEG_2919 | - | 8e-14 | 26.83% (328) | 2-dehydropantoate 2-reductase |
| M. thermoresistible (build 8) | TH_4612 | - | 2e-14 | 27.30% (359) | PUTATIVE putative 2-dehydropantoate 2-reductase |
| M. ulcerans Agy99 | MUL_0617 | apbA | 4e-19 | 28.57% (329) | ketopantoate reductase, ApbA |
| M. vanbaalenii PYR-1 | Mvan_0557 | - | 7e-18 | 25.08% (331) | ketopantoate reductase ApbA/PanE |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2919|M.smegmatis_MC2_155 MTDTTPHPVVVYGTGAVGGVIAAQLRLGGFDVTAVA-RGDHLRAIRAGGL
TH_4612|M.thermoresistible__bu ---------VIVGSGAIGGTVGGLLARSGADVVLVA-RGAHAQALADRGL
Mb2603|M.bovis_AF2122/97 -----------MHKAGYSPLLCGHTPRAG-----IELRRDGADPIVVPGP
Rv2573|M.tuberculosis_H37Rv -----------MHKAGYSPLLCGHTPRAG-----IELRRDGADPIVVPGP
Mflv_0533|M.gilvum_PYR-GCK ------MRVLILGAGGLGSVLGGYLANIGVDVTLVG-RPAHTEAITRYGL
Mvan_0557|M.vanbaalenii_PYR-1 ------MRVLILGAGGLGSVLGGYLANIGVDVTLVG-RPAHAEAITRYGL
MMAR_0863|M.marinum_M ------MKIAIIGCGAMGSIYAARLAGAGNDVAVIDRHQPNVDQITRTGL
MUL_0617|M.ulcerans_Agy99 ------MKIAIIGCGAMGSIYAARLAGADNDVAVIDRHQPNVDQITRTGL
MAV_4625|M.avium_104 ------MKIAVIGCGAMGSIYAAKLAAAGEQVLAVDRHRPSVERINRDGL
MAB_2908c|M.abscessus_ATCC_199 ------MRIAVAGAGSIGCYVGGRLQAAGHQVVYIG-RPSLGRAIAEHGL
.. . . . : : : *
MSMEG_2919|M.smegmatis_MC2_155 KLV-TQAGERTVP-LPAAADAGEVDWSDEPVVILAVKSHQTGAAL-----
TH_4612|M.thermoresistible__bu TLR-TPDGTFEIG-VTAAADPAEVRLTSRDVLVFATKTQHLEDALHAWVD
Mb2603|M.bovis_AF2122/97 VHT-SPR----------------EVAGPVDVLILAVKATQNDAAR-----
Rv2573|M.tuberculosis_H37Rv VHT-SPR----------------EVAGPVDVLILAVKATQNDAAR-----
Mflv_0533|M.gilvum_PYR-GCK RIT-GRRGDLVITDNLTAVDQTAKATGHFDYLVLAVKGKDTAQAL-----
Mvan_0557|M.vanbaalenii_PYR-1 RIT-GRRGDLVITDNLTAVDQTAKATGHFDYLVLAVKGKDTAQAL-----
MMAR_0863|M.marinum_M RVS-GPGTDQLVS----LRAATTAPTEVMDLVVLAVKAADVAAGA-----
MUL_0617|M.ulcerans_Agy99 RVS-GPGTDQLVS----LRAATTAPTEVMDLVVLAVKAADVAAGA-----
MAV_4625|M.avium_104 RVT-GPGCDQVVP----LRASTGAVDETMDLVVLAVKAADVEAAA-----
MAB_2908c|M.abscessus_ATCC_199 SLSDYLGWSAAIPASECAFSEDIDTVRSADIVLVTVKSAATAQMA-----
::.:.*
MSMEG_2919|M.smegmatis_MC2_155 ------DDLATHAPAHTAIFAAQNGVANEMAILRRFADVYGVTVMLPAAH
TH_4612|M.thermoresistible__bu RPVHHGDTVVGTAGSTLPVLTALNGVVAEEMALRFFARVFGVCVWMPAAH
Mb2603|M.bovis_AF2122/97 ------PWLTRLCDERTVVAVLQNGVEQVEQVQPHCPSSA---VVP-AIV
Rv2573|M.tuberculosis_H37Rv ------PWLTRLCDERTVVAVLQNGVEQVEQVQPHCPSSA---VVP-AIV
Mflv_0533|M.gilvum_PYR-GCK ------AEADGLRDCVSSALSVQNTVEKDATLAGWLGPDR---VIG-AST
Mvan_0557|M.vanbaalenii_PYR-1 ------AEADGLRDCVSSALSVQNTVEKDATLARWLGPDR---VIG-AST
MMAR_0863|M.marinum_M ------RQALCMLGADTPVLTIQNGLGSAETVADIVGEQR---VAVGIAS
MUL_0617|M.ulcerans_Agy99 ------RQALCMLGADTPVLTIQNGLGSAETVADIVGEQR---VAVGIAS
MAV_4625|M.avium_104 ------RQALPMLGPDTAVLTIQNGLGSAETVAGVVGAQR---VAVGIAS
MAB_2908c|M.abscessus_ATCC_199 ------ESLAGRLEPGAVVVSLQNGIRNPAQLSRYIKQHN----VITGIV
* :
MSMEG_2919|M.smegmatis_MC2_155 LEPGVVVQQSHPLAGILDLGRYPSG-----ADAVAHDVAAMLRASQFLSE
TH_4612|M.thermoresistible__bu VVPGEVIVRSWPVAGQFHISRWPADLADAEDDRLLSDIAATWTPAGLLVA
Mb2603|M.bovis_AF2122/97 WCSAETQPQGWVRLRGEAALVVPTGP-------AAEQFAGLLRGAGATVD
Rv2573|M.tuberculosis_H37Rv WCSAETQPQGWVRLRGEAALVVPTGP-------AAEQFAGLLRGAGATVD
Mflv_0533|M.gilvum_PYR-GCK IEGGTLLEPGLVRNHLTAEVTAYFGELDGTSSARVDDLTAAFTNAGLPAK
Mvan_0557|M.vanbaalenii_PYR-1 IEGGTLLEPGLVRNHLTAEVTAYFGELDGTSSARVDDLTAAFTNAGLPAK
MMAR_0863|M.marinum_M GFGAARLAPG--HVHHNAMKAMRFGAYSSLPHETVERIAHAWTEAGFDAA
MUL_0617|M.ulcerans_Agy99 GFGAARLAPGHVHVHHNAMKAMRFGAYSSLPHETVERIAHAWTEVGFDAA
MAV_4625|M.avium_104 GFGASRVAPG--HVHHNAMRAMRFGPYSSLPHARVESIARTWAHAGFDAA
MAB_2908c|M.abscessus_ATCC_199 GFNVAQVGAAHFHQGTQGKLSLSTG---------AESLAGALTHGGLLTT
. . .:
MSMEG_2919|M.smegmatis_MC2_155 VRPDIMAWKHRKLIMNLGNGVTAI------FRPGPAADELAAQARAEAE-
TH_4612|M.thermoresistible__bu RPPDVAPWKYRKLLANLANAVVAL------TGSGRGDPVVIAAAQREGE-
Mb2603|M.bovis_AF2122/97 CDPDFTTAAWRKLLVNALAGFMVL------SGRR----SAMFRRDDVAA-
Rv2573|M.tuberculosis_H37Rv CDPDFTTAAWRKLLVNALAGFMVL------SGRR----SAMFRRDDVAA-
Mflv_0533|M.gilvum_PYR-GCK AVGNIEQVEWEKLAQIALAAAWSV------TALGAIPDASVFEGMEVREG
Mvan_0557|M.vanbaalenii_PYR-1 AVGNIEQVEWEKLAQIALAAAWSV------TALGAIPDASVFEGMEVREG
MMAR_0863|M.marinum_M AVTDIAAMQWEKLICNVAYSAP--------CALTGMTVGQVLDDAELGP-
MUL_0617|M.ulcerans_Agy99 AVTDIAAMQWEKLICNVAYSAP--------CALTGMTVGQVLDDAEMGP-
MAV_4625|M.avium_104 AVTDIAAMQWEKLICNVAYSAP--------CALTGMTVGQVMDDAEMGP-
MAB_2908c|M.abscessus_ATCC_199 VRDDMAAVQWGKLVVNLNNSVNALSGLPLKAELGDRDYRLVLAAAQREAL
:. ** .
MSMEG_2919|M.smegmatis_MC2_155 ----EVLGAAGIPVVPPEQ--------------------DTERRGRFLAG
TH_4612|M.thermoresistible__bu ----AVLRHAGIEFVPAEV--------------------EREARRHGPRD
Mb2603|M.bovis_AF2122/97 --LSRRYVAECLAVARAEG-----------------ARLDDDVVDEVVRL
Rv2573|M.tuberculosis_H37Rv --LSRRYVAECLAVARAEG-----------------ARLDDDVVDEVVRL
Mflv_0533|M.gilvum_PYR-GCK AMYFVALAKDLLGVYRAKGYEPMNFFAPLSRLKELDALPTADAIEFVIGQ
Mvan_0557|M.vanbaalenii_PYR-1 AMYFVALAKDLLGVYRAKGYEPMNFFAPLSRLKELDALPTADAIEFVIGQ
MMAR_0863|M.marinum_M --VSRAAATEAWAVARASG----------------IAVAVTDPVAHARAF
MUL_0617|M.ulcerans_Agy99 --VSRAAATEAWAVARASG----------------IAVAVTDPVAHARAF
MAV_4625|M.avium_104 --VSRAAATEAWSVARASG----------------VAIAVADAVEHVRAF
MAB_2908c|M.abscessus_ATCC_199 GLLRRAGQPVVSPLAAPLS---------------LMPWVLTMPNPIFTRA
. .
MSMEG_2919|M.smegmatis_MC2_155 R----VRDDVHGSTWQSVARGHTEVETDYFNGEIALQARLIGRSAPVNEY
TH_4612|M.thermoresistible__bu RDVADAGDVVANSTWQSLARNSGSVETDYLNGEIVRIAHRHGMTAPVNAG
Mb2603|M.bovis_AF2122/97 VRSAPQD---MGTSMLADRAAHRPLEWDLRNGVIVRKARAHGLATPISDV
Rv2573|M.tuberculosis_H37Rv VRSAPQD---MGTSMLADRAAHRPLEWDLRNGVIVRKARAHGLATPISDV
Mflv_0533|M.gilvum_PYR-GCK GRAMREKGNSGHPSMYEDVLRRRKTEVDFMLAPYLAAAQELGMDTPTLRV
Mvan_0557|M.vanbaalenii_PYR-1 GRVMREKGNLGHPSMYEDVLRRRKTEVDFMLAPYLAAAQELGMDTPTLRV
MMAR_0863|M.marinum_M GAAMPN----AKPSALLDHEARRASEIDVINGAVGRHGARVGVPTPVNTT
MUL_0617|M.ulcerans_Agy99 GAAMPN----AKPSALLDHEARRASEIDVINGAVG-------VPTPVNTT
MAV_4625|M.avium_104 GAQMPD----AKPSALLDHEARRVSEIDVINGAVPRQGARVGVDAPVNAT
MAB_2908c|M.abscessus_ATCC_199 ARQMVAMDPQARSSMLDDITLGRPTEIDYINGEVVELAKRLGAKAPVNAA
.: * * . :*
MSMEG_2919|M.smegmatis_MC2_155 LQRVTADHARHGRPP---RSLDAAEALSHITAGAAAPEHL---
TH_4612|M.thermoresistible__bu LARLARAAARDGHPPGRYSGGELAEALGLVGEALGADVMVEGR
Mb2603|M.bovis_AF2122/97 LVPLLAAASDGPG------------------------------
Rv2573|M.tuberculosis_H37Rv LVPLLAAASDGPG------------------------------
Mflv_0533|M.gilvum_PYR-GCK AYQIIKTVDRFLA------------------------------
Mvan_0557|M.vanbaalenii_PYR-1 AYQIIKTVDRFLA------------------------------
MMAR_0863|M.marinum_M LTALVKSVERQWSAVNSD-------------------------
MUL_0617|M.ulcerans_Agy99 LTALVKSVERQWSAVNSD-------------------------
MAV_4625|M.avium_104 LTAVVKSIERRWR------------------------------
MAB_2908c|M.abscessus_ATCC_199 LVSLIRDVTSSHEITRWPGPKLRREINHRAAASHMLS------
: