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MEAIVLNGTNDVGLTSVPDPAPQDGEVIIEVAATGLCGTDLHEYVAGPTFSQPPVVLGHEVSGRIVEVGA GVDQSRIGQGAAVIPMDFCGSCHYCHRSLYHLCQRPGWIGFTRNGGLANYVAVPSRLAVRVPDVVDLEEA ALTEPTAVAFHAVRRAELLLGETVMVLGAGALGLTVIQCARAAGAARIFVTEPSGVRASLARDLGATLVL DPHDPGTTACILEETRGVGVDVVFHVAGSAEAFTQGLDCLRKQGRFMEMSSWAGAASLDVNRHLLKEIQL RMVFGYDMFDDFPAVLALIADGKLALAPQITARVPLDRAVKEGLGGLLEGREGLVKVLVKP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0490 | - | - | 100% (341) | alcohol dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0527 | - | 4e-75 | 41.35% (341) | alcohol dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0788 | - | 4e-53 | 36.47% (351) | alcohol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3753 | - | 2e-22 | 27.42% (383) | putative dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0660 | - | 0.0 | 99.71% (341) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv1895 | - | 4e-32 | 32.23% (332) | dehydrogenase |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 2e-19 | 30.33% (244) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_2084 | - | 2e-27 | 30.77% (351) | zinc-type alcohol dehydrogenase AdhD |
| M. marinum M | MMAR_2790 | - | 5e-34 | 31.90% (348) | dehydrogenase |
| M. avium 104 | MAV_2804 | - | 6e-33 | 31.14% (350) | zinc-binding dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5021 | - | 1e-49 | 33.90% (351) | alcohol dehydrogenase, zinc-containing |
| M. thermoresistible (build 8) | TH_4349 | - | 1e-30 | 34.17% (240) | PUTATIVE Alcohol dehydrogenase GroES domain protein |
| M. ulcerans Agy99 | MUL_2962 | - | 1e-32 | 31.32% (348) | dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0490|M.vanbaalenii_PYR-1 ----MEAIVLNGTNDVGLTSVPD-PAPQDGEVIIEVAATGLCGTDLH---
Mflv_0660|M.gilvum_PYR-GCK ----MEAIVLNGTNDVGLTSVPD-PAPQDGEVIIEVAATGLCGTDLH---
MSMEG_5021|M.smegmatis_MC2_155 ----MKAAVYHGPNKLEIADLPE-PQPGPGTVKVKVGFNGICGTDLH---
MMAR_2790|M.marinum_M ----MRTVVIDGPGSIRVDNRPDPALPGSDGVIVAVSAAGICGSDLH---
MUL_2962|M.ulcerans_Agy99 ----MRTVVIDGPGSIRVDNRPDPALPGSDGVIVVVSAAGICGSDLH---
Rv1895|M.tuberculosis_H37Rv ----MRAVVIDGAGSVRVNTQPDPALPGPDGVVVAVTAAGICGSDLH---
MAV_2804|M.avium_104 ----MRTVVVDGPRSIRVDTRPDPVLPGPDGAIVEVSAAGICGSDLH---
TH_4349|M.thermoresistible__bu ----MKALRLMDWKSEPELVEVPDPTPGPGQVLVKIGGAGACHSDLHL-M
MAB_2084|M.abscessus_ATCC_1997 --MKTRAAVLWGLEQKWEVEEVDLDPPGPGEVLVRLAATGLCHSDEH---
MLBr_01784|M.leprae_Br4923 MSQTVRGVISRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCHTDLT---
Mb3753|M.bovis_AF2122/97 ----MKAVTCTN--AKLEVVDRPSPAPAKGQLLLDVLRCGICGSDLHARL
. * . : : * * :*
Mvan_0490|M.vanbaalenii_PYR-1 -EYVAGPTFS----------QPPVVLGHEVSGRIVEVGAGVDQS-RIGQG
Mflv_0660|M.gilvum_PYR-GCK -EYVAGPTFS----------QPPVVLGHEVSGRIVEVGAGVDQS-RIGEG
MSMEG_5021|M.smegmatis_MC2_155 -EYYAGPIFVPTEPHPLTGQVMPLTMGHEFAGTITDVGAGVTGF-APGDR
MMAR_2790|M.marinum_M --FYEGEYPLA----------EPVALGHEAVGTVVEKGPDVHTV-EVGDQ
MUL_2962|M.ulcerans_Agy99 --FYEGEYPLA----------EPVALGHEAVGTVVEKGPDVHTV-EVGDQ
Rv1895|M.tuberculosis_H37Rv --FYEGEYPFT----------EPVALGHEAVGTIVEAGPQVRTV-GVGDL
MAV_2804|M.avium_104 --FYEADFPMP----------DPIALGHEAIGTVVEAGPQVRNV-KVGDQ
TH_4349|M.thermoresistible__bu HDFEPGMMPWQ----------LPFTLGHENAGWVAAVGAGVGTV-TEGDA
MAB_2084|M.abscessus_ATCC_1997 --LVTGDLPIP----------LPVVGGHEGAGTVVECGEGVEDL-SEGDS
MLBr_01784|M.leprae_Br4923 --YREGGINDR----------YPFLLGHEAAGTVEVVGPGVTAV-EPGDF
Mb3753|M.bovis_AF2122/97 HCDELADVMAESGYHAFMRSNQQVVFGHEFCGEVVDYGPGTRRTPRRGTP
. . *** * : * . *
Mvan_0490|M.vanbaalenii_PYR-1 AAVIPMDFCGSCHYCHRSLYHLCQR---PGWIGFTR--------------
Mflv_0660|M.gilvum_PYR-GCK AAVIPMDFCGSCHYCHRSLYHLCQR---PGWIGFTR--------------
MSMEG_5021|M.smegmatis_MC2_155 VAIEPIYRCGHCAPCRAGNYNVCQQ---IGFHGLMC--------------
MMAR_2790|M.marinum_M VMVSSVAGCGACAGCATRDPAMCVS--GPQIFGSGA--------------
MUL_2962|M.ulcerans_Agy99 VMVSSVAGCGACAGCATRDPAMCVS--GPQIFGSGA--------------
Rv1895|M.tuberculosis_H37Rv VMVSSVAGCGVCPGCETHDPVMCFS--GPMIFGAGV--------------
MAV_2804|M.avium_104 VMVSSVAGCGSCAGCATRDPVLCHS--GFQIFGGGV--------------
TH_4349|M.thermoresistible__bu VAVYGPWGCGTCERCMGGAENYCENPAGAPVLSGGAG-------------
MAB_2084|M.abscessus_ATCC_1997 VILTFLPSCGRCSYCARGMGNLCELG-AALMMGPQIDGTYRFHARGEDVG
MLBr_01784|M.leprae_Br4923 VILNWRAVCGQCRACKRGRPSYCFDTFNAQQKMTLIDG--------TELT
Mb3753|M.bovis_AF2122/97 VVAMPLLRRGNKEVHGIGLSTMAPG-------------------------
. * .
Mvan_0490|M.vanbaalenii_PYR-1 ----NGGLANYVAVP--SRLAVRVPDVVD-LEEAALTEPTAVAFHAVRR-
Mflv_0660|M.gilvum_PYR-GCK ----NGGLANYVAVP--SRLAVRVPDVVD-LEEAALTEPTAVAFHAVRR-
MSMEG_5021|M.smegmatis_MC2_155 ----DGGMAEYTVVP--VDMLHKLPDNVS-LQLGALVEPMSVAYHAATL-
MMAR_2790|M.marinum_M ---LGGAQADLLAVPAADFQVLKIPAAITTEQALLLTDNLATGWAAARR-
MUL_2962|M.ulcerans_Agy99 ---LGGAQADLLAVPATDFQVLKIPAAITTEQALLLTDNLATGWAAARR-
Rv1895|M.tuberculosis_H37Rv ---LGGAQADLLAVPAADFQVLKIPEGITTEQALLLTDNLATGWAAAQR-
MAV_2804|M.avium_104 ---LGGAQADLLAVPAADFQLLKIPEGISTEQALLLTDNLATGWAAAQR-
TH_4349|M.thermoresistible__bu -LGMDGGMAEYLLVP-AERLVVKLPESMTPVTAAALTDAGLTPYHAIRRS
MAB_2084|M.abscessus_ATCC_1997 QMCLLGTFSEYTVVP--QASVVKIDGGIPLDRAALIGCGVTTGYGSAVR-
MLBr_01784|M.leprae_Br4923 PALGIGAFADKTLVH--SGQCTKVDPAADPAVAGLLGCGVMAGLGAAIN-
Mb3753|M.bovis_AF2122/97 ------AYAERLVVE--QSLTFPVPNGLA-PEIAALTEPMAVGWHAVRR-
:: * : : . :
Mvan_0490|M.vanbaalenii_PYR-1 -AELLLGETVMVLGAGALGLTVIQCARAAGAARIFVTEPSGVRASLARDL
Mflv_0660|M.gilvum_PYR-GCK -AELLLGETVMVLGAGALGLTVIQCARAAGAARIFVTEPSGVRASLARDL
MSMEG_5021|M.smegmatis_MC2_155 -GDVGAGDTAVVFGAGPIGIGLWFALRGKGLESVYVAEPSPTRRAAIEAL
MMAR_2790|M.marinum_M -ADILFGATVAVIGLGAVGLCAVRSALAQGAATVFAVDRVQGRLQRASEW
MUL_2962|M.ulcerans_Agy99 -ADIPFGATVAVIGLGAVGLCAVRSALAQGAATVFAVDRVQGRLQRAAEW
Rv1895|M.tuberculosis_H37Rv -ADISFGSAVAVIGLGAVGLCALRSAFIHGAATVFAVDRVKGRLQRAATW
MAV_2804|M.avium_104 -ADIPFGGTVAVIGLGAVGLCALRSALFQGAATVFAVDQVDGRLARAARW
TH_4349|M.thermoresistible__bu WPKLTPTSTAVVIGVGGLGHVAVQLVKATTAARLIAVDNRSEALELAREM
MAB_2084|M.abscessus_ATCC_1997 TGEVRAGDTVVVVGAGGIGMNAIQGARIAGALAIVAVDPVNFKREQASGF
MLBr_01784|M.leprae_Br4923 TAAVSRDDTVAVIGCGGVGDAAISGAALVGANRIIAVDIDDTKLEWARTF
Mb3753|M.bovis_AF2122/97 -GEVGKGDVAIVIGCGPIGLAVICMLKSRGVHTVIASDFSPGRRALATAC
: .. *.* * :* : . :
Mvan_0490|M.vanbaalenii_PYR-1 GATLVLDPHDPGTTACILEETRGV-----GVDVVFHVAGSAEA-------
Mflv_0660|M.gilvum_PYR-GCK GATLVLDPHDPGTTACILEETRGV-----GVDVVFHVAGSAEA-------
MSMEG_5021|M.smegmatis_MC2_155 G-AQTLDPTQVDVPAFIADVTGGR-----GADAAFDAAGVAPA-------
MMAR_2790|M.marinum_M GATAVASP----AAEAIVAATGGR-----GADSVIDAVGTDAS-------
MUL_2962|M.ulcerans_Agy99 GATAVASP----AAEAIVAATSGR-----GADSVIDAVDTDAS-------
Rv1895|M.tuberculosis_H37Rv GATPIPSP----AAETILAATRGR-----GADSVIDAVGTDAS-------
MAV_2804|M.avium_104 GATPLKAP----ALEAILAATGGR-----GADAVIDAVATDAS-------
TH_4349|M.thermoresistible__bu GADHVVRSDEQ-AVEAIWELTGGR-----GADVLLDFVGADAT-------
MAB_2084|M.abscessus_ATCC_1997 GATHTAAS-MDEAWSLVSDMTRGK-----LADVCILTTDVAEGSY-----
MLBr_01784|M.leprae_Br4923 GATHTVNALELEVVKTIQDLTSGF-----GVDVVIDTVGRPET-------
Mb3753|M.bovis_AF2122/97 GADSVVDPVQDSPYAVAAGLGQGNRHLQSILDAFDLAVGTVESLQRLRLP
* . * * .
Mvan_0490|M.vanbaalenii_PYR-1 ------------------------------FTQGLDCLRKQGRFMEMSSW
Mflv_0660|M.gilvum_PYR-GCK ------------------------------FTQGLDCLRKQGRFMEMSSW
MSMEG_5021|M.smegmatis_MC2_155 ------------------------------IEAATASVGSRRPTISVAIY
MMAR_2790|M.marinum_M ------------------------------MTDALNAVRAGGTVSVVGVH
MUL_2962|M.ulcerans_Agy99 ------------------------------MTDALNAVRAGGTVSVVGVH
Rv1895|M.tuberculosis_H37Rv ------------------------------MSDALNAVRPGGTVSVVGVH
MAV_2804|M.avium_104 ------------------------------LTEALNAVRPGGTVSVVGVH
TH_4349|M.thermoresistible__bu ------------------------------IELARAAARPLGDVTIVGIA
MAB_2084|M.abscessus_ATCC_1997 ------------------------------TAEALALVGKRGRVVVTAIG
MLBr_01784|M.leprae_Br4923 ------------------------------WKQAFYARDLAGTVVLVGVP
Mb3753|M.bovis_AF2122/97 WWHLWRAAEAAGAATPKRPVIFECVGVPGIIDGIIASAPLFSRVVVVGVC
.
Mvan_0490|M.vanbaalenii_PYR-1 AGAASLDVNRHLLKEIQLRMVF-----GYDMFDDFPAVLALIADGKLALA
Mflv_0660|M.gilvum_PYR-GCK AGAASLDVNRHLLKEIQLRMVF-----GYDMFDDFPAVLALIADGKLALA
MSMEG_5021|M.smegmatis_MC2_155 EKPLTTPLLNLVMNESRIQGSL-----CYTS-ADFEAVIALMADGVYDTT
MMAR_2790|M.marinum_M DLQPFPLPALTCLLRSITLRLT-----IAPVQRTWSELIPLLESGRLDVD
MUL_2962|M.ulcerans_Agy99 DLQPFPLPALTCLLRSITLRLT-----IAPVQRTWSELIPLLESGRLDVD
Rv1895|M.tuberculosis_H37Rv DLQPFPVPALTCLLRSITLRMT-----MAPVQRTWPELIPLLQSGRLDVD
MAV_2804|M.avium_104 DMNPFPLNALGCLIRSITLRMT-----TAPVQRTWPELIPLLQSGRLDVD
TH_4349|M.thermoresistible__bu GGS----VPLSFFSQPYEVSIQ-----TTYWG-TRPELVELLDLAARGLV
MAB_2084|M.abscessus_ATCC_1997 HPDESSISGSLLEMTLYEKQIRGALYGSSNAPHDIPRLVELYSAGLLKLD
MLBr_01784|M.leprae_Br4923 TPDMRLDMPLLDFFSHGGSLKSSWYG-DCLPERDFPTLVDLYLQGRLPLG
Mb3753|M.bovis_AF2122/97 MGSDHIRPAMAINKEINLRFVLG------YTPLEFRDTLHMLADGKVNAA
: : .
Mvan_0490|M.vanbaalenii_PYR-1 PQITARVPLDRAVKEGLGGLLEGREGLVKVLVKP----------------
Mflv_0660|M.gilvum_PYR-GCK PQITARVPLDRAVKEGLGGLLEGREGLVKVLVKP----------------
MSMEG_5021|M.smegmatis_MC2_155 GWVTT-IGIDDVIDEGFEALHAGRK--MKVLIDPAI--------------
MMAR_2790|M.marinum_M GIFTTSLPLDEAAKG-YSIAGSRSGNDVKVLLKV----------------
MUL_2962|M.ulcerans_Agy99 GIFTTSLPLDEAAKG-YSIAGSRSGNDVKVLLKV----------------
Rv1895|M.tuberculosis_H37Rv GIFTTTLPLDEAAKG-YATARARSGEELRFCLRPDSRDVLGAHETVDLYV
MAV_2804|M.avium_104 GIFTTTMPLDEAAIG-YATAGSRSGDDVKILLKP----------------
TH_4349|M.thermoresistible__bu HVESTTYPLDDALQA-YRDLRAGRVRGRAVIVP-----------------
MAB_2084|M.abscessus_ATCC_1997 ELVTREYSLDQINEG-YQDMRSGRNIRGLVRF------------------
MLBr_01784|M.leprae_Br4923 KFVSERIGLGDVEEA-FHKIHGGKVLRSVVML------------------
Mb3753|M.bovis_AF2122/97 PLITGTVGLPGVAAA--FDALGDPEAHAKIMIDPKSNAASPQPFRVE---
: : . .
Mvan_0490|M.vanbaalenii_PYR-1 ---------------------------
Mflv_0660|M.gilvum_PYR-GCK ---------------------------
MSMEG_5021|M.smegmatis_MC2_155 ---------------------------
MMAR_2790|M.marinum_M ---------------------------
MUL_2962|M.ulcerans_Agy99 ---------------------------
Rv1895|M.tuberculosis_H37Rv HVRRCQSVADLQLEGAADGVDGPSMLN
MAV_2804|M.avium_104 ---------------------------
TH_4349|M.thermoresistible__bu ---------------------------
MAB_2084|M.abscessus_ATCC_1997 ---------------------------
MLBr_01784|M.leprae_Br4923 ---------------------------
Mb3753|M.bovis_AF2122/97 ---------------------------